Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: Challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine

Fundamental and Clinical Pharmacology

Volumn 26, Issue 1, 2012, Pages 86-117

  Babizhayev, Mark A ^a,b  

^a Innovative Vision Products Incorporated   (United States)

^b MOSCOW HELMHOLTZ RESEARCH INSTITUTE OF EYE DISEASES   (Russian Federation)

Author keywords

Age related ophthalmic diseases; Biomarkers; Blindness prevention; Cataract; Lens and trabecular meshwork of anterior eye segment; Mechanism of degenerative alterations; N acetylcarnosine lubricant eye drops; Oral supplement of nonhydrolyzed carnosine; Oxidative stress; Primary open angle glaucoma

Indexed keywords

BIOLOGICAL MARKER; CARNOSINE; EYE DROPS; LIPID; N ACETYLCARNOSINE; OXYGEN RADICAL; SCHIFF BASE; SCLEROPROTEIN; UNCLASSIFIED DRUG;

ANTERIOR EYE SEGMENT; AQUEOUS HUMOR; AQUEOUS HUMOR OUTFLOW; CATARACT; CELL AGING; CELL DEATH; CYTOSKELETON; DISEASE COURSE; EYE INJURY; HUMAN; LENS; LIPID PEROXIDATION; NONHUMAN; OPEN ANGLE GLAUCOMA; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SCHLEMM CANAL; TISSUE STRUCTURE; TRABECULAR MESHWORK;

ADMINISTRATION, OPHTHALMIC; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL MARKERS; BLINDNESS; CARNOSINE; CATARACT; GLAUCOMA, OPEN-ANGLE; HUMANS; OPHTHALMIC SOLUTIONS; OXIDATIVE STRESS; TRABECULAR MESHWORK;

EID: 84855704350     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2011.00969.x     Document Type: Review

References (207)

1. Ohira A., Ueda T., Ohishi K., Hiramitsu T., Akeo K., Obara Y. Oxidative stress in ocular disease. Nippon Ganka Gakkai Zasshi. (2008) 112 22-29.
2. Babizhayev M.A. Current ocular drug delivery challenges for N-acetylcarnosine: novel patented routes and modes of delivery, design for enhancement of therapeutic activity and drug delivery relationships. Recent Pat. Drug Deliv. Formul. (2009) 3 229-265.
3. Watkins R. Foundations of a solution to cataract blindness. Clin. Exp. Optom. (2002) 85 59-60.
4. Apple D.J., Ram J., Foster A., Peng Q. Elimination of cataract blindness: a global perspective entering the new millenium. Surv. Ophthalmol. (2000) 45(Suppl 1) S1-S196.
5. Javitt J.C., Wang F., West S.K. Blindness due to cataract: epidemiology and prevention. Annu. Rev. Public Health (1996) 17 159-177.
6. Ates O., Alp H.H., Kocer I., Baykal O., Salman I.A. Oxidative DNA damage in patients with cataract. Acta Ophthalmol. (2010) 88 891-895.
7. Schwab L. Cataract blindness in developing nations. Int. Ophthalmol. Clin. (1990) 30 16-18.
8. Foster A. Cataract and "Vision 2020 - the right to sight" initiative. Br. J. Ophthalmol. (2001) 85 635-639.
9. Murthy G., Gupta S.K., John N., Vashist P. Current status of cataract blindness and Vision 2020: the right to sight initiative in India. Indian J. Ophthalmol. (2008) 56 489-494.
10. Tabin G., Chen M., Espandar L. Cataract surgery for the developing world. Curr. Opin. Ophthalmol. (2008) 19 55-59.
11. Ellwein L.B., Kupfer C. Strategic issues in preventing cataract blindness in developing countries. Bull. World Health Organ. (1995) 73 681-690.
12. Yorston D. Cataract complications. Community Eye Res. J. (2008) 21(65) 1-3.
13. Gierhart D.L., Dorey K.C., Kelly P.D.: US20060039954 (2006).
14. Spector A. Oxidative stress-induced cataract: mechanism of action. FASEB J. (1995) 9 1173-1182.
15. Wannemacher C.F., Spector A. Protein synthesis in the core of calf lens. Exp. Eye Res. (1968) 7 623-625.
16. Rink H. Growth potential, repair capacity and protein synthesis in lens epithelial cells during aging in vitro. Monogr. Dev. Biol. (1984) 17 94-107.
17. Harding J.J., Dilley K.J. Structural proteins of the mammalian lens: a review with emphasis on changes in development, aging and cataract. Exp. Eye Res. (1976) 22 1-73.
18. Hockwin O., Ohrloff C. Enzymes in normal aging and cataractous lenses. in: Bloemendal H. (Ed), Molecular and cellular biology of the eye lens. John Wiley & Sons, New York, 1981, pp 367.
19. Spector A. The search for a solution to senile cataracts. Proctor lecture. Invest. Ophthalmol. Vis. Sci. (1984) 25 130-146.
20. Ottonello S., Foroni C., Carta A., Petrucco S., Maraini G. Oxidative stress and age-related cataract. Ophthalmologica (2000) 214 78-85.
21. Babizhayev M.A., Deyev A.I., Linberg L.F. Lipid peroxidation as a possible cause of cataract. Mech. Ageing Dev. (1988) 44 69-89.
22. Spector A., Wang G.M., Wang R.R., Garner W.H., Moll H. The prevention of cataract caused by oxidative stress in cultured rat lenses. I. H2O2 and photochemically induced cataract. Curr. Eye Res. (1993) 12 163-179.
