-
1
-
-
39749110083
-
Small non-coding RNAs in animal development
-
Stefani, G. and Slack, F.J. (2008) Small non-coding RNAs in animal development. Nat. Rev. Mol. Cell Biol., 9, 219-230.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 219-230
-
-
Stefani, G.1
Slack, F.J.2
-
2
-
-
33645294070
-
Oncomirs - MicroRNAs with a role in cancer
-
Esquela-Kerscher, A. and Slack, F.J. (2006) Oncomirs - microRNAs with a role in cancer. Nat. Rev. Cancer, 6, 259-269.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 259-269
-
-
Esquela-Kerscher, A.1
Slack, F.J.2
-
3
-
-
44449179366
-
Expression and function of micro-RNAs in immune cells during normal or disease state
-
Tili, E., Michaille, J.J. and Calin, G.A. (2008) Expression and function of micro-RNAs in immune cells during normal or disease state. Int. J. Med. Sci., 5, 73-79.
-
(2008)
Int. J. Med. Sci.
, vol.5
, pp. 73-79
-
-
Tili, E.1
Michaille, J.J.2
Calin, G.A.3
-
4
-
-
54849408182
-
An analysis of human microRNA and disease associations
-
Lu, M., Zhang, Q., Deng, M., Miao, J., Guo, Y., Gao, W. and Cui, Q. (2008) An analysis of human microRNA and disease associations. PloS one, 3, e3420.
-
(2008)
PloS One
, vol.3
, pp. e3420
-
-
Lu, M.1
Zhang, Q.2
Deng, M.3
Miao, J.4
Guo, Y.5
Gao, W.6
Cui, Q.7
-
5
-
-
0001359591
-
Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans
-
Napoli, C., Lemieux, C. and Jorgensen, R. (1990) Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell, 2, 279-289.
-
(1990)
Plant Cell
, vol.2
, pp. 279-289
-
-
Napoli, C.1
Lemieux, C.2
Jorgensen, R.3
-
6
-
-
0025405838
-
Flavonoid genes in petunia: Addition of a limited number of gene copies may lead to a suppression of gene expression
-
van der Krol, A.R. (1990) Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression. Plant Cell Online, 2, 291-299.
-
(1990)
Plant Cell Online
, vol.2
, pp. 291-299
-
-
Van Der-Krol, A.R.1
-
7
-
-
0026441194
-
Quelling: Transient inactivation of gene expression in neurospora crassa by transformation with homologous sequences
-
Romano, N. and Macino, G. (1992) Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences. Mol Microbiol, 6, 3343-3353.
-
(1992)
Mol Microbiol
, vol.6
, pp. 3343-3353
-
-
Romano, N.1
Macino, G.2
-
8
-
-
0027145973
-
Induction of a highly specific antiviral state in transgenic plants: Implications for regulation of gene expression and virus resistance
-
Lindbo, J.A., Silva-Rosales, L., Proebsting, W.M. and Dougherty, W.G. (1993) Induction of a highly specific antiviral state in transgenic plants: implications for regulation of gene expression and virus resistance. Plant Cell, 5, 1749-1759.
-
(1993)
Plant Cell
, vol.5
, pp. 1749-1759
-
-
Lindbo, J.A.1
Silva-Rosales, L.2
Proebsting, W.M.3
Dougherty, W.G.4
-
9
-
-
0027751663
-
The C. Elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
-
Lee, R.C., Feinbaum, R.L. and Ambros, V. (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 75, 843-854.
-
(1993)
Cell
, vol.75
, pp. 843-854
-
-
Lee, R.C.1
Feinbaum, R.L.2
Ambros, V.3
-
10
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
-
Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E. and Mello, C.C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391, 806-811.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
11
-
-
84877766936
-
Molecular mechanisms of RNA interference
-
Wilson, R.C. and Doudna, J.A. (2013) Molecular mechanisms of RNA interference. Annu. Rev. Biophys., 42, 217-239.
-
(2013)
Annu. Rev. Biophys.
, vol.42
, pp. 217-239
-
-
Wilson, R.C.1
Doudna, J.A.2
-
12
-
-
77952043572
-
RNAi-based therapeutics-current status, challenges and prospects
-
Tiemann, K. and Rossi, J.J. (2009) RNAi-based therapeutics-current status, challenges and prospects. EMBO Mol. Med., 1, 142-151.
