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Volumn 15, Issue 11, 2016, Pages 2524-2535

Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NERVE GROWTH FACTOR;

EID: 84974718795     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.05.024     Document Type: Article
Times cited : (54)

References (68)
  • 3
    • 79952638264 scopus 로고    scopus 로고
    • Cellular decision making and biological noise: from microbes to mammals
    • Balázsi G., van Oudenaarden A., Collins J.J. Cellular decision making and biological noise: from microbes to mammals. Cell 2011, 144:910-925.
    • (2011) Cell , vol.144 , pp. 910-925
    • Balázsi, G.1    van Oudenaarden, A.2    Collins, J.J.3
  • 5
    • 84861204172 scopus 로고    scopus 로고
    • Identifying sources of variation and the flow of information in biochemical networks
    • Bowsher C.G., Swain P.S. Identifying sources of variation and the flow of information in biochemical networks. Proc. Natl. Acad. Sci. USA 2012, 109:E1320-E1328.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. E1320-E1328
    • Bowsher, C.G.1    Swain, P.S.2
  • 8
    • 0242490781 scopus 로고    scopus 로고
    • Fast evaluation of fluctuations in biochemical networks with the linear noise approximation
    • Elf J., Ehrenberg M. Fast evaluation of fluctuations in biochemical networks with the linear noise approximation. Genome Res. 2003, 13:2475-2484.
    • (2003) Genome Res. , vol.13 , pp. 2475-2484
    • Elf, J.1    Ehrenberg, M.2
  • 10
    • 80051716158 scopus 로고    scopus 로고
    • Commitment to a cellular transition precedes genome-wide transcriptional change
    • Eser U., Falleur-Fettig M., Johnson A., Skotheim J.M. Commitment to a cellular transition precedes genome-wide transcriptional change. Mol. Cell 2011, 43:515-527.
    • (2011) Mol. Cell , vol.43 , pp. 515-527
    • Eser, U.1    Falleur-Fettig, M.2    Johnson, A.3    Skotheim, J.M.4
  • 11
    • 38349133325 scopus 로고    scopus 로고
    • A hierarchy of approximations of the master equation scaled by a size parameter
    • Ferm L., Lötstedt P., Hellander A. A hierarchy of approximations of the master equation scaled by a size parameter. J. Sci. Comput. 2008, 34:127-151.
    • (2008) J. Sci. Comput. , vol.34 , pp. 127-151
    • Ferm, L.1    Lötstedt, P.2    Hellander, A.3
  • 12
    • 0030746219 scopus 로고    scopus 로고
    • Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase
    • Ferrell J.E., Bhatt R.R. Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase. J. Biol. Chem. 1997, 272:19008-19016.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19008-19016
    • Ferrell, J.E.1    Bhatt, R.R.2
  • 13
    • 84918819267 scopus 로고    scopus 로고
    • Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback
    • Ferrell J.E., Ha S.H. Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback. Trends Biochem. Sci. 2014, 39:556-569.
    • (2014) Trends Biochem. Sci. , vol.39 , pp. 556-569
    • Ferrell, J.E.1    Ha, S.H.2
  • 14
    • 77956637961 scopus 로고    scopus 로고
    • Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics
    • Fujita K.A., Toyoshima Y., Uda S., Ozaki Y., Kubota H., Kuroda S. Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics. Sci. Signal. 2010, 3:ra56.
    • (2010) Sci. Signal. , vol.3 , pp. ra56
    • Fujita, K.A.1    Toyoshima, Y.2    Uda, S.3    Ozaki, Y.4    Kubota, H.5    Kuroda, S.6
  • 16
    • 84926627675 scopus 로고    scopus 로고
    • Bayesian inference for Markov jump processes with informative observations
    • Golightly A., Wilkinson D.J. Bayesian inference for Markov jump processes with informative observations. Stat. Appl. Genet. Mol. Biol. 2015, 14:169-188.
    • (2015) Stat. Appl. Genet. Mol. Biol. , vol.14 , pp. 169-188
    • Golightly, A.1    Wilkinson, D.J.2
  • 17
    • 0345704610 scopus 로고
    • Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
    • Greene L.A., Tischler A.S. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 1976, 73:2424-2428.
