Emblica officinalis gaertn. attentuates N-nitrosodiethylamine-induced apoptosis, autophagy, and inflammation in rat livers

Journal of Medicinal Food

Volumn 14, Issue 7-8, 2011, Pages 746-755

  Chen, Kuo Hsin ^a   Lin, Bor Ru ^b   Chien, Chiang Ting ^b   Ho, Chien Hsin ^c  

^a FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c KUANG TIEN GENERAL HOSPITAL   (Taiwan)

Author keywords

antioxidant; apoptosis; autophagy; inflammation; liver injury; reactive oxygen species

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; ALANINE AMINOTRANSFERASE; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; BECLIN 1; CATALASE; CYTOCHROME P450 2E1; DIETHYLNITROSAMINE; EMBLICA OFFICINALIS EXTRACT; GAMMA GLUTAMYLTRANSFERASE; HYDROGEN PEROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; NITRIC OXIDE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUNAMLA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOPHAGY; BILE; CELL INFILTRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; EMBLICA OFFICINALIS; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEPATITIS; KUPFFER CELL; LEUKOCYTE; LIVER; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; AUTOPHAGY; DIETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; LIVER; LIVER NEOPLASMS; MALE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PHYLLANTHUS EMBLICA; PLANT EXTRACTS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

PHYLLANTHUS EMBLICA; RATTUS;

EID: 79960458862     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2010.1459     Document Type: Article

References (52)

