S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway

Oxidative Medicine and Cellular Longevity

Volumn 2016, Issue , 2016, Pages

  Li, Wenwen ^a   Ma, Fenfen ^a   Zhang, Laiyin ^b   Huang, Yong ^a   Li, Xinghui ^a   Zhang, Aijie ^a   Hou, Cuilan ^a   Zhu, Yichun ^a   Zhu, Yi Zhun ^a,c  

^a FUDAN UNIVERSITY   (China)

^b LINYI PEOPLE'S HOSPITAL   (China)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; DISEASES; ENZYMES; SULFUR COMPOUNDS;

ANTIOXIDATIVE EFFECTS; MOLECULAR MECHANISM; NON-ALCOHOLIC FATTY LIVER; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2; PHOSPHOINOSITIDE 3-KINASE; PROTECTIVE EFFECTS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE ACTIVITIES;

AMINO ACIDS;

2 MORPHOLINO 8 PHENYLCHROMONE; ANTIOXIDANT; CHOLINE; CYSTATHIONINE GAMMA LYASE; HEME OXYGENASE 1; METHIONINE; OLEIC ACID; PROPARGYLGLYCINE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; S PROPARGYLCYSTEINE; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; BIOLOGICAL MARKER; CYSTEINE; HMOX1 PROTEIN, HUMAN; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, HUMAN; NFE2L2 PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3 KINASE; S-PROPYLCYSTEINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUTRITIONAL DEFICIENCY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CELL PROTECTION; COMPLICATION; DEFICIENCY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HEP-G2 CELL LINE; LIPID PEROXIDATION; LIVER; METABOLISM; NON-ALCOHOLIC FATTY LIVER DISEASE; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; VITAMIN DEFICIENCY;

ANIMALS; ANTIOXIDANTS; BIOMARKERS; CHOLINE DEFICIENCY; CYSTEINE; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEME OXYGENASE-1; HEP G2 CELLS; HUMANS; LIPID PEROXIDATION; LIVER; MALE; MEMBRANE PROTEINS; METHIONINE; NF-E2-RELATED FACTOR 2; NON-ALCOHOLIC FATTY LIVER DISEASE; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84975112976     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/4690857     Document Type: Article

References (37)

