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Volumn 3, Issue 3, 2015, Pages

Intracellular probes for imaging oxygen concentration: How good are they?

Author keywords

3D tissue models; FLIM; Hypoxia; Intracellular and cell permeable probes; Phosphorescence quenching; Phosphorescent oxygen sensitive probes

Indexed keywords


EID: 84974603095     PISSN: None     EISSN: 20506120     Source Type: Journal    
DOI: 10.1088/2050-6120/3/3/034001     Document Type: Article
Times cited : (56)

References (95)
  • 1
    • 84884595367 scopus 로고    scopus 로고
    • Biological detection by optical oxygen sensing
    • Papkovsky D B and Dmitriev R I 2013 Biological detection by optical oxygen sensing Chem. Soc. Rev. 42 8700-32
    • (2013) Chem. Soc. Rev. , vol.42 , pp. 8700-8732
    • Papkovsky, D.B.1    Dmitriev, R.I.2
  • 2
    • 84887129663 scopus 로고    scopus 로고
    • Regulation of cellular gas exchange, oxygen sensing, and metabolic control
    • Clanton T L, Hogan M C and Gladden L B 2013 Regulation of cellular gas exchange, oxygen sensing, and metabolic control Compr. Physiol. 3 1135-90
    • (2013) Compr. Physiol. , vol.3 , pp. 1135-1190
    • Clanton, T.L.1    Hogan, M.C.2    Gladden, L.B.3
  • 3
    • 84856460295 scopus 로고    scopus 로고
    • The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism
    • Jespersen S N and Østergaard L 2011 The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism J. Cereb. Blood Flow Metab. 32 264-77
    • (2011) J. Cereb. Blood Flow Metab. , vol.32 , pp. 264-277
    • Jespersen, S.N.1    Østergaard, L.2
  • 6
    • 0023664339 scopus 로고
    • An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence
    • Vanderkooi J M, Maniara G, Green T J and Wilson D F 1987 An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence J. Biol. Chem. 262 5476-82
    • (1987) J. Biol. Chem. , vol.262 , pp. 5476-5482
    • Vanderkooi, J.M.1    Maniara, G.2    Green, T.J.3    Wilson, D.F.4
  • 7
    • 84862887718 scopus 로고    scopus 로고
    • Optical probes and techniques for O2 measurement in live cells and tissue
    • Dmitriev R and Papkovsky D 2012 Optical probes and techniques for O2 measurement in live cells and tissue Cell Mol. Life Sci. 69 2025-39
    • (2012) Cell Mol. Life Sci. , vol.69 , pp. 2025-2039
    • Dmitriev, R.1    Papkovsky, D.2
  • 8
    • 84899094220 scopus 로고    scopus 로고
    • Optical methods for sensing and imaging oxygen: Materials, spectroscopies and applications
    • Wang X-D and Wolfbeis O S 2014 Optical methods for sensing and imaging oxygen: materials, spectroscopies and applications Chem. Soc. Rev. 43 3666-761
    • (2014) Chem. Soc. Rev. , vol.43 , pp. 3666-3761
    • Wang, X.-D.1    Wolfbeis, O.S.2
  • 9
    • 0001322362 scopus 로고
    • Continuous recording of blood oxygen tensions by polarography
    • Clark L C, Wolf R, Granger D and Taylor Z 1953 Continuous recording of blood oxygen tensions by polarography J. Appl. Physiol. 6 189-93
    • (1953) J. Appl. Physiol. , vol.6 , pp. 189-193
    • Clark, L.C.1    Wolf, R.2    Granger, D.3    Taylor, Z.4
  • 10
    • 84863422636 scopus 로고    scopus 로고
    • Frontiers in optical imaging of cerebral blood flow and metabolism
    • Devor A et al 2012 Frontiers in optical imaging of cerebral blood flow and metabolism J. Cereb. Blood Flow Metab. 32 1259-76
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 1259-1276
    • Devor, A.1
  • 12
    • 0025032599 scopus 로고
    • Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo highresolution optical imaging of intrinsic signals
    • Frostig R D, Lieke E E, Ts'o D Y and Grinvald A 1990 Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo highresolution optical imaging of intrinsic signals Proc. Natl Acad. Sci. USA 87 6082-6
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 6082-6086
    • Frostig, R.D.1    Lieke, E.E.2    Ts'O, D.Y.3    Grinvald, A.4
  • 13
    • 34548014282 scopus 로고    scopus 로고
    • Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
    • Fox M D and Raichle M E 2007 Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging Nat. Rev. Neurosci. 8 700-11
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 700-711
    • Fox, M.D.1    Raichle, M.E.2
