Chemopreventive efficacy of Phyllanthus emblica L. (amla) fruit extract on 7,12-dimethylbenz(a)anthracene induced oral carcinogenesis -A dose-response study

Environmental Toxicology and Pharmacology

Volumn 34, Issue 3, 2012, Pages 801-810

  Krishnaveni, Mani ^a   Mirunalini, Sankaran ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

7,12 Dimetylbenz a anthracene (DMBA); Buccal pouch carcinogenesis; Lipid peroxidation; Phyllanthus emblica

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ALPHA TOCOPHEROL; ASCORBIC ACID; CATALASE; ELLAGIC ACID; EMBLICA OFFICINALIS EXTRACT; GALLIC ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; METHANOL; QUERCETIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PREVENTION; CHEEK POUCH; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; ENZYME ACTIVITY; FRUIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOUTH CARCINOMA; NONHUMAN; PRIORITY JOURNAL; SYRIAN HAMSTER;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTICARCINOGENIC AGENTS; ASCORBIC ACID; CATALASE; CRICETINAE; FRUIT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALE; MOUTH NEOPLASMS; PHYLLANTHUS EMBLICA; PLANT EXTRACTS; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN E;

ANIMALIA; CRICETINAE; EUPHORBIACEAE; PHYLLANTHUS EMBLICA;

EID: 84871747101     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2012.09.006     Document Type: Article

References (47)

