Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics

Science Signaling

Volumn 3, Issue 132, 2010, Pages

  Fujita, Kazuhiro A ^a   Toyoshima, Yu ^a   Uda, Shinsuke ^a   Ozaki, Yu Ichi ^a   Kubota, Hiroyuki ^a   Kuroda, Shinya ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; LAPATINIB; PROTEIN KINASE B; PROTEIN S6;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL STRAIN; DOWNSTREAM PROCESSING; FILTRATION; FREQUENCY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; RECEPTOR DECOUPLING; SIGNAL TRANSDUCTION; STIMULUS;

ANIMALS; EPIDERMAL GROWTH FACTOR; IMMUNOBLOTTING; MODELS, BIOLOGICAL; PC12 CELLS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; QUINAZOLINES; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RIBOSOMAL PROTEIN S6; SIGNAL TRANSDUCTION;

EID: 77956637961     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000810     Document Type: Article

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46. Acknowledgments: We thank our laboratory members and N. Tanimura for critically reading this manuscript, R. Kunihiro for technical assistance, and M. Nakafuku (Cincinnati Children's Hospital Medical Center, Cincinnati, OH) for the PC12 cells. Funding: This work was supported by The Dynamic Mechanism of and Fundamental Technology for Biological System, CREST, Japan Science and Technology, and KAKENHI Scientific Research (A) (#21240025) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and a grant-in-aid from the Uehara Memorial Foundation. K.A.F. was supported by the Grant-in-Aid for the Global COE Program "Deciphering Biosphere from Genome Big Bang" from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Author contributions: K.A.F. and S.K. conceived and designed this study. K.A.F. and Y.T. performed and analyzed the experiments and simulation. K.A.F. conceived the application of Fourier transform to the frequency response analysis and implemented it with the assistance of S.U. and Y.T. Y.T. together with K.A.F. and S.K. conceived the decoupling effect of inhibitor. S.U. supported the data analysis. Y.T., S.U., Y.O., and H.K. supported the design of this study. K.A.F., Y.T., and S.K. wrote the manuscript. Accession numbers: BioModels Database MODEL1004060001 (EGF-dependent Akt pathway model), MODEL1004060002 (NGF-dependent Akt pathway model), and MODEL1004060003 (EGF inhibitor model).