  • 14
    • 33645932912 scopus 로고    scopus 로고
    • Human skeletal muscle intracellular oxygenation: The impact of ambient oxygen availability
    • Richardson R S, Duteil S, Wary C, Wray D W, Hoff J and Carlier P G 2006 Human skeletal muscle intracellular oxygenation: the impact of ambient oxygen availability J. Physiol. 571 415-24
    • (2006) J. Physiol. , vol.571 , pp. 415-424
    • Richardson, R.S.1    Duteil, S.2    Wary, C.3    Wray, D.W.4    Hoff, J.5    Carlier, P.G.6
  • 16
    • 84867317909 scopus 로고    scopus 로고
    • Ratiometric optical oxygen sensing: A review in respect of material design
    • Feng Y, Cheng J, Zhou L, Zhou X and Xiang H 2012 Ratiometric optical oxygen sensing: a review in respect of material design Analyst 137 4885-901
    • (2012) Analyst , vol.137 , pp. 4885-4901
    • Feng, Y.1    Cheng, J.2    Zhou, L.3    Zhou, X.4    Xiang, H.5
  • 17
    • 84870613559 scopus 로고    scopus 로고
    • A phosphorescent nanoparticlebased probe for sensing and imaging of (intra)cellular oxygen in multiple detection modalities
    • Kondrashina A V et al 2012 A phosphorescent nanoparticlebased probe for sensing and imaging of (intra)cellular oxygen in multiple detection modalities Adv. Funct. Mater. 22 4931-9
    • (2012) Adv. Funct. Mater. , vol.22 , pp. 4931-4939
    • Kondrashina, A.V.1
  • 18
    • 84884240762 scopus 로고    scopus 로고
    • Editorial: Probes, sensors, and labels: Why is real progress slow?
    • Wolfbeis O S 2013 Editorial: probes, sensors, and labels: why is real progress slow? Angew. Chem. Int. Edn 52 9864-5
    • (2013) Angew. Chem. Int. Edn , vol.52 , pp. 9864-9865
    • Wolfbeis, O.S.1
  • 20
    • 84555186708 scopus 로고    scopus 로고
    • Cell-penetrating conjugates of coproporphyrins with oligoarginine peptides: Rational design and application for sensing intracellular O2
    • Dmitriev R I, Ropiak H M, Ponomarev G V, Yashunsky D V and Papkovsky D B 2011 Cell-penetrating conjugates of coproporphyrins with oligoarginine peptides: rational design and application for sensing intracellular O2 Bioconjug. Chem. 22 2507-18
    • (2011) Bioconjug. Chem. , vol.22 , pp. 2507-2518
    • Dmitriev, R.I.1    Ropiak, H.M.2    Ponomarev, G.V.3    Yashunsky, D.V.4    Papkovsky, D.B.5
  • 21
  • 24
    • 84861424170 scopus 로고    scopus 로고
    • Complexes of IrIII-octaethylporphyrin with peptides as probes for sensing cellular O2
    • Koren K, Dmitriev R I, Borisov S M, Papkovsky D B and Klimant I 2012 Complexes of IrIII-octaethylporphyrin with peptides as probes for sensing cellular O2 ChemBioChem 13 1184-90
    • (2012) ChemBioChem , vol.13 , pp. 1184-1190
    • Koren, K.1    Dmitriev, R.I.2    Borisov, S.M.3    Papkovsky, D.B.4    Klimant, I.5
  • 25
    • 84900317531 scopus 로고    scopus 로고
    • Small molecule phosphorescent probes for O2 imaging in 3D tissue models
    • Dmitriev R I et al 2014 Small molecule phosphorescent probes for O2 imaging in 3D tissue models Biomater. Sci. 2 853-66
    • (2014) Biomater. Sci. , vol.2 , pp. 853-866
    • Dmitriev, R.I.1
  • 26
    • 84908614338 scopus 로고    scopus 로고
    • Peptide-bridged dinuclear Ru(II) complex for mitochondrial targeted monitoring of dynamic changes to oxygen concentration and ROS generation in live mammalian cells
    • Martin A, Byrne A, Burke C S, Forster R J and Keyes T E 2014 Peptide-bridged dinuclear Ru(II) complex for mitochondrial targeted monitoring of dynamic changes to oxygen concentration and ROS generation in live mammalian cells J. Am. Chem. Soc. 136 15300-9
    • (2014) J. Am. Chem. Soc. , vol.136 , pp. 15300-15309
    • Martin, A.1    Byrne, A.2    Burke, C.S.3    Forster, R.J.4    Keyes, T.E.5
  • 27
    • 77958027693 scopus 로고    scopus 로고
    • Near infrared luminescent oxygen nanosensors with nanoparticle matrix tailored sensitivity
    • Koo Lee Y-E et al 2010 Near infrared luminescent oxygen nanosensors with nanoparticle matrix tailored sensitivity Anal. Chem. 82 8446-55
    • (2010) Anal. Chem. , vol.82 , pp. 8446-8455
    • Koo Lee, Y.-E.1
  • 28
    • 74049143462 scopus 로고    scopus 로고
    • Probing intracellular oxygen by quenched phosphorescence lifetimes of nanoparticles containing polyacrylamide-embedded [Ru (dpp (SO3Na) 2) 3] Cl2
