RGD-based cell ligands for cell-targeted drug delivery act as potent trophic factors

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 8, Issue 8, 2012, Pages 1263-1266

  Domingo Espín, Joan ^a,b   Petegnief, Valérie ^c   de Vera, Núria ^c   Conchillo Solé, Oscar ^a   Saccardo, Paolo ^a,b   Unzueta, Ugutz ^a,b   Vazquez, Esther ^a,b   Cedano, Juan ^d   Negro, Luciana ^e   Daura, Xavier ^a,e   Peluffo, Hugo ^f,g   Planas, Anna M ^c   Villaverde, Antonio ^a,b   Ferrer Miralles, Neus ^a,b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c INST D INVESTIGACIONS B   (Spain)

^d UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^e INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^f INSTITUT PASTEUR DE MONTEVIDEO   (Uruguay)

^g DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

Author keywords

Biomaterials; Integrins; Neurons; Protein nanoparticles; RGD

Indexed keywords

ARG GLY ASPS; EXTRACELLULAR- SIGNAL-REGULATED KINASE 1/2; FUNCTIONALIZATIONS; IMAGING AGENT; INTEGRINS; NANOCARRIERS; NEURONAL MARKERS; PC12 CELLS; RGD; RGD MOTIF; RGD PEPTIDE; TARGETED DRUG DELIVERY;

BIOMATERIALS; CELL PROLIFERATION; CELLS; DRUG DELIVERY; NANOPARTICLES; NEURONS; PEPTIDES; SIGNAL TRANSDUCTION;

CYTOLOGY;

ARGINYLGLYCYLASPARTIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; NERVE CELL;

BINDING SITES; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; HUMANS; INTEGRINS; LIGANDS; MAP KINASE SIGNALING SYSTEM; NANOPARTICLES; NEURONS; OLIGOPEPTIDES; PEPTIDES; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 84867876713     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2012.06.005     Document Type: Article

References (10)

1. Ruoslahti E., Pierschbacher M.D. New perspectives in cell adhesion: RGD and integrins. Science 1987, 238:491-497.
2. Meyer A., Auernheimer J., Modlinger A., Kessler H. Targeting RGD recognizing integrins: drug development, biomaterial research, tumor imaging and targeting. Curr Pharm Des 2006, 12:2723-2747.
3. Yue W., Sun Q., Landreneau R., Wu C., Siegfried J.M., Yu J., et al. Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression. Cancer Res 2009, 69:6339-6346.
4. Tanabe N., Wheal B.D., Kwon J., Chen H.H., Shugg R.P., Sims S.M., et al. Osteopontin signals through calcium and nuclear factor of activated T cells (NFAT) in osteoclasts: a novel RGD-dependent pathway promoting cell survival. J Biol Chem 2011, 286:39871-39881.
5. Wang Z., Kundu R.K., Longaker M.T., Quertermous T., Yang G.P. The angiogenic factor Del1 prevents apoptosis of endothelial cells through integrin binding. Surgery 2011, 151:296-305.
6. Eapen A., Ramachandran A., Pratap J., George A. Activation of the ERK1/2 mitogen-activated protein kinase cascade by dentin matrix protein 1 promotes osteoblast differentiation. Cell Tiss Org 2011, 194:255-260.
7. Domingo-Espín J., Vazquez E., Ganz J., Conchillo O., Garcia-Fruitos E., Cedano J., et al. Nanoparticulate architecture of protein-based artificial viruses is supported by protein-DNA interactions. Nanomedicine (Lond) 2011, 6:1047-1061.
8. Dunehoo A.L., Anderson M., Majumdar S., Kobayashi N., Berkland C., Siahaan T.J. Cell adhesion molecules for targeted drug delivery. J Pharm Sci 2006, 95:1856-1872.
9. Nanoparticles in translational science and medicine. From the series: Progress in Molecular Biology and Translational Science 2011, vol. 114. Academic Press (Elsevier), London, UK. A. Villaverde (Ed.).
10. Williams D.F. The role of short synthetic adhesion peptides in regenerative medicine; the debate. Biomaterials 2011, 32:4195-4197.