Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: Role of autophagy

Journal of Hepatology

Volumn 59, Issue 2, 2013, Pages 308-317

  Xu, Xihui ^a   Hueckstaedt, Lindsay K ^a   Ren, Jun ^a  

^a UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

Author keywords

Aging; Autophagy; FFA; Hepatocyte; HepG2; IGF 1 LID

Indexed keywords

3 METHYLADENINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FATTY ACID; LIPOFUSCIN; SMALL INTERFERING RNA; SOMATOMEDIN C; TRIACYLGLYCEROL;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BLOOD SAMPLING; CELL AGING; CELL DAMAGE; CELL STRUCTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER FIBROSIS; LIVER FUNCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; STEATOSIS; SURVIVAL;

3-MA; 3-METHYLADENINE; 5-DODECANOYLAMINOFLUORESCEIN DI-Β-D-GALACTOPYRANOSIDE; AGING; AUTOPHAGY; BAF A1; BAFILOMYCIN A1; C(12)FDG; CDK; CYCLIN-DEPENDENT KINASE; DMEM; DULBECCO'S MODIFIED EAGLE'S MEDIUM; FBS; FETAL BOVINE SERUM; FFA; FREE FATTY ACID; GH; GROWTH HORMONE; HEPATOCYTE; HEPG2; IGF-1; INSULIN-LIKE GROWTH FACTOR-1; LI; LID; LIVER; LIVER IGF-1 DEFICIENCY; MAMMALIAN TARGET OF RAPAMYCIN; MTOR; PA; PALMITIC ACID; WILD TYPE; WT;

AGING; ANIMALS; AUTOPHAGY; CELL AGING; CELL NUCLEUS; ENDOPLASMIC RETICULUM STRESS; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; HEP G2 CELLS; HEPATOCYTES; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LIPOFUSCIN; LIVER; LIVER CIRRHOSIS; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 84880319364     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.03.037     Document Type: Article

References (56)

