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Volumn 21, Issue 6, 2016, Pages

Trans-fatty acids aggravate obesity, insulin resistance and hepatic steatosis in C57BL/6 mice, possibly by suppressing the IRS1 dependent pathway

Author keywords

Hepatic steatosis; Insulin resistance; Obesity; Trans fatty acid

Indexed keywords

INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; LIPID; TRANS FATTY ACID;

EID: 84976406883     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules21060705     Document Type: Article
Times cited : (29)

References (36)
  • 3
    • 84898549329 scopus 로고    scopus 로고
    • The effects of changing dairy intake on trans and saturated fatty acid levels - Results from a randomized controlled study
    • Benatar, J.R.; Stewart, R.A. The effects of changing dairy intake on trans and saturated fatty acid levels - Results from a randomized controlled study. Nutr. J. 2014, 13.
    • (2014) Nutr. J , vol.13
    • Benatar, J.R.1    Stewart, R.A.2
  • 4
    • 80053175486 scopus 로고    scopus 로고
    • The intake of high fat diet with different trans fatty acid levels differentially induces oxidative stress and nonalcoholic fatty liver disease (NAFLD) in rats
    • Dhibi, M.; Brahmi, F.; Mnari, A.; Houas, Z.; Chargui, I.; Bchir, L.; Gazzah, N.; Alsaif, M.A.; Hammami, M. The intake of high fat diet with different trans fatty acid levels differentially induces oxidative stress and nonalcoholic fatty liver disease (NAFLD) in rats. Nutr. Metab. (Lond.) 2011, 8.
    • (2011) Nutr. Metab. (Lond.) , vol.8
    • Dhibi, M.1    Brahmi, F.2    Mnari, A.3    Houas, Z.4    Chargui, I.5    Bchir, L.6    Gazzah, N.7    Alsaif, M.A.8    Hammami, M.9
  • 7
    • 77951632831 scopus 로고    scopus 로고
    • Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
    • Rector, R.S.; Thyfault, J.P.; Uptergrove, G.M.; Morris, E.M.; Naples, S.P.; Borengasser, S.J.; Mikus, C.R.; Laye, M.J.; Laughlin, M.H.; Booth, F.W.; et al. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J. Hepatol. 2010, 52, 727-736.
    • (2010) J. Hepatol. , vol.52 , pp. 727-736
    • Rector, R.S.1    Thyfault, J.P.2    Uptergrove, G.M.3    Morris, E.M.4    Naples, S.P.5    Borengasser, S.J.6    Mikus, C.R.7    Laye, M.J.8    Laughlin, M.H.9    Booth, F.W.10
  • 10
    • 33644764922 scopus 로고    scopus 로고
    • Adipose triglyceride lipase: Function, regulation by insulin, and comparison with adiponutrin
    • Kershaw, E.E.; Hamm, J.K.; Verhagen, L.A.; Peroni, O.; Katic, M.; Flier, J.S. Adipose triglyceride lipase: Function, regulation by insulin, and comparison with adiponutrin. Diabetes 2006, 55, 148-157.
    • (2006) Diabetes , vol.55 , pp. 148-157
    • Kershaw, E.E.1    Hamm, J.K.2    Verhagen, L.A.3    Peroni, O.4    Katic, M.5    Flier, J.S.6
  • 14
    • 63249101983 scopus 로고    scopus 로고
    • Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues
    • Wang, H.; Knaub, L.A.; Jensen, D.R.; Young, J.D.; Hong, E.G.; Ko, H.J.; Coates, A.M.; Goldberg, I.J.; de la Houssaye, B.A.; Janssen, R.C.; et al. Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues. Diabetes 2009, 58, 116-124.
    • (2009) Diabetes , vol.58 , pp. 116-124
    • Wang, H.1    Knaub, L.A.2    Jensen, D.R.3    Young, J.D.4    Hong, E.G.5    Ko, H.J.6    Coates, A.M.7    Goldberg, I.J.8    De La Houssaye, B.A.9    Janssen, R.C.10
  • 16
    • 0026708888 scopus 로고
    • Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity
    • Groop, L.C.; Bonadonna, R.C.; Simonson, D.C.; Petrides, A.S.; Shank, M.; DeFronzo, R.A. Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity. Am. J. Physiol. 1992, 263, E79-E84.
    • (1992) Am. J. Physiol. , vol.263 , pp. E79-E84
    • Groop, L.C.1    Bonadonna, R.C.2    Simonson, D.C.3    Petrides, A.S.4    Shank, M.5    DeFronzo, R.A.6
  • 17
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn, S.E.; Hull, R.L.; Utzschneider, K.M. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006, 444, 840-846.
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 18
    • 34249650125 scopus 로고    scopus 로고
    • Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences
    • Leclercq, I.A.; Da, S.M.A.; Schroyen, B.; Van Hul, N.; Geerts, A. Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J. Hepatol. 2007, 47, 142-156.
