Free Energy Landscape of Lipid Interactions with Regulatory Binding Sites on the Transmembrane Domain of the EGF Receptor

Journal of Physical Chemistry B

Volumn 120, Issue 33, 2016, Pages 8154-8163

  Hedger, George ^a   Shorthouse, David ^a,b   Koldsø, Heidi ^a,c   Sansom, Mark S P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c D E SHAW RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BINDING ENERGY; BINS; BIOLOGICAL MEMBRANES; DIMERS; FREE ENERGY; LIPID BILAYERS; LIPIDS; PHOSPHOLIPIDS; PROTEINS;

AMINO ACID RESIDUES; BINDING FREE ENERGY; FREE ENERGY LANDSCAPE; INTEGRAL MEMBRANE PROTEINS; INTERACTION FREE ENERGIES; PHOSPHOINOSITIDES; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE HELICES;

BINDING SITES;

EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; GANGLIOSIDE GM3; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN BINDING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMISTRY; KINETICS; LIPID BILAYER; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUTATION; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; THERMODYNAMICS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; G(M3) GANGLIOSIDE; KINETICS; LIPID BILAYERS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; THERMODYNAMICS;

EID: 84975472044     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/acs.jpcb.6b01387     Document Type: Article

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