23. Spector A., Wang G.M., Wang R.R. Photochemically induced cataracts in rat lenses can be prevented by AL-3823A, a glutathione peroxidase mimic. Proc. Natl. Acad. Sci. USA (1993) 90 7485-7489.
24. Zigler J.S. Jr, Huang Q.L., Du X.Y. Oxidative modification of lens crystallins by H2O2 and chelated iron. Free Radic. Biol. Med. (1989) 7 499-505.
25. Bhuyan K.C., Bhuyan D.K. Molecular mechanism of cataractogenesis: III. Toxic metabolites of oxygen as initiators of lipid peroxidation and cataract. Curr. Eye Res. (1984) 3 67-81.
26. Kleiman N.J., Spector A. DNA single strand breaks in human lens epithelial cells from patients with cataract. Curr. Eye Res. (1993) 12 423-431.
27. Kleiman N.J., Wang R.R., Spector A. Hydrogen peroxide-induced DNA damage in bovine lens epithelial cells. Mutat. Res. (1990) 240 35-45.
28. Spector A., Kleiman N.J., Huang R.R., Wang R.R. Repair of H2O2-induced DNA damage in bovine lens epithelial cell cultures. Exp. Eye Res. (1989) 49 685-698.
29. Kleiman N.J., Wang R.R., Spector A. Ultraviolet light induced DNA damage and repair in bovine lens epithelial cells. Curr. Eye Res. (1990) 9 1185-1193.
30. Truscott R.J. Age-related nuclear cataract-oxidation is the key. Exp. Eye Res. (2005) 80 709-725.
31. Martínez-Cayuela M. Oxygen free radicals and human disease. Biochimie. (1995) 77 147-161.
32. Babizhayev M.A., Costa E.B. Lipid peroxide and reactive oxygen species generating systems of the crystalline lens. Biochim. Biophys. Acta (1994) 1225 326-337.
33. Irshad M., Chaudhuri P.S. Oxidant-antioxidant system: role and significance in human body. Indian J. Exp. Biol. (2002) 40(11) 1233-1239.
34. Zigman S., Griess G., Yulo T., Schultz J. Ocular protein alterations by near UV light. Exp. Eye Res. (1973) 15(3) 255-264.
35. Reddy V.N., Giblin F.J., Lin L.R., Chakrapani B. The effect of aqueous humor ascorbate on ultraviolet-B-induced DNA damage in lens epithelium. Invest. Ophthalmol. Vis. Sci. (1998) 39(2) 344-350.
36. Alberti G., Oguni M., Podgor M. et al. Glutathione S-transferase M1 genotype and age-related cataracts. Lack of association in an Italian population. Invest. Ophthalmol. Vis. Sci. (1996) 37(6) 1167-1173.
37. Halliwell B., Gutteridge J.M.C. Free radicals in biology and medicine, 2nd edn. Clarendon Press, Oxford, 1985:123-126.
38. Zigler J.S. Jr, Jernigan H.M., Garland D., Reddy V.N. The effect of 'oxygen radicals' generated in the medium on lenses in organ culture: inhibition of damage by chelated iron. Arch. Biochem. Biophys. (1985) 24l l63-l72.
39. Varma S.D., Kumar S., Richards R.D. Light-induced damage to ocular lens cation pump: prevention by vitamin C. Proc. Natl. Acad. Sci. U S A (1979) 76(7) 3504-3506.
40. Goosey J.D., Zigler J.S. Jr, Kinoshita J.H. Cross-linking of lens crystallins in a photodynamic system: a process mediated by singlet oxygen. Science (1980) 208(4449) 1278-1280.
41. Goosey J.D., Zigler J.S. Jr, Matheson I.B., Kinoshita J.H. Effects of singlet oxygen on human lens crystallins in vitro. Invest. Ophthalmol. Vis. Sci. (1981) 20(5) 679-683.
42. Andley U.P. Photodamage to the eye. Photochem. Photobiol. (1987) 46(6) 1057-1066.
43. Zorić L. Parameters of oxidative stress in the lens, aqueous humor and blood in patients with diabetes and senile cataracts. Srp. Arh. Celok. Lek. (2003) 131(3-4) 137-142.
44. Babizhayev M.A. Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention. Drugs R D. (2005) 6(6) 345-369.
45. Williams D.L. Oxidative stress and the eye. Vet. Clin. North Am. Small Anim. Pract. (2008) 38(1) 179-192. vii.
46. Babizhayev M.A., Deyev A.I., Yermakova V.N., Remenshchikov V.V., Bours J. Revival of the lens transparency with N-acetylcarnosine. Curr. Drug Ther. (2006) 1(1) 91-116.
47. Loft S., Fischer-Nielsen A., Jeding I.B., Vistisen K., Poulsen H.E. 8-Hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage. J. Toxicol. Environ. Health (1993) 40(2-3) 391-404.
48. Floyd R.A. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis (1990) 11(9) 1447-1450.
49. Dong Q.Y., Cui Y., Chen L., Song J., Sun L. Urinary 8-hydroxydeoxyguanosine levels in diabetic retinopathy patients. Eur. J. Ophthalmol. (2008) 18(1) 94-98.
50. Clayton R.M., Cuthbert J., Duffy J. et al. Some risk factors associated with cataract in S.E. Scotland: a pilot study. Trans. Ophthalmol. Soc. UK (1982) 102(Pt 3) 331-336.
51. Harding J.J., Crabbe M.J.C. The eye (Dawson H. ed) Vol. 1B, Academic Press, London, UK, 1984, pp. 207-492.
52. Costagliola C., Iuliano G., Menzione M., Nesti A., Simonelli F., Rinaldi E. Systemic human diseases as oxidative risk factors in cataractogenesis. I. Diabetes. Ophthalmic Res. (1988) 20(5) 308-316.
