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Volumn 20, Issue 2, 2014, Pages 151-155

CAR T cells for solid tumors: Armed and ready to go?

Author keywords

chimeric antigen receptors; gene therapy; Immunotherapy; solid tumors; T cells

Indexed keywords

CHIMERIC ANTIGEN RECEPTOR T LYMPHOCYTE; LYMPHOCYTE ANTIGEN RECEPTOR; TISSUE ANTIGEN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

EID: 84897484486     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0000000000000032     Document Type: Review
Times cited : (173)

References (63)
  • 1
    • 84877669593 scopus 로고    scopus 로고
    • The basic principles of chimeric antigen receptor design
    • Sadelain M, Brentjens R, Riviere I. The basic principles of chimeric antigen receptor design. Cancer Discov. 2013;3:388-398.
    • (2013) Cancer Discov. , vol.3 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2    Riviere, I.3
  • 3
    • 41149097574 scopus 로고    scopus 로고
    • Adoptive cell transfer: A clinical path to effective cancer immunotherapy
    • Rosenberg SA, Restifo NP, Yang JC, et al. Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer. 2008;8:299-308.
    • (2008) Nat Rev Cancer , vol.8 , pp. 299-308
    • Rosenberg, S.A.1    Restifo, N.P.2    Yang, J.C.3
  • 4
    • 0030810446 scopus 로고    scopus 로고
    • Genetic treatment of the haemoglobinopathies: Recombinations and new combinations
    • Sadelain M. Genetic treatment of the haemoglobinopathies: recombinations and new combinations. Br J Haematol. 1997;98:247-253.
    • (1997) Br J Haematol , vol.98 , pp. 247-253
    • Sadelain, M.1
  • 5
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, KalosM, et al. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med. 2011;365:725-733.
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3
  • 6
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp SA, Kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med. 2013;368:1509-1518.
    • (2013) N Engl J Med , vol.368 , pp. 1509-1518
    • Grupp, S.A.1    Kalos, M.2    Barrett, D.3
  • 7
    • 80455179612 scopus 로고    scopus 로고
    • Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
    • Brentjens RJ, Riviere I, Park JH, et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood. 2011;118:4817-4828.
    • (2011) Blood , vol.118 , pp. 4817-4828
    • Brentjens, R.J.1    Riviere, I.2    Park, J.H.3
  • 8
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
    • Kochenderfer JN, Dudley ME, Feldman SA, et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood. 2012;119:2709-2720.
    • (2012) Blood , vol.119 , pp. 2709-2720
    • Kochenderfer, J.N.1    Dudley, M.E.2    Feldman, S.A.3
  • 9
    • 78149254368 scopus 로고    scopus 로고
    • Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
    • Sampson JH, Heimberger AB, Archer GE, et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol. 2010;28:4722-4729.
    • (2010) J Clin Oncol , vol.28 , pp. 4722-4729
    • Sampson, J.H.1    Heimberger, A.B.2    Archer, G.E.3
  • 10
    • 66349117960 scopus 로고    scopus 로고
    • CAR mechanics: Driving T cells into the MUC of cancer
    • Maher J, Wilkie S. CAR mechanics: driving T cells into the MUC of cancer. Cancer Res. 2009;69:4559-4562.
    • (2009) Cancer Res , vol.69 , pp. 4559-4562
    • Maher, J.1    Wilkie, S.2
  • 11
    • 84862513344 scopus 로고    scopus 로고
    • Targeting of a conformationally exposed, tumor-specific epitope of EGFR as a strategy for cancer therapy
    • Gan HK, Burgess AW, Clayton AH, et al. Targeting of a conformationally exposed, tumor-specific epitope of EGFR as a strategy for cancer therapy. Cancer Res. 2012;72:2924-2930.
    • (2012) Cancer Res , vol.72 , pp. 2924-2930
    • Gan, H.K.1    Burgess, A.W.2    Clayton, A.H.3
  • 12
    • 10744228315 scopus 로고    scopus 로고
    • Differential EphA2 epitope display on normal versus malignant cells
    • Coffman KT, Hu M, Carles-Kinch K, et al. Differential EphA2 epitope display on normal versus malignant cells. Cancer Res. 2003;63:7907-7912.
