Role of Macrophage (M1 and M2) in Titanium-Dioxide Nanoparticle-Induced Oxidative Stress and Inflammatory Response in Rat

Applied Biochemistry and Biotechnology

Volumn 180, Issue 7, 2016, Pages 1257-1275

  Kumar, Sumit ^a   Meena, Ramovatar ^a   Paulraj, R ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Apoptosis; Inflammation; Macrophage phenotype; Oxidative stress; Spleen; Splenocyte; TiO2; Titanium dioxide nanoparticles

Indexed keywords

BIOINFORMATICS; CELL DEATH; CELL MEMBRANES; MITOCHONDRIA; NANOPARTICLES; NITRIC OXIDE; OXIDATIVE STRESS; TISSUE; TITANIUM DIOXIDE;

INFLAMMATION; MACROPHAGE PHENOTYPES; SPLEEN; SPLENOCYTE; TIO2; TITANIUM DIOXIDE NANOPARTICLES;

MACROPHAGES;

CYCLOOXYGENASE 2; CYTOCHROME C; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 4; INTERLEUKIN 6; PROTEIN BAX; PROTEIN BCL 2; TITANIUM DIOXIDE NANOPARTICLE; TUMOR NECROSIS FACTOR; NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; HELPER CELL; IMMUNOPHENOTYPING; INFLAMMATION; MACROPHAGE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; RAT; SPLEEN CELL; TISSUE INJURY; UPREGULATION; ANIMAL; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; INTRAVENOUS DRUG ADMINISTRATION; MACROPHAGE ACTIVATION; METABOLISM; PATHOLOGY; SPLEEN; WISTAR RAT;

ADMINISTRATION, INTRAVENOUS; ANIMALS; APOPTOSIS; CELL PROLIFERATION; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-4; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NANOPARTICLES; OXIDATIVE STRESS; RATS, WISTAR; SPLEEN; TITANIUM;

EID: 84975123041     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-016-2165-x     Document Type: Article

References (32)

