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Volumn 22, Issue 12, 2016, Pages 3105-3117

NDUFA4L2 fine-tunes oxidative stress in hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR INHIBITOR; PROTEIN INHIBITOR; TRANSCRIPTOME; UNCLASSIFIED DRUG; DIGOXIN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MICROSATELLITE DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SMALL INTERFERING RNA;

EID: 84975055719     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-15-1987     Document Type: Article
Times cited : (68)

References (45)
  • 1
    • 84859212951 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet 2012;379:1245-55.
    • (2012) Lancet , vol.379 , pp. 1245-1255
    • Forner, A.1    Llovet, J.M.2    Bruix, J.3
  • 2
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, etal. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009;10:25-34.
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3    Tsao, C.J.4    Qin, S.5    Kim, J.S.6
  • 4
    • 84897626823 scopus 로고    scopus 로고
    • The impact of hypoxia in hepatocellular carcinoma metastasis
    • Wong CC, Kai AK, Ng IO. The impact of hypoxia in hepatocellular carcinoma metastasis. Front Med. 2014;8:33-41.
    • (2014) Front Med , vol.8 , pp. 33-41
    • Wong, C.C.1    Kai, A.K.2    Ng, I.O.3
  • 5
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell 2012;148:399-408.
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 6
    • 17944375360 scopus 로고    scopus 로고
    • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54.
    • (2001) Cell , vol.107 , pp. 43-54
    • Epstein, A.C.1    Gleadle, J.M.2    McNeill, L.A.3    Hewitson, K.S.4    O'Rourke, J.5    Mole, D.R.6
  • 7
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin WGJr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008;30:393-402.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 8
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 1995;92:5510-4.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 9
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006;3:177-85.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 10
    • 15444342958 scopus 로고    scopus 로고
    • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
    • Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 1998;12:149-62.
    • (1998) Genes Dev , vol.12 , pp. 149-162
    • Iyer, N.V.1    Kotch, L.E.2    Agani, F.3    Leung, S.W.4    Laughner, E.5    Wenger, R.H.6
  • 11
    • 35649014840 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    • Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007;27:7381-93.
    • (2007) Mol Cell Biol , vol.27 , pp. 7381-7393
    • Kim, J.W.1    Gao, P.2    Liu, Y.C.3    Semenza, G.L.4    Dang, C.V.5
  • 12
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza GL, Roth PH, Fang HM, Wang GL. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 1994;269:23757-63.
    • (1994) J Biol Chem , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 13
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin VR, St-Pierre J, Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006;9:425-34.
    • (2006) Cancer Cell , vol.9 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 14
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, et al. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 1996;271:32529-37.
    • (1996) J Biol Chem , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6
  • 15
    • 84883768176 scopus 로고    scopus 로고
    • Redox regulation of cancer cell migration and invasion
    • Tochhawng L, Deng S, Pervaiz S, Yap CT. Redox regulation of cancer cell migration and invasion. Mitochondrion 2013;13:246-53.
    • (2013) Mitochondrion , vol.13 , pp. 246-253
    • Tochhawng, L.1    Deng, S.2    Pervaiz, S.3    Yap, C.T.4
  • 16
    • 0020508747 scopus 로고
    • Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases
    • Ames BN. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 1983;221:1256-64.
    • (1983) Science , vol.221 , pp. 1256-1264
    • Ames, B.N.1
  • 17
    • 0030865646 scopus 로고    scopus 로고
    • Dual regulation of caspase activity by hydrogen peroxide: Implications for apoptosis
    • Hampton MB, Orrenius S. Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett 1997;414:552-6.
    • (1997) FEBS Lett , vol.414 , pp. 552-556
    • Hampton, M.B.1    Orrenius, S.2
  • 18
    • 84868007565 scopus 로고    scopus 로고
    • Physiological roles of mitochondrial reactive oxygen species
    • Sena LA, Chandel NS. Physiological roles of mitochondrial reactive oxygen species. Mol Cell 2012;48:158-67.
    • (2012) Mol Cell , vol.48 , pp. 158-167
    • Sena, L.A.1    Chandel, N.S.2
  • 19
    • 4143066896 scopus 로고    scopus 로고
    • The emerging role of reactive oxygen species in cancer therapy
    • Renschler MF. The emerging role of reactive oxygen species in cancer therapy. Eur J Cancer 2004;40:1934-40.
    • (2004) Eur J Cancer , vol.40 , pp. 1934-1940
    • Renschler, M.F.1
  • 20
    • 34248217605 scopus 로고    scopus 로고
    • Selective enhancement of cellular oxidative stress by chloroquine: Implications for the treatment of glioblastoma multiforme
    • Toler SM, Noe D, Sharma A. Selective enhancement of cellular oxidative stress by chloroquine: implications for the treatment of glioblastoma multiforme. Neurosurg Focus 2006;21:E10.
    • (2006) Neurosurg Focus , vol.21 , pp. E10
    • Toler, S.M.1    Noe, D.2    Sharma, A.3
  • 21
    • 33947724515 scopus 로고    scopus 로고
    • HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    • Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 2007;129:111-22.
