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Volumn 376, Issue 1, 2013, Pages 62-73

BMP and TGF-Β pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells

Author keywords

BMP; Human pluripotent stem cells; Midbrain dopaminergic differentiation; SHH; SMAD; TGF beta; Wnt

Indexed keywords

DOPAMINE; SECRETED FRIZZLED RELATED PROTEIN 1; SMAD1 PROTEIN; TRANSCRIPTION FACTOR MSX1; WNT3A PROTEIN; WNT5A PROTEIN;

EID: 84875262810     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2013.01.012     Document Type: Article
Times cited : (42)

References (65)
  • 2
    • 0036096908 scopus 로고    scopus 로고
    • Stem cells in the treatment of Parkinson's disease
    • Arenas E. Stem cells in the treatment of Parkinson's disease. Brain Res. Bull. 2002, 57:795-808.
    • (2002) Brain Res. Bull. , vol.57 , pp. 795-808
    • Arenas, E.1
  • 3
    • 22044443783 scopus 로고    scopus 로고
    • Engineering a dopaminergic phenotype in stem/precursor cells: role of Nurr1, glia-derived signals, and Wnts
    • Arenas E. Engineering a dopaminergic phenotype in stem/precursor cells: role of Nurr1, glia-derived signals, and Wnts. Ann. N Y Acad. Sci. 2005, 1049:51-66.
    • (2005) Ann. N Y Acad. Sci. , vol.1049 , pp. 51-66
    • Arenas, E.1
  • 4
    • 10444252732 scopus 로고    scopus 로고
    • Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats
    • Ben-Hur T., Idelson M., Khaner H., Pera M., Reinhartz E., Itzik A., Reubinoff B.E. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells 2004, 22:1246-1255.
    • (2004) Stem Cells , vol.22 , pp. 1246-1255
    • Ben-Hur, T.1    Idelson, M.2    Khaner, H.3    Pera, M.4    Reinhartz, E.5    Itzik, A.6    Reubinoff, B.E.7
  • 5
    • 33744536299 scopus 로고    scopus 로고
    • Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
    • Blaess S., Corrales J.D., Joyner A.L. Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 2006, 133:1799-1809.
    • (2006) Development , vol.133 , pp. 1799-1809
    • Blaess, S.1    Corrales, J.D.2    Joyner, A.L.3
  • 7
    • 59849099441 scopus 로고    scopus 로고
    • The role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson's disease model
    • Cai J., Donaldson A., Yang M., German M.S., Enikolopov G., Iacovitti L. The role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson's disease model. Stem Cells 2009, 27:220-229.
    • (2009) Stem Cells , vol.27 , pp. 220-229
    • Cai, J.1    Donaldson, A.2    Yang, M.3    German, M.S.4    Enikolopov, G.5    Iacovitti, L.6
  • 8
    • 77954932494 scopus 로고    scopus 로고
    • Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats
    • Cai J., Yang M., Poremsky E., Kidd S., Schneider J.S., Iacovitti L. Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats. Stem Cells Dev. 2010, 19:1017-1023.
    • (2010) Stem Cells Dev. , vol.19 , pp. 1017-1023
    • Cai, J.1    Yang, M.2    Poremsky, E.3    Kidd, S.4    Schneider, J.S.5    Iacovitti, L.6
  • 10
    • 73049085665 scopus 로고    scopus 로고
    • SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells
    • Chng Z., Teo A., Pedersen R.A., Vallier L. SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell 2010, 6:59-70.
    • (2010) Cell Stem Cell , vol.6 , pp. 59-70
    • Chng, Z.1    Teo, A.2    Pedersen, R.A.3    Vallier, L.4
  • 11
    • 70649111336 scopus 로고    scopus 로고
    • Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway
    • Chung S., Leung A., Han B.-S., Chang M.-Y., Moon J.-I., Kim C.-H., Hong S., Pruszak J., Isacson O., Kim K.-S. Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell 2009, 5:646-658.
    • (2009) Cell Stem Cell , vol.5 , pp. 646-658
    • Chung, S.1    Leung, A.2    Han, B.-S.3    Chang, M.-Y.4    Moon, J.-I.5    Kim, C.-H.6    Hong, S.7    Pruszak, J.8    Isacson, O.9    Kim, K.-S.10
  • 12
    • 77956613688 scopus 로고    scopus 로고
    • Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid
    • Cooper O., Hargus G., Deleidi M., Blak A., Osborn T., Marlow E., Lee K., Levy A., Perez-Torres E., Yow A., Isacson O. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol. Cell. Neurosci. 2010, 45:258-266.
