Structure-activity relationship study of indole-2-carboxamides identifies a potent allosteric modulator for the cannabinoid receptor 1 (CB1)

Journal of Medicinal Chemistry

Volumn 56, Issue 20, 2013, Pages 7965-7975

  Mahmoud, Mariam M ^a   Ali, Hamed I ^b   Ahn, Kwang H ^a   Damaraju, Aparna ^b   Samala, Sushma ^b   Pulipati, Venkata K ^b   Kolluru, Srikanth ^b   Kendall, Debra A ^a   Lu, Dai ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 BENZYL 5 CHLORO N [4 (PIPERIDIN 1 YL)PHENETHYL] 1H INDOLE 2 CARBOXAMIDE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 CHLORO 3 (CYCLOHEXYLMETHYL) N [4 (PIPERIDIN 1 YL)PHENETHYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 ETHYL N [4 (PIPERIDIN 1 YL)PHENETHYL]BENZOFURAN 2 CARBOXAMIDE; 5 CHLORO 3 HEPTYL N [4 (PIPERIDIN 1 YL)PHENETHYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 NONYL N [4 (PIPERIDIN 1 YL)PHENETHYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 PENTYL 1H INDOLE 2 CARBOXYLIC ACID [2 (4 PHENOXYPHENYL)ETHYL]AMIDE; 5 CHLORO 3 PENTYL N [4 (PIPERIDIN 1 YL)BENZYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 PENTYL N [4 (PIPERIDIN 1 YL)PHENETHYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 PHENYL N [4 (PIPERIDIN 1 YL)PHENETHYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO N (4 MORPHOLINOPHENETHYL) 3 PENTYL 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO N [1 [4 (DIMETHYLAMINO)PHENYL] 3 HYDROXYPROPAN 2 YL] 3 PENTYL 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO N [4 (DIMETHYLAMINO)PHENETHYL)BENZOFURAN 2 CARBOXAMIDE; 5 CHLORO N [4 (DIMETHYLAMINO)PHENETHYL] 3 ETHYL 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO N [4 (DIMETHYLAMINO)PHENETHYL] 3 ETHYLBENZOFURAN 2 CARBOXAMIDE; 5 CHLORO N [4 (DIMETHYLAMINO)PHENETHYL] 3 PENTYL 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO N [4 (PIPERIDIN 1 YL)PHENETHYL]BENZOFURAN 2 CARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AFFECTING AGENT; CHLORO 3 ETHYL N [4 (PIPERIDIN 1 YL)PHENETHYL] 1H INDOLE 2 CARBOXAMIDE; COUMARILAMIDE DERIVATIVE; INDOLE 2 CARBOXAMIDE DERIVATIVE; ORG 27569; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FRIEDEL CRAFTS REACTION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; BINDING, COMPETITIVE; HEK293 CELLS; HUMANS; INDOLES; KINETICS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PIPERIDINES; RADIOLIGAND ASSAY; RECEPTOR, CANNABINOID, CB1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84886571455     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4009828     Document Type: Article

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