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 142-151
-
-
Tiemann, K.1
Rossi, J.J.2
-
13
-
-
0034673638
-
An RNA-directed nuclease mediates post-transcriptional gene silencing in drosophila cells
-
Hammond, S.M., Bernstein, E., Beach, D. and Hannon, G.J. (2000) An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature, 404, 293-296.
-
(2000)
Nature
, vol.404
, pp. 293-296
-
-
Hammond, S.M.1
Bernstein, E.2
Beach, D.3
Hannon, G.J.4
-
14
-
-
0035863097
-
RNA interference is mediated by 21- and 22-nucleotide RNAs
-
Elbashir, S.M., Lendeckel, W. and Tuschl, T. (2001) RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev., 15, 188-200.
-
(2001)
Genes Dev.
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
15
-
-
58749113430
-
A three-dimensional view of the molecular machinery of RNA interference
-
Jinek, M. and Doudna, J.A. (2009) A three-dimensional view of the molecular machinery of RNA interference. Nature, 457, 405-412.
-
(2009)
Nature
, vol.457
, pp. 405-412
-
-
Jinek, M.1
Doudna, J.A.2
-
16
-
-
78650004201
-
MicroRNA: Biogenesis, function and role in cancer
-
Macfarlane, L.A. and Murphy, P.R. (2010) MicroRNA: biogenesis, function and role in cancer. Curr. Genomics, 11, 537-561.
-
(2010)
Curr. Genomics
, vol.11
, pp. 537-561
-
-
Macfarlane, L.A.1
Murphy, P.R.2
-
17
-
-
58449134534
-
Small silencing RNAs: An expanding universe
-
Ghildiyal, M. and Zamore, P.D. (2009) Small silencing RNAs: an expanding universe. Nat. Rev. Genet., 10, 94-108.
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 94-108
-
-
Ghildiyal, M.1
Zamore, P.D.2
-
18
-
-
0035798415
-
ATP requirements and small interfering RNA structure in the RNA interference pathway
-
Nykanen, A., Haley, B. and Zamore, P.D. (2001) ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell, 107, 309-321.
-
(2001)
Cell
, vol.107
, pp. 309-321
-
-
Nykanen, A.1
Haley, B.2
Zamore, P.D.3
-
19
-
-
3242736704
-
Human argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
-
Meister, G., Landthaler, M., Patkaniowska, A., Dorsett, Y., Teng, G. and Tuschl, T. (2004) Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol. Cell, 15, 185-197.
-
(2004)
Mol. Cell
, vol.15
, pp. 185-197
-
-
Meister, G.1
Landthaler, M.2
Patkaniowska, A.3
Dorsett, Y.4
Teng, G.5
Tuschl, T.6
-
20
-
-
4444368187
-
Argonaute2 is the catalytic engine of mammalian RNAi
-
Liu, J., Carmell, M.A., Rivas, F.V., Marsden, C.G., Thomson, J.M., Song, J.J., Hammond, S.M., Joshua-Tor, L. and Hannon, G.J. (2004) Argonaute2 is the catalytic engine of mammalian RNAi. Science, 305, 1437-1441.
-
(2004)
Science
, vol.305
, pp. 1437-1441
-
-
Liu, J.1
Carmell, M.A.2
Rivas, F.V.3
Marsden, C.G.4
Thomson, J.M.5
Song, J.J.6
Hammond, S.M.7
Joshua-Tor, L.8
Hannon, G.J.9
-
22
-
-
3042602447
-
Kinetic analysis of the RNAi enzyme complex
-
Haley, B. and Zamore, P.D. (2004) Kinetic analysis of the RNAi enzyme complex. Nat. Struct. Mol. Biol., 11, 599-606.
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 599-606
-
-
Haley, B.1
Zamore, P.D.2
-
23
-
-
18744407284
-
Purified argonaute2 and an siRNA form recombinant human RISC
-
Rivas, F.V., Tolia, N.H., Song, J.J., Aragon, J.P., Liu, J., Hannon, G.J. and Joshua-Tor, L. (2005) Purified Argonaute2 and an siRNA form recombinant human RISC. Nat. Struct. Mol. Biol., 12, 340-349.
