PO2 measurements in the microcirculation using phosphorescence quenching microscopy at high magnification

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 6, 2008, Pages

  Golub, Aleksander S ^a   Pittman, Roland N ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Oxygen consumption; Oxygen gradient; Oxygen tension

Indexed keywords

ARTICLE; BREATHING RATE; MICROCIRCULATION; OXYGEN CONSUMPTION; OXYGEN TENSION; OXYGEN TRANSPORT; PHOSPHORESCENCE; PRIORITY JOURNAL; ANIMAL; ARTERIOLE; ARTIFACT; BLOOD; BLOOD FLOW; BLOOD FLOW VELOCITY; BLOOD RHEOLOGY; CHEMICAL MODEL; CHEMISTRY; HUMAN; INSTRUMENTATION; LUMINESCENCE; METABOLISM; METHODOLOGY; MICROSCOPY; PHOTOCHEMISTRY; PRESSURE; VENULE;

OXYGEN;

ANIMALS; ARTERIOLES; ARTIFACTS; BLOOD FLOW VELOCITY; HEMORHEOLOGY; HUMANS; LUMINESCENT MEASUREMENTS; MICROSCOPY; MODELS, CHEMICAL; OXYGEN; OXYGEN CONSUMPTION; PARTIAL PRESSURE; PHOTOCHEMISTRY; REGIONAL BLOOD FLOW; VENULES;

EID: 49249089019     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01347.2007     Document Type: Article

References (75)

