Benzophenone 1 induced photogenotoxicity and apoptosis via release of cytochrome c and Smac/DIABLO at environmental UV radiation

Toxicology Letters

Volumn 239, Issue 3, 2015, Pages 182-193

  Amar, Saroj Kumar ^a,b   Goyal, Shruti ^a,b   Dubey, Divya ^a   Srivastav, Ajeet K ^a   Chopra, Deepti ^a   Singh, Jyoti ^a   Shankar, Jai ^c   Chaturvedi, Rajnish K ^a   Ray, Ratan Singh ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^c CSIR IITR   (India)

Author keywords

Caspase 3; Cytochrome c; DNA damage; Photomicronuclei; Phototoxicity; Smac DIABLO

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BENZOPHENONE 1; BENZOPHENONE DERIVATIVE; CASPASE 3; CASPASE INHIBITOR; CYTOCHROME C; LACTATE DEHYDROGENASE; PROCASPASE 3; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SUNSCREEN; UNCLASSIFIED DRUG; APAF1 PROTEIN, HUMAN; BAX PROTEIN, HUMAN; BENZOPHENONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASP3 PROTEIN, HUMAN; DIABLO PROTEIN, HUMAN; LIPOCORTIN 5; MITOCHONDRIAL PROTEIN; PEPTIDE CHLOROMETHYL KETONE; SIGNAL PEPTIDE;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; DOWN REGULATION; ENVIRONMENTAL RADIOACTIVITY; FLOW CYTOMETRY; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; KERATINOCYTE; LIPID PEROXIDATION; LIPID PEROXIDATION ASSAY; PHOTOCYTOTOXICITY; PHOTODEGRADATION; PHOTOSENSITIZATION; PHOTOTOXICITY; PRIORITY JOURNAL; SOLAR RADIATION; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET RADIATION; UPREGULATION; WESTERN BLOTTING; ADVERSE EFFECTS; CELL LINE; CHEMISTRY; DNA DAMAGE; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; POLYACRYLAMIDE GEL ELECTROPHORESIS;

AMINO ACID CHLOROMETHYL KETONES; ANNEXIN A5; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BCL-2-ASSOCIATED X PROTEIN; BENZOPHENONES; CASPASE 3; CELL LINE; COMET ASSAY; CYTOCHROMES C; DNA DAMAGE; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KERATINOCYTES; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIAL PROTEINS; REACTIVE OXYGEN SPECIES; SUNSCREENING AGENTS; ULTRAVIOLET RAYS;

EID: 84944067491     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2015.09.024     Document Type: Article

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