    • (1976) Proc. Natl. Acad. Sci. USA , vol.73 , pp. 2424-2428
    • Greene, L.A.1    Tischler, A.S.2
  • 18
    • 84861152188 scopus 로고    scopus 로고
    • Mathematical modeling reveals the functional implications of the different nuclear shuttling rates of Erk1 and Erk2
    • Harrington H.A., Komorowski M., Beguerisse-Diaz M., Ratto G.M., Stumpf M.P.H. Mathematical modeling reveals the functional implications of the different nuclear shuttling rates of Erk1 and Erk2. Phys. Biol. 2012, 9:36001.
    • (2012) Phys. Biol. , vol.9 , pp. 36001
    • Harrington, H.A.1    Komorowski, M.2    Beguerisse-Diaz, M.3    Ratto, G.M.4    Stumpf, M.P.H.5
  • 19
    • 84876366258 scopus 로고    scopus 로고
    • Cellular compartments cause multistability and allow cells to process more information
    • Harrington H.A., Feliu E., Wiuf C., Stumpf M.M.P. Cellular compartments cause multistability and allow cells to process more information. Biophys. J. 2013, 104:1824-1831.
    • (2013) Biophys. J. , vol.104 , pp. 1824-1831
    • Harrington, H.A.1    Feliu, E.2    Wiuf, C.3    Stumpf, M.M.P.4
  • 20
    • 79961051673 scopus 로고    scopus 로고
    • Separating intrinsic from extrinsic fluctuations in dynamic biological systems
    • Hilfinger A., Paulsson J. Separating intrinsic from extrinsic fluctuations in dynamic biological systems. Proc. Natl. Acad. Sci. USA 2011, 108:12167-12172.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 12167-12172
    • Hilfinger, A.1    Paulsson, J.2
  • 22
    • 58149279827 scopus 로고    scopus 로고
    • Activation of the MAPK module from different spatial locations generates distinct system outputs
    • Inder K., Harding A., Plowman S.J., Philips M.R., Parton R.G., Hancock J.F. Activation of the MAPK module from different spatial locations generates distinct system outputs. Mol. Biol. Cell 2008, 19:4776-4784.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4776-4784
    • Inder, K.1    Harding, A.2    Plowman, S.J.3    Philips, M.R.4    Parton, R.G.5    Hancock, J.F.6
  • 24
    • 84892755107 scopus 로고    scopus 로고
    • Determinants of cell-to-cell variability in protein kinase signaling
    • Jeschke M., Baumgärtner S., Legewie S. Determinants of cell-to-cell variability in protein kinase signaling. PLoS Comput. Biol. 2013, 9:e1003357.
    • (2013) PLoS Comput. Biol. , vol.9 , pp. e1003357
    • Jeschke, M.1    Baumgärtner, S.2    Legewie, S.3
  • 25
    • 84902474441 scopus 로고    scopus 로고
    • Efficient parametric inference for stochastic biological systems with measured variability
    • Johnston I.G. Efficient parametric inference for stochastic biological systems with measured variability. Stat. Appl. Genet. Mol. Biol. 2014, 13:379-390.
    • (2014) Stat. Appl. Genet. Mol. Biol. , vol.13 , pp. 379-390
    • Johnston, I.G.1
  • 27
    • 70350452750 scopus 로고    scopus 로고
    • Cell type-specific importance of Ras-c-Raf complex association rate constants for MAPK signaling
    • Kiel C., Serrano L. Cell type-specific importance of Ras-c-Raf complex association rate constants for MAPK signaling. Sci. Signal 2009, 2:ra38.
    • (2009) Sci. Signal , vol.2 , pp. ra38
    • Kiel, C.1    Serrano, L.2
  • 28
    • 84881027074 scopus 로고    scopus 로고
    • Model selection in systems and synthetic biology
    • Kirk P., Thorne T., Stumpf M.P. Model selection in systems and synthetic biology. Curr. Opin. Biotechnol. 2013, 24:767-774.
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 767-774
    • Kirk, P.1    Thorne, T.2    Stumpf, M.P.3
  • 29
    • 77953547027 scopus 로고    scopus 로고
    • Using a single fluorescent reporter gene to infer half-life of extrinsic noise and other parameters of gene expression
    • Komorowski M., Finkenstädt B., Rand D. Using a single fluorescent reporter gene to infer half-life of extrinsic noise and other parameters of gene expression. Biophys. J. 2010, 98:2759-2769.