1. Altman PL, Dittmer DS. Respiration and Circulation. Bethesda, MD: FASEB, 1971, p. 930.
2. Bohlen HG, Lash JM. Resting oxygenation of rat and rabbit intestine: arteriolar and capillary contributions. Am J Physiol Heart Circ Physiol 269: H1342-H1348, 1995.
3. Boyle J 3rd. Microcirculatory hematocrit and blood flow. J Theor Biol 131: 223-229, 1988.
4. Buerk DG, Goldstick TK. Arterial wall oxygen consumption rate varies spatially. Am J Physiol Heart Circ Physiol 243: H948-H958, 1982.
5. 2 microelectrodes and phosphorescence quenching are in agreement. Microcirculation 5: 219-225, 1998.
6. Cabrales P, Intaglietta M. Time-dependent oxygen partial pressure in capillaries and tissue in the hamster window chamber model. Antioxid Redox Signal 9: 845-853, 2007.
7. Cabrales P, Tsai AG, Johnson PC, Intaglietta M. Oxygen release from arterioles with normal flow and no-flow conditions. J Appl Physiol 100: 1569-1576, 2006.
8. 2 transport in capillary-perfused tissue containing an arteriole and venule pair. Ann Biomed Eng 35: 517-529, 2007.
9. Crank J. The Mathematics of Diffusion. London: Oxford University Press, 1975.
10. Duling BR, Berne RM. Longitudinal gradients in periarteriolar oxygen tension. A possible mechanism for the participation of oxygen in local regulation of blood flow. Circ Res 27: 669-678, 1970.
11. Farrell KJ, Witte CL, Witte MH, Mobley WP, Kintner K. Oxygen exchange in the mesenteric microcirculation of the dog. Am J Physiol Heart Circ Physiol 236: H846-H853, 1979.
12. Fatt I. An ultramicro oxygen electrode. J Appl Physiol 19: 326-329, 1964.
13. Fleming BP, Klitzman B, Johnson WO. Measurement of erythrocyte velocity by use of a periodic differential detector. Am J Physiol Heart Circ Physiol 249: H899-H905, 1985.
14. Foote CS. Mechanisms of photooxygenation. Prog Clin Biol Res 170: 3-18, 1984.
15. Foote CS. Mechanisms of photosensitized oxidation. Science 162: 963-970, 1968.
16. Friesenecker B. Does the vessel wall partition oxygen away from the tissue? Antioxid Redox Signal 9: 985-989, 2007.
17. Friesenecker B, Tsai AG, Dunser MW, Martini J, Hasibeder W, Intaglietta M. Lowered microvascular vessel wall oxygen consumption augments tissue pO2 during PgE1-induced vasodilation. Eur J Appl Physiol 99: 405-414, 2007.
18. Friesenecker B, Tsai AG, Dunser MW, Mayr AJ, Martini J, Knotzer H, Hasibeder W, Intaglietta M. Oxygen distribution in microcirculation after arginine vasopressin-induced arteriolar vasoconstriction. Am J Physiol Heart Circ Physiol 287: H1792-H1800, 2004.
19. Frietsch T, Gassmann M, Groth G, Waschke KF, Vogel J, Cabrales P, Vajkoczi P, Dorn-Beineke A, Intaglietta M, Kerger H. Excessive erythrocytosis does not elevate capillary oxygen delivery in subcutaneous mouse tissue. Microcirculation 14: 111-123, 2007.
20. Golub AS, Barker MC, Pittman RN. Microvascular oxygen tension in the rat mesentery. Am J Physiol Heart Circ Physiol 294: H21-H28, 2008.
21. 2 profiles near arterioles and tissue oxygen consumption in the rat mesentery. Am J Physiol Heart Circ Physiol 293: H1097-H1106, 2007.
22. Golub AS, Popel AS, Zheng L, Pittman RN. Analysis of phosphorescence decay for nonuniform oxygen tension. Consequences of finite excitation flash duration. Adv Exp Med Biol 471: 649-659, 1999.
23. Golub AS, Popel AS, Zheng L, Pittman RN. Analysis of phosphorescence decay in heterogeneous systems: consequences of finite excitation flash duration. Photochem Photobiol 69: 624-632, 1999.
24. Golub AS, Popel AS, Zheng L, Pittman RN. Analysis of phosphorescence in heterogeneous systems using distributions of quencher concentration. Biophys J 73: 452-465, 1997.
25. 2 measurements in the steady state]. Pflügers Arch 320: 24-44, 1970.
26. Hangai-Hoger N, Cabrales P, Briceno JC, Tsai AG, Intaglietta M. Microlymphatic and tissue oxygen tension in the rat mesentery. Am J Physiol Heart Circ Physiol 286: H878-H883, 2004.