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, pp. 340-349
-
-
Rivas, F.V.1
Tolia, N.H.2
Song, J.J.3
Aragon, J.P.4
Liu, J.5
Hannon, G.J.6
Joshua-Tor, L.7
-
24
-
-
0037144546
-
A microRNA in a multiple-turnover RNAi enzyme complex
-
Hutvagner, G. and Zamore, P.D. (2002) A microRNA in a multiple-turnover RNAi enzyme complex. Science, 297, 2056-2060.
-
(2002)
Science
, vol.297
, pp. 2056-2060
-
-
Hutvagner, G.1
Zamore, P.D.2
-
25
-
-
20444427566
-
Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
-
Sen, G.L. and Blau, H.M. (2005) Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. Nat. Cell Biol., 7, 633-636.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 633-636
-
-
Sen, G.L.1
Blau, H.M.2
-
26
-
-
28544435974
-
Disruption of GWbodies impairs mammalian RNA interference
-
Jakymiw, A., Lian, S., Eystathioy, T., Li, S., Satoh, M., Hamel, J.C., Fritzler, M.J. and Chan, E.K. (2005) Disruption of GWbodies impairs mammalian RNA interference. Nat. Cell. Biol., 7, 1267-1274.
-
(2005)
Nat. Cell. Biol.
, vol.7
, pp. 1267-1274
-
-
Jakymiw, A.1
Lian, S.2
Eystathioy, T.3
Li, S.4
Satoh, M.5
Hamel, J.C.6
Fritzler, M.J.7
Chan, E.K.8
-
27
-
-
38649111931
-
In vitro reconstitution of the human RISC-loading complex
-
MacRae, I.J., Ma, E., Zhou, M., Robinson, C.V. and Doudna, J.A. (2008) In vitro reconstitution of the human RISC-loading complex. Proc. Natl. Acad. Sci. U. S. A., 105, 512-517.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 512-517
-
-
MacRae, I.J.1
Ma, E.2
Zhou, M.3
Robinson, C.V.4
Doudna, J.A.5
-
28
-
-
41649115420
-
GW182 interaction with argonaute is essential for miRNA-mediated translational repression and mRNA decay
-
Eulalio, A., Huntzinger, E. and Izaurralde, E. (2008) GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat. Struct. Mol. Biol., 15, 346-353.
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, pp. 346-353
-
-
Eulalio, A.1
Huntzinger, E.2
Izaurralde, E.3
-
29
-
-
79958268109
-
MicroRNAses and the regulated degradation of mature animal miRNAs
-
Grosshans, H. and Chatterjee, S. (2010) MicroRNAses and the regulated degradation of mature animal miRNAs. Adv. Exp. Med. Biol., 700, 140-155.
-
(2010)
Adv. Exp. Med. Biol.
, vol.700
, pp. 140-155
-
-
Grosshans, H.1
Chatterjee, S.2
-
30
-
-
84861866572
-
The mechanics of miRNA-mediated gene silencing: A look under the hood of miRISC
-
Fabian, M.R. and Sonenberg, N. (2012) The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat. Struct. Mol. Biol., 19, 586-593.
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 586-593
-
-
Fabian, M.R.1
Sonenberg, N.2
-
31
-
-
0141705385
-
Mathematical models of RNA silencing: Unidirectional amplification limits accidental self-directed reactions
-
Bergstrom, C.T., McKittrick, E. and Antia, R. (2003) Mathematical models of RNA silencing: unidirectional amplification limits accidental self-directed reactions. Proc. Natl. Acad. Sci. U. S. A., 100, 11511-11516.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 11511-11516
-
-
Bergstrom, C.T.1
McKittrick, E.2
Antia, R.3
-
32
-
-
31544433310
-
The RNA silencing pathway: The bits and pieces that matter
-
Groenenboom, M.A., Maree, A.F. and Hogeweg, P. (2005) The RNA silencing pathway: the bits and pieces that matter. PLoS Comput. Biol., 1, 155-165.
-
(2005)
PLoS Comput. Biol.
, vol.1
, pp. 155-165
-
-
Groenenboom, M.A.1
Maree, A.F.2
Hogeweg, P.3
-
33
-
-
6344249316
-
Dynamics of gene silencing by RNA interference
-
Raab, R.M. and Stephanopoulos, G. (2004) Dynamics of gene silencing by RNA interference. Biotechnol. Bioeng., 88, 121-132.
