Wilson disease at a single cell level: Intracellular copper trafficking activates compartment-specific responses in hepatocytes

Journal of Biological Chemistry

Volumn 285, Issue 40, 2010, Pages 30875-30883

  Ralle, Martina ^a   Huster, Dominik ^b,c   Vogt, Stefan ^d   Schirrmeister, Wiebke ^c   Burkhead, Jason L ^a   Capps, Tony R ^a   Gray, Lawrence ^f   Lai, Barry ^d   Maryon, Edward ^e   Lutsenko, Svetlana ^f  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

^d ARGONNE NATIONAL LABORATORY   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^f JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; COPPER; DEPOSITS; ENZYME ACTIVITY; FLUORESCENCE; LAWS AND LEGISLATION; METABOLISM; SIZE DISTRIBUTION; SYNCHROTRONS;

COPPER CONCENTRATION; COPPER DISTRIBUTION; DOWN-REGULATION; DYNAMIC ROLES; EXTRACELLULAR; HEPATOCYTES; HIGH RESOLUTION; IN-SITU; LIPID METABOLISMS; METABOLIC PATHWAYS; NEUROLOGIC DISORDERS; PLASMA MEMBRANES; SINGLE-CELL LEVEL; SUB-CELLULAR; TEMPORAL AND SPATIAL DISTRIBUTION; TIME-DEPENDENT; TRANSCRIPTOMES; WILSON DISEASE; X-RAY FLUORESCENCE IMAGING;

COPPER DEPOSITS;

CELL MEMBRANE PROTEIN; COPPER; LIPID; MESSENGER RNA; PROTEIN CTR1; TRANSCRIPTOME; UNCLASSIFIED DRUG; WILSON DISEASE PROTEIN; ADENOSINE TRIPHOSPHATASE; ATP7A PROTEIN, MOUSE; BIOLOGICAL MARKER; CATION TRANSPORT PROTEIN; CTR1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL NUCLEUS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR SPACE; INTRACELLULAR TRANSPORT; LIPID METABOLISM; LIVER CELL; LYMPHOCYTE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN LOCALIZATION; UPREGULATION; WILSON DISEASE; X RAY FLUORESCENCE; ADULT; ANIMAL; CELL MEMBRANE; CHILD; DISEASE MODEL; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PRESCHOOL CHILD;

ADENOSINE TRIPHOSPHATASES; ADULT; ANIMALS; BIOLOGICAL MARKERS; CATION TRANSPORT PROTEINS; CELL MEMBRANE; CHILD; CHILD, PRESCHOOL; COPPER; DISEASE MODELS, ANIMAL; HEPATOCYTES; HEPATOLENTICULAR DEGENERATION; HUMANS; LIPID METABOLISM; LYMPHOCYTES; MICE; MICE, KNOCKOUT;

EID: 77957261427     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.114447     Document Type: Article

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