    • (2010) Biophys. J. , vol.98 , pp. 2759-2769
    • Komorowski, M.1    Finkenstädt, B.2    Rand, D.3
  • 30
    • 84857816317 scopus 로고    scopus 로고
    • StochSens--Matlab package for sensitivity analysis of stochastic chemical systems
    • Komorowski M., Zurauskiene J., Stumpf M.P.H. StochSens--Matlab package for sensitivity analysis of stochastic chemical systems. Bioinformatics 2012, 28:731-733.
    • (2012) Bioinformatics , vol.28 , pp. 731-733
    • Komorowski, M.1    Zurauskiene, J.2    Stumpf, M.P.H.3
  • 31
    • 84876357659 scopus 로고    scopus 로고
    • Decomposing noise in biochemical signaling systems highlights the role of protein degradation
    • Komorowski M., Miekisz J., Stumpf M.P. Decomposing noise in biochemical signaling systems highlights the role of protein degradation. Biophys. J. 2013, 104:1783-1793.
    • (2013) Biophys. J. , vol.104 , pp. 1783-1793
    • Komorowski, M.1    Miekisz, J.2    Stumpf, M.P.3
  • 32
    • 25444489027 scopus 로고    scopus 로고
    • Phenotypic diversity, population growth, and information in fluctuating environments
    • Kussell E., Leibler S. Phenotypic diversity, population growth, and information in fluctuating environments. Science 2005, 309:2075-2078.
    • (2005) Science , vol.309 , pp. 2075-2078
    • Kussell, E.1    Leibler, S.2
  • 33
    • 84942021497 scopus 로고    scopus 로고
    • Information processing by simple molecular motifs and susceptibility to noise
    • Mc Mahon S.S., Lenive O., Filippi S., Stumpf M.P.H. Information processing by simple molecular motifs and susceptibility to noise. J. R. Soc. Interface 2015, 12:0597.
    • (2015) J. R. Soc. Interface , vol.12 , pp. 0597
    • Mc Mahon, S.S.1    Lenive, O.2    Filippi, S.3    Stumpf, M.P.H.4
  • 35
    • 84858800729 scopus 로고    scopus 로고
    • Control of ground-state pluripotency by allelic regulation of Nanog
    • Miyanari Y., Torres-Padilla M.-E. Control of ground-state pluripotency by allelic regulation of Nanog. Nature 2012, 483:470-473.
    • (2012) Nature , vol.483 , pp. 470-473
    • Miyanari, Y.1    Torres-Padilla, M.-E.2
  • 36
    • 64049090878 scopus 로고    scopus 로고
    • Modularity of MAP kinases allows deformation of their signalling pathways
    • Mody A., Weiner J., Ramanathan S. Modularity of MAP kinases allows deformation of their signalling pathways. Nat. Cell Biol. 2009, 11:484-491.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 484-491
    • Mody, A.1    Weiner, J.2    Ramanathan, S.3
  • 38
    • 33747429073 scopus 로고    scopus 로고
    • Bistability from double phosphorylation in signal transduction. Kinetic and structural requirements
    • Ortega F., Garcés J.L., Mas F., Kholodenko B.N., Cascante M. Bistability from double phosphorylation in signal transduction. Kinetic and structural requirements. FEBS J. 2006, 273:3915-3926.
    • (2006) FEBS J. , vol.273 , pp. 3915-3926
    • Ortega, F.1    Garcés, J.L.2    Mas, F.3    Kholodenko, B.N.4    Cascante, M.5
  • 39
    • 77956334999 scopus 로고    scopus 로고
    • A quantitative image cytometry technique for time series or population analyses of signaling networks
    • Ozaki Y., Uda S., Saito T.H., Chung J., Kubota H., Kuroda S. A quantitative image cytometry technique for time series or population analyses of signaling networks. PLoS ONE 2010, 5:e9955.
    • (2010) PLoS ONE , vol.5 , pp. e9955
    • Ozaki, Y.1    Uda, S.2    Saito, T.H.3    Chung, J.4    Kubota, H.5    Kuroda, S.6
  • 41
    • 84908592829 scopus 로고    scopus 로고
    • MAP kinase modules: the excursion model and the steps that count
    • Piala A.T., Humphreys J.M., Goldsmith E.J. MAP kinase modules: the excursion model and the steps that count. Biophys. J. 2014, 107:2006-2015.
