Major role of cathepsin L for producing the peptide hormones ACTH, β-endorphin, and α-MSH, illustrated by protease gene knockout and expression

Journal of Biological Chemistry

Volumn 283, Issue 51, 2008, Pages 35652-35659

  Funkelstein, Lydiane ^a   Toneff, Thomas ^a   Mosier, Charles ^a   Hwang, Shin Rong ^a   Beuschlein, Felix ^c,d   Lichtenauer, Urs D ^c   Reinheckel, Thomas ^c   Peters, Christoph ^c   Hook, Vivian ^a,b,e  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; ENDOCRINOLOGY; PEPTIDES;

ADRENOCORTICOTROPIC HORMONES; GENE KNOCKOUTS; IMMUNOFLUORESCENCE MICROSCOPIES; KNOCKOUT MOUSE; PEPTIDE HORMONES; PROTEOLYTIC ENZYMES; PROTEOLYTIC PROCESSING; REDUCED PRODUCTIONS; SECRETORY PATHWAYS; SECRETORY VESICLES; SPECIFIC INHIBITORS; STIMULATING HORMONES;

HORMONES;

ALPHA INTERMEDIN; BETA ENDORPHIN; CATHEPSIN L; CORTICOTROPIN; PROOPIOMELANOCORTIN; PROTEINASE;

ADENOHYPOPHYSIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HORMONE SYNTHESIS; IMMUNOFLUORESCENCE MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SECRETORY VESICLE;

ADRENOCORTICOTROPIC HORMONE; ALPHA-MSH; ANIMALS; BETA-ENDORPHIN; CATHEPSINS; CATTLE; CYSTEINE ENDOPEPTIDASES; GENE EXPRESSION; LYSOSOMES; MICE; MICE, KNOCKOUT; PITUITARY GLAND; PRO-OPIOMELANOCORTIN; SECRETORY VESICLES;

MUS;

EID: 58149101263     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709010200     Document Type: Article

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