    • Coogan M, Court J B, Gray V L, Hayes A J, Lloyd S H, Millet C O, Pope S J A and Lloyd D 2010 Probing intracellular oxygen by quenched phosphorescence lifetimes of nanoparticles containing polyacrylamide-embedded [Ru (dpp (SO3Na) 2) 3] Cl2 Photochem. Photobiol. Sci. 9 103-9
    • (2010) Photochem. Photobiol. Sci. , vol.9 , pp. 103-109
    • Coogan, M.1    Court, J.B.2    Gray, V.L.3    Hayes, A.J.4    Lloyd, S.H.5    Millet, C.O.6    Pope, S.J.A.7    Lloyd, D.8
  • 29
    • 79961093455 scopus 로고    scopus 로고
    • Intracellular O2 sensing probe based on cell-penetrating phosphorescent nanoparticles
    • Fercher A, Borisov S M, Zhdanov A V, Klimant I and Papkovsky D B 2011 Intracellular O2 sensing probe based on cell-penetrating phosphorescent nanoparticles ACS Nano 5 5499-508
    • (2011) ACS Nano , vol.5 , pp. 5499-5508
    • Fercher, A.1    Borisov, S.M.2    Zhdanov, A.V.3    Klimant, I.4    Papkovsky, D.B.5
  • 30
    • 79955641976 scopus 로고    scopus 로고
    • Self-referenced RGB colour imaging of intracellular oxygen
    • Wang X-D et al 2011 Self-referenced RGB colour imaging of intracellular oxygen Chem. Sci. 2 901-6
    • (2011) Chem. Sci. , vol.2 , pp. 901-906
    • Wang, X.-D.1
  • 31
    • 84881304513 scopus 로고    scopus 로고
    • Imaging of cellular oxygen via twophoton excitation of fluorescent sensor nanoparticles
    • Wang X-D et al 2013 Imaging of cellular oxygen via twophoton excitation of fluorescent sensor nanoparticles Sensors Actuators B 188 257-62
    • (2013) Sensors Actuators B , vol.188 , pp. 257-262
    • Wang, X.-D.1
  • 33
    • 84884274411 scopus 로고    scopus 로고
    • Development of polymeric nanoprobes with improved lifetime dynamic range and stability for intracellular oxygen sensing
    • Liu H et al 2013 Development of polymeric nanoprobes with improved lifetime dynamic range and stability for intracellular oxygen sensing Small 9 2639-48
    • (2013) Small , vol.9 , pp. 2639-2648
    • Liu, H.1
  • 34
    • 84930205944 scopus 로고    scopus 로고
    • Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles
    • Dmitriev R et al 2014 Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles Cell Mol. Life Sci. 72 367-81
    • (2014) Cell Mol. Life Sci. , vol.72 , pp. 367-381
    • Dmitriev, R.1
  • 35
    • 84905750358 scopus 로고    scopus 로고
    • Ultrasmall phosphorescent polymer dots for ratiometric oxygen sensing and photodynamic cancer therapy
    • Shi H et al 2014 Ultrasmall phosphorescent polymer dots for ratiometric oxygen sensing and photodynamic cancer therapy Adv. Funct. Mater. 24 4823-30
    • (2014) Adv. Funct. Mater. , vol.24 , pp. 4823-4830
    • Shi, H.1
  • 36
    • 84904015911 scopus 로고    scopus 로고
    • Ultrasensitive nanosensors based on upconversion nanoparticles for selective hypoxia imaging in vivo upon near-infrared excitation
    • Liu J, Liu Y, Bu W, Bu J, Sun Y, Du J and Shi J 2014 Ultrasensitive nanosensors based on upconversion nanoparticles for selective hypoxia imaging in vivo upon near-infrared excitation J. Am. Chem. Soc. 13 9701-9
    • (2014) J. Am. Chem. Soc. , vol.13 , pp. 9701-9709
    • Liu, J.1    Liu, Y.2    Bu, W.3    Bu, J.4    Sun, Y.5    Du, J.6    Shi, J.7
  • 37
    • 84933577919 scopus 로고    scopus 로고
    • Targetable phosphorescent oxygen nanosensors for the assessment of tumor mitochondrial dysfunction by monitoring the respiratory activity
    • Wang X-H et al 2014 Targetable phosphorescent oxygen nanosensors for the assessment of tumor mitochondrial dysfunction by monitoring the respiratory activity Angew. Chem. Int. Edn 126 12679-83
    • (2014) Angew. Chem. Int. Edn , vol.126 , pp. 12679-12683
    • Wang, X.-H.1
  • 38
    • 37249064670 scopus 로고    scopus 로고
    • Analysis of intracellular oxygen and metabolic responses of mammalian cells by time-resolved fluorometry
    • O'Riordan T C, Zhdanov A V, Ponomarev G V and Papkovsky D B 2007 Analysis of intracellular oxygen and metabolic responses of mammalian cells by time-resolved fluorometry Anal. Chem. 79 9414-9
    • (2007) Anal. Chem. , vol.79 , pp. 9414-9419
    • O'Riordan, T.C.1    Zhdanov, A.V.2    Ponomarev, G.V.3    Papkovsky, D.B.4
  • 39