1. K.M. Mak, A.J. Kwong, E. Chu, and N.M. Hoo Hepatic steatosis, fibrosis, and cancer in elderly cadavers Anat Rec (Hoboken) 295 2012 40 50
2. J.L. Kuk, T.J. Saunders, L.E. Davidson, and R. Ross Age-related changes in total and regional fat distribution Ageing Res Rev 8 2009 339 348
3. M.D. Chipchase, M. O'Neill, and D.W. Melton Characterization of premature liver polyploidy in DNA repair (Ercc1)-deficient mice Hepatology 38 2003 958 966
4. J. Jin, G.L. Wang, P. Iakova, X. Shi, S. Haefliger, and M. Finegold Epigenetic changes play critical role in age-associated dysfunctions of the liver Aging Cell 9 2010 895 910
5. S. Elis, Y. Wu, H.W. Courtland, H. Sun, C.J. Rosen, and M.L. Adamo Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression Aging Cell 10 2011 547 550
6. J. Svensson, K. Sjogren, J. Faldt, N. Andersson, O. Isaksson, and J.O. Jansson Liver-derived IGF-I regulates mean life span in mice PLoS One 6 2011 e22640
7. H. Ooka, S. Fujita, and E. Yoshimoto Pituitary-thyroid activity and longevity in neonatally thyroxine-treated rats Mech Ageing Dev 22 1983 113 120
8. H. Ooka, and T. Shinkai Effects of chronic hyperthyroidism on the lifespan of the rat Mech Ageing Dev 33 1986 275 282
9. S.J. Hauck, and A. Bartke Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase Free Radic Biol Med 28 2000 970 978
10. C. Kenyon, J. Chang, E. Gensch, A. Rudner, and R. Tabtiang A C. elegans mutant that lives twice as long as wild type Nature 366 1993 461 464
11. M. Tatar, A. Bartke, and A. Antebi The endocrine regulation of aging by insulin-like signals Science 299 2003 1346 1351
12. M. Tatar, A. Kopelman, D. Epstein, M.P. Tu, C.M. Yin, and R.S. Garofalo A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function Science 292 2001 107 110
13. C. Selman, S. Lingard, A.I. Choudhury, R.L. Batterham, M. Claret, and M. Clements Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice FASEB J 22 2008 807 818
14. A. Taguchi, L.M. Wartschow, and M.F. White Brain IRS2 signaling coordinates life span and nutrient homeostasis Science 317 2007 369 372
15. M. Holzenberger, J. Dupont, B. Ducos, P. Leneuve, A. Geloen, and P.C. Even IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice Nature 421 2003 182 187
16. Q. Li, A.F. Ceylan-Isik, J. Li, and J. Ren Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction Rejuvenation Res 11 2008 725 733
17. R.C. Wang, and B. Levine Autophagy in cellular growth control FEBS Lett 584 2010 1417 1426
18. H. Su, F. Li, M.J. Ranek, N. Wei, and X. Wang COP9 signalosome regulates autophagosome maturation Circulation 124 2011 2117 2128
19. J.S. Pattison, H. Osinska, and J. Robbins Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes Circ Res 109 2011 151 160
20. N. Mizushima, B. Levine, A.M. Cuervo, and D.J. Klionsky Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075
21. F. Madeo, N. Tavernarakis, and G. Kroemer Can autophagy promote longevity? Nat Cell Biol 12 2010 842 846
22. E. Morselli, M.C. Maiuri, M. Markaki, E. Megalou, A. Pasparaki, and K. Palikaras The life span-prolonging effect of sirtuin-1 is mediated by autophagy Autophagy 6 2010 186 188
23. Y. Hua, Y. Zhang, A.F. Ceylan-Isik, L.E. Wold, J.M. Nunn, and J. Ren Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy Basic Res Cardiol 106 2011 1173 1191
24. C. Zhang, and A.M. Cuervo Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function Nat Med 14 2008 959 965
25. A. Bitto, C. Lerner, C. Torres, M. Roell, M. Malaguti, and V. Perez Long-term IGF-I exposure decreases autophagy and cell viability PLoS One 5 2010 e12592
26. A.J. Levine, Z. Feng, T.W. Mak, H. You, and S. Jin Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways Genes Dev 20 2006 267 275
27. S. Yakar, J.L. Liu, B. Stannard, A. Butler, D. Accili, and B. Sauer Normal growth and development in the absence of hepatic insulin-like growth factor I Proc Natl Acad Sci U S A 96 1999 7324 7329
28. Y. Hua, Y. Zhang, and J. Ren IGF-1 deficiency resists cardiac hypertrophy and myocardial contractile dysfunction: role of microRNA-1 and microRNA-133a J Cell Mol Med 16 2012 83 95
29. Y. Li, S. Xu, M.M. Mihaylova, B. Zheng, X. Hou, and B. Jiang AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice Cell Metab 13 2011 376 388
