Antioxidant effects of hydrogen sulfide on left ventricular remodeling in smoking rats are mediated via PI3K/Akt-dependent activation of Nrf2

Toxicological Sciences

Volumn 144, Issue 1, 2015, Pages 197-203

  Zhou, Xiang ^a   Zhao, Liangping ^a   Mao, Jinning ^a   Huang, Jian ^a   Chen, Jianchang ^a  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Hydrogen sulfide; Left ventricular remodeling; Nrf2; Oxidative stress; PI3K Akt; Smoking

Indexed keywords

CIGARETTE SMOKE CONDENSATE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; GLUTATHIONE PEROXIDASE; GLYCOGEN SYNTHASE KINASE 3BETA; HO 1 PROTEIN; HYDROGEN SULFIDE; MALONALDEHYDE; NQO1 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE B; PROTEIN KINASE FYN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIOXIDANT; NFE2L2 PROTEIN, RAT; PASSIVE SMOKING; SMOKE; SODIUM BISULFIDE; SULFIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; HEART; HEART MUSCLE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; IMMUNOHISTOCHEMISTRY; LEFT VENTRICULAR REMODELING; MALE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PASSIVE SMOKING; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TWO DIMENSIONAL ECHOCARDIOGRAPHY; UBIQUITINATION; UPREGULATION; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; CELL CULTURE; CELL PROTECTION; DISEASE MODEL; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; FIBROSIS; GENETICS; HEART LEFT VENTRICLE FUNCTION; HYPERTROPHY, LEFT VENTRICULAR; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SMOKE; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; CELLS, CULTURED; CYTOPROTECTION; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FIBROSIS; HYDROGEN SULFIDE; HYPERTROPHY, LEFT VENTRICULAR; MALE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOKE; SULFIDES; TOBACCO SMOKE POLLUTION; TRANSFECTION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84924509089     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu272     Document Type: Article

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