53. Costagliola C., Iuliano G., Menzione M. et al. Systemic human diseases as oxidative risk factors in cataractogenesis. II. Chronic renal failure. Exp. Eye Res. (1990) 51(6) 631-635.
54. Simonelli F., Nesti A., Pensa M. et al. Lipid peroxidation and human cataractogenesis in diabetes and severe myopia. Exp. Eye Res. (1989) 49(2) 181-187.
55. Babizhayev M.A. Accumulation of lipid peroxidation products in human cataracts. Acta Ophthalmol. (1989) 67(3) 281-287.
56. Bhuyan K.C., Master R.W., Coles R.S., Bhuyan D.K. Molecular mechanisms of cataractogenesis: IV. Evidence of phospholipid malondialdehyde adduct in human senile cataract. Mech. Ageing Dev. (1986) 34(3) 289-296.
57. Borchman D., Yappert M.C., Rubini R.Q., Paterson C.A. Distribution of phospholipid-malondialdehyde-adduct in the human lens. Curr. Eye Res. (1989) 8(9) 939-946.
58. Bhuyan K.C., Bhuyan D.K., Podos S.M. Lipid peroxidation in cataract of the human. Life Sci. (1986) 38(16) 1463-1471.
59. Bhuyan K.C., Bhuyan D.K., Podos S.M. Free radical enhancer xenobiotic is an inducer of cataract in rabbit. Free Radic. Res. Commun. (1991) 12-13(Pt 2) 609-620.
60. Mibu H., Nagata M., Hikida M. A study on lipid peroxide-induced lens damage in vitro. Exp. Eye Res. (1994) 58(1) 85-90.
61. Srivastava S.K., Awasthi S., Wang L., Bhatnagar A., Awasthi Y.C., Ansari N.H. Attenuation of 4-hydroxynonenal-induced cataractogenesis in rat lens by butylated hydroxytoluene. Curr. Eye Res. (1996) 15(7) 749-754.
62. Nishigori H., Lee J.W., Yamauchi Y., Iwatsuru M. The alteration of lipid peroxide in glucocorticoid-induced cataract of developing chick embryos and the effect of ascorbic acid. Curr. Eye Res. (1986) 5(1) 37-40.
63. Yagi K., Komura S., Ihara N., Abe H., Konishi H., Arichi S. Serum lipid peroxide levels in rats with inherited cataracts. J. Appl. Biochem. (1985) 7(3) 202-206.
64. Zigler J.S. Jr, Bodaness R.S., Gery I., Kinoshita J.H. Effects of lipid peroxidation products on the rat lens in organ culture: a possible mechanism of cataract initiation in retinal degenerative disease. Arch. Biochem. Biophys. (1983) 225(1) 149-156.
65. Zigler J.S. Jr, Gery I., Kessler D., Kinoshita J.H. Macrophage mediated damage to rat lenses in culture: a possible model for uveitis-associated cataract. Invest. Ophthalmol. Vis. Sci. (1983) 24(5) 651-654.
66. Goosey J.D., Tuan W.M., Garcia C.A. A lipid peroxidative mechanism for posterior subcapsular cataract formation in the rabbit: a possible model for cataract formation in tapetoretinal diseases. Invest. Ophthalmol. Vis. Sci. (1984) 25(5) 608-612.
67. Zigler J.S. Jr, Hess H.H. Cataracts in the Royal College of Surgeons rat: evidence for initiation by lipid peroxidation products. Exp. Eye Res. (1985) 41(1) 67-76.
68. Babizhayev M.A., Dainyak B.A., Maxina A.H. ESR spin label and ultrastructural monitoring of protein-lipid interactions in the lens fiber-cell plasma membranes in relation to human ageing and cataractogenesis. Mech. Ageing Dev. (1992) 64(1-2) 133-147.
69. Borchman D., Lamba O.P., Salmassi S., Lou M., Yappert M.C. The dual effect of oxidation on lipid bilayer structure. Lipids (1992) 27(4) 261-265.
70. Borchman D., Lamba O.P., Yappert M.C. Structural characterization of lipid membranes from clear and cataractous human lenses. Exp. Eye Res. (1993) 57(2) 199-208.
71. Huang L., Estrada R., Yappert M.C., Borchman D. Oxidation-induced changes in human lens epithelial cells. 1. Phospholipids. Free Radic. Biol. Med. (2006) 41(9) 1425-1432. Epub 2006 Aug 4.
72. Huang L., Tang D., Yappert M.C., Borchman D. Oxidation-induced changes in human lens epithelial cells 2. Mitochondria and the generation of reactive oxygen species. Free Radic. Biol. Med. (2006) 41(6) 926-936. Epub 2006 May 26.
73. 2+-ATPase in the rabbit lens. Invest. Ophthalmol. Vis. Sci. (1989) 30(7) 1633-1637.
74. Kagan V.E. Lipid peroxidation in biomembranes. CRC Press, Boca Raton, FL, 1988, p. 181.
75. Park J.W., Floyd R.A. Lipid peroxidation products mediate the formation of 8-hydroxydeoxyguanosine in DNA. Free Radic. Biol. Med. (1992) 12(4) 245-250.
76. Babizhayev M.A. Lipid fluorophores of the human crystalline lens with cataract. Graefes Arch. Clin. Exp. Ophthalmol. (1989) 227(4) 384-391.
77. Babizhayev M.A. Antioxidant activity of L-carnosine, a natural histidine-containing dipeptide in crystalline lens. Biochim. Biophys. Acta (1989) 1004(3) 363-371.