1. Bagchi D., Bagchi M., Stohs J.S., Das K.D., Ray D.S., Kuszynski A.C., Joshi S.S., Pruess G.H. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 2000, 148:187-197.
2. Bewick M., Coutie W., Tudhope G.R. Superoxide dismutase, glutathione peroxidase and catalase in the red cells of patients with malignant lymphoma. Br. J. Haematol. 1987, 65:347-350.
3. Bishayee A., Oinam S., Basu M., Chatterjee M. Vanadium chemoprevention of 7,12-dimethylbenz[a]anthracene induced rat mammary carcinogenesis: probable involvement of representative hepatic phase I and phase II xenobiotic metabolizing enzymes. Breast Cancer Res. Treat. 2000, 63:133-145.
4. Braakhuis B.J., Leemans C.R., Brakenhoff R.H. A genetic progression model of oral cancer: current evidence and clinical implications. J. Oral Pathol. Med. 2004, 33(6):317-322.
5. Chen Y.K., Lin L.M. DMBA-induced hamster buccal pouch carcinoma and VX-2 induced rabbit cancer as a model for human oral carcinogenesis. Expert Rev. Anticancer Ther. 2010, 10:1262-1272.
6. Chew Y.L., Lim Y.Y., Omar M., Khoo K.S. Antioxidant activity of three edible seaweeds from two areas in South East Asia. LWT -Food. Sci. Technol. 2008, 41:1067-1072.
7. Das S. Vitamin E in the genesis and prevention of cancer -a review. Acta Oncol. 1994, 33:615-619.
8. Desai F.D. Vitamin E analysis methods for animal tissues. Methods in Enzymology 1984, vol. 105:138-147. Academic Press, New York.
9. Diplock A.T., Rice-Evans A.C., Burton R.H. Is there a significant role for lipid peroxidation in the causation of malignancy and for antioxidants in cancer prevention?. Cancer Res. 1994, 54:1952-1956.
10. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
11. Giri U., Sharma S.D., Abdulla M., Athar M. Evidence that in situ generated reactive oxygen species act as a potent stage I tumor promoter in mouse skin. Biochem. Biophys. Res. Commun. 1995, 209:689-705.
12. Goshal S., Tripathi V.K., Chauhan S. Active constituents of Emblica officinalis. The chemistry and antioxidative effects of two new hydrolysable tannins: Emblicanin A and B, Indian. J. Chem. 1996, 35:941-948.
13. Hahn M., Hagedorn G., Kuhlisch E., Schackert H.K., Edkelt U. Genetic of drug-metabolizing enzymes and susceptibility to oral cavity cancer. Oral Oncol. 2002, 38:486-490.
14. Hail N.J., Cortes M., Drake E.N., Spallholz J.E. Cancer chemoprevention: a radical perspective. Free Radic. Biol. Med. 2008, 45:97-110.
15. Halliwell B., Zhao K., Whiteman M. The gastrointestinal tract: a major site of antioxidant action?. Free Radic. Res. 2000, 33:819-830.
16. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
17. Jia Z.S., Tang M.C., Wu J.M. The determination of flavonoid content in mulberry and their scavenging effects on superoxide radicals. Food Chem. 1999, 64:555-559.
18. Kahlos K., Paakko P., Kurttila E., Soini Y., Kinnula V.L. Manganese superoxide dismutase as a diagnostic marker for malignant pleural mesothelioma. Br. J. Cancer 2000, 82:1022-1029.
19. Kakkar P., Das B., Viswanathan P.N. A modified spectrophotometric assay of superoxide dismutase. Indian J. Biochem. Biophys. 1984, 21:130-132.
20. 450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]-anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation. Chem. Res. Toxicol. 2002, 15:226-235.
21. Koehn F.E., Carter G.T. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov. 2005, 4:206-220.
22. Krishnaveni M., Mirunalini S. Therapeutic potential of Phyllanthus emblica (Amla): the ayurvedic wonder. J. Basic Clin. Physiol. Pharmacol. 2010, 21:93-105.
23. Larsson S.C., Bergkvist L., Wolk A. Fruit and vegetable consumption and incidence of gastric cancer: a prospective study. Cancer Epidemiol. Biomarkers Prev. 2006, 15:1998-2001.
24. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
25. Mans D.R., Schuurhuis G.J., Treskes M., Lafleur M.V., Retel J., Pinedo H.M., Lankelma J. Modulation by DL-butathione-S, R-sulphomixine of etoposide toxicity on human non-small cell lung, ovarian and breast carcinoma cell line. Br. J. Cancer 1992, 28A:1447-1452.
26. Mirunalini S., Ramachandran C.R., Nagini S. Chemoprevention of experimental hamster buccal pouch carcinogenesis by garlic oil. J. Herbs. Sp. Med. Plants 2004, 10:89-101.
27. Moody J.D., Fu P.P., Freeman J.P., Cerniglia C.E. Regio-and stereoselective metabolism of 7,12-Dimethylbenz[a]anthracene by Mycobacterium vanbaalenii PYR-1. Appl. Environ. Microbiol. 2003, 69:3924-3931.
28. Ohkawa H., Ohisi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
29. Omaye S.T., Turnbull T.D., Sauberlich H.E. Selected method for the determination of ascorbic acid in animal cells, tissues and fluids. Methods in Enzymology 1979, 3-11. Academic Press, New York. D.B. Mc, D.L. Cormic, Wright (Eds.).
30. Polshettiwar S.A., Ganjiwale R.O., Wadher S.J., Yeole P.G. Spectrophotometric estimation of total tannins in some ayurvedic eye drops. Indian J. Pharm. Sci. 2007, 69:574-576.
31. Rani P., Khullar N. Antimcrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant Salmonella typhi. J. Phytother. Res. 2004, 18:670-673.
32. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium: Biochemical roles as a component of glutathione peroxidase. Science 1973, 179:588-590.
33. Russo G.L. Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem. Pharmacol. 2007, 74:533-544.
34. Salley J.J. Experimental carcinogenesis in the cheek pouch of the Syrian hamster. J. Dent. Res. 1954, 33:253-262.
35. Sancheti G., Jindal A., Kumara R., Goyal P.K. Chemopreventive action of Emblica officinalis on skin carcinogenesis in mice. Asian Pac. J. Cancer Prev. 2005, 6:197-201.
36. Scartezzini P., Speroni E. Review on some plants of Indian traditional medicine with antioxidant activity. J. Ethnopharmacol. 2000, 71:23-43.
37. Scartezzini P., Antognoni F., Raggi M.A., Poli F., Sabbioni C. Vitamin C content and antioxidant activity of the fruit and of the ayurvedic preparation of Emblica officinalis Gaertn. J. Ethnopharmacol. 2006, 104:113-118.
38. Schliephake H. Prognostic relevance of molecular markers of oral cancer -a review. Int. J. Oral Maxillofac. Surg. 2003, 32:233-245.
39. Sinha A.K. Colorimetric assay of catalase. Anal. Biochem. 1972, 47:389-394.
40. Skrzydlewska E., Stankiewicz A., Sulkowska M., Sulkowski S., Kasacka I. Antioxidant status and lipid peroxidation in colorectal cancer. J. Toxicol. Environ. Health 2001, 64:213-222.
41. Slater T.F., Benedetto C., Burton G.W., Cheeseman K.H., Ingold K.U., Nodes J.T. Lipid peroxidation in animal tumours: a disturbance in the control of cell division. Icosanoids and Cancer 1984, 21-29. Raven Press, New York. H. Thaler-Dao, R. Paoletti, A. Crastes de Paulet (Eds.).
42. Sulak O., Altuntas I., Karahan N., Yildirim B., Akturk O., Yilmaz R., Delibas N. Nephrotoxicity in rats induced by organophosphate insecticide methidathion and ameliorating effects of vitamin E and C. Pestic. Biochem. Physiol. 2005, 83:21-28.
43. Valko M., Rhodes C.J., Moncol J., Izakovic M., Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 2006, 160:1-4.
44. Vasquez-Garzon V.R., Arellanes-Robledo J., Garca-Roman R., Aparicio-Rautista D.I., Villa-Trevino S. Inhibition of reactive oxygen species and preneoplastic lesions by quercetin through an antioxidant defense mechanism. Free Radic. Res. 2009, 43:128-137.
45. Wu G., Fang Y.Z., Yang S., Lupton J.R., Turner N.D. Glutathione metabolism and its implications for health. J. Nutr. 2004, 134:489-492.
46. Yagi K. Lipid peroxides and human disease. Chem. Physiol. Lipids 1978, 45:337-351.
47. Zhang L., Mock D. Alteration in glutathione level during carcinogenesis in hamster buccal pouch mucosa. J. Dent. Res. 1991, 70:1061-1063.