Core-shell nanocarriers with high paclitaxel loading for passive and active targeting

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Jin, Zhu ^a   Lv, Yaqi ^a   Cao, Hui ^a   Yao, Jing ^a   Zhou, Jianping ^a   He, Wei ^a   Yin, Lifang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ARGINYL-GLYCYL-ASPARTIC ACID; DRUG CARRIER; LIGAND; LIPID; NANOCAPSULE; OLIGOPEPTIDE; PACLITAXEL;

A-549 CELL LINE; ANIMAL; APOPTOSIS; CANCER TRANSPLANTATION; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ENDOCYTOSIS; HUMAN; MEMBRANE MICRODOMAIN; NANOMEDICINE; PARTICLE SIZE; PROCEDURES; RAT; SOLUBILITY; TUMOR CELL LINE;

A549 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; ENDOCYTOSIS; HUMANS; LIGANDS; LIPIDS; MEMBRANE MICRODOMAINS; NANOCAPSULES; NANOMEDICINE; NEOPLASM TRANSPLANTATION; OLIGOPEPTIDES; PACLITAXEL; PARTICLE SIZE; RATS; SOLUBILITY;

EID: 84974593859     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep27559     Document Type: Article

References (51)

1. Lin, Z. et al. Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: High drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity. J Control Release 174, 161-170 (2014).
2. Zhang, L., He, Y., Ma, G., Song, C., Sun, H. Paclitaxel-loaded polymeric micelles based on poly(-caprolactone)-poly(ethylene glycol)-poly(-caprolactone) triblock copolymers: in vitro and in vivo evaluation. Nanomedicine: NBM 8, 925-934 (2012).
3. Deng, J., Huang, L., Liu, F. Extraction issues of paclitaxel in nanocrystals. J Biomed Nanotechnol 6, 198-201 (2010).
4. Zhang, Z., Mei, L., Feng, S. S. Paclitaxel drug delivery systems. Expert Opin Drug Deliv 10, 325-340 (2013).
5. Creixell, M., Peppas, N. A. Co-delivery of siRNA and therapeutic agents using nanocarriers to overcome cancer resistance. Nano Today 7, 367-379 (2012).
6. Milane, L., Duan, Z.-F., Amiji, M. Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer. Nanomedicine: NBM 7, 435-444 (2011).
7. Parvathy, S. S., Masocha, W. Coadministration of indomethacin and minocycline attenuates established paclitaxel-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors. Sci Rep 5, 10541 (2015).
8. He, W. et al. Nanoemulsion-templated shell-crosslinked nanocapsules as drug delivery systems. Int J Pharm 445, 69-78 (2013).
9. Singodia, D., Talegaonkar, S., Khar, R. K., Mishra, P. R. Novel polymer coupled lipid nanoparticle of paclitaxel with synergistic enhanced efficacy against cancer. J Biomed Nanotechnol 7, 125-126 (2011).
10. Couvreur, P., Barratt, G., Fattal, E., Legrand, P., Vauthier, C. Nanocapsule technology: a review. Crit Rev Ther Drug Carrier Syst 19, 99-134 (2002).
11. Ferrari, M. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 5, 161-171 (2005).
12. Chen, E. Y. et al. Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration. Sci Rep 2, 211 (2012).
13. Han, U., Seo, Y., Hong, J. Effect of pH on the structure and drug release profiles of layer-by-layer assembled films containing polyelectrolyte, micelles, and graphene oxide. Sci Rep 6, 24158 (2016).
14. Mo, J., Eggers, P. K., Yuan, Z. X., Raston, C. L., Lim, L. Y. Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform. Sci Rep 6, 23489 (2016).
15. Sato, Y. T. et al. Engineering hybrid exosomes by membrane fusion with liposomes. Sci Rep 6, 21933 (2016).
16. Yan, M. et al. A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol 5, 48-53 (2010).
17. Tagliazucchi, M., Peleg, O., Kroger, M., Rabin, Y., Szleifer, I. Effect of charge, hydrophobicity, and sequence of nucleoporins on the translocation of model particles through the nuclear pore complex. PNAS 110, 3363-3368 (2012).
18. Nassar, T., Rom, A., Nyska, A., Benita, S. Novel double coated nanocapsules for intestinal delivery and enhanced oral bioavailability of tacrolimus, a P-gp substrate drug. J Control Release 133, 77-84 (2009).
19. Shen, Y. et al. Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery. J Am Chem Soc 132, 4259-4265 (2010).
20. Mazzarino, L. et al. Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: an in vitro and in vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study. J Biomed Nanotechnol 7, 406-414 (2011).
21. Frozza, R. L. et al. Characterization of trans-resveratrol-loaded lipid-core nanocapsules and tissue distribution studies in rats. J Biomed Nanotechnol 6, 694-703 (2010).
22. Peer, D. et al. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2, 751-760 (2007).
