In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity

Metabolism: Clinical and Experimental

Volumn 64, Issue 2, 2015, Pages 315-322

  Pereira, Sandra ^a   Breen, Danna M ^a   Naassan, Anthony E ^a   Wang, Penny Y T ^a   Uchino, Hiroshi ^a   Fantus, I George ^a   Carpentier, André C ^b   Gutierrez Juarez, Roger ^c   Brindley, David N ^d   Lam, Tony K T ^a   Giacca, Adria ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Fat; Hyperinsulinemic euglycemic clamp; Liver

Indexed keywords

GLUCOSE; HEPARIN; INSULIN; LARD; MONOUNSATURATED FATTY ACID; OLIVE OIL; POLYUNSATURATED FATTY ACID; PROTEIN KINASE C; SATURATED FATTY ACID; SODIUM CHLORIDE; SOYBEAN OIL EMULSION; TRIACYLGLYCEROL; EDIBLE OIL; FAT INTAKE; FATTY ACID; LIPID EMULSION; PRKCD PROTEIN, RAT; PROTEIN KINASE C DELTA; SOYBEAN OIL; UNSATURATED FATTY ACID; VEGETABLE OIL;

ANIMAL EXPERIMENT; ARTICLE; DIETARY INTAKE; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; IN VIVO STUDY; INSULIN CLEARANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER; NONHUMAN; PERIPHERAL CIRCULATION; RAT; ANIMAL; BLOOD; CELL MEMBRANE; CHEMISTRY; COMPARATIVE STUDY; ENZYME ACTIVATION; ENZYMOLOGY; FAT INTAKE; GLUCOSE CLAMP TECHNIQUE; METABOLISM; PROTEIN TRANSPORT; UPREGULATION; WISTAR RAT;

ANIMALS; CELL MEMBRANE; DIETARY FATS; DIETARY FATS, UNSATURATED; ENZYME ACTIVATION; FAT EMULSIONS, INTRAVENOUS; FATTY ACIDS; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, NONESTERIFIED; FATTY ACIDS, UNSATURATED; FEMALE; GLUCOSE CLAMP TECHNIQUE; INSULIN RESISTANCE; LIVER; PLANT OILS; PROTEIN KINASE C-DELTA; PROTEIN TRANSPORT; RATS, WISTAR; SOYBEAN OIL; UP-REGULATION;

EID: 84920628213     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.10.019     Document Type: Article

References (41)