78. Kikugawa K., Kato T., Beppu M., Hayasaka A. Development of fluorescence and cross-links in eye lens crystallin by interaction with lipid peroxy radicals. Biochim. Biophys. Acta (1991) 1096(2) 108-114.
79. Ferrer J.V., Gascó E., Sastre J., Pallardó F.V., Asensi M., Viña J. Age-related changes in glutathione synthesis in the eye lens. Biochem. J. (1990) 269(2) 531-534.
80. Shin A.H., Oh C.J., Park J.W. Glycation-induced inactivation of antioxidant enzymes and modulation of cellular redox status in lens cells. Arch. Pharm. Res. (2006) 29(7) 577-581.
81. Egorov S.Iu., Babizhaev M.A., Krasnovskiǐ A.A. Jr, Shvedova A.A. Photosensitized generation of singlet molecular oxygen by endogenous substances of the eye lens. Biofizika (1987) 32(1) 169-171.
82. Bhuyan K.C., Bhuyan D.K. Regulation of hydrogen peroxide in eye humors. Effect of 3-amino-1H-1, 2, 4-triazole on catalase and glutathione peroxidase of rabbit eye. Biochim. Biophys. Acta (1977) 497(3) 641-651.
83. Bhuyan K.C., Bhuyan D.K., Chiu W., Malik S., Fridovich I. Desferal-Mn(III) in the therapy of diquat-induced cataract in rabbit. Arch. Biochem. Biophys. (1991) 288(2) 525-532.
84. Bhuyan K.C., Bhuyan D.K., Santos O., Podos S.M. Antioxidant and anticataractogenic effects of topical captopril in diquat-induced cataract in rabbits. Free Radic. Biol. Med. (1992) 12(4) 251-261.
85. Bhuyan D.K., Bhuyan K.C. Oxy radicals in the eye tissues of rabbits after diquat in vivo. Free Radic. Res. Commun. (1991) 12-13(Pt 2) 621-627.
86. Bhuyan K.C., Bhuyan D.K. Superoxide dismutase of the eye: relative functions of superoxide dismutase and catalase in protecting the ocular lens from oxidative damage. Biochim. Biophys. Acta (1978) 542(1) 28-38.
87. Babizhaev M.A., Deev A.I., Vladimirov Iu.A., Deeva I.B. Decomposition of H2O2 by human cataractous lenses. Biull. Eksp. Biol. Med. (1986) 102(8) 158-160.
88. Fecondo J.V., Augusteyn R.C. Superoxide dismutase, catalase and glutathione peroxidase in the human cataractous lens. Exp. Eye Res. (1983) 36(1) 15-23.
89. Rao G.N., Sadasivudu B., Cotlier E. Studies on glutathione S-transferase, glutathione peroxidase and glutathione reductase in human normal and cataractous lenses. Ophthalmic Res. (1983) 15(4) 173-179.
90. Fris M., Cejková J., Midelfart A. The effect of single and repeated UVB radiation on rabbit lens. Graefes Arch. Clin. Exp. Ophthalmol. (2008) 246(4) 551-558. Epub 2008 Jan 12.
91. Spector A., Garner W.H. Hydrogen peroxide and human cataract. Exp. Eye Res. (1981) 33(6) 673-681.
92. Pirie A. Glutathione peroxidase in lens and a source of hydrogen peroxide in aqueous humour. Biochem. J. (1965) 96 244-253.
93. Pirie A. A light-catalysed reaction in the aqueous humor of the eye. Nature (1965) 205 500-501.
94. Dwivedi R.S., Pratap V.B. Alteration in glutathione metabolism during cataract progression. Ophthalmic Res. (1987) 19(1) 41-44.
95. Scharf J., Dovrat A., Gershon D. Defective superoxide-dismutase molecules accumulate with age in human lenses. Graefes Arch. Clin. Exp. Ophthalmol. (1987) 225(2) 133-136.
96. Reddy V.N. Glutathione and its function in the lens - an overview. Exp. Eye Res. (1990) 50(6) 771-778.
97. Rathbun W.B. Glutathione: chemical, biochemical, and medical aspects, part B. Dolphin D., Poulson R., Avramovic O. (ed). Wiley, New York, 1989, pp. 467-510.
98. Harding J.J. Free and protein-bound glutathione in normal and cataractous human lenses. Biochem. J. (1970) 117(5) 957-960.
99. Wolff S.P., Wang G.M., Spector A. Pro-oxidant activation of ocular reductants. 1. Copper and riboflavin stimulate ascorbate oxidation causing lens epithelial cytotoxicity in vitro. Exp. Eye Res. (1987) 45(6) 777-789.
100. Saez G., Thornalley P.J., Hill H.A., Hems R., Bannister J.V. The production of free radicals during the autoxidation of cysteine and their effect on isolated rat hepatocytes. Biochim. Biophys. Acta (1982) 719(1) 24-31.
101. Nath R., Srivastava S.K., Singh K. Accumulation of copper and inhibition of lactate dehydrogenase activity in human senile cataractous lens. Indian J. Exp. Biol. (1969) 7(1) 25-26.
102. Gerhard J.P. Study of copper in the aqueous humor. Doc. Ophthalmol. (1966) 20 104-110.
103. Harman D. The free radical theory of aging: effect of age on serum copper levels. J. Gerontol. (1965) 20 151-153.
104. Noto R., Alicata R., Sfogliano L., Neri S., Bifarella M. A study of cupremia in a group of elderly diabetics. Acta Diabetol. Lat. (1983) 20(1) 81-85.
105. Babizhayev M.A., Guiotto A., Kasus-Jacobi A. N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications. J. Drug Target. (2009) 17(1) 36-63.
