Cellular uptake, antitumor response and tumor penetration of cisplatin-loaded milk protein nanoparticles

Biomaterials

Volumn 34, Issue 4, 2013, Pages 1372-1382

  Zhen, Xu ^a   Wang, Xin ^a   Xie, Chen ^a   Wu, Wei ^a   Jiang, Xiqun ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Casein; Drug delivery; Multicellular tumor spheroids; Protein nanoparticles; Tumor penetration

Indexed keywords

3-DIMENSIONAL; ANTI-TUMORS; ANTITUMOR DRUGS; ANTITUMOR EFFECT; CELLULAR UPTAKE; CISPLATIN; DRUG LOADING; IN-VIVO; INTRAVENOUS ADMINISTRATION; MICE MODELS; MILK PROTEIN; MULTICELLULAR TUMOR SPHEROIDS; NEAR-INFRARED FLUORESCENCE; PLASMA MASS SPECTROMETRY; SPHERICAL SHAPE; TRANSGLUTAMINASES; TRANSMISSION ELECTRON MICROSCOPY TEM; TUMOR GROWTH; TUMOR PENETRATION; TUMOR TISSUES; VASCULATURE;

CASEIN; CELL MEMBRANES; CYTOLOGY; DRUG DELIVERY; DYNAMIC LIGHT SCATTERING; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; LOADING; PLATINUM COMPOUNDS; PROTEINS; TRANSMISSION ELECTRON MICROSCOPY; TUMORS; ZETA POTENTIAL;

NANOPARTICLES;

CASEIN; CISPLATIN; NANOCARRIER; POLYACRYLIC ACID; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER TISSUE; CONTROLLED STUDY; CROSS LINKING; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; DRUG STABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; LIGHT SCATTERING; LIVER TUMOR; MASS SPECTROMETRY; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SYNTHESIS; TEMPERATURE DEPENDENCE; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CISPLATIN; DIFFUSION; HUMANS; METABOLIC CLEARANCE RATE; MICE; MILK PROTEINS; NANOCAPSULES; NEUROBLASTOMA; TREATMENT OUTCOME;

MUS;

EID: 84870363964     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.10.061     Document Type: Article

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