-
2
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
-
Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, etal. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009;10:25-34.
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
Tsao, C.J.4
Qin, S.5
Kim, J.S.6
-
3
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-90.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
-
4
-
-
84897626823
-
The impact of hypoxia in hepatocellular carcinoma metastasis
-
Wong CC, Kai AK, Ng IO. The impact of hypoxia in hepatocellular carcinoma metastasis. Front Med. 2014;8:33-41.
-
(2014)
Front Med
, vol.8
, pp. 33-41
-
-
Wong, C.C.1
Kai, A.K.2
Ng, I.O.3
-
5
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell 2012;148:399-408.
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
6
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
-
7
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin WGJr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008;30:393-402.
-
(2008)
Mol Cell
, vol.30
, pp. 393-402
-
-
Kaelin, W.G.1
Ratcliffe, P.J.2
-
8
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 1995;92:5510-4.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
9
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006;3:177-85.
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
10
-
-
15444342958
-
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
-
Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 1998;12:149-62.
-
(1998)
Genes Dev
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
-
11
-
-
35649014840
-
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007;27:7381-93.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7381-7393
-
-
Kim, J.W.1
Gao, P.2
Liu, Y.C.3
Semenza, G.L.4
Dang, C.V.5
-
12
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza GL, Roth PH, Fang HM, Wang GL. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 1994;269:23757-63.
-
(1994)
J Biol Chem
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
13
-
-
33744783432
-
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
-
Fantin VR, St-Pierre J, Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006;9:425-34.
-
(2006)
Cancer Cell
, vol.9
, pp. 425-434
-
-
Fantin, V.R.1
St-Pierre, J.2
Leder, P.3
-
14
-
-
0030460724
-
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
-
Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, et al. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 1996;271:32529-37.
-
(1996)
J Biol Chem
, vol.271
, pp. 32529-32537
-
-
Semenza, G.L.1
Jiang, B.H.2
Leung, S.W.3
Passantino, R.4
Concordet, J.P.5
Maire, P.6
-
16
-
-
0020508747
-
Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases
-
Ames BN. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 1983;221:1256-64.
-
(1983)
Science
, vol.221
, pp. 1256-1264
-
-
Ames, B.N.1
-
17
-
-
0030865646
-
Dual regulation of caspase activity by hydrogen peroxide: Implications for apoptosis
-
Hampton MB, Orrenius S. Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett 1997;414:552-6.
-
(1997)
FEBS Lett
, vol.414
, pp. 552-556
-
-
Hampton, M.B.1
Orrenius, S.2
-
18
-
-
84868007565
-
Physiological roles of mitochondrial reactive oxygen species
-
Sena LA, Chandel NS. Physiological roles of mitochondrial reactive oxygen species. Mol Cell 2012;48:158-67.
-
(2012)
Mol Cell
, vol.48
, pp. 158-167
-
-
Sena, L.A.1
Chandel, N.S.2
-
19
-
-
4143066896
-
The emerging role of reactive oxygen species in cancer therapy
-
Renschler MF. The emerging role of reactive oxygen species in cancer therapy. Eur J Cancer 2004;40:1934-40.
-
(2004)
Eur J Cancer
, vol.40
, pp. 1934-1940
-
-
Renschler, M.F.1
-
20
-
-
34248217605
-
Selective enhancement of cellular oxidative stress by chloroquine: Implications for the treatment of glioblastoma multiforme
-
Toler SM, Noe D, Sharma A. Selective enhancement of cellular oxidative stress by chloroquine: implications for the treatment of glioblastoma multiforme. Neurosurg Focus 2006;21:E10.
-
(2006)
Neurosurg Focus
, vol.21
, pp. E10
-
-
Toler, S.M.1
Noe, D.2
Sharma, A.3
-
21
-
-
33947724515
-
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
-
Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 2007;129:111-22.
-
(2007)
Cell
, vol.129
, pp. 111-122
-
-
Fukuda, R.1
Zhang, H.2
Kim, J.W.3
Shimoda, L.4
Dang, C.V.5
Semenza, G.L.6
-
22
-
-
70349478990
-
MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
-
Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 2009;10:273-84.
-
(2009)
Cell Metab
, vol.10
, pp. 273-284
-
-
Chan, S.Y.1
Zhang, Y.Y.2
Hemann, C.3
Mahoney, C.E.4
Zweier, J.L.5
Loscalzo, J.6
-
23
-
-
82955237531
-
Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting Complex I activity
-
Tello D, Balsa E, Acosta-Iborra B, Fuertes-Yebra E, Elorza A, Ordonez A, et al. Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting Complex I activity. Cell Metab 2011;14:768-79.
