Vitamin D deficiency is associated with inflammation in older irish adults

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 5, 2014, Pages 1807-1815

  Laird, E ^a   McNulty, H ^b   Ward, M ^b   Hoey, L ^b   McSorley, E ^b   Wallace, J M W ^b   Carson, E ^b   Molloy, A M ^a   Healy, M ^c   Casey, M C ^c   Cunningham, C ^c   Strain, J J ^b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF ULSTER   (United Kingdom)

^c ST JAMES S HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; C REACTIVE PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ETHNIC GROUP; FEMALE; HUMAN; IMMUNE RESPONSE; INFLAMMATION; IRISH; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TANDEM MASS SPECTROMETRY; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CYTOKINES; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; NORTHERN IRELAND; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84899908990     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-3507     Document Type: Article

References (55)

1. Mathieu C, Adorini L. The coming of age of 1,25-dihydroxyvitamin D3 analogs as immunomodulatory agents. Trends Mol Med. 2002; 8:174-179.
2. Holick MF. High prevalence of vitamin D inadequacy and implications for health Mayo Clin Proc. 2006 81 353-373.
3. Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D3 receptor in the immune system. Arch Biochem Biophys. 2000;374:334-338.
4. van Etten E, Mathieu C. Immu noregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol. 2005;97: 93-101.
5. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008;4:80-90.
6. Zhang Y, Leung DY, Richers BN, et al. Vitamin D inhibits monocyte/macrophage pro-inflammatory cytokine production by tar geting MAPK phosphatase-1. J Immunol. 2012;188:2127-2135.
7. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080S-1086S.
8. van SchoorNM,Lips P. Worldwide vitaminDstatus. Best Pract Res Clin Endocrinol Metab. 2011;25(4):671-680.
9. Ponsonby AL, McMichael A, Van-Der Mei I. Ultraviolet radiation and autoimmune disease: insights from epidemiological research. Toxicology. 2002;181-182:71-78.
10. Ginde AA, Mansbach JM, Camargo CA. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169:384-390.
11. Staples JA, Ponsonby AL, Lim LL, McMichael AJ. Ecologic analysis of some immune-related disorders, including type 1 diabetes, in Australia: latitude, regional ultraviolet radiation, and disea se prevalence. Environ Health Perspect. 2003;111:518-523.
12. Deluca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J. 2001;15:2579-2585.
13. Smolders J, Damoiseaux J, Menheere P, Hupperts R. Vitamin D as an immune modulator in multiple sclerosis, a review. J Neuroimmunol. 2008;194:7-17.
14. Correale J, Ysrraelit MC, Gai tán MI. Immunomodulatory effects of vitamin D in multiple sclerosis. Brain. 2009;132:1146-1160.
15. Türk U, Akbulut M, Yildiz A, et al. Comparative effect of oral pulse and intravenous calci triol treatment in hemodialysis patients: The effect on serum IL-1 and IL-6 levels and bone mineral density. Nephron. 2002;90:188-194.
16. Borazan A, Ustün H, Cefle A, Sekitmez N, Yilmaz A. C omparative efficacy of oral and intravenous calcitriol treatment in haemodialysis patients: effects on serum biochemistry and cytokine levels. J Int Med Res. 2003;31:489-496.
17. Inanir A, Ozoran K, Tutka k H, Mermerci B. The effects of calcitriol therapy on serum interleukin-1, interleukin-6 and tumour necrosis factor-concentrations in post-menopausal patients with osteoporosis. J Int Med Res. 2004;32:570-582.
18. Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlle d trial. Am J Clin Nutr. 2006;83:754-759.
19. Gannagé-Yared MH, Azoury M, Mansour I, Baddoura R, Halaby G, Naaman R. Effects of a short-term calcium and vitamin D treatment on serum cytok ines, bone markers, insulin and lipid concentrations in healthy post-menopausal women. J Endocrinol Invest. 2003;26:748-753.
20. MahonBD, Gordon SA, Cruz J, Cosman F, CantornaMT.Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. J Neuroimmunol. 2003;134:128-132.
21. Jorde R, Sneve M, Torjesen PA, Figenschau Y, Gøransson LG, Omdal R. No effect of supplementation with cholecalciferol on cytokines and markers of inflammation in overweight and obese subjects. Cytokine. 2010;50:175-180.
22. Yusupov E, Li-Ng M, Pollack S, Yeh JK, Mikhail M, Aloia JF. Vitamin D and serum cytokines in a randomized clinical trial. Int J Endocrinol. 2010;pii:305054.
23. Barnes MS Horigan G Cashman KD et al. Maintenance of wintertime vitaminDstatus w ith cholecalciferol supplementation is not associated with alterations in serum cytokine concentrations among apparently healthy younger or older adults J Nut. 2011 141 476-481
24. Souberbielle JC, Body JJ, Lappe JM, et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Autoimmun Rev. 2010;9: 709-7 15.
25. Dodoo D, Omer FM, Todd J, Akanmori BD, Koram KA, Riley EM. Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodium falc iparum malaria. J Infect Dis. 2002;185:971-979.