    • (2010) Mol. Cell. Neurosci. , vol.45 , pp. 258-266
    • Cooper, O.1    Hargus, G.2    Deleidi, M.3    Blak, A.4    Osborn, T.5    Marlow, E.6    Lee, K.7    Levy, A.8    Perez-Torres, E.9    Yow, A.10    Isacson, O.11
  • 13
    • 70350774069 scopus 로고    scopus 로고
    • Signals involved in neural differentiation of human embryonic stem cells
    • Denham M., Dottori M. Signals involved in neural differentiation of human embryonic stem cells. Neurosignals 2009, 17:234-241.
    • (2009) Neurosignals , vol.17 , pp. 234-241
    • Denham, M.1    Dottori, M.2
  • 14
    • 78149239104 scopus 로고    scopus 로고
    • Chronic activation of the D2 autoreceptor inhibits both glutamate and dopamine synapse formation and alters the intrinsic properties of mesencephalic dopamine neurons in vitro
    • Fasano C., Kortleven C., Trudeau L.-E. Chronic activation of the D2 autoreceptor inhibits both glutamate and dopamine synapse formation and alters the intrinsic properties of mesencephalic dopamine neurons in vitro. Eur. J. Neurosci. 2010, 32:1433-1441.
    • (2010) Eur. J. Neurosci. , vol.32 , pp. 1433-1441
    • Fasano, C.1    Kortleven, C.2    Trudeau, L.-E.3
  • 16
    • 79551681371 scopus 로고    scopus 로고
    • SFRP1 reduction results in an increased sensitivity to TGF-Β signaling
    • Gauger K.J., Chenausky K.L., Murray M.E., Schneider S.S. SFRP1 reduction results in an increased sensitivity to TGF-Β signaling. BMC Cancer 2011, 11:59.
    • (2011) BMC Cancer , vol.11 , pp. 59
    • Gauger, K.J.1    Chenausky, K.L.2    Murray, M.E.3    Schneider, S.S.4
  • 19
    • 48649111174 scopus 로고    scopus 로고
    • Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease
    • Hedlund E., Pruszak J., Lardaro T., Ludwig W., Viñuela A., Kim K.-S., Isacson O. Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease. Stem Cells 2008, 26:1526-1536.
    • (2008) Stem Cells , vol.26 , pp. 1526-1536
    • Hedlund, E.1    Pruszak, J.2    Lardaro, T.3    Ludwig, W.4    Viñuela, A.5    Kim, K.-S.6    Isacson, O.7
  • 20
    • 33845277826 scopus 로고    scopus 로고
    • A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: studies in vitro and in vivo
    • Iacovitti L., Donaldson A.E., Marshall C.E., Suon S., Yang M. A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: studies in vitro and in vivo. Brain Res. 2007, 1127:19-25.
    • (2007) Brain Res. , vol.1127 , pp. 19-25
    • Iacovitti, L.1    Donaldson, A.E.2    Marshall, C.E.3    Suon, S.4    Yang, M.5
  • 22
    • 0037185010 scopus 로고    scopus 로고
    • Stoichiometry of active smad-transcription factor complexes on DNA
    • Inman G.J., Hill C.S. Stoichiometry of active smad-transcription factor complexes on DNA. Journal Biol. Chem. 2002, 277:51008-51016.
    • (2002) Journal Biol. Chem. , vol.277 , pp. 51008-51016
    • Inman, G.J.1    Hill, C.S.2
  • 23
    • 80053084933 scopus 로고    scopus 로고
    • Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cells
    • Jaeger I., Arber C., Risner-Janiczek J.R., Kuechler J., Pritzsche D., Chen I.-C., Naveenan T., Ungless M.A., Li M. Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cells. Development 2011, 4374:4363-4374.
    • (2011) Development , vol.4374 , pp. 4363-4374
    • Jaeger, I.1    Arber, C.2    Risner-Janiczek, J.R.3    Kuechler, J.4    Pritzsche, D.5    Chen, I.-C.6    Naveenan, T.7    Ungless, M.A.8    Li, M.9
  • 25
    • 67649417877 scopus 로고    scopus 로고
    • Integrative genomic analyses of ZEB2: transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB
    • Katoh M., Katoh M. Integrative genomic analyses of ZEB2: transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB. Int. J. Oncol. 2009, 34:1737-1742.
    • (2009) Int. J. Oncol. , vol.34 , pp. 1737-1742
    • Katoh, M.1    Katoh, M.2
  • 29
    • 38549159511 scopus 로고    scopus 로고
    • The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age
    • Kittappa R., Chang W.W., Awatramani R.B., McKay R.D.G. The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 2007, 5:e325.
    • (2007) PLoS Biol. , vol.5