    • 84901433676 scopus 로고    scopus 로고
    • Kinetic analysis of local oxygenation and respiratory responses of mammalian cells using intracellular oxygen-sensitive probes and time-resolved fluorometry
    • Zhdanov A V, Dmitriev R I, Hynes J and Papkovsky D B 2014 Kinetic analysis of local oxygenation and respiratory responses of mammalian cells using intracellular oxygen-sensitive probes and time-resolved fluorometry Methods in Enzymol. 542 183-207
    • (2014) Methods in Enzymol. , vol.542 , pp. 183-207
    • Zhdanov, A.V.1    Dmitriev, R.I.2    Hynes, J.3    Papkovsky, D.B.4
  • 40
    • 84863876597 scopus 로고    scopus 로고
    • Fluorescence lifetime imaging-techniques and applications
    • Becker W 2012 Fluorescence lifetime imaging-techniques and applications J. Microsc. 247 119-36
    • (2012) J. Microsc. , vol.247 , pp. 119-136
    • Becker, W.1
  • 42
    • 82555175835 scopus 로고    scopus 로고
    • Targeted luminescent near-infrared polymernanoprobes for in vivo imaging of tumor hypoxia
    • Napp J et al 2011 Targeted luminescent near-infrared polymernanoprobes for in vivo imaging of tumor hypoxia Anal. Chem. 83 9039-46
    • (2011) Anal. Chem. , vol.83 , pp. 9039-9046
    • Napp, J.1
  • 43
    • 79955157780 scopus 로고    scopus 로고
    • Fluorescence lifetime imaging to quantify sub-cellular oxygen measurements in live macrophage during bacterial invasion
    • Dragavon J, Amiri M, Marteyn B, Sansonetti P and Shorte S 2011 Fluorescence lifetime imaging to quantify sub-cellular oxygen measurements in live macrophage during bacterial invasion Proc. SPIE 7910 19
    • (2011) Proc. SPIE , vol.7910 , pp. 19
    • Dragavon, J.1    Amiri, M.2    Marteyn, B.3    Sansonetti, P.4    Shorte, S.5
  • 44
    • 70349916218 scopus 로고    scopus 로고
    • Ratiometric single-nanoparticle oxygen sensors for biological imaging
    • Wu C, Bull B, Christensen K and McNeill J 2009 Ratiometric single-nanoparticle oxygen sensors for biological imaging Angew. Chem. Int. Edn 48 2741-5
    • (2009) Angew. Chem. Int. Edn , vol.48 , pp. 2741-2745
    • Wu, C.1    Bull, B.2    Christensen, K.3    McNeill, J.4
  • 45
    • 77949275769 scopus 로고    scopus 로고
    • Evaluation of the derivates of phosphorescent Ptcoproporphyrin as intracellular oxygen-sensitive probes
    • Fercher A, Ponomarev G V, Yashunski D and Papkovsky D 2010 Evaluation of the derivates of phosphorescent Ptcoproporphyrin as intracellular oxygen-sensitive probes Anal. Bioanal. Chem. 396 1793-803
    • (2010) Anal. Bioanal. Chem. , vol.396 , pp. 1793-1803
    • Fercher, A.1    Ponomarev, G.V.2    Yashunski, D.3    Papkovsky, D.4
  • 46
    • 84858665557 scopus 로고    scopus 로고
    • Endocytosis at the nanoscale
    • Canton I and Battaglia G 2012 Endocytosis at the nanoscale Chem. Soc. Rev. 41 2718-39
    • (2012) Chem. Soc. Rev. , vol.41 , pp. 2718-2739
    • Canton, I.1    Battaglia, G.2
  • 49
    • 84884331345 scopus 로고    scopus 로고
    • Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling
    • Zhdanov A V, Waters A H, Golubeva A V, Dmitriev R I and Papkovsky D B 2014 Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling Biochim. Biophys. Acta 1837 51-62
    • (2014) Biochim. Biophys. Acta , vol.1837 , pp. 51-62
    • Zhdanov, A.V.1    Waters, A.H.2    Golubeva, A.V.3    Dmitriev, R.I.4    Papkovsky, D.B.5
  • 50
    • 84858713743 scopus 로고    scopus 로고
    • Assessment of cellular oxygen gradients with a panel of phosphorescent oxygen-sensitive probes
    • Dmitriev R I, Zhdanov A V, Jasionek G and Papkovsky D B 2012 Assessment of cellular oxygen gradients with a panel of phosphorescent oxygen-sensitive probes Anal. Chem. 84 2930-8
    • (2012) Anal. Chem. , vol.84 , pp. 2930-2938
    • Dmitriev, R.I.1    Zhdanov, A.V.2    Jasionek, G.3    Papkovsky, D.B.4
  • 51
    • 0035448944 scopus 로고    scopus 로고
    • A real-time ratiometric method for the determination of molecular oxygen inside living cells using sol-gel-based spherical optical nanosensors with applications to rat C6 glioma
    • Xu H, Aylott J W, Kopelman R, Miller T J and Philbert M A 2001 A real-time ratiometric method for the determination of molecular oxygen inside living cells using sol-gel-based spherical optical nanosensors with applications to rat C6 glioma Anal. Chem. 73 4124-33