    • (2003) Cancer Res , vol.63 , pp. 7907-7912
    • Coffman, K.T.1    Hu, M.2    Carles-Kinch, K.3
  • 13
    • 77954748206 scopus 로고    scopus 로고
    • Prostate stem cell antigen: A Jekyll and Hyde molecule?
    • Saeki N, Gu J, Yoshida T, et al. Prostate stem cell antigen: a Jekyll and Hyde molecule? Clin Cancer Res. 2010;16:3533-3538.
    • (2010) Clin Cancer Res , vol.16 , pp. 3533-3538
    • Saeki, N.1    Gu, J.2    Yoshida, T.3
  • 14
    • 79952304769 scopus 로고    scopus 로고
    • Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
    • Robbins PF, Morgan RA, Feldman SA, et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol. 2011;29:917-924.
    • (2011) J Clin Oncol , vol.29 , pp. 917-924
    • Robbins, P.F.1    Morgan, R.A.2    Feldman, S.A.3
  • 15
    • 84873991752 scopus 로고    scopus 로고
    • Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
    • Morgan RA, Chinnasamy N, Abate-Daga D, et al. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother. 2013;36:133-151.
    • (2013) J Immunother , vol.36 , pp. 133-151
    • Morgan, R.A.1    Chinnasamy, N.2    Abate-Daga, D.3
  • 16
    • 0035186913 scopus 로고    scopus 로고
    • A phage display selected fab fragment with MHC class I-restricted specificity forMAGE-A1 allows for retargeting of primary human T lymphocytes
    • Willemsen RA, Debets R, Hart E, et al. A phage display selected fab fragment with MHC class I-restricted specificity forMAGE-A1 allows for retargeting of primary human T lymphocytes. Gene Ther. 2001;8:1601-1608.
    • (2001) Gene Ther. , vol.8 , pp. 1601-1608
    • Willemsen, R.A.1    Debets, R.2    Hart, E.3
  • 17
    • 84872196489 scopus 로고    scopus 로고
    • Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
    • Kloss CC, Condomines M, Cartellieri M, et al. Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells. Nat Biotechnol. 2013;31:71-75.
    • (2013) Nat Biotechnol , vol.31 , pp. 71-75
    • Kloss, C.C.1    Condomines, M.2    Cartellieri, M.3
  • 18
    • 84866740895 scopus 로고    scopus 로고
    • Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling
    • Wilkie S, van Schalkwyk MC, Hobbs S, et al. Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling.JClin Immunol. 2012;32:1059-1070.
    • (2012) JClin Immunol , vol.32 , pp. 1059-1070
    • Wilkie, S.1    Van Schalkwyk, M.C.2    Hobbs, S.3
  • 19
    • 84890174110 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo
    • Lanitis E, Poussin M, Klattenhof A, et al. Chimeric antigen receptor T cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo. Cancer Immunol Res. 2013;1:43-53.
    • (2013) Cancer Immunol Res. , vol.1 , pp. 43-53
    • Lanitis, E.1    Poussin, M.2    Klattenhof, A.3
  • 20
    • 84880259439 scopus 로고    scopus 로고
    • TanCAR: A novel bispecific chimeric antigen receptor for cancer immunotherapy
    • Grada Z, Hegde M, Byrd T, et al. TanCAR: a novel bispecific chimeric antigen receptor for cancer immunotherapy. Mol Ther Nucleic Acids. 2013;2:e105.
    • (2013) Mol Ther Nucleic Acids. , vol.2
    • Grada, Z.1    Hegde, M.2    Byrd, T.3
  • 21
    • 84859383718 scopus 로고    scopus 로고
    • A universal strategy for adoptive immunotherapy of cancer through use of a novel T-cell antigen receptor
    • Urbanska K, Lanitis E, Poussin M, et al. A universal strategy for adoptive immunotherapy of cancer through use of a novel T-cell antigen receptor. Cancer Res. 2012;72:1844-1852.
