N-Acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress

Neuroscience Letters

Volumn 560, Issue , 2014, Pages 71-76

  Unnithan, Ajay S ^a   Jiang, Yiran ^a   Rumble, Jennifer L ^a   Pulugulla, Sree H ^a   Posimo, Jessica M ^a   Gleixner, Amanda M ^a   Leak, Rehana K ^a  

^a DUQUESNE UNIVERSITY   (United States)

Author keywords

Alzheimer's; Antioxidant; Dual hit; Glutathione; Parkinson's

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; GLUTATHIONE; HYDROGEN PEROXIDE; PARAQUAT;

ANIMAL CELL; ARTICLE; BLAST INJURY; COGNITIVE DEFECT; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ALZHEIMER'S; ANTIOXIDANT; DIMETHYL SULFOXIDE; DMSO; DUAL HIT; GLUTATHIONE; GSH; N-ACETYL CYSTEINE; NAC; PARKINSON'S;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; CATALASE; CELL COUNT; CELL DEATH; CELL LINE, TUMOR; DRUG SYNERGISM; GLUTATHIONE; HYDROGEN PEROXIDE; MICE; NEURONS; OXIDATIVE STRESS; PARAQUAT;

EID: 84891407440     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.12.023     Document Type: Article

References (44)

1. Leak R.K., Liou A.K., Zigmond M.J. Effect of sublethal 6-hydroxydopamine on the response to subsequent oxidative stress in dopaminergic cells: evidence for preconditioning. Journal of Neurochemistry 2006, 99:1151-1163.
2. Leak R.K., Zigmond M.J., Liou A.K. Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism. Journal of Neurochemistry 2008, 106:860-874.
3. Stenzel-Poore M.P., Stevens S.L., King J.S., Simon R.P. Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis. Stroke: A Journal of Cerebral Circulation 2007, 38:680-685.
4. Kitagawa K. Ischemic tolerance in the brain: endogenous adaptive machinery against ischemic stress. Journal of Neuroscience Research 2012, 90:1043-1054.
5. Zhu X., Raina A.K., Perry G., Smith M.A. Alzheimer's disease: the two-hit hypothesis. Lancet Neurology 2004, 3:219-226.
6. Boger H.A., Granholm A.C., McGinty J.F., Middaugh L.D. A dual-hit animal model for age-related parkinsonism. Progress in Neurobiology 2010, 90:217-229.
7. Carvey P.M., Punati A., Newman M.B. Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis. Cell Transplantation 2006, 15:239-250.
8. Gao H.M., Hong J.S. Gene-environment interactions: key to unraveling the mystery of Parkinson's disease. Progress in Neurobiology 2011, 94:1-19.
9. Weidong L., Shen C., Jankovic J. Etiopathogenesis of Parkinson disease: a new beginning?. Neuroscientist 2009, 15:28-35.
10. Sulzer D. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease. Trends in Neurosciences 2007, 30:244-250.
11. Gao H.M., Zhang F., Zhou H., Kam W., Wilson B., Hong J.S. Neuroinflammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environmental Health Perspectives 2011, 119:807-814.
12. Gao H.M., Liu B., Zhang W., Hong J.S. Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. FASEB Journal 2003, 17:1957-1959.
13. Ling Z., Chang Q.A., Tong C.W., Leurgans S.E., Lipton J.W., Carvey P.M. Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally. Experimental Neurology 2004, 190:373-383.
14. Kiraly M., Kiraly S.J. Traumatic brain injury and delayed sequelae: a review-traumatic brain injury and mild traumatic brain injury (concussion) are precursors to later-onset brain disorders, including early-onset dementia. Scientific World Journal 2007, 7:1768-1776.
15. Unnithan A.S., Choi H.J., Titler A.M., Posimo J.M., Leak R.K. Rescue from a two hit, high-throughput model of neurodegeneration with N-acetyl cysteine. Neurochemistry International 2012, 61:356-368.
16. Jellinger K.A. Recent advances in our understanding of neurodegeneration. Journal of Neural Transmission 2009, 116:1111-1162.
17. Morimoto R.I. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes & Development 2008, 22:1427-1438.
18. Jimenez-Del-Rio M., Velez-Pardo C. The bad, the good, and the ugly about oxidative stress. Oxidative Medicine and Cellular Longevity 2012, 2012:1-13. Article ID 163913.
19. Johnson W.M., Wilson-Delfosse A.L., Mieyal J.J. Dysregulation of glutathione homeostasis in neurodegenerative diseases. Nutrients 2012, 4:1399-1440.
20. Lloret A., Badia M.C., Mora N.J., Pallardo F.V., Alonso M.D., Vina J. Vitamin E paradox in Alzheimer's disease: it does not prevent loss of cognition and may even be detrimental. Journal of Alzheimer's Disease 2009, 17:143-149.
21. Zeevalk G.D., Razmpour R., Bernard L.P. Glutathione and Parkinson's disease: is this the elephant in the room?. Biomedicine & Pharmacotherapy 2008, 62:236-249.
22. Sian J., Dexter D.T., Lees A.J., Daniel S., Agid Y., Javoy-Agid F., Jenner P., Marsden C.D. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Annals of Neurology 1994, 36:348-355.