    • (2001) Anal. Chem. , vol.73 , pp. 4124-4133
    • Xu, H.1    Aylott, J.W.2    Kopelman, R.3    Miller, T.J.4    Philbert, M.A.5
  • 52
    • 84867560375 scopus 로고    scopus 로고
    • Ultra-small, highly stable, and sensitive dual nanosensors for imaging intracellular oxygen and pH in cytosol
    • Wang X-D et al 2012 Ultra-small, highly stable, and sensitive dual nanosensors for imaging intracellular oxygen and pH in cytosol J. Am. Chem. Soc. 134 17011-4
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 17011-17014
    • Wang, X.-D.1
  • 53
    • 33846500915 scopus 로고    scopus 로고
    • Particokinetics in vitro: Dosimetry considerations for in vitro nanoparticle toxicity assessments
    • Teeguarden J G, Hinderliter P M, Orr G, Thrall B D and Pounds J G 2007 Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments Toxicol. Sci. 95 300-12
    • (2007) Toxicol. Sci. , vol.95 , pp. 300-312
    • Teeguarden, J.G.1    Hinderliter, P.M.2    Orr, G.3    Thrall, B.D.4    Pounds, J.G.5
  • 55
    • 60749093701 scopus 로고    scopus 로고
    • Analytical methods to assess nanoparticle toxicity
    • Marquis B J, Love S A, Braun K L and Haynes C L 2009 Analytical methods to assess nanoparticle toxicity Analyst 134 425-39
    • (2009) Analyst , vol.134 , pp. 425-439
    • Marquis, B.J.1    Love, S.A.2    Braun, K.L.3    Haynes, C.L.4
  • 56
    • 80155133554 scopus 로고    scopus 로고
    • Comparative bioenergetic assessment of transformed cells using a cell energy budget platform
    • Zhdanov A V et al 2011 Comparative bioenergetic assessment of transformed cells using a cell energy budget platform Integr. Biol. 3 1135-42
    • (2011) Integr. Biol. , vol.3 , pp. 1135-1142
    • Zhdanov, A.V.1
  • 57
    • 49249089019 scopus 로고    scopus 로고
    • PO2 measurements in the microcirculation using phosphorescence quenching microscopy at high magnification
    • Golub A S and Pittman RN 2008 PO2 measurements in the microcirculation using phosphorescence quenching microscopy at high magnification Am. J. Physiol. Heart Circ. Physiol. 294 H2905-16
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.294 , pp. H2905-H2916
    • Golub, A.S.1    Pittman, R.N.2
  • 58
    • 79958058759 scopus 로고    scopus 로고
    • Evaluation of phototoxicity of dendritic porphyrin-based phosphorescent oxygen probes: An in vitro study
    • Ceroni P et al 2011 Evaluation of phototoxicity of dendritic porphyrin-based phosphorescent oxygen probes: an in vitro study Photochem. Photobiol. Sci. 10 1056-65
    • (2011) Photochem. Photobiol. Sci. , vol.10 , pp. 1056-1065
    • Ceroni, P.1
  • 61
    • 84885659516 scopus 로고    scopus 로고
    • Modulation of hydrogel nanoparticle intracellular trafficking by multivalent surface engineering with tumor targeting peptide
    • Karamchand L et al 2013 Modulation of hydrogel nanoparticle intracellular trafficking by multivalent surface engineering with tumor targeting peptide Nanoscale 5 10327-44
    • (2013) Nanoscale , vol.5 , pp. 10327-10344
    • Karamchand, L.1
  • 62
    • 51249083709 scopus 로고    scopus 로고
    • Oxygen microscopy by two-photonexcited phosphorescence
    • Finikova O S et al 2008 Oxygen microscopy by two-photonexcited phosphorescence ChemPhysChem 9 1673-9
    • (2008) ChemPhysChem , vol.9 , pp. 1673-1679
    • Finikova, O.S.1
  • 63
    • 33750288526 scopus 로고    scopus 로고
    • Mitochondrial PO2 measured by delayed fluorescence of endogenous protoporphyrin IX
    • Mik E G et al 2006 Mitochondrial PO2 measured by delayed fluorescence of endogenous protoporphyrin IX Nat. Methods 3 939-45
    • (2006) Nat. Methods , vol.3 , pp. 939-945
    • Mik, E.G.1
  • 64
    • 77955126792 scopus 로고    scopus 로고
    • Going deeper than microscopy: The optical imaging frontier in biology
    • Ntziachristos V 2010 Going deeper than microscopy: the optical imaging frontier in biology Nat. Methods 7 603-14
    • (2010) Nat. Methods , vol.7 , pp. 603-614
    • Ntziachristos, V.1
  • 65
    • 34648834682 scopus 로고    scopus 로고
    • The third dimension bridges the gap between cell culture and live tissue