    • (2012) Cancer Res. , vol.72 , pp. 1844-1852
    • Urbanska, K.1    Lanitis, E.2    Poussin, M.3
  • 22
    • 84870309981 scopus 로고    scopus 로고
    • Redirecting gene-modified T cells toward various cancer types using tagged antibodies
    • Tamada K, Geng D, Sakoda Y, et al. Redirecting gene-modified T cells toward various cancer types using tagged antibodies. Clin Cancer Res. 2012;18:6436-6445.
    • (2012) Clin Cancer Res. , vol.18 , pp. 6436-6445
    • Tamada, K.1    Geng, D.2    Sakoda, Y.3
  • 23
    • 0037058993 scopus 로고    scopus 로고
    • Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells
    • Yee C, Thompson JA, Byrd D, et al. Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc Natl Acad Sci U S A. 2002;99:16168-16173.
    • (2002) Proc Natl Acad Sci U S A. , vol.99 , pp. 16168-16173
    • Yee, C.1    Thompson, J.A.2    Byrd, D.3
  • 24
    • 84887474711 scopus 로고    scopus 로고
    • Reassessing target antigens for adoptive T-cell therapy
    • Hinrichs CS, Restifo NP. Reassessing target antigens for adoptive T-cell therapy. Nat Biotechnol. 2013;31:999-1008.
    • (2013) Nat Biotechnol , vol.31 , pp. 999-1008
    • Hinrichs, C.S.1    Restifo, N.P.2
  • 25
    • 33646440024 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: First clinical experience
    • Lamers CH, Sleijfer S, Vulto AG, et al. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol. 2006;24:e20-e22.
    • (2006) J Clin Oncol. , vol.24
    • Lamers, C.H.1    Sleijfer, S.2    Vulto, A.G.3
  • 26
    • 84878605813 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: Clinical evaluation and management of on-target toxicity
    • Lamers CH, Sleijfer S, van SS, et al. Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity. Mol Ther. 2013;21:904-912.
    • (2013) Mol Ther. , vol.21 , pp. 904-912
    • Lamers, C.H.1    Sleijfer, S.2    Van, S.S.3
  • 27
    • 33947265424 scopus 로고    scopus 로고
    • Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
    • Park JR, Digiusto DL, Slovak M, et al. Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther. 2007;15:825-833.
    • (2007) Mol Ther. , vol.15 , pp. 825-833
    • Park, J.R.1    Digiusto, D.L.2    Slovak, M.3
  • 28
    • 33750699642 scopus 로고    scopus 로고
    • A phase i study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
    • Kershaw MH, Westwood JA, Parker LL, et al. A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res. 2006;12:6106-6115.
    • (2006) Clin Cancer Res. , vol.12 , pp. 6106-6115
    • Kershaw, M.H.1    Westwood, J.A.2    Parker, L.L.3
  • 29
    • 77958063691 scopus 로고    scopus 로고
    • Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b
    • Craddock JA, Lu A, Bear A, et al. Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b. J Immunother. 2010;33:780-788.
    • (2010) J Immunother , vol.33 , pp. 780-788
    • Craddock, J.A.1    Lu, A.2    Bear, A.3
  • 30
    • 0036428790 scopus 로고    scopus 로고
    • Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2
    • Kershaw MH, Wang G, Westwood JA, et al. Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. Hum Gene Ther. 2002;13:1971-1980.
    • (2002) Hum Gene Ther , vol.13 , pp. 1971-1980
    • Kershaw, M.H.1    Wang, G.2    Westwood, J.A.3
  • 31
    • 55549145071 scopus 로고    scopus 로고
    • Virus-specific T cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
    • Pule MA, Savoldo B, Myers GD, et al. Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med. 2008;14:1264-1270.
