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Volumn 21, Issue , 2015, Pages 1025-1037

Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; CHOLESTEROL; CRYOPYRIN; GLUCOSE TRANSPORTER 4; HIGH DENSITY LIPOPROTEIN; I KAPPA B; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

EID: 84975141182     PISSN: 10761551     EISSN: 15283658     Source Type: Journal    
DOI: 10.2119/molmed.2015.00104     Document Type: Article
Times cited : (54)

References (46)
  • 1
    • 84875136149 scopus 로고    scopus 로고
    • Turning off the inflammatory, but not the metabolic, flames
    • Calay ES, Hotamisligil GS. (2013) Turning off the inflammatory, but not the metabolic, flames. Nat. Med. 19:265-7.
    • (2013) Nat. Med , vol.19 , pp. 265-267
    • Calay, E.S.1    Hotamisligil, G.S.2
  • 2
    • 84901920026 scopus 로고    scopus 로고
    • Targeting inflammation in the treatment of type 2 diabetes: Time to start
    • Donath MY. (2014) Targeting inflammation in the treatment of type 2 diabetes: Time to start. Nat. Rev. Drug. Discov. 13:465-76.
    • (2014) Nat. Rev. Drug. Discov , vol.13 , pp. 465-476
    • Donath, M.Y.1
  • 3
    • 84872130535 scopus 로고    scopus 로고
    • Anti-inflammatory therapy in chronic disease: Challenges and opportunities
    • Tabas I, Glass CK. (2013) Anti-inflammatory therapy in chronic disease: Challenges and opportunities. Science. 339:166-72.
    • (2013) Science , vol.339 , pp. 166-172
    • Tabas, I.1    Glass, C.K.2
  • 4
    • 84865289995 scopus 로고    scopus 로고
    • Inflammation links excess fat to insulin resistance: The role of the interleukin-1 family
    • Tack CJ, Stienstra R, Joosten LA, Netea MG. (2012) Inflammation links excess fat to insulin resistance: The role of the interleukin-1 family. Immunol. Rev. 249:239-52.
    • (2012) Immunol. Rev , vol.249 , pp. 239-252
    • Tack, C.J.1    Stienstra, R.2    Joosten, L.A.3    Netea, M.G.4
  • 5
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K, Tschopp J. (2010) The inflammasomes. Cell. 140:821-32.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 6
    • 84880162141 scopus 로고    scopus 로고
    • The NLRP3 inflammasome as a novel player of the intercellular crosstalk in metabolic disorders
    • Benetti E, Chiazza F, Patel NS, Collino M. (2013) The NLRP3 inflammasome as a novel player of the intercellular crosstalk in metabolic disorders. Mediators Inflamm. 2013:678627.
    • (2013) Mediators Inflamm , vol.2013
    • Benetti, E.1    Chiazza, F.2    Patel, N.S.3    Collino, M.4
  • 7
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • Wen H, et al. (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat. Immunol. 12:408-15.
    • (2011) Nat. Immunol , vol.12 , pp. 408-415
    • Wen, H.1
  • 8
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • Duewell P, et al. (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 464:1357-61.
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1
  • 9
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar B, et al. (2011) The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17:179-88.
    • (2011) Nat. Med , vol.17 , pp. 179-188
    • Vandanmagsar, B.1
  • 10
    • 78649498271 scopus 로고    scopus 로고
    • The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
    • Stienstra R, et al. (2010) The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell. Metab. 12:593-605.
    • (2010) Cell. Metab , vol.12 , pp. 593-605
    • Stienstra, R.1
  • 11
    • 84865108051 scopus 로고    scopus 로고
    • Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance
    • Reynolds CM, et al. (2012) Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. Mol. Nutr. Food Res. 56:1212-22.
    • (2012) Mol. Nutr. Food Res , vol.56 , pp. 1212-1222
    • Reynolds, C.M.1
  • 12
    • 84872027781 scopus 로고    scopus 로고
    • Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation
    • Collino M, et al. (2013) Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation. Biochem. Pharmacol. 85:257-64.