1. Shi, H., Magaye, R., Castranova, V., & Zhao, J. (2013). Titanium dioxide nanoparticles: a review of current toxicological data. Particle and Fibre Toxicology, 10, 15.
2. Chen, Z., Wang, Y., Zhuo, L., Chen, S., Zhao, L., Luan, X., et al. (2015). Effect of titanium dioxide nanoparticles on the cardiovascular system after oral administration. Toxicology Letters, 239, 123–130.
3. Makumire, S., Chakravadhanula, V. S. K., Köllisch, G., Redel, E., & Shonhai, A. (2014). Immunomodulatory activity of zinc peroxide (ZnO2) and titanium dioxide (TiO2) nanoparticles and their effects on DNA and protein integrity. Toxicology Letters, 227, 56–64.
4. Mocan, T. (2013). Hemolysis as expression of nanoparticles-induced cytotoxicity in red blood cells. Biotechnology, Molecular Biology and Nanomedicine (BMBN), 1, 7–12.
5. Sunil, V. R., Patel-Vayas, K., Shen, J., Laskin, J. D., & Laskin, D. L. (2012). Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress. Toxicology and Applied Pharmacology, 263, 195–202.
6. Husain, M., & Wu, D. (2015). Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice. Nanotoxicology, 9, 1–10.
7. Ling, M. P., Chio, C. P., Chou, W. C., Chen, W. Y., Hsieh, N. H., Lin, Y. J., et al. (2011). Assessing the potential exposure risk and control for airborne titanium dioxide and carbon black nanoparticles in the workplace. Environmental Science and Pollution Research International, 18, 877–889.
8. Grassian, V. H., O’Shaughnessy, P. T., Adamcakova-Dodd, A., Pettibone, J. M., & Thorne, P. S. (2007). Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. Environmental Health Perspectives, 115, 397–402.
9. Park, E. J., Yoon, J., Choi, K., Yi, J., & Park, K. (2009). Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation. Toxicology, 260, 37–46.
10. Mosser, D. M., & Edwards, J. P. (2008). Exploring the full spectrum of macrophage activation. Nature Reviews. Immunology, 8, 958–969.
11. Sang, X., Li, B., Ze, Y., Hong, J., Ze, X., Gui, S., et al. (2013). Toxicological mechanisms of nanosized titanium dioxide-induced spleen injury in mice after repeated peroral application. Journal of Agricultural and Food Chemistry, 61, 5590–5599.
12. Meena, R., Kumar, S., & Paulraj, R. (2015). Titanium oxide (TiO2) nanoparticles in induction of apoptosis and inflammatory response in brain. Journal of Nanoparticle Research, 17, 1–14.
13. Kumar, S., & Tiku, A. B. (2015). Biochemical and Molecular Mechanisms of Radioprotective Effects of Naringenin, a Phytochemical from Citrus Fruits. Journal of Agricultural and Food Chemistry, 64, 1676–1685.
14. Beebee, T. J., & Carty, D. S. (1983). A study of lactate dehydrogenase levels and turnover rates during postnatal development in the rat. Biochimica et Biophysica Acta, 757, 209–218.
15. Paulraj, R., & Behari, J. (2006). Single strand DNA breaks in rat brain cells exposed to microwave radiation. Mutation Research, 596, 76–80.
16. Hayashi, M., Morita, T., Kodama, Y., Sofuni, T., & Ishidate, J. M. (1990). The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutation Research, 245, 245–249.
17. Nowak, J. E., Gomez-Flores, R., Calderon, S. N., Rice, K. C., & Weber, R. J. (1998). Rat natural killer cell, T cell and macrophage functions after intracerebroventricular injection of SNC 80. The Journal of Pharmacology and Experimental Therapeutics, 286, 931–937.
18. Westphal, O., & Jann, J. (1965). Bacterial lipopolysaccharides: extraction with phenol-water and further applications of the procedure. New York: Academic Press Inc.
19. Manke, A., Wang, L., & Rojanasakul, Y. (2013). Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Research International, 2013, 15.
20. Schanen, B. C., Das, S., Reilly, C. M., Warren, W. L., Self, W. T., Seal, S., et al. (2013). Immunomodulation and T helper TH(1)/TH(2) response polarization by CeO(2) and TiO(2) nanoparticles. PloS One, 8, e62816.
21. Fu, Y., Zhang, Y., Chang, X., Ma, S., Sui, J., Yin, L., et al. (2014). Systemic immune effects of titanium dioxide nanoparticles after repeated intratracheal instillation in rat. International Journal of Molecular Sciences, 15, 6961–6973.
22. Valitutti, S., Coombs, D., & Dupré, L. (2010). The space and time frames of T cell activation at the immunological synapse. FEBS Letters, 584, 4851–4857.
23. Arnold, C. E., Gordon, P., Barker, R. N., & Wilson, H. M. (2015). The activation status of human macrophages presenting antigen determines the efficiency of Th17 responses. Immunobiology, 220, 10–19.
24. Laskin, D. L., Sunil, V. R., Gardner, C. R., & Laskin, J. D. (2011). Macrophages and tissue injury: agents of defense or destruction? Annual Review of Pharmacology and Toxicology, 51, 267–288.
25. Kim, H. R., Shin, D. Y., & Chung, K. H. (2015). The role of NF-κB signaling pathway in polyhexamethylene guanidine phosphate induced inflammatory response in mouse macrophage RAW264.7 cells. Toxicology Letters, 233, 148–155.
26. Ozkok, A., Ravichandran, K., Wang, Q., Ljubanovic, D., & Edelstein, C. L. (2016). NF-kappaB transcriptional inhibition ameliorates cisplatin-induced acute kidney injury (AKI). Toxicology Letters, 240, 105–113.
27. Tak, P. P., & Firestein, G. S. (2001). NF-kappaB: a key role in inflammatory diseases. The Journal of Clinical Investigation, 107, 7–11.
28. Lee, H., Park, J. R., Kim, E. J., Kim, W. J., Hong, S. H., Park, S. M., et al. (2016). Cigarette smoke-mediated oxidative stress induces apoptosis via the MAPKs/STAT1 pathway in mouse lung fibroblasts. Toxicology Letters, 240, 140–148.
29. Amar, S. K., Goyal, S., Chopra, D., Singh, J., Shankar, J., Chaturvedi, R. K., et al. (2015). Benzophenone 1 induced photogenotoxicity and apoptosis via release of cytochrome c and Smac/DIABLO at environmental UV radiation. Toxicology Letters, 239, 182–193.
30. Liu, H., Yang, J., Liang, J., Huang, Y., & Tang, C. (2008). ZnO nanofiber and nanoparticle synthesized through electrospinning and their photocatalytic activity under visible light. Journal of the American Ceramic Society, 91, 1287–1291.
31. Goncalves, D. M., Chiasson, S., & Girard, D. (2010). Activation of human neutrophils by titanium dioxide (TiO2) nanoparticles. Toxicology In Vitro, 24, 1002–1008.
32. Sica, A., & Mantovani, A. (2012). Macrophage plasticity and polarization: in vivo veritas. The Journal of Clinical Investigation, 122, 787–795.