-
(2004)
Biotechnol. Bioeng.
, vol.88
, pp. 121-132
-
-
Raab, R.M.1
Stephanopoulos, G.2
-
34
-
-
77955840320
-
Numerical modelling of microRNA-mediated mRNA decay identifies novel mechanism of microRNA controlled mRNA downregulation
-
Vohradsky, J., Panek, J. and Vomastek, T. (2010) Numerical modelling of microRNA-mediated mRNA decay identifies novel mechanism of microRNA controlled mRNA downregulation. Nucleic Acids Res., 38, 4579-4585.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 4579-4585
-
-
Vohradsky, J.1
Panek, J.2
Vomastek, T.3
-
35
-
-
84857226910
-
Analysis of miRNA regulation suggests an explanation for 'unexpected' increase in target protein levels
-
Gokhale, S.A. and Gadgil, C.J. (2012) Analysis of miRNA regulation suggests an explanation for 'unexpected' increase in target protein levels. Mol. Biosyst., 8, 760-765.
-
(2012)
Mol. Biosyst.
, vol.8
, pp. 760-765
-
-
Gokhale, S.A.1
Gadgil, C.J.2
-
36
-
-
31544456413
-
Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging
-
Bartlett, D.W. and Davis, M.E. (2006) Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res., 34, 322-333.
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 322-333
-
-
Bartlett, D.W.1
Davis, M.E.2
-
37
-
-
34447306000
-
Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing
-
Bartlett, D.W. and Davis, M.E. (2007) Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing. Biotechnol. Bioeng., 97, 909-921.
-
(2007)
Biotechnol. Bioeng.
, vol.97
, pp. 909-921
-
-
Bartlett, D.W.1
Davis, M.E.2
-
38
-
-
34848918210
-
Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
-
Bartlett, D.W., Su, H., Hildebrandt, I.J., Weber, W.A. and Davis, M.E. (2007) Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging. Proc. Natl. Acad. Sci. U. S. A., 104, 15549-15554.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 15549-15554
-
-
Bartlett, D.W.1
Su, H.2
Hildebrandt, I.J.3
Weber, W.A.4
Davis, M.E.5
-
39
-
-
79251538918
-
Modeling RNA interference in mammalian cells
-
Cuccato, G., Polynikis, A., Siciliano, V., Graziano, M., di Bernardo, M. and di Bernardo, D. (2011) Modeling RNA interference in mammalian cells. BMC Syst. Biol., 5, 19.
-
(2011)
BMC Syst. Biol.
, vol.5
, pp. 19
-
-
Cuccato, G.1
Polynikis, A.2
Siciliano, V.3
Graziano, M.4
Di Bernardo, M.5
Di Bernardo, D.6
-
40
-
-
78449310037
-
mRNA turnover rate limits siRNA and microRNA efficacy
-
Larsson, E., Sander, C. and Marks, D. (2010) mRNA turnover rate limits siRNA and microRNA efficacy. Mol. Syst. Biol., 6, 433.
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 433
-
-
Larsson, E.1
Sander, C.2
Marks, D.3
-
41
-
-
56249145105
-
Structure of the guide-strand-containing argonaute silencing complex
-
Wang, Y., Sheng, G., Juranek, S., Tuschl, T. and Patel, D.J. (2008) Structure of the guide-strand-containing argonaute silencing complex. Nature, 456, 209-213.
-
(2008)
Nature
, vol.456
, pp. 209-213
-
-
Wang, Y.1
Sheng, G.2
Juranek, S.3
Tuschl, T.4
Patel, D.J.5
-
42
-
-
57749206034
-
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
-
Wang, Y., Juranek, S., Li, H., Sheng, G., Tuschl, T. and Patel, D.J. (2008) Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature, 456, 921-926.
-
(2008)
Nature
, vol.456
, pp. 921-926
-
-
Wang, Y.1
Juranek, S.2
Li, H.3
Sheng, G.4
Tuschl, T.5
Patel, D.J.6
-
43
-
-
70349961432
-
Nucleation, propagation and cleavage of target RNAs in ago silencing complexes
-
Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G.S., Tuschl, T. and Patel, D.J. (2009) Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 754-761.