    • (2013) Biochem. Pharmacol , vol.85 , pp. 257-264
    • Collino, M.1
  • 13
    • 80053087484 scopus 로고    scopus 로고
    • Inflammasome is a central player in the induction of obesity and insulin resistance
    • Stienstra R, et al. (2011) Inflammasome is a central player in the induction of obesity and insulin resistance. Proc. Natl. Acad. Sci. U. S. A. 108:15324-9.
    • (2011) Proc. Natl. Acad. Sci. U. S. A , vol.108 , pp. 15324-15329
    • Stienstra, R.1
  • 14
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 440:237-41.
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Pétrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 15
    • 84862786890 scopus 로고    scopus 로고
    • Suppression of NF-κB and NF-κB regulated oxidative stress and neuroinflammation by BAY 11-7082 (IκB phosphorylation inhibitor) in experimental diabetic neuropathy
    • Kumar A, Negi G, Sharma SS. (2012) Suppression of NF-κB and NF-κB regulated oxidative stress and neuroinflammation by BAY 11-7082 (IκB phosphorylation inhibitor) in experimental diabetic neuropathy. Biochimie. 94:1158-65.
    • (2012) Biochimie , vol.94 , pp. 1158-1165
    • Kumar, A.1    Negi, G.2    Sharma, S.S.3
  • 16
    • 64149097786 scopus 로고    scopus 로고
    • The MIQE guidelines: Minimum information for publication of quantitative real-time PCR experiments
    • Bustin SA, et al. (2009) The MIQE guidelines: Minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 55:611-22.
    • (2009) Clin. Chem , vol.55 , pp. 611-622
    • Bustin, S.A.1
  • 17
    • 84919359718 scopus 로고    scopus 로고
    • A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice
    • Collino M, et al. (2014) A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice. Br. J. Pharmacol. 171:5802-15.
    • (2014) Br. J. Pharmacol , vol.171 , pp. 5802-5815
    • Collino, M.1
  • 18
    • 84857364150 scopus 로고    scopus 로고
    • Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans
    • Goossens GH, et al. (2012) Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans. Mol. Immunol. 50:142-9.
    • (2012) Mol. Immunol , vol.50 , pp. 142-149
    • Goossens, G.H.1
  • 19
    • 84872018875 scopus 로고    scopus 로고
    • Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes
    • Lee HM, et al. (2013) Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes. 62:194-204.
    • (2013) Diabetes , vol.62 , pp. 194-204
    • Lee, H.M.1
  • 20
    • 84862235344 scopus 로고    scopus 로고
    • Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation
    • Wang C, Pan Y, Zhang QY, Wang FM, Kong LD. (2012) Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation. PLoS One. 7:e38285.
    • (2012) Plos One , vol.7
    • Wang, C.1    Pan, Y.2    Zhang, Q.Y.3    Wang, F.M.4    Kong, L.D.5
  • 21
    • 84899461863 scopus 로고    scopus 로고
    • Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation
    • Yang SJ, Lim Y. (2014) Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation. Metabolism. 63:693-701.
    • (2014) Metabolism , vol.63 , pp. 693-701
    • Yang, S.J.1    Lim, Y.2
  • 22
    • 84914132421 scopus 로고    scopus 로고
    • Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation
    • Honda H, et al. (2014) Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. J. Leukoc. Biol. 96:1087-100.
    • (2014) J. Leukoc. Biol , vol.96 , pp. 1087-1100
    • Honda, H.1
  • 23
    • 84901375574 scopus 로고    scopus 로고
    • Purple sweet potato color ameliorates kidney damage via inhibiting oxidative stress mediated NLRP3 inflammasome activation in high fat diet mice
    • Shan Q, et al. (2014) Purple sweet potato color ameliorates kidney damage via inhibiting oxidative stress mediated NLRP3 inflammasome activation in high fat diet mice. Food Chem. Toxicol. 69:339-46.