    • (2014) Biophys. J. , vol.107 , pp. 2006-2015
    • Piala, A.T.1    Humphreys, J.M.2    Goldsmith, E.J.3
  • 42
    • 84858414016 scopus 로고    scopus 로고
    • Regulated noise in the epigenetic landscape of development and disease
    • Pujadas E., Feinberg A.P. Regulated noise in the epigenetic landscape of development and disease. Cell 2012, 148:1123-1131.
    • (2012) Cell , vol.148 , pp. 1123-1131
    • Pujadas, E.1    Feinberg, A.P.2
  • 44
    • 34248591612 scopus 로고    scopus 로고
    • Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
    • Roberts P.J., Der C.J. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007, 26:3291-3310.
    • (2007) Oncogene , vol.26 , pp. 3291-3310
    • Roberts, P.J.1    Der, C.J.2
  • 45
    • 84923647413 scopus 로고    scopus 로고
    • Cell dynamics and gene expression control in tissue homeostasis and development
    • Rué P., Martinez Arias A. Cell dynamics and gene expression control in tissue homeostasis and development. Mol. Syst. Biol. 2015, 11:792.
    • (2015) Mol. Syst. Biol. , vol.11 , pp. 792
    • Rué, P.1    Martinez Arias, A.2
  • 46
    • 84874631184 scopus 로고    scopus 로고
    • Temporal decoding of MAP kinase and CREB phosphorylation by selective immediate early gene expression
    • Saito T.H., Uda S., Tsuchiya T., Ozaki Y., Kuroda S. Temporal decoding of MAP kinase and CREB phosphorylation by selective immediate early gene expression. PLoS ONE 2013, 8:e57037.
    • (2013) PLoS ONE , vol.8 , pp. e57037
    • Saito, T.H.1    Uda, S.2    Tsuchiya, T.3    Ozaki, Y.4    Kuroda, S.5
  • 47
    • 33847355217 scopus 로고    scopus 로고
    • Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
    • Santos S.D.M., Verveer P.J., Bastiaens P.I.H. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat. Cell Biol. 2007, 9:324-330.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 324-330
    • Santos, S.D.M.1    Verveer, P.J.2    Bastiaens, P.I.H.3
  • 48
    • 84862682760 scopus 로고    scopus 로고
    • Spatial positive feedback at the onset of mitosis
    • Santos S.D.M., Wollman R., Meyer T., Ferrell J.E.J. Spatial positive feedback at the onset of mitosis. Cell 2012, 149:1500-1513.
    • (2012) Cell , vol.149 , pp. 1500-1513
    • Santos, S.D.M.1    Wollman, R.2    Meyer, T.3    Ferrell, J.E.J.4
  • 49
    • 17344362384 scopus 로고    scopus 로고
    • Prediction and validation of the distinct dynamics of transient and sustained ERK activation
    • Sasagawa S., Ozaki Y.-i., Fujita K., Kuroda S. Prediction and validation of the distinct dynamics of transient and sustained ERK activation. Nat. Cell Biol. 2005, 7:365-373.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 365-373
    • Sasagawa, S.1    Ozaki, Y.-I.2    Fujita, K.3    Kuroda, S.4
  • 50
    • 0036212767 scopus 로고    scopus 로고
    • Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
    • Schoeberl B., Eichler-Jonsson C., Gilles E.D., Müller G. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat. Biotechnol. 2002, 20:370-375.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 370-375
    • Schoeberl, B.1    Eichler-Jonsson, C.2    Gilles, E.D.3    Müller, G.4
  • 51
    • 84983209674 scopus 로고    scopus 로고
    • FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells
    • Schröter C., Rué P., Mackenzie J.P., Martinez Arias A. FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells. Development 2015, 142:4205-4216.
    • (2015) Development , vol.142 , pp. 4205-4216
    • Schröter, C.1    Rué, P.2    Mackenzie, J.P.3    Martinez Arias, A.4
  • 52
    • 84918571678 scopus 로고    scopus 로고
    • Systems biology. Accurate information transmission through dynamic biochemical signaling networks
    • Selimkhanov J., Taylor B., Yao J., Pilko A., Albeck J., Hoffmann A., Tsimring L., Wollman R. Systems biology. Accurate information transmission through dynamic biochemical signaling networks. Science 2014, 346:1370-1373.
