Bcl-2 regulates reactive oxygen species signaling and a redox-sensitive mitochondrial proton leak in mouse pancreatic β-cells

Endocrinology

Volumn 157, Issue 6, 2016, Pages 2270-2281

  Aharoni Simon, Michal ^a   Shumiatcher, Rose ^a   Yeung, Anthony ^a   Shih, Alexis Z L ^a   Dolinsky, Vernon W ^b   Doucette, Christine A ^b   Luciani, Dan S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CALCIUM ION; COPPER ZINC SUPEROXIDE DISMUTASE; IRON SUPEROXIDE DISMUTASE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCOUPLING PROTEIN 2; VENETOCLAX; FUSED HETEROCYCLIC RINGS; PROTON; SULFONAMIDE; SUPEROXIDE DISMUTASE;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL DEATH; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; IN VITRO STUDY; INTRACELLULAR SIGNALING; LOSS OF FUNCTION MUTATION; MIN6 CELL LINE; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTON TRANSPORT; RESPIRATION CONTROL; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; FEMALE; MALE; METABOLISM; OXIDATION REDUCTION REACTION; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRIDGED BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE, TUMOR; FEMALE; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTONS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SULFONAMIDES; SUPEROXIDE DISMUTASE;

EID: 84974602614     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2015-1964     Document Type: Article

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