    • (2014) Food Chem. Toxicol , vol.69 , pp. 339-346
    • Shan, Q.1
  • 24
    • 77951240589 scopus 로고    scopus 로고
    • Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
    • Juliana C, et al. (2010) Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J. Biol. Chem. 285:9792-802.
    • (2010) J. Biol. Chem , vol.285 , pp. 9792-9802
    • Juliana, C.1
  • 25
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR. (2006) Critical nodes in signalling pathways: Insights into insulin action. Nat. Rev. Mol. Cell. Biol. 7:85-96.
    • (2006) Nat. Rev. Mol. Cell. Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 26
    • 33745668478 scopus 로고    scopus 로고
    • SiRNA-based gene silencing reveals specialized roles of IRS-1/ Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
    • Bouzakri K, et al. (2006) siRNA-based gene silencing reveals specialized roles of IRS-1/ Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell. Metab. 4:89-96.
    • (2006) Cell. Metab , vol.4 , pp. 89-96
    • Bouzakri, K.1
  • 27
    • 84861444859 scopus 로고    scopus 로고
    • Regulation of glucose transport by insulin: Traffic control of GLUT4
    • Leto D, Saltiel AR. (2012) Regulation of glucose transport by insulin: Traffic control of GLUT4. Nat. Rev. Mol. Cell. Biol. 13:383-96.
    • (2012) Nat. Rev. Mol. Cell. Biol , vol.13 , pp. 383-396
    • Leto, D.1    Saltiel, A.R.2
  • 28
    • 84863880301 scopus 로고    scopus 로고
    • Knockdown of NYGGF4 increases glucose transport in C2C12 mice skeletal myocytes by activation IRS-1/PI3K/ AKT insulin pathway
    • Zeng XQ, et al. (2012) Knockdown of NYGGF4 increases glucose transport in C2C12 mice skeletal myocytes by activation IRS-1/PI3K/ AKT insulin pathway. J. Bioenerg. Biomembr. 44:351-55.
    • (2012) J. Bioenerg. Biomembr , vol.44 , pp. 351-355
    • Zeng, X.Q.1
  • 29
    • 61749100743 scopus 로고    scopus 로고
    • Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis
    • Semple RK, et al. (2009) Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. J. Clin. Invest. 119:315-22.
    • (2009) J. Clin. Invest , vol.119 , pp. 315-322
    • Semple, R.K.1
  • 30
    • 84894385818 scopus 로고    scopus 로고
    • Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing
    • Boini KM, et al. (2014) Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing. Biochim. Biophys. Acta. 1843:836-45.
    • (2014) Biochim. Biophys. Acta , vol.1843 , pp. 836-845
    • Boini, K.M.1
  • 31
    • 84922876430 scopus 로고    scopus 로고
    • Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis
    • Dattaroy D, et al. (2015) Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 308:G298-312.
    • (2015) Am. J. Physiol. Gastrointest. Liver Physiol , vol.308 , pp. G298-G312
    • Dattaroy, D.1
  • 32
    • 84864148484 scopus 로고    scopus 로고
    • TGF-beta/Smad signaling in kidney disease
    • Lan HY, Chung AC. (2012) TGF-beta/Smad signaling in kidney disease. Sem. Nephrol. 32:236-43.
    • (2012) Sem. Nephrol , vol.32 , pp. 236-243
    • Lan, H.Y.1    Chung, A.C.2
  • 33
    • 84890892243 scopus 로고    scopus 로고
    • SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity
    • Nomura M, et al. (2014) SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity. Diabetologia. 57:157-66.
    • (2014) Diabetologia , vol.57 , pp. 157-166
    • Nomura, M.1
  • 34
    • 63349101854 scopus 로고    scopus 로고
    • VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice
    • Velayudham A, et al. (2009) VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. Hepatology. 49:989-97.