    • Kittappa, R.1    Chang, W.W.2    Awatramani, R.B.3    McKay, R.D.G.4
  • 32
    • 84856085947 scopus 로고    scopus 로고
    • Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells
    • Kunisada Y., Tsubooka-Yamazoe N., Shoji M., Hosoya M. Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells. Stem Cell Res. 2012, 8:274-284.
    • (2012) Stem Cell Res. , vol.8 , pp. 274-284
    • Kunisada, Y.1    Tsubooka-Yamazoe, N.2    Shoji, M.3    Hosoya, M.4
  • 35
    • 84860342025 scopus 로고    scopus 로고
    • The expanding role of miR-302-367 in pluripotency and reprogramming
    • Lipchina I., Studer L., Betel D. The expanding role of miR-302-367 in pluripotency and reprogramming. Cell Cycle 2012, 11:1517-1523.
    • (2012) Cell Cycle , vol.11 , pp. 1517-1523
    • Lipchina, I.1    Studer, L.2    Betel, D.3
  • 39
    • 0035923738 scopus 로고    scopus 로고
    • Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway
    • Monuki E.S., Porter F.D., Walsh C.A. Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway. Neuron 2001, 32:591-604.
    • (2001) Neuron , vol.32 , pp. 591-604
    • Monuki, E.S.1    Porter, F.D.2    Walsh, C.A.3
  • 40
    • 77649182947 scopus 로고    scopus 로고
    • Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon
    • Nakatani T., Kumai M., Mizuhara E., Minaki Y., Ono Y. Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon. Dev. Biol. 2010, 339:101-113.
    • (2010) Dev. Biol. , vol.339 , pp. 101-113
    • Nakatani, T.1    Kumai, M.2    Mizuhara, E.3    Minaki, Y.4    Ono, Y.5
  • 41
    • 34548163305 scopus 로고    scopus 로고
    • Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon
    • Nakatani T., Minaki Y., Kumai M., Ono Y. Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. Development 2007, 134:2783-2793.
    • (2007) Development , vol.134 , pp. 2783-2793
    • Nakatani, T.1    Minaki, Y.2    Kumai, M.3    Ono, Y.4
  • 42
    • 84862855779 scopus 로고    scopus 로고
    • Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells
    • Nefzger C.M., Su C.T., Fabb S.A., Hartley B.J., Beh S.J., Zeng W.R., Haynes J.M., Pouton C.W. Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells. Stem Cells 2012, 30:1349-1361.
    • (2012) Stem Cells , vol.30 , pp. 1349-1361
    • Nefzger, C.M.1    Su, C.T.2    Fabb, S.A.3    Hartley, B.J.4    Beh, S.J.5    Zeng, W.R.6    Haynes, J.M.7    Pouton, C.W.8
  • 43
    • 84861222857 scopus 로고    scopus 로고
    • Postnatal subventricular zone of the neocortex contributes GFAP+ cells to the rostral migratory stream under the control of Sip1
    • Nityanandam A., Parthasarathy S., Tarabykin V. Postnatal subventricular zone of the neocortex contributes GFAP+ cells to the rostral migratory stream under the control of Sip1. Dev. Biol. 2012, 366:341-356.
    • (2012) Dev. Biol. , vol.366 , pp. 341-356
    • Nityanandam, A.1    Parthasarathy, S.2    Tarabykin, V.3
  • 44
    • 0030944065 scopus 로고    scopus 로고
    • Beta-catenin as oncogene: the smoking gun
    • Peifer M. Beta-catenin as oncogene: the smoking gun. Science 1997, 275:1752-1753.
    • (1997) Science , vol.275 , pp. 1752-1753
    • Peifer, M.1
  • 45
    • 45649083351 scopus 로고    scopus 로고
    • Fibroblast growth factor induces a neural stem cell phenotype in foetal forebrain progenitors and during embryonic stem cell differentiation
    • Pollard S.M., Wallbank R., Tomlinson S., Grotewold L., Smith A. Fibroblast growth factor induces a neural stem cell phenotype in foetal forebrain progenitors and during embryonic stem cell differentiation. Mol. Cell. Neurosci. 2008, 38:393-403.
    • (2008) Mol. Cell. Neurosci. , vol.38 , pp. 393-403
    • Pollard, S.M.1    Wallbank, R.2    Tomlinson, S.3    Grotewold, L.4    Smith, A.5
  • 46
    • 0038324070 scopus 로고    scopus 로고
    • Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
    • Postigo A.A., Depp J.L., Taylor J.J., Kroll K.L. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J. 2003, 22:2453-2462.
    • (2003) EMBO J. , vol.22 , pp. 2453-2462
    • Postigo, A.A.1    Depp, J.L.2    Taylor, J.J.3    Kroll, K.L.4
