Generation of reactive oxygen species in the anterior eye segment. Synergistic codrugs of N-acetylcarnosine lubricant eye drops and mitochondria-targeted antioxidant act as a powerful therapeutic platform for the treatment of cataracts and primary open-angle glaucoma

BBA Clinical

Volumn 6, Issue , 2016, Pages 49-68

  Babizhayev, Mark A ^a  

^a Innovative Vision Products Incorporated   (United States)

Author keywords

Age related cataracts; Aging eye; Eye lens and aqueous humor; Lipid peroxidation and phospholipid hydroperoxides; Membrane derangement; Mitochondria and lens epithelial cells; Ophthalmic compositions of N acetylcarnosine and mitochondria targeted antioxidants; Reactive oxygen species

Indexed keywords

CARDIOLIPIN; CARNOSINE; CHAPERONE; EYE DROPS; GLUTATHIONE PEROXIDASE; HEAT SHOCK PROTEIN; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; SUPEROXIDE DISMUTASE; TETRAMETHYLRHODAMINE ETHYL ESTER; THIOREDOXIN;

ANTERIOR EYE SEGMENT; ANTIOXIDANT ACTIVITY; APOPTOSIS; CATARACT; CATARACTOGENESIS; CELL DEATH; GENE THERAPY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL TARGETING SIGNAL; OPEN ANGLE GLAUCOMA; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN CARBONYLATION; REVIEW; VISUAL IMPAIRMENT;

EID: 84975470598     PISSN: 22146474     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbacli.2016.04.004     Document Type: Review

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