Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor

European Journal of Medicinal Chemistry

Volumn 121, Issue , 2016, Pages 517-529

  Qiao, Chang Jiang ^a,c   Ali, Hamed I ^a   Ahn, Kwang H ^b   Kolluru, Srikanth ^a   Kendall, Debra A ^b   Lu, Dai ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Allosteric modulator; Cannabinoid receptor; Photoactivatable ligands; Photoaffinity labeling

Indexed keywords

3 (AZIDOMETHYL) 5 CHLORO N [4 (PIPERIDIN 1 YL)PHENETHYL] 1H INDOLE 2 CARBOXAMIDE; 3 (AZIDOMETHYL) N (4 BENZOPHENETHYL) 5 CHLORO 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 ETHYL N (4 ETHYLBENZOPHENONE) 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 ETHYL N [4 (PIPERIDIN 1 YL)PHENETHYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 HEXYL N [(4 AZIDO)PHENETHYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 HEXYL N [4 (3 TRIFLUOROMETHYL 3H DIAZIRIN 3 YL) PHENETHYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 HEXYL N [4 (DIMETHYLAMINO)PHENETHYL] 3 (HYDROXYMETHYL) 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 HEXYL N [4 (PIPERIDIN 1 YL)PHENETHYL] 3 (HYDROXYMETHYL) 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 PENTYL N (4 ETHYLBENZOPHENONE) 1H INDOLE 3 CARBOXAMIDE; 5 CHLORO N [4 (DIMETHYLAMINO)PHENETHYL] 3 (AZIDOMETHYL) 1H INDOLE 2 CARBOXAMIDE; AMIDE; BENZOPHENONE DERIVATIVE; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; GUANINE NUCLEOTIDE BINDING PROTEIN; N (4 BENZOPHENETHYL) 5 CHLORO 3 (HYDROXYMETHYL) 1H INDOLE 2 CARBOXAMIDE; UNCLASSIFIED DRUG; INDOLE DERIVATIVE;

ALLOSTERISM; ARTICLE; DISSOCIATION CONSTANT; DRUG SYNTHESIS; HEK293 CELL LINE; HUMAN; HUMAN CELL; CHEMISTRY; DRUG EFFECTS; LIGHT; METABOLISM; RADIATION RESPONSE; SYNTHESIS;

ALLOSTERIC REGULATION; CHEMISTRY TECHNIQUES, SYNTHETIC; HEK293 CELLS; HUMANS; INDOLES; LIGHT; RECEPTOR, CANNABINOID, CB1;

EID: 84975142572     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1021/acschemneuro.6b00041     Document Type: Article

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