Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria

Journal of Pineal Research

Volumn 60, Issue 3, 2016, Pages 291-302

  Xu, Shangcheng ^a   Pi, Huifeng ^a   Zhang, Lei ^a   Zhang, Nixian ^a   Li, YuMing ^a   Zhang, Huiliang ^b   Tang, Ju ^a   Li, Huijuan ^a   Feng, Min ^a   Deng, Ping ^a   Guo, Pan ^a   Tian, Li ^a   Xie, Jia ^a   He, Mindi ^a   Lu, Yonghui ^a   Zhong, Min ^a   Zhang, Yanwen ^a   Wang, Wang ^b   Reiter, Russel J ^c   Yu, Zhengping ^a   Zhou, Zhou ^a   more..

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

cadmium; Drp1; melatonin; mitochondrial dynamics; neurotoxicity

Indexed keywords

ADENOSINE TRIPHOSPHATE; CADMIUM CHLORIDE; CALCIUM ION; CARDIOLIPIN; CYTOCHROME C OXIDASE; DYNAMIN RELATED PROTEIN 1; GUANOSINE TRIPHOSPHATASE; MALONALDEHYDE; MELATONIN; MITOCHONDRIAL DNA; PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CADMIUM; CALCIUM; DRP1 PROTEIN, RAT; DYNAMIN; MITOCHONDRIAL PROTEIN; NEUROTOXIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN MITOCHONDRION; BRAIN TISSUE; CALCIUM CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; IN VIVO STUDY; LIPID PEROXIDATION; MALE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL TOXICITY; MORPHOLOGY; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN PHOSPHORYLATION; RAT; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; BRAIN CORTEX; DRUG EFFECTS; METABOLISM; MITOCHONDRION; NERVE CELL; PATHOLOGY; PROTEIN TRANSPORT; SPRAGUE DAWLEY RAT; TRANSCRIPTION INITIATION;

ANIMALS; CADMIUM; CALCIUM; CEREBRAL CORTEX; DYNAMINS; MELATONIN; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEURONS; NEUROTOXINS; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TRANSCRIPTIONAL ACTIVATION;

EID: 84975686907     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12310     Document Type: Article

References (49)

