Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1

Journal of Functional Foods

Volumn 25, Issue , 2016, Pages 267-278

  Vadde, Ramakrishna ^a,c   Radhakrishnan, Sridhar ^a   Eranda Karunathilake Kurundu, Hewage ^a   Reddivari, Lavanya ^a   Vanamala, Jairam K P ^a,b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENN STATE CANCER INSTITUTE   (United States)

^c YOGI VEMANA UNIVERSITY   (India)

Author keywords

Amla (Emblica officinalis Gaertn.) seed and pulp; Apoptosis; Cancer stem cells; Colon cancer; Proliferation; Wnt catenin signalling

Indexed keywords

EID: 84975252027     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2016.06.007     Document Type: Article

References (40)

1. Ajani J.A., Song S., Hochster H.S., Steinberg I.B. Cancer stem cells: The promise and the potential. Seminars in Oncology 2015, 42(1):S3-S17.
2. Amado N.G., Predes D., Moreno M.M., Carvalbo I.O., Mendes F.A., Abreu J.G. Flavanoids and Wnt/β-catenin signaling: Potential role in colorectal cancer therapies. International Journal of Molecular Sciences 2014, 15:12094-12106.
3. Amendola D., De Salvo M., Marchese R., Verga Falzacappa C., Stigliano A., Carico E., Brunetti E., Moscarini M., Bucci B. Myc down-regulation affects cyclin D1/cdk4 activity and induces apoptosis via smac/Diablo pathway in an astrocytoma cell line. Cell Proliferation 2009, 42(1):94-109.
4. Anastas J.N., Moon R.T. WNT signalling pathways as therapeutic targets in cancer. Nature Reviews. Cancer 2013, 13:11-26.
5. Baliga M.S., Dsouza J.J. Amla (Emblica officinalis Gaertn.), a wonder berry in the treatment and prevention of cancer. European Journal of Cancer Prevention 2011, 20(3):225-239.
6. Benetou V., Orfanos P., Lagiou P., Trichopoulos D., Boffetta P., Trichopoulou A. Vegetables and fruits in relation to cancer risk: Evidence from the Greek EPIC cohort study. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 2008, 17(2):387-392.
7. Broeckling C.D., Heuberger A.L., Prince J.A., Ingelsson E., Prenni J.E. Assigning precursor - product ion relationships in indiscriminant MS/MS data from non-targeted metabolite profiling studies. Metabolomics 2013, 9:33-43.
8. Chen B.J., Wu Y.L., Tanaka Y., Zhang W. Small molecules targeting c-Myc oncogene: Promising anti-cancer therapeutics. International Journal of Biological Sciences 2014, 10(10):1084-1096.
9. Chen K.H., Lin B.R., Chien C.T., Ho C.H. Emblica officinalis Gaertn. attenuates N-nitrosodiethylamine-induced apoptosis, autophagy, and inflammation in rat livers. Journal of Medicinal Food 2011, 14(7-8):746-755.
10. Deng Y.H., Pu X.X., Huang M.J., Xiao J.M., Lin T.Y., Lin E.N. 5-Fluorouracil upregulates the activity of Wnt signaling pathway in CD133-positive colon cancer stem-like cells. Chinese Journal of Cancer 2010, 29(9):810-815.
11. Hanahan D., Weinberg R.A. Hallmarks of cancer: The next generation. Cell 2011, 144:646-674.
12. Haupt S., Berger M., Goldberg Z., Haupt Y. Apoptosis - The p53 network. Journal of Cell Science 2003, 116:4077-4085.
13. Holland J.D., Klaus A., Garratt A., Birchmeier W. Wnt signaling in stem and cancer stem cells. Current Opinion in Cell Biology 2013, 25:254-264.
14. Kasdagly M., Radhakrishnan S., Reddivari L., Rao Veeramachaneni D.N., Vanamala J. Colon carcinogenesis: Influence of Western diet-induced obesity and targeting stem cells using dietary bioactive compounds. Nutrition 2014, 30:1242-1256.
15. Kim J., Zhang X., Rieger-Christ K.M., Summerhavyes I.C., Wazerm D.E., Paulson K.E., Yee A.S. Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. The Journal of Biological Chemistry 2006, 281:10865-10875.
16. Krishnaveni M., Mirunalini S. Chemopreventive efficacy of Phyllanthus emblica L. fruit extract on 7,12-dimenthylbenz(a)anthracene induced oral carcinogenesis - A dose response study. Environmental Toxicology and Pharmacology 2012, 34(3):801-810.
17. Li H., Yang B., Huang J., Yin X., Wan J., Luo F., Zhang L., Li H., Ren G. Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway. Toxicology Letters 2013, 220(3):219-228.
18. Madiwale G.P., Reddivari L., Holm D.G., Vanamala J. Storage elevates phenolic content and antioxidant activity but suppresses antiproliferative and pro-apoptotic properties of colored-flesh potatoes against human colon cancer cell lines. Journal of Agricultural and Food Chemistry 2011, 59(15):8155-8166.
19. Markowitz S.D., Bertagnolli M.M. Molecular origins of cancer: Molecular basis of colorectal cancer. The New England Journal of Medicine 2009, 361:2449-2460.
