메뉴 건너뛰기




Volumn 62, Issue 2, 1997, Pages 133-140

[123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease

Author keywords

Dopamine transporter imaging; Parkinson's disease; SPECT

Indexed keywords

2 CARBOMETHOXY 8 (3 FLUOROPROPYL) 3 (4 IODOPHENYL)TROPANE; 2-CARBOMETHOXY-8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)TROPANE; CARRIER PROTEIN; DIAGNOSTIC AGENT; DOPAMINE; DOPAMINE TRANSPORTER; MEMBRANE PROTEIN; NERVE PROTEIN; RADIOACTIVE IODINE; TROPANE DERIVATIVE; IODINE 123; RADIOLIGAND;

EID: 0030614902     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.62.2.133     Document Type: Article
Times cited : (378)

References (40)
  • 2
    • 0025988478 scopus 로고
    • Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's-diseased striatum
    • Kaufman MJ, Madras BK. Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's-diseased striatum. Synapse 1991; 9;43-9.
    • (1991) Synapse , vol.9 , pp. 43-49
    • Kaufman, M.J.1    Madras, B.K.2
  • 3
    • 0023263919 scopus 로고
    • Biochemical pathophysiology of Parkinson's disease
    • Hornykiewicz O, Kish SJ. Biochemical pathophysiology of Parkinson's disease. Adv Neurol 1976;45;19-34.
    • (1976) Adv Neurol , vol.45 , pp. 19-34
    • Hornykiewicz, O.1    Kish, S.J.2
  • 4
    • 0025695511 scopus 로고
    • The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson's disease
    • Leenders KL, Salmon EP, Tyrrell P, et al. The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson's disease. Arch Neurol 1990; 47:1290-8.
    • (1990) Arch Neurol , vol.47 , pp. 1290-1298
    • Leenders, K.L.1    Salmon, E.P.2    Tyrrell, P.3
  • 5
    • 0023936741 scopus 로고
    • 11C-nomifensine and positron emission tomography: The effects of age and Parkinson's disease
    • 11C-nomifensine and positron emission tomography: the effects of age and Parkinson's disease. Acta Neurol Scand 1988;77:192-201.
    • (1988) Acta Neurol Scand , vol.77 , pp. 192-201
    • Tedroff, J.1    Aquilonius, S.-M.2    Hartvig, P.3
  • 8
    • 0027131948 scopus 로고
    • Single photon computed imaging demonstrates loss of striatal dopamine transporters in Parkinson's disease
    • Innis RB, Seibyl JB, Scanley BE, et al. Single photon computed imaging demonstrates loss of striatal dopamine transporters in Parkinson's disease. Prac Natl Acad Sci USA 1993;90:11965-9.
    • (1993) Prac Natl Acad Sci USA , vol.90 , pp. 11965-11969
    • Innis, R.B.1    Seibyl, J.B.2    Scanley, B.E.3
  • 10
    • 0029094141 scopus 로고
    • 123I}β-CIT striatal uptake correlates with symptom severity in Parkinson's disease
    • 123I}β-CIT striatal uptake correlates with symptom severity in Parkinson's disease. Ann Neurol 1995;38:589-98.
    • (1995) Ann Neurol , vol.38 , pp. 589-598
    • Seibyl, J.P.1    Marek, K.L.2    Quinlan, D.3
  • 11
    • 0027296568 scopus 로고
    • 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease
    • 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Ann Neurol 1993;34:423-31.
    • (1993) Ann Neurol , vol.34 , pp. 423-431
    • Frost, J.J.1    Rosier, A.J.2    Reich, S.G.3
  • 14
    • 0028939735 scopus 로고
    • 123I]N-fluoroalkyl-2β-carboxy-3β-(4-iodophenyl)nortropane esters in baboons
    • 123I]N-fluoroalkyl-2β-carboxy-3β-(4-iodophenyl)nortropane esters in baboons. Nucl Med Biol 1995;22:211-9.
    • (1995) Nucl Med Biol , vol.22 , pp. 211-219
    • Baldwin, R.M.1    Zea-Ponce, Y.2    Al-Tikriti, M.S.3
  • 15
    • 0028241283 scopus 로고
    • N-ω-fluoroalkyl analogs of (1R)-2β-carbomethoxy-3-β-(4-iodophenyl)-tropane (β-CIT): Radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters
    • Neumeyer JL, Wang S, Gao Y, et al. N-ω-fluoroalkyl analogs of (1R)-2β-carbomethoxy-3-β-(4-iodophenyl)-tropane (β-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters. J Med Chem 1994;37:1558-61.