30. S. Kobayashi, P. Volden, D. Timm, K. Mao, X. Xu, and Q. Liang Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death J Biol Chem 285 2010 793 804
31. F. Debacq-Chainiaux, T. Pascal, E. Boilan, C. Bastin, E. Bauwens, and O. Toussaint Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts Free Radic Biol Med 44 2008 1817 1832
32. R. Skoien, E.E. Powell, M. Melino, A.D. Clouston, B.G. Gabrielli, and J.R. Jonsson Fatty acids induce hepatocyte senescence in vitro: implications for pathogenesis in non-alcoholic steatohepatitis J Gastroenterol Hepatol 25 2010 A13 A14 [ERA 2012 Listed] [ERA 2010 Rank B]
33. F. Debacq-Chainiaux, J.D. Erusalimsky, J. Campisi, and O. Toussaint Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo Nat Protoc 4 2009 1798 1806
34. W. Ge, R. Guo, and J. Ren AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol Free Radic Biol Med 51 2011 1736 1748
35. K. Shinmura, K. Tamaki, M. Sano, M. Murata, H. Yamakawa, and H. Ishida Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging J Mol Cell Cardiol 50 2011 117 127
36. Y. Hua, M.R. Kandadi, M. Zhu, J. Ren, and N. Sreejayan Tauroursodeoxycholic acid attenuates lipid accumulation in endoplasmic reticulum-stressed macrophages J Cardiovasc Pharmacol 55 2010 49 55
37. N. Gagliano, B. Arosio, F. Grizzi, S. Masson, J. Tagliabue, and N. Dioguardi Reduced collagenolytic activity of matrix metalloproteinases and development of liver fibrosis in the aging rat Mech Ageing Dev 123 2002 413 425
38. M.D. McGee, D. Weber, N. Day, C. Vitelli, D. Crippen, and L.A. Herndon Loss of intestinal nuclei and intestinal integrity in aging C. elegans Aging Cell 10 2011 699 710
39. D.C. Rubinsztein, G. Marino, and G. Kroemer Autophagy and aging Cell 146 2011 682 695
40. H.J. Kwon, Y.S. Won, Y.D. Yoon, W.K. Yoon, K.H. Nam, and I.P. Choi Vitamin D3 up-regulated protein 1 deficiency accelerates liver regeneration after partial hepatectomy in mice J Hepatol 54 2011 1168 1176
41. G. Bjorkoy, T. Lamark, A. Brech, H. Outzen, M. Perander, and A. Overvatn P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on Huntingtin-induced cell death J Cell Biol 171 2005 603 614
42. A. Aravinthan, C. Scarpini, P. Tachtatzis, S. Verma, S. Penrhyn-Lowe, and R. Harvey Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease J Hepatol 58 2013 549 556
43. C. Berasain New therapeutic targets in HCC: reptin ATPase and HCC senescence J Hepatol 52 2010 633 634
44. N. Naidoo, M. Ferber, M. Master, Y. Zhu, and A.I. Pack Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling J Neurosci 28 2008 6539 6548
45. J. Li, and N.J. Holbrook Elevated gadd153/chop expression and enhanced c-Jun N-terminal protein kinase activation sensitizes aged cells to ER stress Exp Gerontol 39 2004 735 744
46. S. Bernales, S. Schuck, and P. Walter ER-phagy: selective autophagy of the endoplasmic reticulum Autophagy 3 2007 285 287
47. L. Yang, P. Li, S. Fu, E.S. Calay, and G.S. Hotamisligil Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance Cell Metab 11 2010 467 478
48. U.T. Brunk, and A. Terman Lipofuscin: mechanisms of age-related accumulation and influence on cell function Free Radic Biol Med 33 2002 611 619
49. I. Davies, A. Fotheringham, and C. Roberts The effect of lipofuscin on cellular function Mech Ageing Dev 23 1983 347 356
50. G. Ferland, M. Audet, and B. Tuchweber Effect of dietary restriction on lysosomal bodies and total protein synthesis in hepatocytes of aging rats Mech Ageing Dev 64 1992 49 59
51. E.F. Neufeld Lysosomal storage diseases Annu Rev Biochem 60 1991 257 280
52. A. Terman, N. Abrahamsson, and U.T. Brunk Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress Exp Gerontol 34 1999 755 770
53. A. Terman, H. Dalen, and U.T. Brunk Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation Exp Gerontol 34 1999 943 957
54. Y. Stroikin, H. Dalen, S. Loof, and A. Terman Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material Eur J Cell Biol 83 2004 583 590
55. N. Gagliano, B. Arosio, D. Santambrogio, M.R. Balestrieri, G. Padoani, and J. Tagliabue Age-dependent expression of fibrosis-related genes and collagen deposition in rat kidney cortex J Gerontol A Biol Sci Med Sci 55 2000 B365 B372
56. C. Wang, D. Jurk, M. Maddick, G. Nelson, C. Martin-Ruiz, and T. von Zglinicki DNA damage response and cellular senescence in tissues of aging mice Aging Cell 8 2009 311 323