20. Massey A.R., Reddivari L., Vanamala J. The dermal layer of sweet sorghum (Sorghum bicolor) stalk, a byproduct of biofuel production and source of unique 3-deoxyanthocyanidins, has more antiproliferative and proapoptotic activity than the pith in p53 variants of HCT116 and colon cancer stem cells. Journal of Agricultural and Food Chemistry 2014, 62:3150-3159.
21. Medema J.P. Cancer stem cells: The challenges ahead. Nature Cell Biology 2013, 15:338-344.
22. Mishra P., Dutta N., Mhanta C.L. Partial extraction and identification of phenolics in Amla (Emblica officinalis) seed coat powder. Journal of Food Science & Technology 2015, 52(11):6990-7001.
23. Ngamkitidechakul C., Jaijoy K., Hansakul P., Soonthorncharenonnon N., Sireerataworng S. Antitumour effects of Phyllanthus emblica L.: Induction of cancer cell apoptosis and inhibition of in vivo tumour promotion and in vitro invasion of human cancer cells. Phytotherapy Research 2010, 24:1405-1413.
24. Ola M.S., Nawaz M., Ahsan H. Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Molecular and Cellular Biochemistry 2011, 351:41-58.
25. Ottinger S., Klöppel A., Rausch V., Liu L., Kallifatidis G., Gross W., Gebhard M.M., Brümmer F., Herr I. Targeting of pancreatic and prostate cancer stem cell characteristics by Crambecrambe marine sponge extract. International Journal of Cancer 2012, 130:1671-1681.
26. Oyebode O., Gordon-Dseagu V., Walker A., Mindell J.S. Fruit and vegetable consumption and all-cause, cancer and CVD mortality: Analysis of health survey for England data. Journal of Epidemiology and Community Health 2014, 68(9):856-862. 10.1136/jech-2013-203500.
27. Park C.H., Chang J.Y., Hahm E.R., Park S., Kim H.-K., Yang C.H. Quercetin, a potent inhibitor against β-catenin/Tcf signaling in SW480 colon cancer cells. Biochemical and Biophysical Research Communications 2005, 328:227-234.
28. Park S., Choi J. Inhibition of beta-catenin/Tcf signaling by flavonoids. Journal of Cellular Biochemistry 2010, 110(6):1376-1385.
29. Pistollato F., Giampieri F., Battino M. The use of plant derived bioactive compounds to target cancer stem cells and modulate tumour microenvironment. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 2015, 75:58-70.
30. Qiu W., Wang X., Leibowitz B., Liu H., Barker N., Okada H., Que N., Yasui W., Clevers H., Schoen R.E., Yu J., Zhang L. Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(46):20027-20032.
31. Radhakrishnan S., Reddivari L., Sclafani R., Das U.N., Vanamala J. Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis. Frontiers in Bioscience (Elite Edition) 2011, 3:1509-1523.
32. Ramakrishna V., Radhakrishnan S., Reddivari L., Vanamala J. Triphala extract suppresses proliferation and induces apoptosis in human colon cancer stem cells via suppressing c-Myc/Cyclin D1 and elevation of Bax/Bcl-2 ratio. BioMed Research International 2015, 2015. Article ID 649263. http://dx.doi.org/10.1155/2015/649263.
33. Reddivari L., Vanamala J., Chintharlapalli S., Safe S.H., Miller J.C. Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways. Carcinogenesis 2007, 28:2227-2235.
34. Ricciardiello L., Bazzoli F., Fogliano V. Phytochemicals and colorectal cancer prevention - myth or reality?. Nature Reviews. Gastroenterology & Hepatology 2011, 8(10):592-596.
35. Siegel R.L., Miller K.D., Jemal A. Cancer statistics. CA: A Cancer Journal for Clinicians 2015, 65:5-29.
36. Singh N.B., Shankar S., Srivastava R.K. Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications. Biochemical Pharmacology 2011, 82(12):1807-1821.
37. Singleton V., Orthofer R., Lameula-Raventós M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods in Enzymology 1999, 299:152-178.
38. Sumner L.W., Amberg A., Barrett D., Beger R., Beale M., Daykin C.A., Fan T.W.-M., Fiehn O., Goodacre R., Griffin J.L., Hankemeier T., Hardy N., Harnly J., Higashi R., Kopka J., Lane A.N., Lindon J.C., Marriott P., Nicholls A.W., Reily M.D., Thaden J.J., Viant M.R. Proposed minimum reporting standards for Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI). Metabolomics 2007, 3:211-221.
39. Tarapore R.S., Siddiqui I.A., Mukhtar H. Modulation of Wnt/β-catenin signaling pathway by bioactive food components. Carcinogenesis 2012, 33(3):483-491.
40. Yang Y., Zhao S., Song J. Caspase-dependent apoptosis and -independent poly(ADP-ribose) polymerase cleavage induced by transforming growth factor beta1. The International Journal of Biochemistry & Cell Biology 2004, 36(2):223-234.