23. Sofic E., Lange K.W., Jellinger K., Riederer P. Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease. Neuroscience Letters 1992, 142:128-130.
24. Martin H.L., Teismann P. Glutathione-a review on its role and significance in Parkinson's disease. FASEB Journal 2009, 23:3263-3272. Official publication of the Federation of American Societies for Experimental Biology.
25. Calabrese V., Sultana R., Scapagnini G., Guagliano E., Sapienza M., Bella R., Kanski J., Pennisi G., Mancuso C., Stella A.M., Butterfield D.A. Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease. Antioxidants & Redox Signaling 2006, 8:1975-1986.
26. Baldeiras I., Santana I., Proenca M.T., Garrucho M.H., Pascoal R., Rodrigues A., Duro D., Oliveira C.R. Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease. Journal of Alzheimer's Disease 2008, 15:117-128.
27. Adair J.C., Knoefel J.E., Morgan N. Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease. Neurology 2001, 57:1515-1517.
28. Berk M., Copolov D.L., Dean O., Lu K., Jeavons S., Schapkaitz I., Anderson-Hunt M., Bush A.I. N-acetyl cysteine for depressive symptoms in bipolar disorder-a double-blind randomized placebo-controlled trial. Biological Psychiatry 2008, 64:468-475.
29. Berk M., Copolov D., Dean O., Lu K., Jeavons S., Schapkaitz I., Anderson-Hunt M., Judd F., Katz F., Katz P., Ording-Jespersen S., Little J., Conus P., Cuenod M., Do K.Q., Bush A.I. N-acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial. Biological Psychiatry 2008, 64:361-368.
30. Hoffer M.E., Balaban C., Slade M.D., Tsao J.W., Hoffer B. Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-blind, placebo controlled study. PLoS One 2013, 8:e54163.
31. Holmay M.J., Terpstra M., Coles L.D., Mishra U., Ahlskog M., Oz G., Cloyd J.C., Tuite P.J. N-acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases. Clinical Neuropharmacology 2013, 36:103-106.
32. Remington R., Chan A., Paskavitz J., Shea T.B. Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage Alzheimer's disease: a placebo-controlled pilot study. American Journal of Alzheimer's Disease and Other Dementias 2009, 24:27-33.
33. Moreira P.I., Harris P.L., Zhu X., Santos M.S., Oliveira C.R., Smith M.A., Perry G. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. Journal of Alzheimer's Disease 2007, 12:195-206.
34. Sajja V.S., Galloway M.P., Ghoddoussi F., Thiruthalinathan D., Kepsel A., Hay K., Bir C.A., VandeVord P.J. Blast-induced neurotrauma leads to neurochemical changes and neuronal degeneration in the rat hippocampus. NMR in Biomedicine 2012, 25:1331-1339.
35. Aruoma O.I., Halliwell B., Hoey B.M., Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radical Biology and Medicine 1989, 6:593-597.
36. Jiang Y., Rumble J.L., Gleixner A.M., Unnithan A.S., Pulugulla S.H., Posimo J.M., Choi H.J., Crum T.S., Pant D.B., Leak R.K. N-acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner. Neuroscience 2013, 255C:19-32.
37. Day B.J., Patel M., Calavetta L., Chang L.Y., Stamler J.S. A mechanism of paraquat toxicity involving nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:12760-12765.
38. Bus J.S., Aust S.D., Gibson J.E. Superoxide- and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl viologen) toxicity. Biochemical and Biophysical Research Communications 1974, 58:749-755.
39. Krall J., Bagley A.C., Mullenbach G.T., Hallewell R.A., Lynch R.E. Superoxide mediates the toxicity of paraquat for cultured mammalian cells. The Journal of Biological Chemistry 1988, 263:1910-1914.
40. Bao L., Avshalumov M.V., Patel J.C., Lee C.R., Miller E.W., Chang C.J., Rice M.E. Mitochondria are the source of hydrogen peroxide for dynamic brain-cell signaling. Journal of Neuroscience 2009, 29:9002-9010. The Official Journal of the Society for Neuroscience.
41. Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine 2007, 851. Oxford University Press, Oxford; New York, 8 p. of plates. fourth ed. xxxvi.
42. Titler A.M., Posimo J.M., Leak R.K. Astrocyte plasticity revealed by adaptations to severe proteotoxic stress. Cell and Tissue Research 2013, 352:427-443.
43. Pickering A.M., Koop A.L., Teoh C.Y., Ermak G., Grune T., Davies K.J. The immunoproteasome, the 20S proteasome and the PA28alphabeta proteasome regulator are oxidative-stress-adaptive proteolytic complexes. Biochemical Journal 2010, 432:585-594.
44. Ugarte S.D., Lin E., Klann E., Zigmond M.J., Perez R.G. Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEK. Journal of Neuroscience Research 2003, 73:105-112.