106. Babizhayev M.A., Kasus-Jacobi A. State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases. Curr. Clin. Pharmacol. (2009) 4(1) 4-37.
107. Babizhayev M.A., Micans P., Guiotto A., Kasus-Jacobi A. N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50, 500 patients. Am. J. Ther. (2009). 16 517-533.
108. Babizhayev M.A., Burke L., Micans P., Richer S.P. N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50, 000-patient population. Clin. Interv. Aging. (2009);4(1):31-50. Epub 2009 May 14.
109. Babizhayev M.A., Yegorov Y.E. Advanced drug delivery of N-acetylcarnosine (N-Acetyl-beta-alanyl-L-histidine), carcinine (Beta-alanylhistamine) and L-carnosine (Beta-alanyl-L-histidine) in targeting peptide compounds as pharmacological chaperones for use in tissue engineering, human disease management and therapy: from in vitro to the clinic. Recent Pat. Drug Deliv. Formul. (2010) 4(3) 198-230.
110. Babizhayev M.A., Deyev A.I., Chernikov A.V. Peroxide-metabolizing systems of the crystalline lens. Biochim. Biophys. Acta (1992) 1138(1) 11-19.
111. Sawada H., Fukuchi T., Abe H. Oxidative stress markers in aqueous humor of patients with senile cataracts. Curr. Eye Res. (2009) 34(1) 36-41.
112. Saccà S.C., Izzotti A., Rossi P., Traverso C. Glaucomatous outflow pathway and oxidative stress. Exp. Eye Res. (2007) 84(3) 389-399. Epub 2006 Dec 29.
113. Tian B., Geiger B., Epstein D.L., Kaufman P.L. Cytoskeletal involvement in the regulation of aqueous humor outflow. Invest. Ophthalmol. Vis. Sci. (2000) 41(3) 619-623.
114. Bill A. Editorial: the drainage of aqueous humor. Invest. Ophthalmol. (1975) 14(1) 1-3.
115. Babizhayev M.A., Brodskaya M.W. Fibronectin detection in drainage outflow system of human eyes in ageing and progression of open-angle glaucoma. Mech. Ageing Dev. (1989) 47(2) 145-157.
116. Tamm E.R., Fuchshofer R. What increases outflow resistance in primary open-angle glaucoma? Surv. Ophthalmol. (2007) 52(Suppl 2) S101-S104.
117. Tektas O.Y., Lütjen-Drecoll E. Structural changes of the trabecular meshwork in different kinds of glaucoma. Exp. Eye Res. (2009) 88(4) 769-775. Epub 2008 Dec 6.
118. Mäepea O., Bill A. Pressures in the juxtacanalicular tissue and Schlemm's canal in monkeys. Exp. Eye Res. (1992) 54(6) 879-883.
119. Johnson M. What controls aqueous humour outflow resistance? Exp. Eye Res. (2006) 82(4) 545-557. Epub 2006 Jan 4.
120. Potau J.M., Canals M., Costa J., Merindano M.D., Ruano D. Morphological alterations of the trabecular meshwork in primary open angle glaucoma [Article in Spanish]. Arch. Soc. Esp. Oftalmol. (2000) 75(3) 159-164.
121. Potau J.M., Canals M., Costa J., Merindano M.D., Ruano D. Ultrastructural characteristics of glaucomatous trabecular meshwork [Article in Spanish]. Arch. Soc. Esp. Oftalmol. (2000) 75(1) 21-28.
122. Lütjen-Drecoll E. Morphological changes in glaucomatous eyes and the role of TGFbeta2 for the pathogenesis of the disease. Exp. Eye Res. (2005) 81(1) 1-4.
123. Becker B. The decline in aqueous secretion and outflow facility with age. Am. J. Ophthalmol. (1979) 97 1667-1969.
124. Babizhayev M.A., Bunin A.Ya. Lipid peroxidation in open-angle glaucoma. Acta Ophthalmol. (1989) 67(4) 371-377.
125. Izzotti A., Saccà S.C., Longobardi M., Cartiglia C. Sensitivity of ocular anterior chamber tissues to oxidative damage and its relevance to the pathogenesis of glaucoma. Invest. Ophthalmol. Vis. Sci. (2009) 50(11) 5251-5258. Epub 2009 Jun 10.
126. Izzotti A., Di Marco B., De Flora S., Saccà S. Open angle glaucoma: epidemiology, pathogenesis and prevention [Article in Italian]. Recenti Prog. Med. (2006) 97(1) 37-45.
127. Saccà S.C., Pascotto A., Camicione P., Capris P., Izzotti A. Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma. Arch. Ophthalmol. (2005) 123(4) 458-463.
128. Izzotti A., Saccà S.C., Longobardi M., Cartiglia C. Mitochondrial damage in the trabecular meshwork of patients with glaucoma. Arch. Ophthalmol. (2010) 128(6) 724-730.
129. Knepper P.A., Goossens W., Palmberg P.F. Glycosaminoglycan stratification of the juxtacanalicular tissue in normal and primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. (1996) 37(12) 2414-2425.
130. Lutjen-Drecoll E., Rohen J.W. Morphology of aqueous outflow pathways in normal and glaucomatous eyes. in: Ritch R., Shields M.B., Krupin T. (Eds) The glaucomas, 2nd edn, vol.1. Mosby, St. Louis, 1996, pp. 89-123.
131. Alvarado J.A., Alvarado R.G., Yeh R.F., Franse-Carman L., Marcellino G.R., Brownstein M.J. A new insight into the cellular regulation of aqueous outflow: how trabecular meshwork endothelial cells drive a mechanism that regulates the permeability of Schlemm's canal endothelial cells. Br. J. Ophthalmol. (2005) 89(11) 1500-1505.