-
(2009)
Nature
, vol.461
, pp. 754-761
-
-
Wang, Y.1
Juranek, S.2
Li, H.3
Sheng, G.4
Wardle, G.S.5
Tuschl, T.6
Patel, D.J.7
-
44
-
-
84861451595
-
The crystal structure of human argonaute2
-
Schirle, N.T. and MacRae, I.J. (2012) The crystal structure of human Argonaute2. Science, 336, 1037-1040.
-
(2012)
Science
, vol.336
, pp. 1037-1040
-
-
Schirle, N.T.1
MacRae, I.J.2
-
45
-
-
84863624199
-
The structure of human argonaute-2 in complex with MIR-20a
-
Elkayam, E., Kuhn, C.D., Tocilj, A., Haase, A.D., Greene, E.M., Hannon, G.J. and Joshua-Tor, L. (2012) The structure of human argonaute-2 in complex with miR-20a. Cell, 150, 100-110.
-
(2012)
Cell
, vol.150
, pp. 100-110
-
-
Elkayam, E.1
Kuhn, C.D.2
Tocilj, A.3
Haase, A.D.4
Greene, E.M.5
Hannon, G.J.6
Joshua-Tor, L.7
-
46
-
-
84862558196
-
Structure of yeast argonaute with guide RNA
-
Nakanishi, K., Weinberg, D.E., Bartel, D.P. and Patel, D.J. (2012) Structure of yeast Argonaute with guide RNA. Nature, 486, 368-374.
-
(2012)
Nature
, vol.486
, pp. 368-374
-
-
Nakanishi, K.1
Weinberg, D.E.2
Bartel, D.P.3
Patel, D.J.4
-
47
-
-
84908572838
-
Structural basis for microRNA targeting
-
Schirle, N.T., Sheu-Gruttadauria, J. and MacRae, I.J. (2014) Structural basis for microRNA targeting. Science, 346, 608-613.
-
(2014)
Science
, vol.346
, pp. 608-613
-
-
Schirle, N.T.1
Sheu-Gruttadauria, J.2
MacRae, I.J.3
-
48
-
-
84887045209
-
Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human argonaute 2 protein
-
Deerberg, A., Willkomm, S. and Restle, T. (2013) Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein. Proc. Natl. Acad. Sci. U. S. A., 110, 17850-17855.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 17850-17855
-
-
Deerberg, A.1
Willkomm, S.2
Restle, T.3
-
49
-
-
33845873577
-
Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: Quantitative analysis of uptake and biological effect
-
Veldhoen, S., Laufer, S.D., Trampe, A. and Restle, T. (2006) Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect. Nucleic Acids Res., 34, 6561-6573.
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 6561-6573
-
-
Veldhoen, S.1
Laufer, S.D.2
Trampe, A.3
Restle, T.4
-
50
-
-
1542336952
-
Rational siRNA design for RNA interference
-
Reynolds, A., Leake, D., Boese, Q., Scaringe, S., Marshall, W.S. and Khvorova, A. (2004) Rational siRNA design for RNA interference. Nat. Biotechnol., 22, 326-330.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 326-330
-
-
Reynolds, A.1
Leake, D.2
Boese, Q.3
Scaringe, S.4
Marshall, W.S.5
Khvorova, A.6
-
51
-
-
59849091278
-
Peptide-mediated cellular delivery of oligonucleotide-based therapeutics in vitro: Quantitative evaluation of overall efficacy employing easy to handle reporter systems
-
Laufer, S.D. and Restle, T. (2008) Peptide-mediated cellular delivery of oligonucleotide-based therapeutics in vitro: quantitative evaluation of overall efficacy employing easy to handle reporter systems. Curr. Pharm. Des., 14, 3637-3655.
-
(2008)
Curr. Pharm. Des.
, vol.14
, pp. 3637-3655
-
-
Laufer, S.D.1
Restle, T.2
-
52
-
-
61349129118
-
Noncovalent peptide-mediated delivery of chemically modified steric block oligonucleotides promotes splice correction: Quantitative analysis of uptake and biological effect
-
Laufer, S.D., Recke, A.L., Veldhoen, S., Trampe, A. and Restle, T. (2009) Noncovalent peptide-mediated delivery of chemically modified steric block oligonucleotides promotes splice correction: quantitative analysis of uptake and biological effect. Oligonucleotides, 19, 63-80.