27. House SD, Lipowsky HH. Microvascular hematocrit and red cell flux in rat cremaster muscle. Am J Physiol Heart Circ Physiol 252: H211-H222, 1987.
28. Howard RO, Richardson DW, Smith MH, Patterson JL Jr. Oxygen consumption of arterioles and venules as studied in the Cartesian diver. Circ Res 16: 187-196, 1965.
29. Intaglietta M, Johnson PC, Winslow RM. Microvascular and tissue oxygen distribution. Cardiovasc Res 32: 632-643, 1996.
30. Istratov AA, Vyvenko OF. Exponential analysis in physical phenomena. Rev Sci Instrum 70: 1233-1257, 1999.
31. Johnson PC, Vandegriff K, Tsai AG, Intaglietta M. Effect of acute hypoxia on microcirculatory and tissue oxygen levels in rat cremaster muscle. J Appl Physiol 98: 1177-1184, 2005.
32. Kanofsky JR. Quenching of singlet oxygen by human plasma. Photochem Photobiol 51: 299-303, 1990.
33. Kerger H, Groth G, Kalenka A, Vajkoczy P, Tsai AG, Intaglietta M. pO(2) measurements by phosphorescence quenching: characteristics and applications of an automated system. Microvasc Res 65: 32-38, 2003.
34. 2 dissociation during 4-h hemorrhagic shock in conscious hamsters. Am J Physiol Heart Circ Physiol 270: H827-H836, 1996.
35. Kerger H, Torres Filho IP, Rivas M, Winslow RM, Intaglietta M. Systemic and subcutaneous microvascular oxygen tension in conscious Syrian golden hamsters. Am J Physiol Heart Circ Physiol 268: H802-H810, 1995.
36. Klitzman B, Duling BR. Microvascular hematocrit and red cell flow in resting and contracting striated muscle. Am J Physiol Heart Circ Physiol 237: H481-H490, 1979.
37. Kobayashi H, Takizawa N. Imaging of oxygen transfer among microvessels of rat cremaster muscle. Circulation 105: 1713-1719, 2002.
38. Kobayashi H, Takizawa N. Oxygen saturation and pH changes in cremaster microvessels of the rat. Am J Physiol Heart Circ Physiol 270: H1453-H1461, 1996.
39. 2 in contracting rat spinotrapezius muscle. Am J Physiol Heart Circ Physiol 252: H1192-H1202, 1987.
40. Mitra S, Foster TH. Photochemical oxygen consumption sensitized by a porphyrin phosphorescent probe in two model systems. Biophys J 78: 2597-2605, 2000.
41. Navari RM, Wei EP, Kontos HA, Patterson JL Jr. Oxygen consumption of pial arteries. Am J Physiol Heart Circ Physiol 236: H151-H156, 1979.
42. Pittman RN, Golub AS, Popel AS, Zheng L. Interpretation of phosphorescence quenching measurements made in the presence of oxygen gradients. Adv Exp Med Biol 454: 375-383, 1998.
43. 2 from an arteriole with arrested flow. Adv Exp Med Biol 566: 257-262, 2005.
44. Poole DC, Behnke BJ, McDonough P, McAllister RM, Wilson DF. Measurement of muscle microvascular oxygen pressures: compartmentalization of phosphorescent probe. Microcirculation 11: 317-326, 2004.
45. Pries AR, Secomb TW, Gaehtgens P. Structure and hemodynamics of microvascular networks: heterogeneity and correlations. Am J Physiol Heart Circ Physiol 269: H1713-H1722, 1995.
46. Saltzman DJ, Toth A, Tsai AG, Intaglietta M, Johnson PC. Oxygen tension distribution in postcapillary venules in resting skeletal muscle. Am J Physiol Heart Circ Physiol 285: H1980-H1985, 2003.
47. Schneiderman G, Goldstick TK. Oxygen fields induced by recessed and needle oxygen microelectrodes in homogeneous media. Adv Exp Med Biol 75: 9-16, 1976.
48. 2 measurements in rat skeletal muscle by phosphorescence quenching. J Appl Physiol 91: 321-327, 2001.
49. Shibata M, Ichioka S, Kamiya A. Estimating oxygen consumption rates of arteriolar walls under physiological conditions in rat skeletal muscle. Am J Physiol Heart Circ Physiol 289: H295-H300, 2005.
50. Shibata M, Ichioka S, Togawa T, Kamiya A. Arterioles' contribution to oxygen supply to the skeletal muscles at rest. Eur J Appl Physiol 97: 327-331, 2006.
51. Shonat RD, Johnson PC. Oxygen tension gradients and heterogeneity in venous microcirculation: a phosphorescence quenching study. Am J Physiol Heart Circ Physiol 272: H2233-H2240, 1997.