    • Pampaloni F, Reynaud E G and Stelzer E H 2007 The third dimension bridges the gap between cell culture and live tissue Nat. Rev. Mol. Cell Biol. 8 839-45
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 839-845
    • Pampaloni, F.1    Reynaud, E.G.2    Stelzer, E.H.3
  • 67
    • 80051979063 scopus 로고    scopus 로고
    • FLIM and FCS detection in laser-scanning microscopes: Increased efficiency by GaAsP hybrid detectors
    • Becker W, Su B, Holub O and Weisshart K 2011 FLIM and FCS detection in laser-scanning microscopes: increased efficiency by GaAsP hybrid detectors Microsc. Res. Tech. 74 804-11
    • (2011) Microsc. Res. Tech. , vol.74 , pp. 804-811
    • Becker, W.1    Su, B.2    Holub, O.3    Weisshart, K.4
  • 68
    • 84869495994 scopus 로고    scopus 로고
    • Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
    • Mehta G, Hsiao A Y, Ingram M, Luker G D and Takayama S 2012 Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy J. Control. Rel. 164 192-204
    • (2012) J. Control. Rel. , vol.164 , pp. 192-204
    • Mehta, G.1    Hsiao, A.Y.2    Ingram, M.3    Luker, G.D.4    Takayama, S.5
  • 69
    • 84897423055 scopus 로고    scopus 로고
    • Click-assembled, oxygen-sensing nanoconjugates for depthresolved, near-infrared imaging in a 3D cancer model
    • Nichols A J, Roussakis E, Klein O J and Evans C L 2014 Click-assembled, oxygen-sensing nanoconjugates for depthresolved, near-infrared imaging in a 3D cancer model Angew. Chem. Int. Edn 53 3671-4
    • (2014) Angew. Chem. Int. Edn , vol.53 , pp. 3671-3674
    • Nichols, A.J.1    Roussakis, E.2    Klein, O.J.3    Evans, C.L.4
  • 70
    • 84911924499 scopus 로고    scopus 로고
    • Synthesis of phosphorescent asymmetrically pi-extended porphyrins for two-photon applications
    • Esipova T V and Vinogradov S A 2014 Synthesis of phosphorescent asymmetrically pi-extended porphyrins for two-photon applications J. Org. Chem. 79 8812-25
    • (2014) J. Org. Chem. , vol.79 , pp. 8812-8825
    • Esipova, T.V.1    Vinogradov, S.A.2
  • 71
    • 78649696470 scopus 로고    scopus 로고
    • Rapid wide-field photon counting imaging with microsecond time resolution
    • Suhling K, Sergent N, Levitt J and Green M 2010 Rapid wide-field photon counting imaging with microsecond time resolution Opt. Express 18 25292-8
    • (2010) Opt. Express , vol.18 , pp. 25292-25298
    • Suhling, K.1    Sergent, N.2    Levitt, J.3    Green, M.4
  • 72
    • 79961083401 scopus 로고    scopus 로고
    • Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivo
    • Wotzlaw C, Bernardini A, Berchner-Pfannschmidt U, Papkovsky D, Acker H and Fandrey J 2011 Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivo Am. J. Physiol. 301 C266-71
    • (2011) Am. J. Physiol. , vol.301 , pp. C266-C271
    • Wotzlaw, C.1    Bernardini, A.2    Berchner-Pfannschmidt, U.3    Papkovsky, D.4    Acker, H.5    Fandrey, J.6
  • 73
    • 84920887438 scopus 로고    scopus 로고
    • Type i cell ROS kinetics under hypoxia in the intact mouse carotid body ex vivo: A FRET based study
    • Bernardini A et al 2014 Type I cell ROS kinetics under hypoxia in the intact mouse carotid body ex vivo: a FRET based study Am. J. Physiol. 308 C61-7
    • (2014) Am. J. Physiol. , vol.308 , pp. C61-C67
    • Bernardini, A.1
  • 74
    • 84859508680 scopus 로고    scopus 로고
    • Mitochondriaspecific oxygen probe based on iridium complexes bearing triphenylphosphonium cation
    • Murase T, Yoshihara T and Tobita S 2012 Mitochondriaspecific oxygen probe based on iridium complexes bearing triphenylphosphonium cation Chem. Lett. 41 262-3
    • (2012) Chem. Lett. , vol.41 , pp. 262-263
    • Murase, T.1    Yoshihara, T.2    Tobita, S.3
  • 75
    • 84908306828 scopus 로고    scopus 로고
    • Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota in humans and mice
    • Albenberg L et al 2014 Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota in humans and mice Gastroenterology 147 1055-63
    • (2014) Gastroenterology , vol.147 , pp. 1055-1063
    • Albenberg, L.1
  • 76
    • 0000207008 scopus 로고
    • Photophysics and photochemistry of oxygen sensors based on luminescent transition-metal complexes