-
(2011)
Cell Metab
, vol.14
, pp. 768-779
-
-
Tello, D.1
Balsa, E.2
Acosta-Iborra, B.3
Fuertes-Yebra, E.4
Elorza, A.5
Ordonez, A.6
-
24
-
-
84862587153
-
Thyroid paraganglioma. Report of 3 cases and description of an immunohistochemical profile useful in the differential diagnosis with medullary thyroid carcinoma, based on complementary DNA array results
-
Castelblanco E, Gallel P, Ros S, Gatius S, Valls J, De-Cubas AA, et al. Thyroid paraganglioma. Report of 3 cases and description of an immunohistochemical profile useful in the differential diagnosis with medullary thyroid carcinoma, based on complementary DNA array results. Hum Pathol 2012;43:1103-12.
-
(2012)
Hum Pathol
, vol.43
, pp. 1103-1112
-
-
Castelblanco, E.1
Gallel, P.2
Ros, S.3
Gatius, S.4
Valls, J.5
De-Cubas, A.A.6
-
25
-
-
70349472696
-
The Warburg effect is genetically determined in inherited pheochromocytomas
-
Favier J, Briere JJ, Burnichon N, Riviere J, Vescovo L, Benit P, et al. The Warburg effect is genetically determined in inherited pheochromocytomas. PloS one 2009;4:e7094.
-
(2009)
PloS One
, vol.4
, pp. e7094
-
-
Favier, J.1
Briere, J.J.2
Burnichon, N.3
Riviere, J.4
Vescovo, L.5
Benit, P.6
-
26
-
-
0028845813
-
Prognostic significance of pathologic features of hepatocellular carcinoma. A multivariate analysis of 278 patients
-
Ng IO, Lai EC, Fan ST, Ng MM, So MK. Prognostic significance of pathologic features of hepatocellular carcinoma. A multivariate analysis of 278 patients. Cancer 1995;76:2443-8.
-
(1995)
Cancer
, vol.76
, pp. 2443-2448
-
-
Ng, I.O.1
Lai, E.C.2
Fan, S.T.3
Ng, M.M.4
So, M.K.5
-
27
-
-
84919935255
-
Switching of pyruvate kinase isoform L to m2 promotes metabolic reprogramming in hepatocarcinogenesis
-
Wong CC, Au SL, Tse AP, Xu IM, Lai RK, Chiu DK, et al. Switching of pyruvate kinase isoform L to m2 promotes metabolic reprogramming in hepatocarcinogenesis. PloS one 2014;9:e115036.
-
(2014)
PloS One
, vol.9
-
-
Wong, C.C.1
Au, S.L.2
Tse, A.P.3
Xu, I.M.4
Lai, R.K.5
Chiu, D.K.6
-
28
-
-
78650436438
-
The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2
-
Wong CC, Wong CM, Tung EK, Au SL, Lee JM, Poon RT, et al. The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2. Gastroenterology 2011;140:322-31.
-
(2011)
Gastroenterology
, vol.140
, pp. 322-331
-
-
Wong, C.C.1
Wong, C.M.2
Tung, E.K.3
Au, S.L.4
Lee, J.M.5
Poon, R.T.6
-
29
-
-
77952123055
-
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
-
Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, van Baren MJ, et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 2010;28:511-5.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 511-515
-
-
Trapnell, C.1
Williams, B.A.2
Pertea, G.3
Mortazavi, A.4
Kwan, G.5
Van Baren, M.J.6
-
30
-
-
84860389759
-
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
-
Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, et al. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 2012;31:1757-70.
-
(2012)
Oncogene
, vol.31
, pp. 1757-1770
-
-
Zhang, H.1
Wong, C.C.2
Wei, H.3
Gilkes, D.M.4
Korangath, P.5
Chaturvedi, P.6
-
31
-
-
84877899680
-
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
-
Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, et al. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol Cancer Res 2013;11:456-66.
-
(2013)
Mol Cancer Res
, vol.11
, pp. 456-466
-
-
Gilkes, D.M.1
Bajpai, S.2
Wong, C.C.3
Chaturvedi, P.4
Hubbi, M.E.5
Wirtz, D.6
-
32
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996;16:4604-13.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
-
33
-
-
0035503362
-
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
-
Giatromanolaki A, Koukourakis MI, Sivridis E, Pastorek J, Wykoff CC, Gatter KC, et al. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res 2001;61:7992-8.
-
(2001)
Cancer Res
, vol.61
, pp. 7992-7998
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Sivridis, E.3
Pastorek, J.4
Wykoff, C.C.5
Gatter, K.C.6
-
34
-
-
84873804360
-
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis
-
Chaturvedi P, Gilkes DM, Wong CC, Luo W, Zhang H, Wei H, et al. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest 2013;123:189-205.