    • (2007) J. Hepatol. , vol.47 , pp. 142-156
    • Leclercq, I.A.1    Da, S.M.A.2    Schroyen, B.3    Van Hul, N.4    Geerts, A.5
  • 21
    • 29044447292 scopus 로고    scopus 로고
    • Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver
    • Boden, G.; She, P.; Mozzoli, M.; Cheung, P.; Gumireddy, K.; Reddy, P.; Xiang, X.; Luo, Z.; Ruderman, N. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes 2005, 54, 3458-3465.
    • (2005) Diabetes , vol.54 , pp. 3458-3465
    • Boden, G.1    She, P.2    Mozzoli, M.3    Cheung, P.4    Gumireddy, K.5    Reddy, P.6    Xiang, X.7    Luo, Z.8    Ruderman, N.9
  • 23
    • 77952907602 scopus 로고    scopus 로고
    • High-saturated-fat diet induces gestational diabetes and placental vasculopathy in C57BL/6 mice
    • Liang, C.; DeCourcy, K.; Prater, M.R. High-saturated-fat diet induces gestational diabetes and placental vasculopathy in C57BL/6 mice. Metabolism 2010, 59, 943-950.
    • (2010) Metabolism , vol.59 , pp. 943-950
    • Liang, C.1    DeCourcy, K.2    Prater, M.R.3
  • 24
    • 84901819130 scopus 로고    scopus 로고
    • Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice
    • Fan, S.; Zhang, Y.; Sun, Q.; Yu, L.; Li, M.; Zheng, B.; Wu, X.; Yang, B.; Li, Y.; Huang, C. Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice. J. Nutr. Biochem. 2014, 25, 702-709.
    • (2014) J. Nutr. Biochem. , vol.25 , pp. 702-709
    • Fan, S.1    Zhang, Y.2    Sun, Q.3    Yu, L.4    Li, M.5    Zheng, B.6    Wu, X.7    Yang, B.8    Li, Y.9    Huang, C.10
  • 25
    • 84900345833 scopus 로고    scopus 로고
    • Dissociation of hepatic insulin resistance from susceptibility of nonalcoholic fatty liver disease induced by a high-fat and high-carbohydrate diet in mice
    • Asai, A.; Chou, P.M.; Bu, H.F.; Wang, X.; Rao, M.S.; Jiang, A.; DiDonato, C.J.; Tan, X.D. Dissociation of hepatic insulin resistance from susceptibility of nonalcoholic fatty liver disease induced by a high-fat and high-carbohydrate diet in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2014, 306, G496-G504.
    • (2014) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.306 , pp. G496-G504
    • Asai, A.1    Chou, P.M.2    Bu, H.F.3    Wang, X.4    Rao, M.S.5    Jiang, A.6    DiDonato, C.J.7    Tan, X.D.8
  • 26
    • 84865553250 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism
    • Musso, G.; Cassader, M.; De Michieli, F.; Rosina, F.; Orlandi, F.; Gambino, R. Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. Hepatology 2012, 56, 933-942.
    • (2012) Hepatology , vol.56 , pp. 933-942
    • Musso, G.1    Cassader, M.2    De Michieli, F.3    Rosina, F.4    Orlandi, F.5    Gambino, R.6
  • 30
    • 79551495757 scopus 로고    scopus 로고
    • Role of cardiac steatosis and lipotoxicity in obesity cardiomyopathy
    • Zhang, Y.; Ren, J. Role of cardiac steatosis and lipotoxicity in obesity cardiomyopathy. Hypertension 2011, 57, 148-150.
    • (2011) Hypertension , vol.57 , pp. 148-150
    • Zhang, Y.1    Ren, J.2
  • 31
    • 84885418610 scopus 로고    scopus 로고
    • Dietary trans fats enhance doxorubicin-induced cardiotoxicity in mice
    • Mong, M.; Hsia, T.; Yin, M. Dietary trans fats enhance doxorubicin-induced cardiotoxicity in mice. J. Food Sci. 2013, 78, 1621-1628.
    • (2013) J. Food Sci. , vol.78 , pp. 1621-1628
    • Mong, M.1    Hsia, T.2    Yin, M.3
  • 34
    • 84880319364 scopus 로고    scopus 로고
    • Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: Role of autophagy
    • Xu, X.; Hueckstaedt, L.K.; Ren, J. Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: Role of autophagy. J. Hepatol. 2013, 59, 308-317.
    • (2013) J. Hepatol. , vol.59 , pp. 308-317
    • Xu, X.1    Hueckstaedt, L.K.2    Ren, J.3
  • 36
    • 84919787413 scopus 로고    scopus 로고
    • Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway
    • Shen, C.; Wang, C.; Fan, F.; Yang, Z.; Cao, Q.; Liu, X.; Sun, X.; Zhao, X.; Wang, P.; Ma, X.; et al. Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway. Biochim. Biophys. Acta 2015, 1852, 310-318.
    • (2015) Biochim. Biophys. Acta , vol.1852 , pp. 310-318
    • Shen, C.1    Wang, C.2    Fan, F.3    Yang, Z.4    Cao, Q.5    Liu, X.6    Sun, X.7    Zhao, X.8    Wang, P.9    Ma, X.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.