Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals

Clinical Pharmacokinetics

Volumn 55, Issue 12, 2016, Pages 1573-1589

  Schlender, Jan Frederik ^a,b   Meyer, Michaela ^b   Thelen, Kirstin ^b   Krauss, Markus ^b   Willmann, Stefan ^b   Eissing, Thomas ^b   Jaehde, Ulrich ^a  

^a UNIVERSITY OF BONN   (Germany)

^b BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FUROSEMIDE; MORPHINE;

ADULT; AGED; AGING; ANTHROPOMETRIC PARAMETERS; ARTICLE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; ELIMINATION HALF-LIFE; FEMALE; GERIATRIC PATIENT; GLOMERULUS FILTRATION RATE; GROUPS BY AGE; HEART OUTPUT; HUMAN; KIDNEY BLOOD FLOW; KIDNEY MASS; LIVER BLOOD FLOW; LIVER WEIGHT; MALE; PHARMACEUTICAL CARE; PHARMACODYNAMICS; PRIORITY JOURNAL; SIMULATION; SOFTWARE; SPLANCHNIC BLOOD FLOW; TOTAL BODY WATER; TREATMENT RESPONSE; VOLUME OF DISTRIBUTION AT STEADY-STATE; BIOLOGICAL MODEL; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG ADMINISTRATION ROUTE; HEMODYNAMICS; METABOLISM; MORPHOMETRY; ORGAN SIZE; PHARMACOKINETICS; PHYSIOLOGY; SKELETAL MUSCLE;

AGING; BODY WEIGHTS AND MEASURES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG ADMINISTRATION SCHEDULE; FUROSEMIDE; HEMODYNAMICS; HUMANS; MODELS, BIOLOGICAL; MORPHINE; MUSCLE, SKELETAL; ORGAN SIZE; PHARMACOKINETICS;

EID: 84976433830     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-016-0422-3     Document Type: Article

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