1. Paraskevi A, Ronald A: Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006;6:1-14.
2. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ: Cancer statistics, 2007. CA Cancer J Clin 2007;57:43-66.
3. Brown JL: N-Nitrosamines. Occup Med 1999;14:839-848.
4. Sullivan BP, Meyer TJ, Stershic MT, Keefer LK: Acceleration of N-nitrosation reactions by electrophiles. IARC Sci Publ 1991; 105:370-374.
5. Reh BD, Fajen JM: Worker exposure to nitrosamines in a rubber vehicle sealing plant. Am Ind Hyg Assoc J 1996;57:918-923.
6. Verna L, Whysner J, Williams GM: N-Nitrodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther 1996;71:57-81. (Pubitemid 26323290)
7. Parola M, Robino G: Oxidative stress-related molecules and liver fibrosis. J Hepatol 2001;35:297-306. (Pubitemid 32803489)
8. Hai W, Kim C, Song S, Kang C: Study on mechanism of mul-tistep hepatotumorigenesis in rat: development of hepatotumor-igenesis. J Vet Sci 2001;2:53-58.
9. Yu HJ, Lin BR, Lee HS, Shun CT, Yang CC, Lai TY, Chien CT, Hsu SM: Sympathetic vesicovascular reflex induced by acute urinary retention evokes proinflammatory and proapoptotic injury in rat liver. Am J Physiol Renal Physiol 2005;288: 1005-1014.
10. Gao M, Yeh PY, Lu YS, Hsu CH, Chen KF, Lee WC, Feng WC, Chen CS, Kuo ML, Cheng AL: OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma. Cancer Res 2008;68: 9348-9357.
11. Li PC, Shaw CF, Kuo TB, Chien CT: Inducible nitric oxide synthase evoked nitric oxide counteracts capsaicin-induced airway smooth muscle contraction, but exacerbates plasma extravasation. Neurosci Lett 2005;378:117-122.
12. Zhao X, Zhang JJ, Wang X, Bu XY, Lou YQ, Zhang GL: Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome P450 2E1 and 1A2 activities in diethylnitrosamine-and phenobarbital-treated rats. Biomed Pharmacother 2008;62:567-572.
13. Chien CT, Lee PH, Chen CF, Ma MC, Lai MK, Hsu SM: De novo demonstration and co-localization of free-radical production and apoptosis formation in rat kidney subjected to ischemia/reperfusion. J Am Soc Nephrol 2001;12:973-982.
14. Chien CT, Chang TC, Tsai CY, Shyue SK, Lai MK: Adenovirus-mediated bcl-2 gene transfer inhibits renal ischemia/reperfusion induced tubular oxidative stress and apoptosis. Am J Transplant 2005;5:1194-1203.
15. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B: Bcl-2 antiapoptotic proteins inhibit beclin-1 dependent autophagy. Cell 2005;122:927-939. (Pubitemid 41345209)
16. Zhu C, Wang X, Xu F, Bahr BA, Shibata M, Uchiyama Y, Hagberg H, Blomgren K: The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ 2005;12:162-176. (Pubitemid 40220647)
17. Chien CT, Shyue SK, Lai MK: Bcl-xL augmentation potentially reduces ischemia/reperfusion induced proximal and distal tubular apoptosis and autophagy. Transplantation 2007;84: 1183-1190.
18. Jose K, Kuttan R: Hepatoprotective activity of Emblica offici-nalis and Chyavanaprash. J Ethnopharmacol 2006;72:135-140.
19. Mukherjee SR, Bhattachayya S, Debnath PK, Biswas TK, Jana U, Pandit S, Saha BP, Paul PK: Clinical study of Triphala: a well known phytomedicine from India. Iran J Pharmacol Ther 2006; 5:51-54. (Pubitemid 351325776)
20. Mathur R, Sharma A, Dixit VP, Verma M: Hypolipidaemic effect of fruit juice of Emblica officinalis in cholesterol fed rabbits. J Ethnopharmacol 1996;50:61-68. (Pubitemid 26064144)
21. Jeena KJ, Kuttan G, George J, Kuttan R: Antimutagenic and anticarcinogenic activity of Emblica officinalis Gaertn. J Clin Biochem Nutr 1996;22:171-176.
22. Poltanov EA, Shikov AN, Dorman HJ, Pozharitskaya ON, Ma-karov VG, Tikhonov VP, Hiltunen R: Chemical and antioxidant evaluation of Indian gooseberry (Emblica officinalis Gaertn., syn. Phyllanthus emblica L.) supplements. Phytother Res 2009;23: 1309-1315.
23. Ong T, Whong WZ, Stewart J, Brockman HE: Chlorophyllin: a potent antimutagen against environmental and dietary complex mixture. Mutat Res 1986;173:111-115. (Pubitemid 16126892)
24. Gulati RK, Agarwal S, Agrawal SS: Hepatoprotective studies on Phyllanthus emblica Linn. and quercetin. Indian J Exp Biol 1995: 33:261-268.
25. Jeena KJ, Joy KL, Kuttan K: Effect of Emblica officinalis, Phyl-lanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett 1999;136:11-16. (Pubitemid 29142296)
26. Sultana S, Ahmed S, Sharma S, Jahangir T: Emblica officinalis reverses thioacetamide-induced oxidative stress and early promotional events of primary hepatocarcinogenesis. J Pharm Pharmacol 2004;56:1573-1579. (Pubitemid 39601999)
27. 4 induced hepatic toxicity and DNA synthesis in Wistar rats. Indian J Exp Biol 2005;43:430-436. (Pubitemid 40678887)
28. Yokozawa T, Kim HY, Kim HJ, Okubo T, Chu DC, Juneja LR: Amla (Emblica officinalis Gaertn.) prevents dyslipidaemia and oxidative stress in the ageing process. Br J Nutr 2007;97:1187-1195. (Pubitemid 46925372)