-
(2013)
J Clin Invest
, vol.123
, pp. 189-205
-
-
Chaturvedi, P.1
Gilkes, D.M.2
Wong, C.C.3
Luo, W.4
Zhang, H.5
Wei, H.6
-
35
-
-
58249093939
-
How mitochondria produce reactive oxygen species
-
Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 2009;417:1-13.
-
(2009)
Biochem J
, vol.417
, pp. 1-13
-
-
Murphy, M.P.1
-
36
-
-
84926137241
-
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
-
Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Bio 2015;17:95-103.
-
(2015)
Nat Cell Bio
, vol.17
, pp. 95-103
-
-
Ma, B.1
Chen, Y.2
Chen, L.3
Cheng, H.4
Mu, C.5
Li, J.6
-
37
-
-
84905757105
-
Metformin-mode ofactionand clinical implications for diabetes and cancer
-
Pernicova I, Korbonits M. Metformin-mode ofactionand clinical implications for diabetes and cancer. Nat Rev Endocrinol 2014;10:143-56.
-
(2014)
Nat Rev Endocrinol
, vol.10
, pp. 143-156
-
-
Pernicova, I.1
Korbonits, M.2
-
38
-
-
84861576077
-
The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus
-
Lee JH, Kim TI, Jeon SM, Hong SP, Cheon JH, Kim WH. The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus. Int J Cancer 2012;131:752-9.
-
(2012)
Int J Cancer
, vol.131
, pp. 752-759
-
-
Lee, J.H.1
Kim, T.I.2
Jeon, S.M.3
Hong, S.P.4
Cheon, J.H.5
Kim, W.H.6
-
39
-
-
84864314304
-
Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer
-
He X, Esteva FJ, Ensor J, Hortobagyi GN, Lee MH, Yeung SC. Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer. Ann Oncol 2012;23:1771-80.
-
(2012)
Ann Oncol
, vol.23
, pp. 1771-1780
-
-
He, X.1
Esteva, F.J.2
Ensor, J.3
Hortobagyi, G.N.4
Lee, M.H.5
Yeung, S.C.6
-
40
-
-
79960845901
-
Evidence for biological effects of metformin in operable breast cancer: A pre-operative, window-of-opportunity, randomized trial
-
Hadad S, Iwamoto T, Jordan L, Purdie C, Bray S, Baker L, et al. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res Treat 2011;128:783-94.
-
(2011)
Breast Cancer Res Treat
, vol.128
, pp. 783-794
-
-
Hadad, S.1
Iwamoto, T.2
Jordan, L.3
Purdie, C.4
Bray, S.5
Baker, L.6
-
41
-
-
84908500698
-
PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis
-
Hong X, Song R, Song H, Zheng T, Wang J, Liang Y, et al. PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis. Gut 2014;63:1635-47.
-
(2014)
Gut
, vol.63
, pp. 1635-1647
-
-
Hong, X.1
Song, R.2
Song, H.3
Zheng, T.4
Wang, J.5
Liang, Y.6
-
42
-
-
84907367977
-
Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: Correlation to cell proliferation, tumor size and metabolic syndrome
-
Mollbrink A, Jawad R, Vlamis-Gardikas A, Edenvik P, Isaksson B, Danielsson O, et al. Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome. Int J Immunopathol Pharmacol 2014;27:169-83.
-
(2014)
Int J Immunopathol Pharmacol
, vol.27
, pp. 169-183
-
-
Mollbrink, A.1
Jawad, R.2
Vlamis-Gardikas, A.3
Edenvik, P.4
Isaksson, B.5
Danielsson, O.6
-
43
-
-
84888328045
-
Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma
-
Sun QK, Zhu JY, Wang W, Lv Y, Zhou HC, Yu JH, et al. Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma. Med Oncol 2014;31:786.
-
(2014)
Med Oncol
, vol.31
, pp. 786
-
-
Sun, Q.K.1
Zhu, J.Y.2
Wang, W.3
Lv, Y.4
Zhou, H.C.5
Yu, J.H.6
-
44
-
-
80053304909
-
Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma
-
Guo W, Zhao Y, Zhang Z, Tan N, Zhao F, Ge C, et al. Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma. Cancer Lett 2011;312:55-61.
-
(2011)
Cancer Lett
, vol.312
, pp. 55-61
-
-
Guo, W.1
Zhao, Y.2
Zhang, Z.3
Tan, N.4
Zhao, F.5
Ge, C.6
-
45
-
-
84922783167
-
Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression
-
Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell 2015;27:211-22.
-
(2015)
Cancer Cell
, vol.27
, pp. 211-222
-
-
Harris, I.S.1
Treloar, A.E.2
Inoue, S.3
Sasaki, M.4
Gorrini, C.5
Lee, K.C.6
|