    • (1994) J Med Chem , vol.37 , pp. 1558-1561
    • Neumeyer, J.L.1    Wang, S.2    Gao, Y.3
  • 16
    • 0030070681 scopus 로고    scopus 로고
    • N-substituted analogs of 2β-carbomethoxy-3β-(4′-iodophenyl)tropane (β-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain
    • Neumeyer JL, Tamagnan G, Wang S, et al. N-substituted analogs of 2β-carbomethoxy-3β-(4′-iodophenyl)tropane (β-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain. J Med Chem 1996;39:543-8.
    • (1996) J Med Chem , vol.39 , pp. 543-548
    • Neumeyer, J.L.1    Tamagnan, G.2    Wang, S.3
  • 17
    • 0028970793 scopus 로고
    • 11C]β-CIT-FP, a potential radioligand for quantitation of the dopamine transporter: Preparation, autoradiography, metabolic studies, and positron emission tomography examinations
    • 11C]β-CIT-FP, a potential radioligand for quantitation of the dopamine transporter: preparation, autoradiography, metabolic studies, and positron emission tomography examinations. Nucl Med Biol 1995;22:905-13.
    • (1995) Nucl Med Biol , vol.22 , pp. 905-913
    • Lundkvist, C.1    Halldin, C.2    Swahn, C.-G.3
  • 18
    • 10144264559 scopus 로고    scopus 로고
    • SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of β-CIT
    • Abi-Dargham A, Gandehnan MS, DeErausquin GA, et al. SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of β-CIT. J Nucl Med 1996;37:1129-33.
    • (1996) J Nucl Med , vol.37 , pp. 1129-1133
    • Abi-Dargham, A.1    Gandehnan, M.S.2    DeErausquin, G.A.3
  • 19
    • 0028933124 scopus 로고
    • Comparison of iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl) tropane and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain
    • Kuikka JT, Bergström KA, Ahonen A, et al. Comparison of iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl) tropane and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain. Eur J Nucl Med 1995;22:356-60.
    • (1995) Eur J Nucl Med , vol.22 , pp. 356-360
    • Kuikka, J.T.1    Bergström, K.A.2    Ahonen, A.3
  • 20
    • 0023898945 scopus 로고
    • The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease
    • Gibb WRG, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988;51:745-52.
    • (1988) J Neurol Neurosurg Psychiatry , vol.51 , pp. 745-752
    • Gibb, W.R.G.1    Lees, A.J.2
  • 21
    • 0029034304 scopus 로고
    • Age-related decline in striatal dopamine transporter binding with iodine-123-β-CIT SPECT
    • Van Dyck CH, Seibyl JP, Malison RT, et al. Age-related decline in striatal dopamine transporter binding with iodine-123-β-CIT SPECT. J Nucl Med 1995;36: 1175-81.
    • (1995) J Nucl Med , vol.36 , pp. 1175-1181
    • Van Dyck, C.H.1    Seibyl, J.P.2    Malison, R.T.3
  • 23
    • 0000224448 scopus 로고
    • Unified Parkinson's disease rating scale
    • Fahn S, Marsden CD, Calne DB, Goldstein M, eds. Florham Park, NJ: Macmillan Healthcare Information
    • Fahn S, Elton R, Members of the UPDRS development committee. Unified Parkinson's disease rating scale. In: Fahn S, Marsden CD, Calne DB, Goldstein M, eds. Recent developments in Parkinson's disease. Florham Park, NJ: Macmillan Healthcare Information, 1987:153-64.
    • (1987) Recent Developments in Parkinson's Disease , pp. 153-164
    • Fahn, S.1    Elton, R.2
  • 24
    • 0014082977 scopus 로고
    • Parkinsonism: Onset, progression, and mortality
    • Hoehn MM, Yahr MD. Parkinsonism: onset, progression, and mortality. Neurology 1967;17:427-42.
    • (1967) Neurology , vol.17 , pp. 427-442
    • Hoehn, M.M.1    Yahr, M.D.2
  • 25
    • 0026515731 scopus 로고
    • Core assessment program for intracerebral transplantations (CAPIT)