    • Carraway E, Demas J, DeGraff B and Bacon J 1991 Photophysics and photochemistry of oxygen sensors based on luminescent transition-metal complexes Anal. Chem. 63 337-42
    • (1991) Anal. Chem. , vol.63 , pp. 337-342
    • Carraway, E.1    Demas, J.2    DeGraff, B.3    Bacon, J.4
  • 77
    • 77956323513 scopus 로고    scopus 로고
    • Monitoring of cell oxygenation and responses to metabolic stimulation by intracellular oxygen sensing technique
    • Zhdanov A V, Ogurtsov V I, Taylor C T and Papkovsky D B 2010 Monitoring of cell oxygenation and responses to metabolic stimulation by intracellular oxygen sensing technique Integr. Biol. 2 443-51
    • (2010) Integr. Biol. , vol.2 , pp. 443-451
    • Zhdanov, A.V.1    Ogurtsov, V.I.2    Taylor, C.T.3    Papkovsky, D.B.4
  • 78
    • 79951581400 scopus 로고    scopus 로고
    • Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria
    • Zhdanov A, Dmitriev R and Papkovsky D 2011 Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria Cell Mol. Life Sci. 68 903-17
    • (2011) Cell Mol. Life Sci. , vol.68 , pp. 903-917
    • Zhdanov, A.1    Dmitriev, R.2    Papkovsky, D.3
  • 79
    • 84872423950 scopus 로고    scopus 로고
    • Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling
    • Zhdanov A V, Dmitriev R I and Papkovsky D B 2012 Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling Biosci. Rep. 32 587-95
    • (2012) Biosci. Rep. , vol.32 , pp. 587-595
    • Zhdanov, A.V.1    Dmitriev, R.I.2    Papkovsky, D.B.3
  • 80
    • 84875277824 scopus 로고    scopus 로고
    • A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays
    • Hynes J, Nadanaciva S, Swiss R, Carey C, Kirwan S and Will Y 2013 A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays Toxicol. in Vitro 27 560-9
    • (2013) Toxicol. in Vitro , vol.27 , pp. 560-569
    • Hynes, J.1    Nadanaciva, S.2    Swiss, R.3    Carey, C.4    Kirwan, S.5    Will, Y.6
  • 81
    • 0035920140 scopus 로고    scopus 로고
    • Hypoxia inhibits the peroxisome proliferator-activated receptor α/ retinoid X receptor gene regulatory pathway in cardiac myocytes: A mechanism for O2-dependent modulation of mitochondrial fatty acid oxidation
    • Huss J M, Levy F H and Kelly D P 2001 Hypoxia inhibits the peroxisome proliferator-activated receptor α/ retinoid X receptor gene regulatory pathway in cardiac myocytes: a mechanism for O2-dependent modulation of mitochondrial fatty acid oxidation J. Biol. Chem. 276 27605-12
    • (2001) J. Biol. Chem. , vol.276 , pp. 27605-27612
    • Huss, J.M.1    Levy, F.H.2    Kelly, D.P.3
  • 82
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown J M and Wilson W R 2004 Exploiting tumour hypoxia in cancer treatment Nat. Rev. Cancer 4 437-47
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 83
    • 84904352988 scopus 로고    scopus 로고
    • Oxygen and seizure dynamics: I. Experiments
    • Ingram J et al 2014 Oxygen and seizure dynamics: I. Experiments J. Neurophysiol. 112 205-12
    • (2014) J. Neurophysiol. , vol.112 , pp. 205-212
    • Ingram, J.1
  • 84
    • 84881165223 scopus 로고    scopus 로고
    • Measurement of cell respiration and oxygenation in standard multichannel biochips using phosphorescent O2-sensitive probes
    • Kondrashina A V, Papkovsky D B and Dmitriev R I 2013 Measurement of cell respiration and oxygenation in standard multichannel biochips using phosphorescent O2-sensitive probes Analyst 138 4915-21
    • (2013) Analyst , vol.138 , pp. 4915-4921
    • Kondrashina, A.V.1    Papkovsky, D.B.2    Dmitriev, R.I.3
  • 85
    • 84920527889 scopus 로고    scopus 로고
    • Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems
    • Leedale J et al 2014 Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems Math. Biosci. 258 33-43
    • (2014) Math. Biosci. , vol.258 , pp. 33-43
    • Leedale, J.1
  • 86
    • 84974619185 scopus 로고    scopus 로고
    • In vivo imaging of flavoprotein fluorescence during hypoxia reveals the importance of direct arterial oxygen supply to cerebral cortex tissue
    • at press
    • Chisholm K et al 2014 In vivo imaging of flavoprotein fluorescence during hypoxia reveals the importance of direct arterial oxygen supply to cerebral cortex tissue Adv. Exp. Biol. Med. (at press)
    • (2014) Adv. Exp. Biol. Med.