26. Cox SE, Arthur P, Kirkwood BR, Yeboah-Antwi K, Riley EM. Vitamin A supplementation increases ratios of proinflammatory to anti-inflammatory cytokine responses in pregnancy and lactation. Clin Exp Immunol. 2006;144:392-400.
27. Müller K, Haahr PM, Diamant M, Rieneck K, Kharazmi A, Bendtzen K. 1,25-Dihydroxyvitamin D3 inhibits cytokine production by human blood monocytes at the post-transcriptional level. Cytokine. 1992;4:506-512.
28. Liu N, Nguyen L, Chun RF, et al. Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology. 2008;149:4799-4808.
29. Peterson CA, Heffernan ME. Serum Tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women. J Inflamm (Lond). 2008;5:10.
30. Shea MK, Booth SL, Massaro JM, et al. Vitamin K and vitamin D status: associations with inflammatory markers in the Frami ngham Offspring Study. Am J Epidemiol. 2008;167:313-320.
31. Reid D, Toole BJ, Knox S, et al. The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty. Am J Clin Nutr. 2011;93:1006-1011.
32. Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O'Garra A. 1-,25-Dihydroxyvitamin D3 ha s a direct effect on naive CD4-T cells to enhance the development of Th2 cells. J Immunol. 2001; 167:4974-4980.
33. Nouri-Aria KT, Wachholz PA, Francis JN, et al. Grass pollen immunotherapy indu ces mucosal and peripheral IL-10 responses and blocking IgG activity. J Immunol. 2004;172:3252-3259.
34. Vaidya A, Williams JS, Forman JP. The independent association between 25-hydroxyvitaminDand adiponectin and its relation with BMI in two large cohorts: The NHS and the HPFS. Obesity. 2012; 20:186-191.
35. Zittermann A, Dembinski J, Stehle P. Low vitamin D status is associated with low cord blood levels of the immunosuppressive cytokine interleukin-10. Pediatr Allergy Immunol. 2004;15:242-246.
36. Stewart N, Taylor B, Ponsonby AL, et al. The effect of season on cytokine expression in multiple sclerosis and healthy subjects. J Neuroimmunol. 2007;188:181-186.
37. Plevy SE, Landers CJ, Prehn J, et al. A role for TNF-alpha and mucosalThelper-1 cytokines in the pathogenesis of Crohn's disease. J Immunol. 1997;159:6276-6282.
38. Imitola J, Chitnis T, Khoury SJ. Cytokines in multiple sclerosis: from bench to bedside. Pharmacol Ther. 2005;106:163-177.
39. O'Shea JJ, Ma A, Lipsky P. Cytokines and autoimmunity. Immunology. 2002;2:37-45.
40. Raab Y, Hällgren R, Gerdin B. Enhanced intestinal synthesis of interleukin-6 is related to the disease severity and activity in ulcerative colitis. Digestion. 1994;55:44-49.
41. Giovannoni G, Miller DH, Losseff NA, et al. Serum inflammatory markers and clinical/MRI markers of disease progression in multiple sclerosis. J Neurol. 2001;248:487-495.
42. Spîrchez M, Samas-ca G, Iancu M, Bolba C, Miu N. Relation of interleukin-6, TNF-and interleukin-1-with disease activity and severity in juvenile idiopathic arthritis patients. Clin Lab. 2012;58: 253-260.
43. Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link Atherosclerosis. 2000;148:209-214.
44. Ding C Parameswaran V Udayan R Burgess J Jones G. Circulating levels of inflammatory markers predicts change in bone mineral density and resorption in older adults: a longitudinal study J Clin Endocrinol Metab. 2008 931952-1958.
45. Gorelick PB. Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials.AnnNY Acad Sci. 2010;1207:155-162.
46. Taniguchi T, Koido Y, Aiboshi J, Yamashita T, Suzaki S, Kurokawa A. Change in the ratio of interleukin-6 to interleukin-10 predicts a poor outcome in patients with systemic inflammatory response syndrome. Crit Care Med. 1999;27:1262-1264.
47. Kilic T, Ural D, Ural E, et al. Relation between proinflammatory to anti-inflammatory cytokine ratios and long-term prognosis in patients with non-ST elevation acute coronary syndrome. Heart. 2006; 92:1041-1046.
48. Biswas S, Ghoshal PK, Mandal SC, Mandal N. Relation of anti-to pro-inflammatory cytokine ratios with acute myocardial infarction. Korean J Intern Med. 2010;25:44-50.
49. Cashman KD, Hill TR, Lucey AJ, et al. Estimation of the dietary requirement for vitamin D in healthy adults. Am J Clin Nutr. 2008; 88:1535-1542.
50. Bailey RL, Dodd KW, Goldman JA, et al. Estimation of total usual calcium and vitamin D intakes in the United States. J Nutr. 2010; 140:817-822.
51. Se tte S, Le Donne C, Piccinelli R, Arcella D, Turrini A, Leclercq C. The third Italian National Food Consumption Survey, INRANSCAI 2005-06-part 1: nutrient intakes in Italy. NMCD. 2011;21: 922-932.
52. Irish Universities Nutrition Alliance. National Adult Nutrition Survey. Dublin, Ireland: Irish Universities Nutrition Alliance; 2011.
53. Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Press; 2010.
54. De la Hunty A, Wallace AM, Gibson S, Viljakainen H, Lamberg-Alkardt C, Ashwell M.UKFood Standards Agency Workshop Consensus Re port: The choice of method for measuring 25-hydroxyvitaminDto estimateDstatus for theUKNational Diet and Nutrition Survey. Br J Nutr. 2010;104:612-619.
55. Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2014;2: 76-89.