    • Langston JW, Widner H, Goetz CG, et al. Core assessment program for intracerebral transplantations (CAPIT). Mov Disord 1992;7:2-13.
    • (1992) Mov Disord , vol.7 , pp. 2-13
    • Langston, J.W.1    Widner, H.2    Goetz, C.G.3
  • 29
    • 0025178732 scopus 로고
    • 2-dopamine receptor binding examined in vivo by PET
    • 2-dopamine receptor binding examined in vivo by PET. Acta Psychiatr Scand 1990; 82:67-71.
    • (1990) Acta Psychiatr Scand , vol.82 , pp. 67-71
    • Farde, L.1    Von Bahr, C.2
  • 30
    • 0023874410 scopus 로고
    • Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease
    • Kish SJ, Shannak K, Hornykiewicz O. Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. N Engl J Med 1988;876:876-80.
    • (1988) N Engl J Med , vol.876 , pp. 876-880
    • Kish, S.J.1    Shannak, K.2    Hornykiewicz, O.3
  • 31
    • 0024835910 scopus 로고
    • Subdivisional involvement of nigrostriatal loop in idiopathic Parkinson's disease and striatonigral degeneration
    • Goto S, Hirano A, Matsumoto S. Subdivisional involvement of nigrostriatal loop in idiopathic Parkinson's disease and striatonigral degeneration. Ann Neurol 1989; 26:766-70.
    • (1989) Ann Neurol , vol.26 , pp. 766-770
    • Goto, S.1    Hirano, A.2    Matsumoto, S.3
  • 32
    • 0025763177 scopus 로고
    • Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease
    • Gibb WRG, Lees AJ. Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease. J Neurol Neurosurg Psychiatry 1991;54:388-96.
    • (1991) J Neurol Neurosurg Psychiatry , vol.54 , pp. 388-396
    • Gibb, W.R.G.1    Lees, A.J.2
  • 33
    • 0029138831 scopus 로고
    • 123I]β-CIT in human plasma may obstruct quantitation of the dopamine transporter
    • 123I]β-CIT in human plasma may obstruct quantitation of the dopamine transporter. Synapse 1995;19:297-300.
    • (1995) Synapse , vol.19 , pp. 297-300
    • Bergström, K.A.1    Halldin, C.2    Kuikka, J.T.3
  • 34
    • 0025373167 scopus 로고
    • Compensations after lesions of central dopaminergic neurons: Some clinical and basic implications
    • Zigmond MJ, Abercrombie ED, Berger TW, Grace AA, Stricker EM. Compensations after lesions of central dopaminergic neurons: some clinical and basic implications. TINS 1990;13:290-6.
    • (1990) TINS , vol.13 , pp. 290-296
    • Zigmond, M.J.1    Abercrombie, E.D.2    Berger, T.W.3    Grace, A.A.4    Stricker, E.M.5
  • 36
    • 0025065388 scopus 로고
    • 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and supranuclear palsy
    • 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and supranuclear palsy. Ann Neurol 1990;28:547-55.
    • (1990) Ann Neurol , vol.28 , pp. 547-555
    • Brooks, D.J.1    Ibanez, V.2    Sawle, G.V.3
  • 37
    • 0027516578 scopus 로고
    • Functional imaging in relation to parkinsonian syndromes
    • Brooks DJ. Functional imaging in relation to parkinsonian syndromes. J Neurol Sci 1993;115:1-17.
    • (1993) J Neurol Sci , vol.115 , pp. 1-17
    • Brooks, D.J.1
  • 39
    • 0029664364 scopus 로고    scopus 로고
    • 123I]β-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease
    • 123I]β-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease. Neurology 1996; 46:231-7.
    • (1996) Neurology , vol.46 , pp. 231-237
    • Marek, K.L.1    Seibyl, J.P.2    Zoghbi, S.S.3
  • 40
    • 17144434961 scopus 로고
    • 123I]/β-CIT: Pharmacological characterization of brain uptake in non-human primates
    • 123I]/β-CIT: pharmacological characterization of brain uptake in non-human primates. Synapse 1993;13:295-309.
    • (1993) Synapse , vol.13 , pp. 295-309
    • Laruelle, M.1    Balwin, R.M.2    Malison, R.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.