    • (2009) Hepatology , vol.49 , pp. 989-997
    • Velayudham, A.1
  • 35
    • 72949123737 scopus 로고    scopus 로고
    • Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis
    • Witek RP, et al. (2009) Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology. 50:1421-30.
    • (2009) Hepatology , vol.50 , pp. 1421-1430
    • Witek, R.P.1
  • 36
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: Sensing and reacting to damage
    • Chen GY, Nuñez G. (2010) Sterile inflammation: Sensing and reacting to damage. Nat. Rev. Immunol. 10:826-37.
    • (2010) Nat. Rev. Immunol , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nuñez, G.2
  • 37
    • 79952159132 scopus 로고    scopus 로고
    • Emerging inflammasome effector mechanisms
    • Lamkanfi M. (2011) Emerging inflammasome effector mechanisms. Nat. Rev. Immunol. 11:213-20.
    • (2011) Nat. Rev. Immunol , vol.11 , pp. 213-220
    • Lamkanfi, M.1
  • 38
    • 77957887259 scopus 로고    scopus 로고
    • The NLRP3 inflammasome promotes renal inflammation and contributes to CKD
    • Vilaysane A, et al. (2010) The NLRP3 inflammasome promotes renal inflammation and contributes to CKD. J. Am. Soc. Nephrol. 21:1732-44.
    • (2010) J. Am. Soc. Nephrol , vol.21 , pp. 1732-1744
    • Vilaysane, A.1
  • 39
    • 84885422386 scopus 로고    scopus 로고
    • The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: Possible role of NLRP3 inflammasome activation
    • Solini A, et al. (2013) The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: Possible role of NLRP3 inflammasome activation. J. Pathol. 231:342-53.
    • (2013) J. Pathol , vol.231 , pp. 342-353
    • Solini, A.1
  • 40
    • 79959573042 scopus 로고    scopus 로고
    • Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells
    • Csak T, et al. (2011) Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology. 54:133-44.
    • (2011) Hepatology , vol.54 , pp. 133-144
    • Csak, T.1
  • 41
    • 84896709837 scopus 로고    scopus 로고
    • NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
    • Wree A, et al. (2014) NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology. 59:898-910.
    • (2014) Hepatology , vol.59 , pp. 898-910
    • Wree, A.1
  • 42
    • 84863690805 scopus 로고    scopus 로고
    • BAY 11-7082 is a broad-spectrum inhibitor with anti-inflammatory activity against multiple targets
    • Lee J, Rhee MH, Kim E, Cho JY. (2012) BAY 11-7082 is a broad-spectrum inhibitor with anti-inflammatory activity against multiple targets. Mediators Inflamm. 2012:416036.
    • (2012) Mediators Inflamm , vol.2012
    • Lee, J.1    Rhee, M.H.2    Kim, E.3    Cho, J.Y.4
  • 43
    • 20044387026 scopus 로고    scopus 로고
    • IKK-beta links inflammation to obesity-induced insulin resistance
    • Arkan MC, et al. (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat. Med. 11:191-8.
    • (2005) Nat. Med , vol.11 , pp. 191-198
    • Arkan, M.C.1
  • 44
    • 77949965210 scopus 로고    scopus 로고
    • Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    • Dupaul-Chicoine J, et al. (2010) Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity. 32:367-78.
    • (2010) Immunity , vol.32 , pp. 367-378
    • Dupaul-Chicoine, J.1
  • 45
    • 79955846705 scopus 로고    scopus 로고
    • NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
    • Hirota SA, et al. (2011) NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm. Bowel Dis. 17:1359-72.
    • (2011) Inflamm. Bowel Dis , vol.17 , pp. 1359-1372
    • Hirota, S.A.1
  • 46
    • 84883478660 scopus 로고    scopus 로고
    • Gut microbiota from twins discordant for obesity modulate metabolism in mice
    • Ridaura VK, et al. (2013) Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 341:1241214.
    • (2013) Science , vol.341
    • Ridaura, V.K.1


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