Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity

Cell Death and Disease

Volumn 4, Issue 3, 2013, Pages

  Xu, S ^a   Pi, H ^a   Chen, Y ^a   Zhang, N ^a   Guo, P ^a   Lu, Y ^a   He, M ^a   Xie, J ^a   Zhong, M ^a   Zhang, Y ^a   Yu, Z ^a   Zhou, Z ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cadmium; Dynamin related protein (Drp1); Hepatotoxicity; Mitochondrial dysfunction; Mitochondrial fragmentation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CADMIUM; CADMIUM CHLORIDE; DYNAMIN; DYNAMIN RELATED PROTEIN 1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CALCIUM; DRP1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL LINE; CELL LOSS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENVIRONMENTAL EXPOSURE; FRAGMENTATION REACTION; GENE SILENCING; HUMAN; HUMAN CELL; LIVER INJURY; LIVER TOXICITY; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL FRAGMENTATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REDUCTION; ANIMAL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; LIVER; LIVER CELL; MALE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

RATTUS;

ANIMALS; CADMIUM; CALCIUM; CELL LINE, TUMOR; DYNAMINS; GENE EXPRESSION REGULATION; HEPATOCYTES; HOMEOSTASIS; HUMANS; LIVER; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84875901883     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.7     Document Type: Article

References (35)

1. Waisberg M, Joseph P, Hale B, Beyersmann D. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 2003; 192: 95-117.
2. Klaassen CD, Liu J, Choudhuri S. Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol 1999; 39: 267-294.
3. Satarug S, Baker JR, Urbenjapol S, Haswell-Elkins M, Reilly PE, Williams DJ et al. A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol Lett 2003; 137: 65-83.
4. Akesson A, Lundh T, Vahter M, Bjellerup P, Lidfeldt J, Nerbrand C et al. Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environ Health Perspect 2005; 113: 1627-1631.
5. Schutte R, Nawrot TS, Richart T, Thijs L, Vanderschueren D, Kuznetsova T et al. Bone resorption and environmental exposure to cadmium in women: A population study. Environ Health Perspect 2008; 116: 777-783.
6. Menke A, Muntner P, Silbergeld EK, Platz EA, Guallar E. Cadmium levels in urine and mortality among U.S. adults. Environ Health Perspect 2009; 117: 190-196.
7. Shaikh ZA, Vu TT, Zaman K. Oxidative stress as a mechanism of chronic cadmiuminduced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol Appl Pharmacol 1999; 154: 256-263.
8. Rikans LE, Yamano T. Mechanisms of cadmium-mediated acute hepatotoxicity. J Biochem Mol Toxicol 2000; 14: 110-117.
9. Satarug S, Moore MR. Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ Health Perspect 2004; 112: 1099-1103.
10. Kuester RK, Waalkes MP, Goering PL, Fisher BL, McCuskey RS, Sipes IG. Differential hepatotoxicity induced by cadmium in Fischer 344 and Sprague-Dawley rats. Toxicol Sci 2002; 65: 151-159.
11. Cannino G, Ferruggia E, Luparello C, Rinaldi AM. Cadmium and mitochondria. Mitochondrion 2009; 9: 377-384.
12. Belyaeva EA, Dymkowska D, Wieckowski MR, Wojtczak L. Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells. Toxicol Appl Pharmacol 2008; 231: 34-42.
13. Al-Nasser IA. Cadmium hepatotoxicity and alterations of the mitochondrial function. J Toxicol Clin Toxicol 2000; 38: 407-413.
14. Chen H, Chan DC. Emerging functions of mammalian mitochondrial fusion and fission. Hum Mol Genet 2005; 14 (Spec No. 2): R283-R289.
15. Detmer SA, Chan DC. Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol 2007; 8: 870-879.
16. Su B, Wang X, Zheng L, Perry G, Smith MA, Zhu X. Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochim Biophys Acta 1802; 1: 135-142.
17. Gomez-Lazaro M, Bonekamp NA, Galindo MF, Jordan J, Schrader M. 6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells. Free Radic Biol Med 2008; 44: 1960-1969.
18. Wang X, Su B, Liu W, He X, Gao Y, Castellani RJ et al. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: Implications for Parkinson's disease. Aging Cell 10: 807-823.
19. Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Graber S et al. Nitric oxideinduced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 2006; 25: 3900-3911.
20. Dorta DJ, Leite S, DeMarco KC, Prado IM, Rodrigues T, Mingatto FE et al. A proposed sequence of events for cadmium-induced mitochondrial impairment. J Inorg Biochem 2003; 97: 251-257.
21. Wang Y, Fang J, Leonard SS, Rao KM. Cadmium inhibits the electron transfer chain and induces reactive oxygen species. Free Radic Biol Med 2004; 36: 1434-1443.
22. Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y et al. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci USA 2008; 105: 19318-19323.
23. Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE et al. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation 124: 444-453.
24. Yung LY, Lam WS, Ho MK, Hu Y, Ip FC, Pang H et al. Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types. Planta Med 2012; 78: 115-121.
25. Belyaeva EA, Glazunov VV, Korotkov SM. Cyclosporin A-sensitive permeability transition pore is involved in Cd(2?)-induced dysfunction of isolated rat liver mitochondria: Doubts no more. Arch Biochem Biophys 2002; 405: 252-264.
26. Lemarie A, Lagadic-Gossmann D, Morzadec C, Allain N, Fardel O, Vernhet L. Cadmium induces caspase-independent apoptosis in liver Hep3B cells: Role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor. Free Radic Biol Med 2004; 36: 1517-1531.
27. Wang X, Su B, Lee HG, Li X, Perry G, Smith MA et al. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 2009; 29: 9090-9103.
28. Smirnova E, Shurland DL, Ryazantsev SN, van der Bliek AM. A human dynamin-related protein controls the distribution of mitochondria. J Cell Biol 1998; 143: 351-358.
29. Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lammermann K et al. Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem 2009; 284: 22938-22951.
30. Cereghetti GM, Stangherlin A. Martins de Brito O, Chang CR, Blackstone C, Bernardi P, et al. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci USA 2008; 105: 15803-15808.
31. Breckenridge DG, Stojanovic M, Marcellus RC, Shore GC. Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J Cell Biol 2003; 160: 1115-1127.
32. Hom JR, Gewandter JS, Michael L, Sheu SS, Yoon Y. Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis. J Cell Physiol 2007; 212: 498-508.
33. Yoon Y. Regulation of mitochondrial dynamics: Another process modulated by Ca2? signals? Sci STKE 2005; 2005: Pe18.
34. Brooks C, Wei Q, Feng L, Dong G, Tao Y, Mei L et al. Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Natl Acad Sci USA 2007; 104: 11649-11654.
35. Xu SC, He MD, Zhong M, Zhang YW, Wang Y, Yang L et al. Melatonin protects against Nickel-induced neurotoxicity in vitro by reducing oxidative stress and maintaining mitochondrial function. J Pineal Res 2010; 49: 86-94.