    • (2008) Nat Med. , vol.14 , pp. 1264-1270
    • Pule, M.A.1    Savoldo, B.2    Myers, G.D.3
  • 32
    • 82955207691 scopus 로고    scopus 로고
    • Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
    • Louis CU, Savoldo B, Dotti G, et al. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood. 2011;118:6050-6056.
    • (2011) Blood , vol.118 , pp. 6050-6056
    • Louis, C.U.1    Savoldo, B.2    Dotti, G.3
  • 33
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • Morgan RA, Yang JC, Kitano M, et al. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther. 2010;18:843-851.
    • (2010) Mol Ther , vol.18 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3
  • 34
    • 84890246911 scopus 로고    scopus 로고
    • T cells redirected against HER2 for the adoptive immunotherapy for HER2-positive osteosarcoma
    • Abstract
    • Ahmed N, Brawley V, Diouf O, et al. T cells redirected against HER2 for the adoptive immunotherapy for HER2-positive osteosarcoma. Cancer Res. 2012;72: Abstract.
    • (2012) Cancer Res. , pp. 72
    • Ahmed, N.1    Brawley, V.2    Diouf, O.3
  • 35
    • 33748749338 scopus 로고    scopus 로고
    • Immune resistance orchestrated by the tumor microenvironment
    • Gajewski TF, Meng Y, Blank C, et al. Immune resistance orchestrated by the tumor microenvironment. Immunol Rev. 2006;213:131-145.
    • (2006) Immunol Rev , vol.213 , pp. 131-145
    • Gajewski, T.F.1    Meng, Y.2    Blank, C.3
  • 36
    • 35549007239 scopus 로고    scopus 로고
    • Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes
    • Quintarelli C, Vera JF, Savoldo B, et al. Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes. Blood. 2007;110:2793-2802.
    • (2007) Blood. , vol.110 , pp. 2793-2802
    • Quintarelli, C.1    Vera, J.F.2    Savoldo, B.3
  • 37
    • 77954590000 scopus 로고    scopus 로고
    • Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their antilymphoma/ leukemia effects and safety
    • Hoyos V, Savoldo B, Quintarelli C, et al. Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their antilymphoma/ leukemia effects and safety. Leukemia. 2010;24:1160-1170.
    • (2010) Leukemia. , vol.24 , pp. 1160-1170
    • Hoyos, V.1    Savoldo, B.2    Quintarelli, C.3
  • 38
    • 84871939748 scopus 로고    scopus 로고
    • Interleukin 15 provides relief to CTLs from regulatory T cell-mediated inhibition: Implications for adoptive T cell-based therapies for lymphoma
    • Perna SK, De AB, Pagliara D, et al. Interleukin 15 provides relief to CTLs from regulatory T cell-mediated inhibition: implications for adoptive T cell-based therapies for lymphoma. Clin Cancer Res. 2013;19:106-117.
    • (2013) Clin Cancer Res , vol.19 , pp. 106-117
    • De Perna, S.K.A.B.1    Pagliara, D.2
  • 39
    • 84879696103 scopus 로고    scopus 로고
    • Collapse of the tumor stroma is triggered by IL-12 induction of Fas
    • Kerkar SP, Leonardi AJ, van PN, et al. Collapse of the tumor stroma is triggered by IL-12 induction of Fas. Mol Ther. 2013;21:1369-1377.
    • (2013) Mol Ther. , vol.21 , pp. 1369-1377
    • Kerkar, S.P.1    Leonardi, A.J.2    Van, P.N.3
  • 40
    • 79953325686 scopus 로고    scopus 로고
    • Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment
    • Zhang L, Kerkar SP, Yu Z, et al. Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment. Mol Ther. 2011;19:751-759.
    • (2011) Mol Ther. , vol.19 , pp. 751-759
    • Zhang, L.1    Kerkar, S.P.2    Yu, Z.3
  • 41
    • 77953023274 scopus 로고    scopus 로고
    • TGF-beta and immune cells: An important regulatory axis in the tumor microenvironment and progression
    • Yang L, Pang Y, Moses HL. TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol. 2010;31:220-227.
