Centchroman suppresses breast cancer metastasis by reversing epithelial-mesenchymal transition via downregulation of HER2/ERK1/2/MMP-9 signaling

International Journal of Biochemistry and Cell Biology

Volumn 58, Issue , 2015, Pages 1-16

  Khan, Sajid ^a   Shukla, Samriddhi ^a   Sinha, Sonam ^a   Lakra, Amar Deep ^a   Bora, Himangsu K ^a   Meeran, Syed Musthapa ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Breast cancer; Centchroman; Epithelial to mesenchymal transition; Metastasis; Migration

Indexed keywords

CENTCHROMAN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GELATINASE B; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; TUMOR NECROSIS FACTOR ALPHA; GELATINASE A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; METASTASIS; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR INVASION; UPREGULATION; VALIDATION STUDY; ANIMAL; BAGG ALBINO MOUSE; BREAST NEOPLASMS; CELL LINE; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; METABOLISM; NEOPLASM METASTASIS; TUMOR CELL LINE; WOUND HEALING;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CENTCHROMAN; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; IMMUNOHISTOCHEMISTRY; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; WOUND HEALING;

EID: 84910639102     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.10.028     Document Type: Article

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