1. A.M. Louheranta, A.K. Turpeinen, and U.S. Schwab A high-stearic acid diet does not impair glucose tolerance and insulin sensitivity in healthy women Metabolism 47 1998 529 534
2. J.C. Lovejoy, S.R. Smith, and C.M. Champagne Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults Diabetes Care 25 2002 1283 1288
3. S.J. van Dijk, E.J. Feskens, and M.B. Bos A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome Am J Clin Nutr 90 2009 1656 1664
4. U. Riserus, W.C. Willett, and F.B. Hu Dietary fats and prevention of type 2 diabetes Prog Lipid Res 48 2009 44 51
5. A.C. Tierney, and H.M. Roche The potential role of olive oil-derived MUFA in insulin sensitivity Mol Nutr Food Res 51 2007 1235 1248
6. F. Perez-Jimenez, J. Lopez-Miranda, and M.D. Pinillos A Mediterranean and a high-carbohydrate diet improve glucose metabolism in healthy young persons Diabetologia 44 2001 2038 2043
7. B. Vessby, M. Uusitupa, and K. Hermansen Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU Study Diabetologia 44 2001 312 319
8. C.L. Kien, J.Y. Bunn, and M.E. Poynter A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults Diabetes 62 2013 1054 1063
9. B.J. Brehm, B.L. Lattin, and S.S. Summer One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetes Diabetes Care 32 2009 215 220
10. L.K. Summers, B.A. Fielding, and H.A. Bradshaw Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity Diabetologia 45 2002 369 377
11. R.J. Heine, C. Mulder, and C. Popp-Snijders Linoleic-acid-enriched diet: long-term effects on serum lipoprotein and apolipoprotein concentrations and insulin sensitivity in noninsulin-dependent diabetic patients Am J Clin Nutr 49 1989 448 456
12. L.H. Storlien, A.B. Jenkins, and D.J. Chisholm Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid Diabetes 40 1991 280 289
13. R.L. Dobbins, L.S. Szczepaniak, and J. Myhill The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats Diabetes 51 2002 1825 1833
14. R. Buettner, K.G. Parhofer, and M. Woenckhaus Defining high-fat-diet rat models: metabolic and molecular effects of different fat types J Mol Endocrinol 36 2006 485 501
15. T. Geng, W. Hu, and M.H. Broadwater Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity Diabetologia 56 2013 2078 2087
16. N. de Wit, M. Derrien, and H. Bosch-Vermeulen Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine Am J Physiol Gastrointest Liver Physiol 303 2012 G589 G599
17. J.D. Schertzer, A.K. Tamrakar, and J.G. Magalhaes NOD1 activators link innate immunity to insulin resistance Diabetes 60 2011 2206 2215
18. S. Pereira, W.Q. Yu, and M.E. Frigolet Duration of rise in free fatty acids determines salicylate's effect on hepatic insulin sensitivity J Endocrinol 217 2013 31 43
19. E. Park, V. Wong, and X. Guan Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo J Endocrinol 195 2007 323 331
20. T.K. Lam, G. van de Werve, and A. Giacca Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites Am J Physiol Endocrinol Metab 284 2003 E281 E290
21. S. Pereira, E. Park, and Y. Mori FFA-induced hepatic insulin resistance in vivo is mediated by PKC-delta, NADPH oxidase, and oxidative stress Am J Physiol Endocrinol Metab 307 2014 E34 E46
22. G. Boden, P. She, and M. Mozzoli Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver Diabetes 54 2005 3458 3465
23. W.L. Holland, J.T. Brozinick, and L.P. Wang Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance Cell Metab 5 2007 167 179
24. T.K. Lam, H. Yoshii, and C.A. Haber Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta Am J Physiol Endocrinol Metab 283 2002 E682 E691
25. Fatty acid composition of fats and oils http://www.uccs.edu/Documents/danderso/fats-oil.pdf 2014
26. D.T. Stein, B.E. Stevenson, and M.W. Chester The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation J Clin Invest 100 1997 398 403
27. A.C. Carpentier, F. Frisch, and D. Cyr On the suppression of plasma nonesterified fatty acids by insulin during enhanced intravascular lipolysis in humans Am J Physiol Endocrinol Metab 289 2005 E849 E856
28. D.J. Stetten, I. Welt, and D. Ingle Rates of glucose production and oxidation in normal and diabetic rats J Biol Chem 192 1951 817 830
29. O. Bezy, T.T. Tran, and J. Pihlajamaki PKC regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans J Clin Invest 121 2011 2504 2517
30. D.C. Kim, S.H. Kim, and M.W. Jeong Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia Biochem Biophys Res Commun 337 2005 110 115
31. P. Han, Y.Y. Zhang, and Y. Lu Effects of different free fatty acids on insulin resistance in rats Hepatobiliary Pancreat Dis Int 7 2008 91 96
32. C. Xiao, A. Giacca, and A. Carpentier Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans Diabetologia 49 2006 1371 1379
33. J.L. Jones, M. Comperatore, and J. Barona A Mediterranean-style, low-glycemic-load diet decreases atherogenic lipoproteins and reduces lipoprotein (a) and oxidized low-density lipoprotein in women with metabolic syndrome Metabolism 61 2012 366 372
34. C. Richard, M.M. Royer, and P. Couture Effect of the Mediterranean diet on plasma adipokine concentrations in men with metabolic syndrome Metabolism 62 2013 1803 1810
35. H.J. Silver, H. Kang, and C.D. Keil Consuming a balanced high fat diet for 16 weeks improves body composition, inflammation and vascular function parameters in obese premenopausal women Metabolism 63 2014 562 573
36. C.A. Haber, T.K. Lam, and Z. Yu N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress Am J Physiol Endocrinol Metab 285 2003 E744 E753
37. S. Lopez, B. Bermudez, and Y.M. Pacheco Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids Am J Clin Nutr 88 2008 638 644
38. N. Stefan, H.G. Wahl, and A. Fritsche Effect of the pattern of elevated free fatty acids on insulin sensitivity and insulin secretion in healthy humans Horm Metab Res 33 2001 432 438
39. S. Chen, T.K. Lam, and E. Park Oleate-induced decrease in hepatocyte insulin binding is mediated by PKC-delta Biochem Biophys Res Commun 346 2006 931 937
40. L. Hodson, C.M. Skeaff, and B.A. Fielding Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake Prog Lipid Res 47 2008 348 380
41. E. Coiffier, R. Paris, and J. Lecerf Effects of dietary saturated and polyunsaturated fat on lipoprotein lipase and heptic triglyceride lipase activity Comp Biochem Physiol B 88 1987 187 192