    • (2007) Cell , vol.129 , pp. 111-122
    • Fukuda, R.1    Zhang, H.2    Kim, J.W.3    Shimoda, L.4    Dang, C.V.5    Semenza, G.L.6
  • 22
    • 70349478990 scopus 로고    scopus 로고
    • MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
    • Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 2009;10:273-84.
    • (2009) Cell Metab , vol.10 , pp. 273-284
    • Chan, S.Y.1    Zhang, Y.Y.2    Hemann, C.3    Mahoney, C.E.4    Zweier, J.L.5    Loscalzo, J.6
  • 23
    • 82955237531 scopus 로고    scopus 로고
    • Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting Complex I activity
    • Tello D, Balsa E, Acosta-Iborra B, Fuertes-Yebra E, Elorza A, Ordonez A, et al. Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting Complex I activity. Cell Metab 2011;14:768-79.
    • (2011) Cell Metab , vol.14 , pp. 768-779
    • Tello, D.1    Balsa, E.2    Acosta-Iborra, B.3    Fuertes-Yebra, E.4    Elorza, A.5    Ordonez, A.6
  • 24
    • 84862587153 scopus 로고    scopus 로고
    • Thyroid paraganglioma. Report of 3 cases and description of an immunohistochemical profile useful in the differential diagnosis with medullary thyroid carcinoma, based on complementary DNA array results
    • Castelblanco E, Gallel P, Ros S, Gatius S, Valls J, De-Cubas AA, et al. Thyroid paraganglioma. Report of 3 cases and description of an immunohistochemical profile useful in the differential diagnosis with medullary thyroid carcinoma, based on complementary DNA array results. Hum Pathol 2012;43:1103-12.
    • (2012) Hum Pathol , vol.43 , pp. 1103-1112
    • Castelblanco, E.1    Gallel, P.2    Ros, S.3    Gatius, S.4    Valls, J.5    De-Cubas, A.A.6
  • 26
    • 0028845813 scopus 로고
    • Prognostic significance of pathologic features of hepatocellular carcinoma. A multivariate analysis of 278 patients
    • Ng IO, Lai EC, Fan ST, Ng MM, So MK. Prognostic significance of pathologic features of hepatocellular carcinoma. A multivariate analysis of 278 patients. Cancer 1995;76:2443-8.
    • (1995) Cancer , vol.76 , pp. 2443-2448
    • Ng, I.O.1    Lai, E.C.2    Fan, S.T.3    Ng, M.M.4    So, M.K.5
  • 27
    • 84919935255 scopus 로고    scopus 로고
    • Switching of pyruvate kinase isoform L to m2 promotes metabolic reprogramming in hepatocarcinogenesis
    • Wong CC, Au SL, Tse AP, Xu IM, Lai RK, Chiu DK, et al. Switching of pyruvate kinase isoform L to m2 promotes metabolic reprogramming in hepatocarcinogenesis. PloS one 2014;9:e115036.
    • (2014) PloS One , vol.9
    • Wong, C.C.1    Au, S.L.2    Tse, A.P.3    Xu, I.M.4    Lai, R.K.5    Chiu, D.K.6
  • 28
    • 78650436438 scopus 로고    scopus 로고
    • The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2
    • Wong CC, Wong CM, Tung EK, Au SL, Lee JM, Poon RT, et al. The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2. Gastroenterology 2011;140:322-31.
    • (2011) Gastroenterology , vol.140 , pp. 322-331
    • Wong, C.C.1    Wong, C.M.2    Tung, E.K.3    Au, S.L.4    Lee, J.M.5    Poon, R.T.6
  • 29
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
    • Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, van Baren MJ, et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 2010;28:511-5.
    • (2010) Nat Biotechnol , vol.28 , pp. 511-515
    • Trapnell, C.1    Williams, B.A.2    Pertea, G.3    Mortazavi, A.4    Kwan, G.5    Van Baren, M.J.6
  • 30
    • 84860389759 scopus 로고    scopus 로고
    • HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
    • Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, et al. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 2012;31:1757-70.
    • (2012) Oncogene , vol.31 , pp. 1757-1770
    • Zhang, H.1    Wong, C.C.2    Wei, H.3    Gilkes, D.M.4    Korangath, P.5    Chaturvedi, P.6
  • 31
    • 84877899680 scopus 로고    scopus 로고
    • Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
    • Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, et al. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol Cancer Res 2013;11:456-66.
    • (2013) Mol Cancer Res , vol.11 , pp. 456-466
    • Gilkes, D.M.1    Bajpai, S.2    Wong, C.C.3    Chaturvedi, P.4    Hubbi, M.E.5    Wirtz, D.6
  • 32
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996;16:4604-13.
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6
  • 33
    • 0035503362 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
    • Giatromanolaki A, Koukourakis MI, Sivridis E, Pastorek J, Wykoff CC, Gatter KC, et al. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res 2001;61:7992-8.