132. Alvarado J.A., Yeh R.F., Franse-Carman L., Marcellino G., Brownstein M.J. Interactions between endothelia of the trabecular meshwork and of Schlemm's canal: a new insight into the regulation of aqueous outflow in the eye. Trans. Am. Ophthalmol. Soc. (2005) 103 148-162; discussion 162-3.
133. Alvarado J., Murphy C., Polansky J., Juster R. Studies on pathogenesis of primary open angle glaucoma: regional analyses of trabecular meshwork cellularity and dense collagen. in: Ticho U., David R. (Eds), Recent advances in glaucoma. Elsevier, Amsterdam, 1984, pp. 3-8.
134. Alvarado J., Murphy C., Juster R. Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals. Ophthalmology (1984) 91(6) 564-579.
135. Flammer J. The vascular concept of glaucoma. Surv. Ophthalmol. (1994) 38(Suppl) S3-S6.
136. Flammer J., Haefliger I.O., Orgül S., Resink T. Vascular dysregulation: a principal risk factor for glaucomatous damage? J. Glaucoma (1999) 8(3) 212-219.
137. Tamm E.R. The trabecular meshwork outflow pathways: structural and functional aspects. Exp. Eye Res. (2009) 88(4) 648-655. Epub 2009 Feb 23.
138. Acott T.S., Kelley M.J. Extracellular matrix in the trabecular meshwork. Exp. Eye Res. (2008) 86(4) 543-561. Epub 2008 Jan 25.
139. Zhou L., Li Y., Yue B.Y. Oxidative stress affects cytoskeletal structure and cell-matrix interactions in cells from an ocular tissue: the trabecular meshwork. J. Cell. Physiol. (1999) 180(2) 182-189.
140. Gabelt B.T., Kaufman P.L. Changes in aqueous humor dynamics with age and glaucoma. Prog. Retin. Eye Res. (2005) 24(5) 612-637.
141. Yue B.Y. The extracellular matrix and its modulation in the trabecular meshwork. Surv. Ophthalmol. (1996) 40(5) 379-390.
142. Kahn M.G., Giblin F.J., Epstein D.L. Glutathione in calf trabecular meshwork and its relation to aqueous humor outflow facility. Invest. Ophthalmol. Vis. Sci. (1983) 24(9) 1283-1287.
143. Epstein D.L., De Kater A.W., Lou M., Patel J. Influences of glutathione and sulfhydryl containing compounds on aqueous humor outflow function. Exp. Eye Res. (1990) 50(6) 785-793.
144. Alvarado J., Murphy C., Polansky J., Juster R. Age-related changes in trabecular meshwork cellularity. Invest. Ophthalmol. Vis. Sci. (1981) 21(5) 714-727.
145. WuDunn D. Mechanobiology of trabecular meshwork cells. Exp. Eye Res. (2009) 88(4) 718-723. Epub 2008 Nov 24.
146. Yan D.B., Trope G.E., Ethier C.R., Menon I.A., Wakeham A. Effects of hydrogen peroxide-induced oxidative damage on outflow facility and washout in pig eyes. Invest. Ophthalmol. Vis. Sci. (1991) 32(9) 2515-2520.
147. Padgaonkar V., Giblin F.J., Leverenz V., Lin L.R., Reddy V.N. Studies of H2O2-induced effects on cultured bovine trabecular meshwork cells. J. Glaucoma (1994) (Summer) 3(2) 123-131.
148. Hogg P., Calthorpe M., Batterbury M., Grierson I. Aqueous humor stimulates the migration of human trabecular meshwork cells in vitro. Invest. Ophthalmol. Vis. Sci. (2000) 41(5) 1091-1098.
149. Hassel B., Samuelson D.A., Lewis P.A., Gelatt K.N. Immunocytochemical localization of smooth muscle actin-containing cells in the trabecular meshwork of glaucomatous and nonglaucomatous dogs. Vet. Ophthalmol. (2007) 10(Suppl 1) 38-45.
150. Scott P.A., Lu Z., Liu Y., Gong H. Relationships between increased aqueous outflow facility during washout with the changes in hydrodynamic pattern and morphology in bovine aqueous outflow pathways. Exp. Eye Res. (2009) 89(6) 942-949. Epub 2009 Aug 11.
151. Freedman S.F., Anderson P.J., Epstein D.L. Superoxide dismutase and catalase of calf trabecular meshwork. Invest. Ophthalmol. Vis. Sci. (1985) 26(10) 1330-1335.
152. Nguyen K.P., Weiss H., Karageuzian L.N., Anderson P.J., Epstein D.L. Glutathione reductase of calf trabecular meshwork. Invest. Ophthalmol. Vis. Sci. (1985) 26(6) 887-890.
153. Scott D.R., Karageuzian L.N., Anderson P.J., Epstein D.L. Glutathione peroxidase of calf trabecular meshwork. Invest. Ophthalmol. Vis. Sci. (1984) 25(5) 599-602.
154. De La Paz M.A., Epstein D.L. Effect of age on superoxide dismutase activity of human trabecular meshwork. Invest. Ophthalmol. Vis. Sci. (1996) 37(9) 1849-1853.
155. Russell P., Johnson D.H. Enzymes protective of oxidative damage present in all decades of life in the trabecular meshwork, as detected by two-dimensional gel electrophoresis protein maps. J. Glaucoma (1996) 5(5) 317-324.
156. Barksdale S., Bhuyan K., Podos S. Oxidative stress in cultured human trabecular cells suppression of prostaglandin production. Invest. Ophthalmol. Vis. Sci. (1986) 27(Suppl.) 210-214.