    • (2010) Trends Immunol , vol.31 , pp. 220-227
    • Yang, L.1    Pang, Y.2    Moses, H.L.3
  • 42
    • 0036566184 scopus 로고    scopus 로고
    • Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity
    • Bollard CM, Rossig C, Calonge MJ, et al. Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity. Blood. 2002;99:3179-3187.
    • (2002) Blood , vol.99 , pp. 3179-3187
    • Bollard, C.M.1    Rossig, C.2    Calonge, M.J.3
  • 43
    • 55249117972 scopus 로고    scopus 로고
    • Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor
    • Foster AE, Dotti G, Lu A, et al. Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor. J Immunother. 2008;31:500-505.
    • (2008) J Immunother , vol.31 , pp. 500-505
    • Foster, A.E.1    Dotti, G.2    Lu, A.3
  • 44
    • 84885470877 scopus 로고    scopus 로고
    • Administration of TGF-beta resistant tumor-specific CTL to patienst with EBV-associated HL and NHL
    • Bollard CM, Dotti G, Gottschalk S, et al. Administration of TGF-beta resistant tumor-specific CTL to patienst with EBV-associated HL and NHL. Mol Ther. 2012;20:S22.
    • (2012) Mol Ther. , vol.20
    • Bollard, C.M.1    Dotti, G.2    Gottschalk, S.3
  • 45
    • 77955503406 scopus 로고    scopus 로고
    • Selective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4
    • Wilkie S, Burbridge SE, Chiapero-Stanke L, et al. Selective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4. J Biol Chem. 2010;285:25538-25544.
    • (2010) J Biol Chem , vol.285 , pp. 25538-25544
    • Wilkie, S.1    Burbridge, S.E.2    Chiapero-Stanke, L.3
  • 46
    • 84890244501 scopus 로고    scopus 로고
    • Improved expansion and anti-tumor activity of tumor-specific CTLs using a transgenic chimeric cytokine receptor
    • Leen A, Katari U, Keiman J, et al. Improved expansion and anti-tumor activity of tumor-specific CTLs using a transgenic chimeric cytokine receptor. Mol Ther. 2011;19:S194.
    • (2011) Mol Ther. , vol.19
    • Leen, A.1    Katari, U.2    Keiman, J.3
  • 47
    • 84890221921 scopus 로고    scopus 로고
    • Transgenic expression of a novel immunosuppressive signal converter on T cells
    • Watanabe N, Anurathapan U, Brenner M, et al. Transgenic expression of a novel immunosuppressive signal converter on T cells. Mol Ther. 2013;22:S153.
    • (2013) Mol Ther. , vol.22
    • Watanabe, N.1    Anurathapan, U.2    Brenner, M.3
  • 48
    • 84885461249 scopus 로고    scopus 로고
    • Human T cells engineered to express a programmed death 1/28 costimulatory retargeting molecule display enhanced antitumor activity
    • Ankri C, Shamalov K, Horovitz-Fried M, et al. Human T cells engineered to express a programmed death 1/28 costimulatory retargeting molecule display enhanced antitumor activity. J Immunol. 2013;191:4121-4129.
    • (2013) J Immunol. , vol.191 , pp. 4121-4129
    • Ankri, C.1    Shamalov, K.2    Horovitz-Fried, M.3
  • 49
    • 20444425695 scopus 로고    scopus 로고
    • Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis
    • Dotti G, Savoldo B, Pule M, et al. Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis. Blood. 2005;105:4677-4684.
    • (2005) Blood. , vol.105 , pp. 4677-4684
    • Dotti, G.1    Savoldo, B.2    Pule, M.3
  • 50
    • 78049468066 scopus 로고    scopus 로고
    • T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms
    • Sun J, Dotti G, Huye LE, et al. T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms. Mol Ther. 2010;18:2006-2017.
    • (2010) Mol Ther. , vol.18 , pp. 2006-2017
    • Sun, J.1    Dotti, G.2    Huye, L.E.3
  • 51
  • 52
    • 84881312673 scopus 로고    scopus 로고
    • Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma
    • Kakarla S, Chow KK, Mata M, et al. Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma. Mol Ther. 2013;8:1611-1620.