    • (2001) Cancer Res , vol.61 , pp. 7992-7998
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Pastorek, J.4    Wykoff, C.C.5    Gatter, K.C.6
  • 34
    • 84873804360 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis
    • Chaturvedi P, Gilkes DM, Wong CC, Luo W, Zhang H, Wei H, et al. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest 2013;123:189-205.
    • (2013) J Clin Invest , vol.123 , pp. 189-205
    • Chaturvedi, P.1    Gilkes, D.M.2    Wong, C.C.3    Luo, W.4    Zhang, H.5    Wei, H.6
  • 35
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 2009;417:1-13.
    • (2009) Biochem J , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 36
    • 84926137241 scopus 로고    scopus 로고
    • Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
    • Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Bio 2015;17:95-103.
    • (2015) Nat Cell Bio , vol.17 , pp. 95-103
    • Ma, B.1    Chen, Y.2    Chen, L.3    Cheng, H.4    Mu, C.5    Li, J.6
  • 37
    • 84905757105 scopus 로고    scopus 로고
    • Metformin-mode ofactionand clinical implications for diabetes and cancer
    • Pernicova I, Korbonits M. Metformin-mode ofactionand clinical implications for diabetes and cancer. Nat Rev Endocrinol 2014;10:143-56.
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 143-156
    • Pernicova, I.1    Korbonits, M.2
  • 38
    • 84861576077 scopus 로고    scopus 로고
    • The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus
    • Lee JH, Kim TI, Jeon SM, Hong SP, Cheon JH, Kim WH. The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus. Int J Cancer 2012;131:752-9.
    • (2012) Int J Cancer , vol.131 , pp. 752-759
    • Lee, J.H.1    Kim, T.I.2    Jeon, S.M.3    Hong, S.P.4    Cheon, J.H.5    Kim, W.H.6
  • 39
    • 84864314304 scopus 로고    scopus 로고
    • Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer
    • He X, Esteva FJ, Ensor J, Hortobagyi GN, Lee MH, Yeung SC. Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer. Ann Oncol 2012;23:1771-80.
    • (2012) Ann Oncol , vol.23 , pp. 1771-1780
    • He, X.1    Esteva, F.J.2    Ensor, J.3    Hortobagyi, G.N.4    Lee, M.H.5    Yeung, S.C.6
  • 40
    • 79960845901 scopus 로고    scopus 로고
    • Evidence for biological effects of metformin in operable breast cancer: A pre-operative, window-of-opportunity, randomized trial
    • Hadad S, Iwamoto T, Jordan L, Purdie C, Bray S, Baker L, et al. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res Treat 2011;128:783-94.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 783-794
    • Hadad, S.1    Iwamoto, T.2    Jordan, L.3    Purdie, C.4    Bray, S.5    Baker, L.6
  • 41
    • 84908500698 scopus 로고    scopus 로고
    • PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis
    • Hong X, Song R, Song H, Zheng T, Wang J, Liang Y, et al. PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis. Gut 2014;63:1635-47.
    • (2014) Gut , vol.63 , pp. 1635-1647
    • Hong, X.1    Song, R.2    Song, H.3    Zheng, T.4    Wang, J.5    Liang, Y.6
  • 42
    • 84907367977 scopus 로고    scopus 로고
    • Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: Correlation to cell proliferation, tumor size and metabolic syndrome
    • Mollbrink A, Jawad R, Vlamis-Gardikas A, Edenvik P, Isaksson B, Danielsson O, et al. Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome. Int J Immunopathol Pharmacol 2014;27:169-83.
    • (2014) Int J Immunopathol Pharmacol , vol.27 , pp. 169-183
    • Mollbrink, A.1    Jawad, R.2    Vlamis-Gardikas, A.3    Edenvik, P.4    Isaksson, B.5    Danielsson, O.6
  • 43
    • 84888328045 scopus 로고    scopus 로고
    • Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma
    • Sun QK, Zhu JY, Wang W, Lv Y, Zhou HC, Yu JH, et al. Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma. Med Oncol 2014;31:786.
    • (2014) Med Oncol , vol.31 , pp. 786
    • Sun, Q.K.1    Zhu, J.Y.2    Wang, W.3    Lv, Y.4    Zhou, H.C.5    Yu, J.H.6
  • 44
    • 80053304909 scopus 로고    scopus 로고
    • Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma
    • Guo W, Zhao Y, Zhang Z, Tan N, Zhao F, Ge C, et al. Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma. Cancer Lett 2011;312:55-61.
    • (2011) Cancer Lett , vol.312 , pp. 55-61
    • Guo, W.1    Zhao, Y.2    Zhang, Z.3    Tan, N.4    Zhao, F.5    Ge, C.6
  • 45
    • 84922783167 scopus 로고    scopus 로고
    • Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression
    • Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell 2015;27:211-22.
    • (2015) Cancer Cell , vol.27 , pp. 211-222
    • Harris, I.S.1    Treloar, A.E.2    Inoue, S.3    Sasaki, M.4    Gorrini, C.5    Lee, K.C.6


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