Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System

Journal of Diabetes Research

Volumn 2015, Issue , 2015, Pages

  Litwak, Sara A ^a   Wali, Jibran A ^a,b   Pappas, Evan G ^a,b   Saadi, Hamdi ^a,b   Stanley, William J ^a,b   Varanasi, L Chitra ^a,b   Kay, Thomas W H ^a,b   Thomas, Helen E ^a,b   Gurzov, Esteban N ^a,b  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; PALMITIC ACID; PROTEASOME; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; PUMA PROTEIN; RNA; SULFORAPHANE; UBIQUITIN; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; LEUPEPTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LOSS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; LIPOTOXICITY; MIN6 CELL LINE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UBIQUITINATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; METABOLISM;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; HUMANS; INSULIN-SECRETING CELLS; LEUPEPTINS; MICE; PALMITIC ACID; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS C-BCL-2; UBIQUITIN; UBIQUITINATION;

EID: 84929649878     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2015/280615     Document Type: Article

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