Optimization of chemical functionalities of indole-2-carboxamides to improve allosteric parameters for the cannabinoid receptor 1 (CB1)

Journal of Medicinal Chemistry

Volumn 57, Issue 7, 2014, Pages 3040-3052

  Khurana, Leepakshi ^a   Ali, Hamed I ^b   Olszewska, Teresa ^b   Ahn, Kwang H ^a   Damaraju, Aparna ^b   Kendall, Debra A ^a   Lu, Dai ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 BUTYL 5 CHLORO 1H INDOLE 2 CARBOXYLIC ACID; 3 BUTYL 5 CHLORO N (4 (DIMETHYLAMINO)PHENETHYL) 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 BUTYL N (4 (PIPERIDIN 1 YL)PHENETHYL) 3 PROPYL 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 HEXYL 1H INDOLE 2 CARBOXYLIC ACID; 5 CHLORO 3 HEXYL N (4 (PIPERIDIN 1 YL)PHENETHYL) 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 PROPYL 1H INDOLE 2 CARBOXYLIC ACID; 5 CHLORO N (4 (DIMETHYLAMINO)PHENETHYL) 3 HEXYL 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO N (4 (DIMETHYLAMINO)PHENETHYL) 3 PROPYL 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO N (4 (PIPERIDIN 1 YL)PHENETHYL) 3 PROPYL 1H INDOLE 2 CARBOXAMIDE; AMIDE; BETA ARRESTIN; CANNABINOID 1 RECEPTOR; CARBOXYLIC ACID; ETHYL 3 BUTYL 5 CHLORO 1H INDOLE 2 CARBOXYLATE; ETHYL 3 BUTYRYL 5 CHLORO 1H INDOLE 2 CARBOXYLATE; ETHYL 5 CHLORO 3 HEXANOYL 1H INDOLE 2 CARBOXYLATE; ETHYL 5 CHLORO 3 HEXYL 1H INDOLE 2 CARBOXYLATE; ETHYL 5 CHLORO 3 PROPIONYL 1H INDOLE 2 CARBOXYLATE; ETHYL 5 CHLORO 3 PROPYL 1H INDOLE 2 CARBOXYLATE; INDOLE 2 CARBOXAMIDE DERIVATIVE; METHYL 2 AZIDO 3 (3 METHOXYPHENYL)ACRYLATE; METHYL 2 AZIDO 3 (4 CHLOROPHENYL)ACRYLATE; METHYL 2 AZIDO 3 (4 FLUOROPHENYL)ACRYLATE; METHYL 2 AZIDO 3 (4 METHOXYPHENYL)ACRYLATE; METHYL 2 AZIDOACETATE; METHYL 6 CHLORO 1H INDOLE 2 CARBOXYLATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RETINA S ANTIGEN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; ELECTRON; NONHUMAN; PROTEIN PHOSPHORYLATION;

ALLOSTERIC REGULATION; ANILINE COMPOUNDS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HEK293 CELLS; HUMANS; IMMUNOBLOTTING; INDOLES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHORYLATION; PIPERIDINES; PROTEIN BINDING; RADIOLIGAND ASSAY; RECEPTOR, CANNABINOID, CB1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898460777     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5000112     Document Type: Article

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