157. Tamm E.R., Russell P., Johnson D.H., Piatigorsky J. Human and monkey trabecular meshwork accumulate alpha B-crystallin in response to heat shock and oxidative stress. Invest. Ophthalmol. Vis. Sci. (1996) 37(12) 2402-2413.
158. Welge-Lüssen U., May C.A., Eichhorn M., Bloemendal H., Lütjen-Drecoll E. AlphaB-crystallin in the trabecular meshwork is inducible by transforming growth factor-beta. Invest. Ophthalmol. Vis. Sci. (1999) 40(10) 2235-2241.
159. Knepper P.A., Goossens W., Hvizd M., Palmberg P.F. Glycosaminoglycans of the human trabecular meshwork in primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. (1996) 37(7) 1360-1367.
160. Navajas E.V., Martins J.R., Melo L.A. Jr et al. Concentration of hyaluronic acid in primary open-angle glaucoma aqueous humor. Exp. Eye Res. (2005) 80(6) 853-857. Epub 2005 Jan 26.
161. Schachtschabel D.O., Binninger E. Stimulatory effects of ascorbic acid on hyaluronic acid synthesis of in vitro cultured normal and glaucomatous trabecular meshwork cells of the human eye. Z. Gerontol. (1993) 26(4) 243-246.
162. Ronzière M.C., Roche S., Gouttenoire J., Démarteau O., Herbage D., Freyria A.M. Ascorbate modulation of bovine chondrocyte growth, matrix protein gene expression and synthesis in three-dimensional collagen sponges. Biomaterials (2003) 24(5) 851-861.
163. McCarty M.F. Primary open-angle glaucoma may be a hyaluronic acid deficiency disease: potential for glucosamine in prevention and therapy. Med. Hypotheses (1998) 51(6) 483-484.
164. Alcaín F.J., Burón M.I. Ascorbate on cell growth and differentiation. J. Bioenerg. Biomembr. (1994) 26(4) 393-398.
165. Virno M., Bucci M.G., Pecori-Giraldi J., Missiroli A. Findings on the hypotensive intraocular effect of high oral doses of ascorbic acid. Preliminary results in glaucoma therapy [Article in Italian]. Boll. Ocul. (1967) 46(4) 259-274.
166. Fishbein S.L., Goodstein S. The pressure lowering effect of ascorbic acid. Ann. Ophthalmol. (1972) 4(6) 487-491.
167. Linnér E. The pressure lowering effect of ascorbic acid in ocular hypertension. Acta Ophthalmol. (1969) 47(3) 685-689.
168. Welge-Lüssen U., Birke K. Oxidative stress in the trabecular meshwork of POAG [Article in German]. Klin. Monbl. Augenheilkd. (2010) 227(2) 99-107. Epub 2010 Feb 12.
169. Russell P., Garland D., Epstein D.L. Analysis of the proteins of calf and cow trabecular meshwork: development of a model system to study aging effects and glaucoma. Exp. Eye Res. (1989) 48(2) 251-260.
170. Caballero M., Liton P.B., Epstein D.L., Gonzalez P. Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells. Biochem. Biophys. Res. Commun. (2003) 308(2) 346-352.
171. Liton P.B., Gonzalez P., Epstein D.L. The role of proteolytic cellular systems in trabecular meshwork homeostasis. Exp. Eye Res. (2009) 88(4) 724-728. Epub 2008 Nov 12.
172. Millard C.B., Tripathi B.J., Tripathi R.C. Age-related changes in protein profiles of the normal human trabecular meshwork. Exp. Eye Res. (1987) 45(4) 623-631.
173. Izzotti A., Bagnis A., Saccà S.C. The role of oxidative stress in glaucoma. Mutat. Res. (2006) 612(2) 105-114. Epub 2006 Jan 18.
174. Saccà S.C., Izzotti A. Oxidative stress and glaucoma: injury in the anterior segment of the eye. Prog. Brain Res. (2008) 173 385-407.
175. Izzotti A., Saccà S.C., Cartiglia C., De Flora S. Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients. Am. J. Med. (2003) 114(8) 638-646. Comment in: Am J Med. 2003;114(8):697-8.
176. Ferreira S.M., Lerner S.F., Brunzini R., Evelson P.A., Llesuy S.F. Oxidative stress markers in aqueous humor of glaucoma patients. Am. J. Ophthalmol. (2004) 137(1) 62-69.
177. Ghanem A.A., Arafa L.F., El-Baz A. Oxidative stress markers in patients with primary open-angle glaucoma. Curr. Eye Res. (2010) 35(4) 295-301.
178. Grierson I., Howes R.C. Age-related depletion of the cell population in the human trabecular meshwork. Eye (Lond). (1987) 1(Pt 2) 204-210.
179. Miyazaki M., Segawa K., Urakawa Y. Age-related changes in the trabecular meshwork of the normal human eye. Jpn. J. Ophthalmol. (1987) 31(4) 558-569.
180. Alvarado J.A., Betanzos A., Franse-Carman L., Chen J., González-Mariscal L. Endothelia of Schlemm's canal and trabecular meshwork: distinct molecular, functional, and anatomic features. Am. J. Physiol. Cell Physiol. (2004) 286(3) C621-C634. Epub 2003 Nov 12.
181. Ethier C.R., Coloma F.M., de Kater A.W., Allingham R.R. Retroperfusion studies of the aqueous outflow system. Part 2: studies in human eyes. Invest. Ophthalmol. Vis. Sci. (1995) 36(12) 2466-2475.