    • (2014) Science , vol.346 , pp. 1370-1373
    • Selimkhanov, J.1    Taylor, B.2    Yao, J.3    Pilko, A.4    Albeck, J.5    Hoffmann, A.6    Tsimring, L.7    Wollman, R.8
  • 53
    • 43249118966 scopus 로고    scopus 로고
    • Colored extrinsic fluctuations and stochastic gene expression
    • Shahrezaei V., Ollivier J.F., Swain P.S. Colored extrinsic fluctuations and stochastic gene expression. Mol. Sys. Biol. 2008, 4.
    • (2008) Mol. Sys. Biol. , vol.4
    • Shahrezaei, V.1    Ollivier, J.F.2    Swain, P.S.3
  • 56
    • 66249136447 scopus 로고    scopus 로고
    • Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
    • Spencer S.L., Gaudet S., Albeck J.G., Burke J.M., Sorger P.K. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 2009, 459:428-432.
    • (2009) Nature , vol.459 , pp. 428-432
    • Spencer, S.L.1    Gaudet, S.2    Albeck, J.G.3    Burke, J.M.4    Sorger, P.K.5
  • 60
    • 0036109556 scopus 로고    scopus 로고
    • The role of proofreading in signal transduction specificity
    • Swain P.S., Siggia E.D. The role of proofreading in signal transduction specificity. Biophys. J. 2002, 82:2928-2933.
    • (2002) Biophys. J. , vol.82 , pp. 2928-2933
    • Swain, P.S.1    Siggia, E.D.2
  • 61
    • 0036790975 scopus 로고    scopus 로고
    • Intrinsic and extrinsic contributions to stochasticity in gene expression
    • Swain P.S., Elowitz M.B., Siggia E.D. Intrinsic and extrinsic contributions to stochasticity in gene expression. Proc. Natl. Acad. Sci. USA 2002, 99:12795-12800.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12795-12800
    • Swain, P.S.1    Elowitz, M.B.2    Siggia, E.D.3
  • 62
    • 77249093066 scopus 로고    scopus 로고
    • Spatio-temporal correlations can drastically change the response of a MAPK pathway
    • Takahashi K., Tanase-Nicola S., ten Wolde P.R. Spatio-temporal correlations can drastically change the response of a MAPK pathway. Proc. Natl. Acad. Sci. USA 2010, 107:2473-2478.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 2473-2478
    • Takahashi, K.1    Tanase-Nicola, S.2    ten Wolde, P.R.3
  • 63
    • 84875984016 scopus 로고    scopus 로고
    • Combined model of intrinsic and extrinsic variability for computational network design with application to synthetic biology
    • Toni T., Tidor B. Combined model of intrinsic and extrinsic variability for computational network design with application to synthetic biology. PLoS Comput. Biol. 2013, 9:e1002960.
    • (2013) PLoS Comput. Biol. , vol.9 , pp. e1002960
    • Toni, T.1    Tidor, B.2
  • 64
    • 84862188059 scopus 로고    scopus 로고
    • Elucidating the in vivo phosphorylation dynamics of the ERK MAP kinase using quantitative proteomics data and Bayesian model selection
    • Toni T., Ozaki Y., Kirk P., Kuroda S., Stumpf M.P.H. Elucidating the in vivo phosphorylation dynamics of the ERK MAP kinase using quantitative proteomics data and Bayesian model selection. Mol. Biosyst. 2012, 8:1921-1929.
    • (2012) Mol. Biosyst. , vol.8 , pp. 1921-1929
    • Toni, T.1    Ozaki, Y.2    Kirk, P.3    Kuroda, S.4    Stumpf, M.P.H.5
  • 65
    • 84859167118 scopus 로고    scopus 로고
    • Sensitivity control through attenuation of signal transfer efficiency by negative regulation of cellular signalling
    • Toyoshima Y., Kakuda H., Fujita K.A., Uda S., Kuroda S. Sensitivity control through attenuation of signal transfer efficiency by negative regulation of cellular signalling. Nat. Commun. 2012, 3:743.
    • (2012) Nat. Commun. , vol.3 , pp. 743
    • Toyoshima, Y.1    Kakuda, H.2    Fujita, K.A.3    Uda, S.4    Kuroda, S.5


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