Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis

International Journal of Biochemistry and Cell Biology

Volumn 77, Issue , 2016, Pages 41-56

  Sinha, Sonam ^a   Khan, Sajid ^a   Shukla, Samriddhi ^a   Lakra, Amar Deep ^a   Kumar, Sudhir ^a   Das, Gunjan ^b   Maurya, Rakesh ^a   Meeran, Syed Musthapa ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b CENTRAL AGRICULTURAL UNIVERSITY   (India)

Author keywords

Angiogenesis; Breast cancer; Cancer prevention; Cucurbitacin B; Invasion; Metastasis

Indexed keywords

CD31 ANTIGEN; CUCURBITACIN B; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; TRITERPENOID; UNCLASSIFIED DRUG; VASCULOTROPIN; FOCAL ADHESION KINASE 1; PTK2 PROTEIN, HUMAN; TRITERPENE; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST METASTASIS; CANCER INHIBITION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CHORIOALLANTOIS; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; EMBRYO; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG METASTASIS; MICROVASCULATURE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; BREAST TUMOR; CELL MOTION; CELL SURVIVAL; DRUG EFFECTS; DRUG SCREENING; METABOLISM; METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; TUMOR INVASION; VASCULARIZATION;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; FOCAL ADHESION KINASE 1; HUMANS; MATRIX METALLOPROTEINASE 9; MICE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRITERPENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84975506787     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2016.05.014     Document Type: Article

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