The pharmacokinetics of morphine and morphine glucuronide metabolites after subcutaneous bolus injection and subcutaneous infusion of morphine

British Journal of Clinical Pharmacology

Volumn 49, Issue 3, 2000, Pages 207-214

  Stuart Harris, R ^a,c   Joel, S P ^b   McDonald, P ^a   Currow, D ^a   Slevin, M L ^b  

^a WESTMEAD HOSPITAL   (Australia)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c CANBERRA HOSPITAL   (Australia)

Author keywords

Infusion; Morphine; Morphine 3 glucuronide (M3G); Morphine 6 glucuronide (M6G); Pharmacokinetics; Subcutaneous

Indexed keywords

MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; BOLUS INJECTION; CLINICAL TRIAL; CONCENTRATION LOSS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DROWSINESS; DRUG ADSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG INFUSION; DRUG STABILITY; FEMALE; HUMAN; HUMAN EXPERIMENT; INJECTION PAIN; MALE; NAUSEA; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VOMITING;

ADULT; ANALGESICS, OPIOID; DRUG STABILITY; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MALE; MORPHINE; MORPHINE DERIVATIVES;

EID: 0034098105     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00141.x     Document Type: Article

References (27)

1. 1 World Health Organization. Cancer pain relief program. WHO, Geneva, Switzerland 1986.
2. 2 McDonald P, Graham P, Clayton M, Buhagiar A, Stuart-Harris R. Regular subcutaneous bolus morphine via an indwelling cannula for pain from advanced cancer. Pall Med 1991; 5: 323-329.
3. 3 Yoshimura H, Ida S, Oguri K, Tsukamoto H. Biochemical basis for analgesic activity of morphine-6-glucuronide. I. Penetration of morphine-6-glucuronide in the brain of rats. Biochem Pharmacol 1973; 22: 1423-1430.
4. 4 Abbott FV, Palmour RM. Morphine-6-glucuronide: analgesic effects and receptor binding profile in rats. Life Sci 1988; 43: 1685-1695.
5. 5 Osborne R, Thompson P, Joel S, Trew D, Patel N, Slevin M. The analgesic effects of morphine-6-glucuronide. Br J Clin Pharmacol 1992; 34: 130-138.
6. 6 Peat SJ, Hanna MH, Woodham M, Knibb AA, Ponte J. Morphine-6-glucuronide: effects on ventilation in normal volunteers. Pain 1991; 45: 101-104.
7. 7 Thompson PI, Joel SP, John L, Wedzicha JA, Maclean M, Slevin ML. Respiratory depression following morphine and morphine-6-glucuronide in normal subjects. Br J Clin Pharmacol 1995; 40: 145-152.
8. 8 Pasternak GW, Bodnar RJ, Clark JA, Inturrisi CE. Morphine-6-glucuronide, a potent mu agonist. Life Sci 1987; 41: 2845-2849.
9. 9 Shimomura K, Katama O, Ueki S, Ida S, Oguri K. Analgesic effect of morphine glucuronides. Tohoku J Exp Med 1971; 105: 45-52.
10. 10 Gong QL, Hedner J, Bjorkman Hedner T. Morphine-3-glucuronide may functionally antagonize morphine-6-glucuronide induced antinociception and ventilatory depression in the rat. Pain 1992; 48: 249-255.
11. 11 Smith MT, Watt JA, Cramond T. Morphine-3-glucuronide - a potent antagonist of morphine analgesia. Life Sci 1990; 47: 579-585.
12. 12 Osborne R, Joel S, Trew D, Slevin M. Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide. Pharmacol Ther 1990; 47: 12-19.
13. 13 Joel SP, Osborne R, Slevin M. An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites. J Chromatogr 1988; 430: 394-399.
14. 14 Johnston A, Woollard RC. STRIPE. an interactive computer program for the analysis of drug pharmacokinetics. J Pharmacol Methods 1983; 9: 193-199.
15. 15 Pabst G, Jaeger H. Review of methods and criteria for the evaluation of bioequivalence studies. Eur J Clin Pharmacol 1990; 38: 5-10.
16. 16 Peterson GM, Randall CT, Paterson J. Plasma levels of morphine and morphine glucuronides in the treatment of cancer pain: relationship to renal function and route of administration. Eur J Clin Pharmacol 1990; 38: 121-124.
17. 17 Breda M, Bianchi M, Ripamonti C, Zecca E, Ventafridda V, Panerai AE. Plasma morphine and morphine-6-glucuronide patterns in cancer patients after oral, subcutaneous, sublabial and rectal short-term administration. Int J Clin Pharmacol Res 1991; 11: 93-97.
18. 18 Wolff T, Samuelsson H, Hedner T. Concentrations of morphine and morphine metabolites in CSF and plasma during continuous subcutaneous morphine administration in cancer pain patients. Pain 1996; 68: 209-216.
19. 19 Ashby M, Fleming B, Wood M, Somogyi A. Plasma morphine and glucuronide (M3G and M6G) concentrations in hospice inpatients. J Pain Symptom Manage 1997; 14: 157-167.
20. 20 Vermeire A, Remon JP, Rosseel MT, Belpaire F, Devulder J, Bogaert MG. Variability of morphine disposition during long-term subcutaneous infusion in terminally ill cancer patients. Eur J Clin Pharmacol 1998; 53: 325-330.
21. 21 Sawe J, Odar-Cederlof I. Kinetics of morphine in patients with renal failure. Eur J Clin Pharmacol 1987; 32: 377-382.
22. 22 Bruera E, Fainsinger R, Spachynski K, Babul N, Harsanyi Z, Darke AC. Steady-state pharmacokinetic evaluation of a novel, controlled-release morphine suppository and subcutaneous morphine in cancer pain. J Clin Pharmacol 1995; 35: 666-672.
23. 23 Moulin DE, Kreeft JH, Murray-Parsons N, Bouquillon AI. Comparison of continuous subcutaneous and intravenous morphine infusions for the management of cancer pain. Lancet 1991; 337: 465-468.
24. 24 Waldmann CS, Eason JR, Rambohul E, Hanson GC. Serum morphine levels. A comparison between continuous subcutaneous and continuous intravenous infusion in postoperative patients. Anaesthesia 1984; 39: 768-771.
25. 25 Bray RJ, Davies PA, Seviour JA. The stability of preservative-free morphine in plastic syringes. Anaesthesia 1986; 41: 294-295.
26. 26 Strong ML, Scaaf LJ, Pankaskie MC, Robinson DH. Shelf-lives and factors affecting the stability of morphine sulphate and meperidine (pethidine) hydrochloride in plastic syringes for use in patient-controlled analgesic devices. J Clin Pharm Ther 1994; 19: 361-369.
27. 27 Roos PJ, Glerum JH, Meilink JW. Stability of morphine hydrochloride in a portable pump reservoir. Pharm Weekbl Sci 1992; 14: 23-26.