    • (2013) Mol Ther , vol.8 , pp. 1611-1620
    • Kakarla, S.1    Chow, K.K.2    Mata, M.3
  • 53
    • 84880656055 scopus 로고    scopus 로고
    • Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
    • Tran E, Chinnasamy D, Yu Z, et al. Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia. J Exp Med. 2013;210:1125-1135.
    • (2013) J Exp Med , vol.210 , pp. 1125-1135
    • Tran, E.1    Chinnasamy, D.2    Yu, Z.3
  • 54
    • 84880687861 scopus 로고    scopus 로고
    • Depletion of stromal cells expressing fibroblast activation protein-alpha from skeletal muscle and bone marrow results in cachexia and anemia
    • Roberts EW, Deonarine A, Jones JO, et al. Depletion of stromal cells expressing fibroblast activation protein-alpha from skeletal muscle and bone marrow results in cachexia and anemia. J Exp Med. 2013;210:1137-1151.
    • (2013) J Exp Med , vol.210 , pp. 1137-1151
    • Roberts, E.W.1    Deonarine, A.2    Jones, J.O.3
  • 55
    • 0037076297 scopus 로고    scopus 로고
    • Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors
    • Niederman TM, Ghogawala Z, Carter BS, et al. Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors. Proc Natl Acad Sci U S A. 2002;99:7009-7014.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 7009-7014
    • Niederman, T.M.1    Ghogawala, Z.2    Carter, B.S.3
  • 56
    • 78049436238 scopus 로고    scopus 로고
    • Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice
    • Chinnasamy D, Yu Z, Theoret MR, et al. Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice. J Clin Invest. 2010;120:3953-3968.
    • (2010) J Clin Invest , vol.120 , pp. 3953-3968
    • Chinnasamy, D.1    Yu, Z.2    Theoret, M.R.3
  • 57
    • 66849135251 scopus 로고    scopus 로고
    • Cancer immunotherapy: Co-stimulatory agonists and co-inhibitory antagonists
    • Peggs KS, Quezada SA, Allison JP. Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists. Clin Exp Immunol. 2009;157:9-19.
    • (2009) Clin Exp Immunol , vol.157 , pp. 9-19
    • Peggs, K.S.1    Quezada, S.A.2    Allison, J.P.3
  • 58
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363:711-723.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 59
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL,Hodi FS,Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 60
    • 84862882003 scopus 로고    scopus 로고
    • Tumor immunotherapy directed at PD-1
    • Ribas A. Tumor immunotherapy directed at PD-1. N Engl J Med. 2012;366:2517-2519.
    • (2012) N Engl J Med , vol.366 , pp. 2517-2519
    • Ribas, A.1
  • 61
    • 84863138984 scopus 로고    scopus 로고
    • Epigenetic modulation to enable antigen-specific T-cell therapy of colorectal cancer
    • Chou J, Voong LN, Mortales CL, et al. Epigenetic modulation to enable antigen-specific T-cell therapy of colorectal cancer. J Immunother. 2012;35:131-141.
    • (2012) J Immunother , vol.35 , pp. 131-141
    • Chou, J.1    Voong, L.N.2    Mortales, C.L.3
  • 62
    • 84872514398 scopus 로고    scopus 로고
    • BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice
    • Liu C, PengW, Xu C, et al. BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice. Clin Cancer Res. 2013;19:393-403.
    • (2013) Clin Cancer Res , vol.19 , pp. 393-403
    • Liu, C.1    Peng, W.2    Xu, C.3
  • 63
    • 79955517235 scopus 로고    scopus 로고
    • CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
    • Savoldo B, Ramos CA, Liu E, et al. CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J Clin Invest. 2011;121:1822-1826.
    • (2011) J Clin Invest , vol.121 , pp. 1822-1826
    • Savoldo, B.1    Ramos, C.A.2    Liu, E.3


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