  • 48
    • 30744461567 scopus 로고    scopus 로고
    • Development of dopaminergic neurons in the mammalian brain
    • Prakash N., Wurst W. Development of dopaminergic neurons in the mammalian brain. Cell. Mol. Life Sci.: CMLS 2006, 63:187-206.
    • (2006) Cell. Mol. Life Sci.: CMLS , vol.63 , pp. 187-206
    • Prakash, N.1    Wurst, W.2
  • 49
    • 5444275563 scopus 로고    scopus 로고
    • Induction and specification of midbrain dopaminergic cells: focus on SHH, FGF8, and TGF-beta
    • Roussa E., Krieglstein K. Induction and specification of midbrain dopaminergic cells: focus on SHH, FGF8, and TGF-beta. Cell Tissue Res. 2004, 318:23-33.
    • (2004) Cell Tissue Res. , vol.318 , pp. 23-33
    • Roussa, E.1    Krieglstein, K.2
  • 52
    • 0038051417 scopus 로고    scopus 로고
    • Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors
    • Simon H.H., Bhatt L., Gherbassi D., Sgadó P., Alberí L. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Ann. N. Y. Acad. Sci. 2003, 991:36-47.
    • (2003) Ann. N. Y. Acad. Sci. , vol.991 , pp. 36-47
    • Simon, H.H.1    Bhatt, L.2    Gherbassi, D.3    Sgadó, P.4    Alberí, L.5
  • 53
    • 0036333793 scopus 로고    scopus 로고
    • Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon
    • Theil T., Aydin S., Koch S., Grotewold L., Rüther U. Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon. Development 2002, 129:3045-3054.
    • (2002) Development , vol.129 , pp. 3045-3054
    • Theil, T.1    Aydin, S.2    Koch, S.3    Grotewold, L.4    Rüther, U.5
  • 56
    • 79955756863 scopus 로고    scopus 로고
    • Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus
    • VanDunk C., Hunter L.A., Gray P.A. Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J. Neurosci.: Off. J. Soc. Neurosci. 2011, 31:6457-6467.
    • (2011) J. Neurosci.: Off. J. Soc. Neurosci. , vol.31 , pp. 6457-6467
    • VanDunk, C.1    Hunter, L.A.2    Gray, P.A.3
  • 57
    • 80051471864 scopus 로고    scopus 로고
    • The specificities of small molecule inhibitors of the TGFß and BMP pathways
    • Vogt J., Traynor R., Sapkota G.P. The specificities of small molecule inhibitors of the TGFß and BMP pathways. Cell. Signal. 2011, 23:1831-1842.
    • (2011) Cell. Signal. , vol.23 , pp. 1831-1842
    • Vogt, J.1    Traynor, R.2    Sapkota, G.P.3
  • 60
    • 84864353544 scopus 로고    scopus 로고
    • Specification of midbrain dopamine neurons from primate pluripotent stem cells
    • Xi J., Liu Y., Liu H., Chen H., Emborg M.E., Zhang S.-C. Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells 2012, 30:1655-1663.
    • (2012) Stem Cells , vol.30 , pp. 1655-1663
    • Xi, J.1    Liu, Y.2    Liu, H.3    Chen, H.4    Emborg, M.E.5    Zhang, S.-C.6
  • 61
    • 9344222239 scopus 로고    scopus 로고
    • Studies on the differentiation of dopaminergic traits in human neural progenitor cells in vitro and in vivo
    • Yang M., Donaldson A.E., Marshall C.E., Shen J., Iacovitti L. Studies on the differentiation of dopaminergic traits in human neural progenitor cells in vitro and in vivo. Cell Transplant. 2004, 13:535-547.
    • (2004) Cell Transplant. , vol.13 , pp. 535-547
    • Yang, M.1    Donaldson, A.E.2    Marshall, C.E.3    Shen, J.4    Iacovitti, L.5
  • 63
    • 0032577445 scopus 로고    scopus 로고
    • FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
    • Ye W., Shimamura K., Rubenstein J.L., Hynes M.A., Rosenthal A. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 1998, 93:755-766.
    • (1998) Cell , vol.93 , pp. 755-766
    • Ye, W.1    Shimamura, K.2    Rubenstein, J.L.3    Hynes, M.A.4    Rosenthal, A.5
  • 65
    • 75649107230 scopus 로고    scopus 로고
    • Differentiation of neural precursors and dopaminergic neurons from human embryonic stem cells
    • Zhang X.-Q., Zhang S.-C. Differentiation of neural precursors and dopaminergic neurons from human embryonic stem cells. Methods Mol. Biol. 2010, 584:355-366.
    • (2010) Methods Mol. Biol. , vol.584 , pp. 355-366
    • Zhang, X.-Q.1    Zhang, S.-C.2


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