-
(2009)
Oligonucleotides
, vol.19
, pp. 63-80
-
-
Laufer, S.D.1
Recke, A.L.2
Veldhoen, S.3
Trampe, A.4
Restle, T.5
-
53
-
-
85018731688
-
Selected strategies for the delivery of silencing RNA in vitro and in vivo
-
Erdmann, VA and Barciszewski, J (eds). Springer
-
Laufer, S.D., Detzer, A., Sczakiel, G. and Restle, T. (2010) Selected strategies for the delivery of silencing RNA in vitro and in vivo. In: Erdmann, VA and Barciszewski, J (eds). RNA Technologies and Their Applications. Springer, pp. 29-58.
-
(2010)
RNA Technologies and Their Applications
, pp. 29-58
-
-
Laufer, S.D.1
Detzer, A.2
Sczakiel, G.3
Restle, T.4
-
54
-
-
78649725872
-
Development of a novel method to detect intrinsic mRNA in a living cell by using a molecular beacon-immobilized nanoneedle
-
Kihara, T., Yoshida, N., Kitagawa, T., Nakamura, C., Nakamura, N. and Miyake, J. (2010) Development of a novel method to detect intrinsic mRNA in a living cell by using a molecular beacon-immobilized nanoneedle. Biosens. Bioelectron., 26, 1449-1454.
-
(2010)
Biosens. Bioelectron.
, vol.26
, pp. 1449-1454
-
-
Kihara, T.1
Yoshida, N.2
Kitagawa, T.3
Nakamura, C.4
Nakamura, N.5
Miyake, J.6
-
55
-
-
80052174976
-
High-throughput microfluidic single-cell RT-qPCR
-
White, A.K., VanInsberghe, M., Petriv, O.I., Hamidi, M., Sikorski, D., Marra, M.A., Piret, J., Aparicio, S. and Hansen, C.L. (2011) High-throughput microfluidic single-cell RT-qPCR. Proc. Natl. Acad. Sci. U. S. A., 108, 13999-14004.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 13999-14004
-
-
White, A.K.1
VanInsberghe, M.2
Petriv, O.I.3
Hamidi, M.4
Sikorski, D.5
Marra, M.A.6
Piret, J.7
Aparicio, S.8
Hansen, C.L.9
-
56
-
-
84862731815
-
Comparison of reverse transcription-quantitative polymerase chain reaction methods and platforms for single cell gene expression analysis
-
Fox, B.C., Devonshire, A.S., Baradez, M.O., Marshall, D. and Foy, C.A. (2012) Comparison of reverse transcription-quantitative polymerase chain reaction methods and platforms for single cell gene expression analysis. Anal. Biochem., 427, 178-186.
-
(2012)
Anal. Biochem.
, vol.427
, pp. 178-186
-
-
Fox, B.C.1
Devonshire, A.S.2
Baradez, M.O.3
Marshall, D.4
Foy, C.A.5
-
57
-
-
33845368513
-
COPASI-A complex pathway simulator
-
Hoops, S., Sahle, S., Gauges, R., Lee, C., Pahle, J., Simus, N., Singhal, M., Xu, L., Mendes, P. and Kummer, U. (2006) COPASI-a COmplex PAthway SImulator. Bioinformatics, 22, 3067-3074.
-
(2006)
Bioinformatics
, vol.22
, pp. 3067-3074
-
-
Hoops, S.1
Sahle, S.2
Gauges, R.3
Lee, C.4
Pahle, J.5
Simus, N.6
Singhal, M.7
Xu, L.8
Mendes, P.9
Kummer, U.10
-
58
-
-
33748994704
-
Stochastic mRNA synthesis in mammalian cells
-
Raj, A., Peskin, C.S., Tranchina, D., Vargas, D.Y. and Tyagi, S. (2006) Stochastic mRNA synthesis in mammalian cells. PLoS Biol., 4, e309.
-
(2006)
PLoS Biol.
, vol.4
, pp. e309
-
-
Raj, A.1
Peskin, C.S.2
Tranchina, D.3
Vargas, D.Y.4
Tyagi, S.5
-
59
-
-
0029859509
-
Dissociation of long-chain duplex RNA can occur via strand displacement in vitro: Biological implications
-
Homann, M., Nedbal, W. and Sczakiel, G. (1996) Dissociation of long-chain duplex RNA can occur via strand displacement in vitro: biological implications. Nucleic Acids Res., 24, 4395-4400.