29. Bhattacharya A, Chatterjee A, Ghosal S, Bhattacharya SK: An-tioxidant activity of active tannoid principles of Emblica offici-nalis (amla). Indian J Exp Biol 1999;37:676-680. (Pubitemid 29309692)
30. Damodaran M, Nair KR: A tannin from the Indian gooseberry (Phyllanthus emblica) with a protective action on ascorbic acid. Biochem J 1936;30:1014-1020.
31. Scartezzini P, Antognoni F, Raggi MA, Poli F, Sabbioni C: Vitamin C content and antioxidant activity of the fruit and of the Ayurvedic preparation of Emblica officinalis Gaertn. J Ethno-pharmacol 2006;104:113-118. (Pubitemid 43234090)
32. Yokozawa T, Kim HY, Kim HJ, Tanaka T, Sugino H, Okubo T, Chu DC, Juneja LR: Amla (Emblica officinalis Gaertn.) attenuates age-related renal dysfunction by oxidative stress. J Agric Food Chem 2007;55:7744-7752. (Pubitemid 47522183)
33. Huang KC, Yang CC, Lee KT, Chien CT: Reduced hemodialy-sis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. Kidney Int 2003;64:704-714.
34. Waris G, Ahsan H: Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog 2006;5:14.
35. Hasegawa T, Yoshimura Y, Kikuiri T, Yawaka Y, Takeyama S, Matsumoto A, Oguchi H, Shirakawa T: Expression of receptor activator of NF-kappa B ligand and osteoprotegerin in culture of human periodontal ligament cells. J Periodontal Res 2002;37: 405-411.
36. Nolan JP, Leibowitz AI, Vladutiu AO: Influence of carbon tet-rachloride on circulating endotoxin after exogenous administration of endotoxin in rats. Proc Soc Exp Biol Med 1980;165: 453-456. (Pubitemid 11187610)
37. Bremer C, Bradford BU, Hunt KJ, Knecht KT, Connor HD, Mason RP, Thurman RG: Role of Kupffer cells in the patho-genesis of hepatic reperfusion injury. Am J Physiol 1994;267: G630-G636.
38. Wheeler MD, Thurman RG: Production of superoxide and TNF-alpha from alveolar macrophages is blunted by glycine. Am J Physiol 1999;277:L952-L959.
39. Decker K: Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem 1990;192:245-261. (Pubitemid 20283490)
40. Wang JF, Komarov P, Sies H, de Groot H: Inhibition of super-oxide and nitric oxide release and protection from reoxygenation injury by Ebselen in rat Kupffer cells. Hepatology 1992;15: 1112-1116.
41. Koo AS, Tso CL, Shimabukuro T, Peyret C, deKernion JB, Belldegrun A: Autologous tumor-specific cytotoxicity of tumor-infiltrating lymphocytes derived from human renal cell carcinoma. J Immunother 1991;10:347-354.
42. Vollmar B, Glasz J, Leiderer R, Post S, Menger MD: Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion. Am J Pathol 1994;145: 1421-1431. (Pubitemid 24378496)
43. de la Lastra CA, Villegas I: Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res 2005;49:405-430. (Pubitemid 40780389)
44. Chen TS, Liou SY, Chang YL: Supplementation of Emblica officinalis (Amla) extract reduces oxidative stress in uremic patients. Am J Chin Med 2009;37:19-25.
45. Nicolis E, Lampronti I, Dechecchi MC, Borgatti M, Tamanini A, Bianchi N, Bezzerri V, Mancini I, Giri MG, Rizzotti P, Gambari R, Cabrini G: Pyrogallol, an active compound from the medicinal plant Emblica officinalis, regulates expression of pro-inflammatory genes in bronchial epithelial cells. Int Immunopharmacol 2008;8:1672-1680.
46. Pramyothin P, Samosorn P, Poungshompoo S, Chaichantipyuth C: The protective effects of Phyllanthus emblica Linn. extract on ethanol induced rat hepatic injury. J Ethnopharmacol 2006;107: 361-364. (Pubitemid 44344426)
47. Penolazzi L, Lampronti I, Borgatti M, Khan MT, Zennaro M, Piva R, Gambari R: Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Em-blica officinalis. BMC Complement Altern Med 2008;8:59.
48. McGowan AJ, Ruiz-Ruiz MC, Gorman AM, Lopez-Rivas A, Cotter TG: Reactive oxygen intermediate(s) (ROI): common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis. FEBS Lett 1996;39:299-303. (Pubitemid 26289136)
49. Perskvist N, Long M, Stendahl O, Zheng L: Mycobacterium tuberculosis promotes apoptosis in human neutrophils by activating caspase-3 and altering expression of Bax/Bcl-xL via an oxygen-dependent pathway. J Immunol 2002;168:6358-6365. (Pubitemid 34620059)
50. Petronilli V, Costantini P, Scorrano L, Colonna R, Passamonti S, Bernardi P: The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols: increase of the gating potential by oxi-dants and its reversal by reducing agents. J Biol Chem 1994; 269:16638-16642.
51. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE, Brenner DA: Role of mitochondrial inner membrane permeabi-lization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal 2002;4:769-781. (Pubitemid 35246939)
52. Yanagisawa H, Miyashita T, Nakano Y, Yamamoto D: HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. Cell Death Differ 2003;10:798-807. (Pubitemid 36850241)