1. G. Tarantino, G. Saldalamacchia, P. Conca, and A. Arena, "Nonalcoholic fatty liver disease: further expression of the metabolic syndrome," Journal of Gastroenterology and Hepatology, vol. 22, no. 3, pp. 293-303, 2007.
2. A. E. Feldstein and S. M. Bailey, "Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease," Antioxidants and Redox Signaling, vol. 15, no. 2, pp. 421-424, 2011.
3. C. P. Day and O. F. W. James, "Steatohepatitis: a tale of two 'Hits'?" Gastroenterology, vol. 114, no. 4, pp. 842-845, 1998.
4. G. H. Koek, P. R. Liedorp, and A. Bast, "The role of oxidative stress in non-alcoholic steatohepatitis," Clinica Chimica Acta, vol. 412, no. 15-16, pp. 1297-1305, 2011.
5. M. D. Maines, G. M. Trakshel, and R. K. Kutty, "Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible," The Journal of Biological Chemistry, vol. 261, no. 1, pp. 411-419, 1986.
6. M. D. Maines, "Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications," The FASEB Journal, vol. 2, no. 10, pp. 2557-2568, 1988.
7. G. Scapagnini, V. Sonya, A. G. Nader, C. Calogero, D. Zella, and G. Fabio, "Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders," Molecular Neurobiology, vol. 44, no. 3, pp. 192-201, 2011.
8. L. M. Zipper and R. T. Mulcahy, "Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligasemodulatory gene expression in HepG2 cells," Toxicological Sciences, vol. 73, no. 1, pp. 124-134, 2003.
9. D. Martin, A. I. Rojo, M. Salinas et al., "Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol," The Journal of Biological Chemistry, vol. 279, no. 10, pp. 8919-8929, 2004.
10. 2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2," Biochemical Pharmacology, vol. 76, no. 11, pp. 1577-1589, 2008.
11. L. L. Pan, X. H. Liu, H. M. Zheng, H. B. Yang, Q. H. Gong, and Y. Z. Zhu, "S-propargyl-cysteine, a novel hydrogen sulfidemodulated agent, attenuated tumor necrosis factor-α-induced inflammatory signaling and dysfunction in endothelial cells," International Journal of Cardiology, vol. 155, no. 2, pp. 327-332, 2012.
12. Q. Wang, H.-R. Liu, Q. Mu, P. Rose, and Y. Z. Zhu, "S-propargylcysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway," Journal of Cardiovascular Pharmacology, vol. 54, no. 2, pp. 139-146, 2009.
13. 2S production," Antioxidants and Redox Signaling, vol. 12, no. 10, pp. 1155-1165, 2010.
14. Q.-H. Gong, Q. Wang, L.-L. Pan, X.-H. Liu, H. Xin, and Y.-Z. Zhu, "S-propargyl-cysteine, a novel hydrogen sulfidemodulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-κB pathway in rats," Brain, Behavior, and Immunity, vol. 25, no. 1, pp. 110-119, 2011.
15. J. Kan, W. Guo, C. Huang, G. Bao, Y. Zhu, and Y. Z. Zhu, "S-propargyl-cysteine, a novel water-soluble modulator of endogenous hydrogen sulfide, promotes angiogenesis through activation of signal transducer and activator of transcription 3," Antioxidants and Redox Signaling, vol. 20, no. 15, pp. 2303-2316, 2014.
16. H. Yang, Y. Mao, B. Tan, S. Luo, and Y. Zhu, "The protective effects of endogenous hydrogen sulfidemodulator, S-propargylcysteine, on high glucose-induced apoptosis in cardiomyocytes: a novel mechanism mediated by the activation of Nrf2," European Journal of Pharmacology, vol. 761, pp. 135-143, 2015.
17. J. M. Hourihan, J.G. Kenna, and J.D. Hayes, "The gasotransmitter hydrogen sulfide induces Nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between Cys-226 and Cys-613," Antioxidants and Redox Signaling, vol. 19, no. 5, pp. 465-481, 2013.
18. M. I. Hassan, M. Boosen, L. Schaefer et al., "Platelet-derived growth factor-BB induces cystathionine Iγ-lyase expression in rat mesangial cells via a redox-dependent mechanism," British Journal of Pharmacology, vol. 166, no. 8, pp. 2231-2242, 2012.
19. J. Henao-Mejia, E. Elinav, C. Jin et al., "Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity," Nature, vol. 482, no. 7384, pp. 179-185, 2012.
20. B. Staels, A. Rubenstrunk, B. Noel et al., "Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis," Hepatology, vol. 58, no. 6, pp. 1941-1952, 2013.
21. B. Shen, J. Yu, S. Wang et al., "Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo," Hepatology, vol. 47, no. 2, pp. 473-483, 2008.
22. X. Shen, C. B. Pattillo, S. Pardue, S. C. Bir, R. Wang, and C. G. Kevil, "Measurement of plasma hydrogen sulfide in vivo and in vitro," Free Radical Biology and Medicine, vol. 50, no. 9, pp. 1021-1031, 2011.
23. 2S generation is reduced in ageing diabetic mice," Oxidative Medicine and Cellular Longevity, vol. 2015, Article ID 758358, 14 pages, 2015.
24. W. Cui, S. L. Chen, and K.-Q. Hu, "Quantification and mechanisms of oleic acid-induced steatosis in HepG2 cells," American Journal of Translational Research, vol. 2, no. 1, pp. 95-104, 2010.
25. S. A. Bustin, V. Benes, J. A. Garson et al., "The MIQE guidelines: minimum information for publication of quantitative real-time PCRexperiments," Clinical Chemistry, vol. 55, no. 4, pp.611-622, 2009.
26. S. Satapati, B. Kucejova, J. A. Duarte et al., "Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver," Journal of Clinical Investigation, vol. 125, no. 12, pp. 4447-4462, 2015.
27. K. M. Surapaneni and M. Jainu, "Comparative effect of pioglitazone, quercetin and hydroxy citric acid on the status of lipid peroxidation and antioxidants in experimental non-alcoholic steatohepatitis," Journal of Physiology and Pharmacology, vol. 65, no. 1, pp. 67-74, 2014.
28. M. H. Ghattas, L. T. Chuang, A. Kappas, and N. G. Abraham, "Protective effect of HO-1 against oxidative stress in human hepatoma cell line (HepG2) is independent of telomerase enzyme activity," International Journal of Biochemistry and Cell Biology, vol. 34, no. 12, pp. 1619-1628, 2002.
29. J.W. Kaspar, S. K. Niture, and A. K. Jaiswal, "Nrf2:INrf2 (Keap1) signaling in oxidative stress," Free Radical Biology and Medicine, vol. 47, no. 9, pp. 1304-1309, 2009.
30. B. J. Wu, K. Chen, P. J. Barter, and K.-A. Rye, "Niacin inhibits vascular inflammation via the induction of heme oxygenase-1," Circulation, vol. 125, no. 1, pp. 150-158, 2012.
31. T. Nguyen, C. S. Yang, and C. B. Pickett, "The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress," Free Radical Biology and Medicine, vol. 37, no. 4, pp. 433-441, 2004.
32. J.-M. Lee, J. M. Hanson, W. A. Chu, and J. A. Johnson, "Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in imr-32 human neuroblastoma cells," Journal of Biological Chemistry, vol. 276, no. 23, pp. 20011-20016, 2001.
33. M. C. Garcia, M. Amankwa-Sakyi, and T. J. Flynn, "Cellular glutathione in fatty liver in vitro models," Toxicology in Vitro, vol. 25, no. 7, pp. 1501-1506, 2011.
34. K. Shirozu, K. Tokuda, E. Marutani, D. Lefer, R. Wang, and F. Ichinose, "Cystathionine γ-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure," Antioxidants and Redox Signaling, vol. 20, no. 2, pp. 204-216, 2014.
35. K. Ma, Y. Liu, Q. Zhu et al., "H2S donor, S-propargyl-cysteine, increases CSE in SGC-7901 and cancer-induced mice: evidence for a novel anti-cancer effect of endogenous H2S?" PLoS ONE, vol. 6, no. 6, Article ID e20525, 2011.
36. 2-induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38 MAPK pathway," Free Radical Biology and Medicine, vol. 53, no. 2, pp. 183-193, 2012.
37. X. Zhou, L. Zhao, J. Mao, J. Huang, and J. Chen, "Antioxidant effects of hydrogen sulfide on left ventricular remodeling in smoking rats are mediated via PI3K/Akt-dependent activation of Nrf2," Toxicological Sciences, vol. 144, no. 1, pp. 197-203, 2015.