52. Shonat RD, Richmond KN, Johnson PC. Phosphorescence quenching and the microcirculation: an automated multipoint oxygen tension measuring instrument. Rev Sci Instrum 66: 5075-5084, 1995.
53. Shonat RD, Wilson DF, Riva CE, Pawlowski M. Oxygen distribution in the retinal and choroidal vessels of the cat as measured by a new phosphorescence imaging method. Applied Optics 31: 3711-3718, 1992.
54. 2 during nonhypoxic and hypoxic ventilation. Am J Physiol Heart Circ Physiol 265: H537-H542, 1993.
55. Swain DP, Pittman RN. Oxygen exchange in the microcirculation of hamster retractor muscle. Am J Physiol Heart Circ Physiol 256: H247-H255, 1989.
56. 2 measurements by phosphorescence decay method. Am J Physiol Heart Circ Physiol 265: H1434-H1438, 1993.
57. 2 M. measurements in arteriolar networks. Microvasc Res 51: 202-212, 1996.
58. Torres Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK. Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice. Proc Natl Acad Sci USA 91: 2081-2085, 1994.
59. Torres Filho IP, Terner J, Pittman RN, Somera LG 3rd, Ward KR. Hemoglobin oxygen saturation measurements using resonance Raman intravital microscopy. Am J Physiol Heart Circ Physiol 289: H488-H495, 2005.
60. Tsai AG, Cabrales P, Hangai-Hoger N, Intaglietta M. Oxygen distribution and respiration by the microcirculation. Antioxid Redox Signal 6: 1011-1018, 2004.
61. 2 transients associated with the passage of erythrocytes in capillaries of rat mesentery. Am J Physiol Heart Circ Physiol 289: H1777; author reply H1778-H1779, 2005.
62. Tsai AG, Friesenecker B, Cabrales P, Hangai-Hoger N, Intaglietta M. The vascular wall as a regulator of tissue oxygenation. Curr Opin Nephrol Hypertens 15: 67-71, 2006.
63. Tsai AG, Friesenecker B, Mazzoni MC, Kerger H, Buerk DG, Johnson PC, Intaglietta M. Microvascular and tissue oxygen gradients in the rat mesentery. Proc Natl Acad Sci USA 95: 6590-6595, 1998.
64. Tsai AG, Johnson PC, Intaglietta M. Is the distribution of tissue pO(2) homogeneous? Antioxid Redox Signal 9: 979-984, 2007.
65. Tsai AG, Johnson PC, Intaglietta M. Oxygen gradients in the microcirculation. Physiol Rev 83: 933-963, 2003.
66. Tsai AG, Kerger H, Intaglietta M. Oxygen distribution and consumption by the microcirculation and the determinants of tissue survival. In: Tissue Oxygenation in Acute Medicine, edited by Sibbald WJ, Messmer K, and Fink MP. Berlin: Springer-Verlag, 1998, p. 55-62.
67. Tsukada K, Sekizuka E, Oshio C, Tsujioka K, Minamitani H. Red blood cell velocity and oxygen tension measurement in cerebral microvessels by double-wavelength photoexcitation. J Appl Physiol 96: 1561-1568, 2004.
68. 2 release by human red blood cells in the presence of external sodium dithionite. J Biol Chem 259: 12609-12618, 1984.
69. Vanderkooi JM, Maniara G, Green TJ, Wilson DF. An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence. J Biol Chem 262: 5476-5482, 1987.
70. Vinogradov SA, Wilson DF. Recovery of oxygen distributions in tissue from phosphorescence decay data. Adv Exp Med Biol 361: 67-73, 1994.
71. Vovenko E. Distribution of oxygen tension on the surface of arterioles, capillaries and venules of brain cortex and in tissue in normoxia: an experimental study on rats. Pflügers Arch 437: 617-623, 1999.
72. Weerappuli DP, Popel AS. A model of oxygen exchange between an arteriole or venule and the surrounding tissue. J Biomech Eng 111: 24-31, 1989.
73. Wilson DF, Lee WM, Makonnen S, Finikova O, Apreleva S, Vinogradov SA. Oxygen pressures in the interstitial space and their relationship to those in the blood plasma in resting skeletal muscle. J Appl Physiol 101: 1648-1656, 2006.
74. Wilson DF, Vanderkooi JM, Green TJ, Maniara G, DeFeo SP, Bloomgarden DC. A versatile and sensitive method for measuring oxygen. Adv Exp Med Biol 215: 71-77, 1987.
75. 2 and its heterogeneity in single capillaries. Am J Physiol Heart Circ Physiol 271: H365-H372, 1996.