-
(1996)
Nucleic Acids Res.
, vol.24
, pp. 4395-4400
-
-
Homann, M.1
Nedbal, W.2
Sczakiel, G.3
-
60
-
-
9644290892
-
The activity of siRNA in mammalian cells is related to the kinetics of siRNA-target recognition in vitro: Mechanistic implications
-
Wünsche, W. and Sczakiel, G. (2005) The activity of siRNA in mammalian cells is related to the kinetics of siRNA-target recognition in vitro: mechanistic implications. J. Mol. Biol., 345, 203-209.
-
(2005)
J. Mol. Biol.
, vol.345
, pp. 203-209
-
-
Wünsche, W.1
Sczakiel, G.2
-
61
-
-
84859342130
-
Quantitative functions of argonaute proteins in mammalian development
-
Wang, D., Zhang, Z., O'Loughlin, E., Lee, T., Houel, S., O'Carroll, D., Tarakhovsky, A., Ahn, N.G. and Yi, R. (2012) Quantitative functions of Argonaute proteins in mammalian development. Genes Dev., 26, 693-704.
-
(2012)
Genes Dev.
, vol.26
, pp. 693-704
-
-
Wang, D.1
Zhang, Z.2
O'Loughlin, E.3
Lee, T.4
Houel, S.5
O'Carroll, D.6
Tarakhovsky, A.7
Ahn, N.G.8
Yi, R.9
-
62
-
-
0032706622
-
Analysis of human transcriptomes
-
Velculescu, V.E., Madden, S.L., Zhang, L., Lash, A.E., Yu, J., Rago, C., Lal, A., Wang, C.J., Beaudry, G.A., Ciriello, K.M. et al. (1999) Analysis of human transcriptomes. Nat. Genet., 23, 387-388.
-
(1999)
Nat. Genet.
, vol.23
, pp. 387-388
-
-
Velculescu, V.E.1
Madden, S.L.2
Zhang, L.3
Lash, A.E.4
Yu, J.5
Rago, C.6
Lal, A.7
Wang, C.J.8
Beaudry, G.A.9
Ciriello, K.M.10
-
63
-
-
24344500241
-
Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing
-
Harborth, J., Elbashir, S.M., Vandenburgh, K., Manninga, H., Scaringe, S.A., Weber, K. and Tuschl, T. (2003) Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev., 13, 83-105.
-
(2003)
Antisense Nucleic Acid Drug Dev.
, vol.13
, pp. 83-105
-
-
Harborth, J.1
Elbashir, S.M.2
Vandenburgh, K.3
Manninga, H.4
Scaringe, S.A.5
Weber, K.6
Tuschl, T.7
-
64
-
-
4344580941
-
Relative gene-silencing efficiencies of small interfering RNAs targeting sense and antisense transcripts from the same genetic locus
-
Hu, X., Hipolito, S., Lynn, R., Abraham, V., Ramos, S. and Wong-Staal, F. (2004) Relative gene-silencing efficiencies of small interfering RNAs targeting sense and antisense transcripts from the same genetic locus. Nucleic Acids Res., 32, 4609-4617.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 4609-4617
-
-
Hu, X.1
Hipolito, S.2
Lynn, R.3
Abraham, V.4
Ramos, S.5
Wong-Staal, F.6
-
65
-
-
34547218463
-
Insights into effective RNAi gained from large-scale siRNA validation screening
-
Krueger, U., Bergauer, T., Kaufmann, B., Wolter, I., Pilk, S., Heider-Fabian, M., Kirch, S., Artz-Oppitz, C., Isselhorst, M. and Konrad, J. (2007) Insights into effective RNAi gained from large-scale siRNA validation screening. Oligonucleotides, 17, 237-250.
-
(2007)
Oligonucleotides
, vol.17
, pp. 237-250
-
-
Krueger, U.1
Bergauer, T.2
Kaufmann, B.3
Wolter, I.4
Pilk, S.5
Heider-Fabian, M.6
Kirch, S.7
Artz-Oppitz, C.8
Isselhorst, M.9
Konrad, J.10
-
66
-
-
77955644289
-
Mammalian microRNAs predominantly act to decrease target mRNA levels
-
Guo, H., Ingolia, N.T., Weissman, J.S. and Bartel, D.P. (2010) Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature, 466, 835-840.