1. Archer SL,. Mitochondrial dynamics-mitochondrial fission and fusion in human diseases. N Engl J Med 2013; 369: 2236-2251.
2. Nunnari J, Suomalainen A,. Mitochondria: in sickness and in health. Cell 2012; 148: 1145-1159.
3. Youle RJ, van der Bliek AM,. Mitochondrial fission, fusion, and stress. Science 2012; 337: 1062-1065.
4. Shirihai OS, Song M, Dorn GW 2nd,. How mitochondrial dynamism orchestrates mitophagy. Circ Res 2015; 116: 1835-1849.
5. Detmer SA, Chan DC,. Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol 2007; 8: 870-879.
6. Chen H, Chan DC,. Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Hum Mol Genet 2009; 18: R169-R176.
7. Westermann B,. Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 2010; 11: 872-884.
8. Knott AB, Perkins G, Schwarzenbacher R, et al., Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 2008; 9: 505-518.
9. Cho B, Choi SY, Cho HM, et al., Physiological and pathological significance of dynamin-related protein 1 (drp1)-dependent mitochondrial fission in the nervous system. Exp Neurobiol 2013; 22: 149-157.
10. Qi X, Qvit N, Su YC, et al., A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci 2013; 126: 789-802.
11. Grohm J, Kim SW, Mamrak U, et al., Inhibition of Drp1 provides neuroprotection in vitro and in vivo. Cell Death Differ 2012; 19: 1446-1458.
12. Wang X, Su B, Liu W, et al., DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging Cell 2011; 10: 807-823.
13. Gomez-Lazaro M, Bonekamp NA, Galindo MF, et al., 6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells. Free Radic Biol Med 2008; 44: 1960-1969.
14. Cho DH, Nakamura T, Fang J, et al., S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 2009; 324: 102-105.
15. Viaene MK, Masschelein R, Leenders J, et al., Neurobehavioural effects of occupational exposure to cadmium: a cross sectional epidemiological study. Occup Environ Med 2000; 57: 19-27.
16. Bar-Sela S, Reingold S, Richter ED,. Amyotrophic lateral sclerosis in a battery-factory worker exposed to cadmium. Int J Occup Environ Health 2001; 7: 109-112.
17. Marlowe M, Cossairt A, Moon C, et al., Main and interaction effects of metallic toxins on classroom behavior. J Abnorm Child Psychol 1985; 13: 185-198.
18. Pihl RO, Parkes M,. Hair element content in learning disabled children. Science 1977; 198: 204-206.
19. Okuda B, Iwamoto Y, Tachibana H, et al., Parkinsonism after acute cadmium poisoning. Clin Neurol Neurosurg 1997; 99: 263-265.
20. Xu S, Pi H, Chen Y, et al., Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity. Cell Death Dis 2013; 4: e540.
21. Romero A, Ramos E, de Los Rios C, et al., A review of metal-catalyzed molecular damage: protection by melatonin. J Pineal Res 2014; 56: 343-370.
22. Zhang HM, Zhang Y,. Melatonin: a well-documented antioxidant with conditional pro-oxidant actions. J Pineal Res 2014; 57: 131-146.
23. Manchester LC, Coto-Montes A, Boga JA, et al., Melatonin: an ancient molecule that makes oxygen metabolically tolerable. J Pineal Res 2015; 59: 403-419.
24. Galano A, Medina ME, Tan DX, et al., Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis. J Pineal Res 2015; 58: 107-116.
25. Ali T, Badshah H, Kim TH, et al., Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model. J Pineal Res 2015; 58: 71-85.
26. Miller SL, Yawno T, Alers NO, et al., Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction. J Pineal Res 2014; 56: 283-294.
27. Negi G, Kumar A, Sharma SS,. Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-kappaB and Nrf2 cascades. J Pineal Res 2011; 50: 124-131.
28. Tan DX, Manchester LC, Terron MP, et al., One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007; 42: 28-42.
29. Reiter RJ, Tan DX, Kim SJ, et al., Delivery of pineal melatonin to the brain and SCN: role of canaliculi, cerebrospinal fluid, tanycytes and Virchow-Robin perivascular spaces. Brain Struct Funct 2014; 219: 1873-1887.
30. Paradies G, Paradies V, Ruggiero FM, et al., Protective role of melatonin in mitochondrial dysfunction and related disorders. Arch Toxicol 2015; 89: 923-939.
31. Acuna Castroviejo D, Lopez LC, Escames G, et al., Melatonin-mitochondria interplay in health and disease. Curr Top Med Chem 2011; 11: 221-240.
32. Reiter RJ, Tan DX, Galano A,. Melatonin: exceeding expectations. Physiology (Bethesda) 2014; 29: 325-333.
33. Peng TI, Hsiao CW, Reiter RJ, et al., mtDNA T8993G mutation-induced mitochondrial complex V inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca(2 +), and lipid insults in NARP cybrids: a potential therapeutic target for melatonin. J Pineal Res 2012; 52: 93-106.
34. Parameyong A, Charngkaew K, Govitrapong P, et al., Melatonin attenuates methamphetamine-induced disturbances in mitochondrial dynamics and degeneration in neuroblastoma SH-SY5Y cells. J Pineal Res 2013; 55: 313-323.
35. Ekthuwapranee K, Sotthibundhu A, Govitrapong P,. Melatonin attenuates methamphetamine-induced inhibition of proliferation of adult rat hippocampal progenitor cells in vitro. J Pineal Res 2015; 58: 418-428.
36. Xu SC, He MD, Zhong M, et al., Melatonin protects against Nickel-induced neurotoxicity in vitro by reducing oxidative stress and maintaining mitochondrial function. J Pineal Res 2010; 49: 86-94.
37. Barsoum MJ, Yuan H, Gerencser AA, et al., Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 2006; 25: 3900-3911.
38. Hom JR, Gewandter JS, Michael L, et al., Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis. J Cell Physiol 2007; 212: 498-508.
39. Yu T, Sheu SS, Robotham JL, et al., Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res 2008; 79: 341-351.
40. Xu SC, Chen YB, Lin H, et al., Damage to mtDNA in liver injury of patients with extrahepatic cholestasis: the protective effects of mitochondrial transcription factor A. Free Radic Biol Med 2012; 52: 1543-1551.
41. Cereghetti GM, Stangherlin A, Martins De Brito O, et al., Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci USA 2008; 105: 15803-15808.
42. Baxter LC, Sparks DL, Johnson SC, et al., Relationship of cognitive measures and gray and white matter in Alzheimer's disease. J Alzheimers Dis 2006; 9: 253-260.
43. Pi H, Xu S, Zhang L, et al., Dynamin 1-like-dependent mitochondrial fission initiates overactive mitophagy in the hepatotoxicity of cadmium. Autophagy 2013; 9: 1780-1800.
44. Reddy PH, Tripathi R, Troung Q, et al., Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics. Biochim Biophys Acta 2012; 1822: 639-649.
45. Wang X, Su B, Lee HG, et al., Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 2009; 29: 9090-9103.
46. Wang X, Su B, Siedlak SL, et al., Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci USA 2008; 105: 19318-19323.
47. Korobova F, Ramabhadran V, Higgs HN,. An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Science 2013; 339: 464-467.
48. de Vos KJ, Allan VJ, Grierson AJ, et al., Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission. Curr Biol 2005; 15: 678-683.
49. Liot G, Bossy B, Lubitz S, et al., Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway. Cell Death Differ 2009; 16: 899-909.