23. Xiong, X. B., Lavasanifar, A. Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin. ACS Nano 5, 5202-5213 (2012).
24. Zhang, Z. et al. Biomimetic nanocarrier for direct cytosolic drug delivery. Angew Chem Int Ed Engl 48, 9171-9175 (2009).
25. Sugahara, K. N. et al. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science 328, 1031-1035 (2010).
26. Domingo-Espín, J. et al. RGD-based cell ligands for cell-targeted drug delivery act as potent trophic factors. Nanomedicine: NBM 8, 1263-1266 (2012).
27. Lagunas, A. et al. Cell adhesion and focal contact formation on linear RGD molecular gradients: study of non-linear concentration dependence effects. Nanomedicine: NBM 8, 432-439 (2012).
28. Ruoslahti, E. Peptides as targeting elements and tissue penetration devices for nanoparticles. Adv Mater 24, 3747-3756 (2012).
29. Naik, S., Patel, D., Chuttani, K., Mishra, A. K., Misra, A. In vitro mechanistic study of cell death and in vivo performance evaluation of RGD grafted PEGylated docetaxel liposomes in breast cancer. Nanomedicine: NBM 8, 951-962 (2012).
30. Jiang, Y. Y., Liu, C., Hong, M. H., Zhu, S. J., Pei, Y. Y. Tumor cell targeting of transferrin-PEG-TNF-alpha conjugate via a receptormediated delivery system: design, synthesis, and biological evaluation. Bioconjug Chem 18, 41-49 (2007).
31. Qian, Y. et al. PEGylated poly(2-(dimethylamino) ethyl methacrylate)/DNA polyplex micelles decorated with phage-displayed TGN peptide for brain-targeted gene delivery. Biomaterials 34, 2117-2129 (2013).
32. Ren, J. et al. The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2. Biomaterials 33, 3324-3333 (2012).
33. Nag, A., Mitra, G., Ghosh, P. C. A colorimetric assay for estimation of polyethylene glycol and polyethylene glycolated protein using ammonium ferrothiocyanate. Anal Biochem 237, 224-231 (1996).
34. Brasseur, R., Divita, G. Happy birthday cell penetrating peptides: already 20 years. Biochim Biophys Acta 1798, 2177-2181 (2010).
35. Raagel, H., Saalik, P., Hansen, M., Langel, U., Pooga, M. CPP-protein constructs induce a population of non-acidic vesicles during trafficking through endo-lysosomal pathway. J Control Release 139, 108-117 (2009).
36. Chandran, P. et al. Simultaneous inhibition of aberrant cancer kinome using rationally designed polymer-protein core-shell nanomedicine. Nanomedicine: NBM 9, 1317-1327 (2013).
37. Fuhrmann, K., Schulz, J. D., Gauthier, M. A., Leroux, J. C. PEG nanocages as non-sheddable stabilizers for drug nanocrystals. ACS Nano 6, 1667-1676 (2012).
38. Chen, Y. et al. Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery. ACS Nano 4, 6001-6013 (2010).
39. Marcucci, F., Corti, A. Improving drug penetration to curb tumor drug resistance. Drug Discov Today 17, 1139-1146 (2012).
40. Yamashita, F., Hashida, M. Pharmacokinetic considerations for targeted drug delivery. Adv Drug Deliv Rev 65, 139-147 (2013).
41. Furumoto, K. et al. Effect of coupling of albumin onto surface of PEG liposome on its in vivo disposition. Int J Pharm 329, 110-116 (2007).
42. Ogawara, K.-i. et al. Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles. J Control Release 100, 451-455 (2004).
43. Jaiswal, S. et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 138, 271-285 (2009).
44. Rodriguez, P. L. et al. Minimal "Self " peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science 339, 971-975 (2013).
45. Yang, C. et al. Supramolecular nanostructures designed for high cargo loading capacity and kinetic stability. Nano Today 5, 515-523 (2010).
46. Perry, J. L. et al. PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics. Nano Lett 12, 5304-5310 (2012).
47. He, W. et al. Food protein-stabilized nanoemulsions as potential delivery systems for poorly water-soluble drugs: preparation, in vitro characterization, and pharmacokinetics in rats. Int J Nanomedicine 6, 521-533 (2011).
48. Liu, C. et al. Cell-penetrating hollow spheres based on milk protein. Chem Commun (Camb) 46, 7566-7568 (2010).
49. Zhen, X., Wang, X., Xie, C., Wu, W., Jiang, X. Cellular uptake, antitumor response and tumor penetration of cisplatin-loaded milk protein nanoparticles. Biomaterials 34, 1372-1382 (2013).
50. Gao, H. et al. Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization. Sci Rep 3, 2534 (2013).
51. Kumeta, M., Yamaguchi, H., Yoshimura, S. H., Takeyasu, K. Karyopherin-independent spontaneous transport of amphiphilic proteins through the nuclear pore. J Cell Sci 125, 4979-4984 (2012).