-
(2010)
Nature
, vol.466
, pp. 835-840
-
-
Guo, H.1
Ingolia, N.T.2
Weissman, J.S.3
Bartel, D.P.4
-
67
-
-
84870038812
-
Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties
-
Wee, L.M., Flores-Jasso, C.F., Salomon, W.E. and Zamore, P.D. (2012) Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell, 151, 1055-1067.
-
(2012)
Cell
, vol.151
, pp. 1055-1067
-
-
Wee, L.M.1
Flores-Jasso, C.F.2
Salomon, W.E.3
Zamore, P.D.4
-
68
-
-
34250805982
-
MicroRNA targeting specificity in mammals: Determinants beyond seed pairing
-
Grimson, A., Farh, K.K., Johnston, W.K., Garrett-Engele, P., Lim, L.P. and Bartel, D.P. (2007) MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol. Cell, 27, 91-105.
-
(2007)
Mol. Cell
, vol.27
, pp. 91-105
-
-
Grimson, A.1
Farh, K.K.2
Johnston, W.K.3
Garrett-Engele, P.4
Lim, L.P.5
Bartel, D.P.6
-
69
-
-
0042161890
-
The activity of siRNA in mammalian cells is related to structural target accessibility: A comparison with antisense oligonucleotides
-
Kretschmer-Kazemi Far, R. and Sczakiel, G. (2003) The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides. Nucleic Acids Res., 31, 4417-4424.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 4417-4424
-
-
Kretschmer-Kazemi Far, R.1
Sczakiel, G.2
-
70
-
-
17444365809
-
Local RNA target structure influences siRNA efficacy: A systematic global analysis
-
Overhoff, M., Alken, M., Far, R.K., Lemaitre, M., Lebleu, B., Sczakiel, G. and Robbins, I. (2005) Local RNA target structure influences siRNA efficacy: a systematic global analysis. J. Mol. Biol., 348, 871-881.
-
(2005)
J. Mol. Biol.
, vol.348
, pp. 871-881
-
-
Overhoff, M.1
Alken, M.2
Far, R.K.3
Lemaitre, M.4
Lebleu, B.5
Sczakiel, G.6
Robbins, I.7
-
71
-
-
20444455464
-
Target accessibility dictates the potency of human RISC
-
Brown, K.M., Chu, C.Y. and Rana, T.M. (2005) Target accessibility dictates the potency of human RISC. Nat. Struct. Mol. Biol., 12, 469-470.
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, pp. 469-470
-
-
Brown, K.M.1
Chu, C.Y.2
Rana, T.M.3
-
72
-
-
84875959735
-
Computational identification of biologically functional non-hairpin GC-helices in human argonaute mRNA
-
Dornseifer, S. and Sczakiel, G. (2013) Computational identification of biologically functional non-hairpin GC-helices in human Argonaute mRNA. BMC Bioinformatics, 14, 122.
-
(2013)
BMC Bioinformatics
, vol.14
, pp. 122
-
-
Dornseifer, S.1
Sczakiel, G.2
-
73
-
-
0020590028
-
HipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis
-
Moyed, H.S. and Bertrand, K.P. (1983) hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis. J. Bacteriol., 155, 768-775.
-
(1983)
J. Bacteriol.
, vol.155
, pp. 768-775
-
-
Moyed, H.S.1
Bertrand, K.P.2
-
74
-
-
77955628762
-
Persister cells
-
Lewis, K. (2010) Persister cells. Annu. Rev. Microbiol., 64, 357-372.
-
(2010)
Annu. Rev. Microbiol.
, vol.64
, pp. 357-372
-
-
Lewis, K.1
-
75
-
-
77950809059
-
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
-
Sharma, S.V., Lee, D.Y., Li, B., Quinlan, M.P., Takahashi, F., Maheswaran, S., McDermott, U., Azizian, N., Zou, L., Fischbach, M.A. et al. (2010) A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell, 141, 69-80.
-
(2010)
Cell
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
Lee, D.Y.2
Li, B.3
Quinlan, M.P.4
Takahashi, F.5
Maheswaran, S.6
McDermott, U.7
Azizian, N.8
Zou, L.9
Fischbach, M.A.10
|