    • Chisholm, K.1
  • 87
    • 84856427183 scopus 로고    scopus 로고
    • Immunolabeling artifacts and the need for live-cell imaging
    • Schnell U, Dijk F, Sjollema K A and Giepmans B N 2012 Immunolabeling artifacts and the need for live-cell imaging Nat. Methods 9 152-8
    • (2012) Nat. Methods , vol.9 , pp. 152-158
    • Schnell, U.1    Dijk, F.2    Sjollema, K.A.3    Giepmans, B.N.4
  • 88
    • 78650315949 scopus 로고    scopus 로고
    • Multiphoton fluorescence lifetime imaging of 3D-stem cell spheroids during differentiation
    • König K, Uchugonova A and Gorjup E 2011 Multiphoton fluorescence lifetime imaging of 3D-stem cell spheroids during differentiation Microsc. Res. Tech. 74 9-17
    • (2011) Microsc. Res. Tech. , vol.74 , pp. 9-17
    • König, K.1    Uchugonova, A.2    Gorjup, E.3
  • 90
    • 77952486361 scopus 로고    scopus 로고
    • Fluorescence lifetime measurements and biological imaging
    • Berezin M Y and Achilefu S 2010 Fluorescence lifetime measurements and biological imaging Chem. Rev. 110 2641-84
    • (2010) Chem. Rev. , vol.110 , pp. 2641-2684
    • Berezin, M.Y.1    Achilefu, S.2
  • 91
    • 84871796632 scopus 로고    scopus 로고
    • Targeted nanoparticles in imaging: Paving the way for personalized medicine in the battle against cancer
    • Shin S J, Beech J R and Kelly K A 2013 Targeted nanoparticles in imaging: paving the way for personalized medicine in the battle against cancer Integr. Biol. 5 29-42
    • (2013) Integr. Biol. , vol.5 , pp. 29-42
    • Shin, S.J.1    Beech, J.R.2    Kelly, K.A.3
  • 92
    • 82355191730 scopus 로고    scopus 로고
    • Live-cell 3D super-resolution imaging in thick biological samples
    • Zanacchi F C et al 2011 Live-cell 3D super-resolution imaging in thick biological samples Nat. Methods 8 1047-9
    • (2011) Nat. Methods , vol.8 , pp. 1047-1049
    • Zanacchi, F.C.1
  • 93
    • 84859920287 scopus 로고    scopus 로고
    • Live-cell super-resolution imaging with synthetic fluorophores
    • van de Linde S, Heilemann M and Sauer M 2012 Live-cell super-resolution imaging with synthetic fluorophores Annu. Rev. Phys. Chem. 63 519-40
    • (2012) Annu. Rev. Phys. Chem. , vol.63 , pp. 519-540
    • Van De Linde, S.1    Heilemann, M.2    Sauer, M.3
  • 94
    • 79959870658 scopus 로고    scopus 로고
    • Imaging intracellular pH in live cells with a genetically encoded red fluorescent protein sensor
    • Tantama M, Hung Y P and Yellen G 2011 Imaging intracellular pH in live cells with a genetically encoded red fluorescent protein sensor J. Am. Chem. Soc. 133 10034-7
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 10034-10037
    • Tantama, M.1    Hung, Y.P.2    Yellen, G.3
  • 95
    • 79551526438 scopus 로고    scopus 로고
    • Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing
    • Cheng A, Gonçalves J T, Golshani P, Arisaka K and Portera- Cailliau C 2011 Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing Nat. Methods 8 139-42
    • (2011) Nat. Methods , vol.8 , pp. 139-142
    • Cheng, A.1    Gonçalves, J.T.2    Golshani, P.3    Arisaka, K.4    Portera-Cailliau, C.5


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