182. Overby D.R., Stamer W.D., Johnson M. The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium. Exp. Eye Res. (2009) 88(4) 656-670. Epub 2008 Dec 11.
183. Allingham R.R., de Kater A.W., Ethier C.R., Anderson P.J., Hertzmark E., Epstein D.L. The relationship between pore density and outflow facility in human eyes. Invest. Ophthalmol. Vis. Sci. (1992) 33(5) 1661-1669.
184. Johnson M., Chan D., Read A.T., Christensen C., Sit A., Ethier C.R. The pore density in the inner wall endothelium of Schlemm's canal of glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. (2002) 43(9) 2950-2955.
185. Epstein D.L., Rohen J.W. Morphology of the trabecular meshwork and inner-wall endothelium after cationized ferritin perfusion in the monkey eye. Invest. Ophthalmol. Vis. Sci. (1991) 32(1) 160-171.
186. Ethier C.R., Chan D.W. Cationic ferritin changes outflow facility in human eyes whereas anionic ferritin does not. Invest. Ophthalmol. Vis. Sci. (2001) 42(8) 1795-1802.
187. Sit A.J., Coloma F.M., Ethier C.R., Johnson M. Factors affecting the pores of the inner wall endothelium of Schlemm's canal. Invest. Ophthalmol. Vis. Sci. (1997) 38(8) 1517-1525.
188. Johnstone M.A. The aqueous outflow system as a mechanical pump: evidence from examination of tissue and aqueous movement in human and non-human primates. J. Glaucoma (2004) 13(5) 421-438.
189. Ethier C.R., Read A.T., Chan D. Biomechanics of Schlemm's canal endothelial cells: influence on F-actin architecture. Biophys. J. (2004) 87(4) 2828-2837.
190. Underwood J.L., Murphy C.G., Chen J. et al. Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions. Am. J. Physiol. (1999) 277(2 Pt 1) C330-C342.
191. Stamer W.D., Peppel K., O'Donnell M.E., Roberts B.C., Wu F., Epstein D.L. Expression of aquaporin-1 in human trabecular meshwork cells: role in resting cell volume. Invest. Ophthalmol. Vis. Sci. (2001) 42(8) 1803-1811.
192. Stamer W.D., Seftor R.E., Snyder R.W., Regan J.W. Cultured human trabecular meshwork cells express aquaporin-1 water channels. Curr. Eye Res. (1995) 14(12) 1095-1100.
193. Baetz N.W., Hoffman E.A., Yool A.J., Stamer W.D. Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. Exp. Eye Res. (2009) 89(1) 95-100. Epub 2009 Mar 4.
194. Haefliger I.O., Dettmann E., Liu R. et al. Potential role of nitric oxide and endothelin in the pathogenesis of glaucoma. Surv. Ophthalmol. (1999) 43(Suppl 1) S51-S58.
195. Resch H., Karl K., Weigert G. et al. Effect of dual endothelin receptor blockade on ocular blood flow in patients with glaucoma and healthy subjects. Invest. Ophthalmol. Vis. Sci. (2009) 50(1) 358-363. Epub 2008 Aug 21.
196. Yorio T., Krishnamoorthy R., Prasanna G. Endothelin: is it a contributor to glaucoma pathophysiology? J. Glaucoma (2002) 11(3) 259-270.
197. Wiederholt M. Nitric Oxide and endothelin in aqueous humor outflow regulation. in: Haefliger I.O., Flammer J. (Eds), Nitric oxide and endothelin in the pathogenesis of glaucoma. Lippincott-Raven, New York, 1998, pp. 168-177.
198. Noske W., Hensen J., Wiederholt M. Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract. Graefes Arch. Clin. Exp. Ophthalmol. (1997) 235(9) 551-552.
199. Orgül S., Gugleta K., Flammer J. Physiology of perfusion as it relates to the optic nerve head. Surv. Ophthalmol. (1999) 43(Suppl 1) S17-S26.
200. Chauhan B.C., LeVatte T.L., Jollimore C.A. et al. Model of endothelin-1-induced chronic optic neuropathy in rat. Invest. Ophthalmol. Vis. Sci. (2004) 45(1) 144-152.
201. Orgül S., Cioffi G.A., Bacon D.R., Van Buskirk E.M. An endothelin-1-induced model of chronic optic nerve ischemia in rhesus monkeys. J. Glaucoma (1996) 5(2) 135-138.
202. Cioffi G.A., Orgül S., Onda E., Bacon D.R., Van Buskirk E.M. An in vivo model of chronic optic nerve ischemia: the dose-dependent effects of endothelin-1 on the optic nerve microvasculature. Curr. Eye Res. (1995) 14(12) 1147-1153.
203. Tamm E.R., Lutjen Drecoll E. Nitric oxide in the outflow pathways of the aqueous humor. in: Haefliger I.O., Flammer J. (Eds), Nitric oxide and endothelin in the pathogenesis of glaucoma. Lippincott-Raven, New York, 1998, pp. 158-167.
204. Lipton S.A. Neuronal protection and destruction by NO. Cell Death Differ. (1999) 6(10) 943-951.
205. Prasanna G., Hulet C., Desai D. et al. Effect of elevated intraocular pressure on endothelin-1 in a rat model of glaucoma. Pharmacol. Res. (2005) 51(1) 41-50.
206. Bunin A.Ia. Pathogenetic factors of destructive process in trabecular tissues in primary open-angle glaucoma [Article in Russian]. Vestn. oftalmol. (2000) 116(5) 24-27.
207. Babizhayev M.A., Deyev A.I. Lens opacity induced by lipid peroxidation products as a model of cataract associated with retinal disease. Biochim. Biophys. Acta (1989) 1004(1) 124-133.