메뉴 건너뛰기




Volumn 21, Issue 5, 2016, Pages

Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment

Author keywords

AD; BACE 1; Benzophenone; Chalcone; Metal chelation; Natural products; Reactive oxygen species

Indexed keywords

AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; CHALCONE; CHELATING AGENT; DRUG COMBINATION; ION; LIGAND; METAL; NEUROPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; SECRETASE;

EID: 84973638018     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules21050643     Document Type: Article
Times cited : (16)

References (28)
  • 1
    • 84925880097 scopus 로고    scopus 로고
    • Alzheimer's disease facts and figures
    • Alzheimer's Association. Alzheimer's disease facts and figures. Alzheimers Dement. 2015, 11, 332-384.
    • (2015) Alzheimers Dement. , vol.11 , pp. 332-384
    • Alzheimer's Association1
  • 4
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline
    • Naslund, J.; Haroutunian, V.; Mohs, R.; Davis, K.L.; Davies, P.; Greengard, P.; Buxbaum, J.D. Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline. JAMA 2000, 283, 1571-1577.
    • (2000) JAMA , vol.283 , pp. 1571-1577
    • Naslund, J.1    Haroutunian, V.2    Mohs, R.3    Davis, K.L.4    Davies, P.5    Greengard, P.6    Buxbaum, J.D.7
  • 5
    • 84880187014 scopus 로고    scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis: An update and reappraisal
    • Hardy, J. Alzheimer's disease: The amyloid cascade hypothesis: An update and reappraisal. J. Alzheimers Dis. 2006, 9, 151-153.
    • (2006) J. Alzheimers Dis. , vol.9 , pp. 151-153
    • Hardy, J.1
  • 7
    • 62249167406 scopus 로고    scopus 로고
    • Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease
    • Silvestri, R. Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease. Med. Res. Rev. 2009, 29, 295-338.
    • (2009) Med. Res. Rev. , vol.29 , pp. 295-338
    • Silvestri, R.1
  • 8
    • 0034613320 scopus 로고    scopus 로고
    • Structure of the protease domain of memapsin 2 (β-secretase) complexed with inhibitor
    • Hong, L.; Koelsch, G.; Lin, X.; Wu, S.; Terzyan, S.; Ghosh, A.K.; Zhang, X.C.; Tang, J. Structure of the protease domain of memapsin 2 (β-secretase) complexed with inhibitor. Science 2000, 290, 150-153.
    • (2000) Science , vol.290 , pp. 150-153
    • Hong, L.1    Koelsch, G.2    Lin, X.3    Wu, S.4    Terzyan, S.5    Ghosh, A.K.6    Zhang, X.C.7    Tang, J.8
  • 9
    • 61849126868 scopus 로고    scopus 로고
    • Synthetic strategies of nonpeptidic β-secretase (BACE1) inhibitors
    • La Regina, G.; Piscitelli, F.; Silvestri, R. Synthetic strategies of nonpeptidic β-secretase (BACE1) inhibitors. J. Heter. Chem. 2009, 46, 10-17.
    • (2009) J. Heter. Chem. , vol.46 , pp. 10-17
    • La Regina, G.1    Piscitelli, F.2    Silvestri, R.3
  • 10
    • 70350153272 scopus 로고    scopus 로고
    • The chemistry of Alzheimer's disease
    • Rauk, A. The chemistry of Alzheimer's disease. Chem. Soc. Rev. 2009, 38, 2698-2715.
    • (2009) Chem. Soc. Rev. , vol.38 , pp. 2698-2715
    • Rauk, A.1
  • 11
    • 79955977168 scopus 로고    scopus 로고
    • Myricetin: A Naturally Occurring Regulator of Metal-Induced Amyloid-β Aggregation and Neurotoxicity
    • DeToma, A.S.; Choi, J.-S.; Braymer, J.J.; Lim, M.H. Myricetin: A Naturally Occurring Regulator of Metal-Induced Amyloid-β Aggregation and Neurotoxicity. Chembiochem 2011, 12, 1198-1201.
    • (2011) Chembiochem , vol.12 , pp. 1198-1201
    • DeToma, A.S.1    Choi, J.-S.2    Braymer, J.J.3    Lim, M.H.4
  • 12
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981-2002
    • Newman, D.J.; Cragg, G.M.; Snader, K.M. Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod. 2003, 66, 1022-1037.
    • (2003) J. Nat. Prod. , vol.66 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 13
  • 14
    • 84655167890 scopus 로고    scopus 로고
    • Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease
    • Williams, R.J.; Spencer, J.P. Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radic. Biol. Med. 2012, 52, 35-45.
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 35-45
    • Williams, R.J.1    Spencer, J.P.2
  • 15
    • 70349197543 scopus 로고    scopus 로고
    • Biological activity of metal ions complexes of chromones, coumarins and flavones
    • Grazul, M.; Budzisz, E. Biological activity of metal ions complexes of chromones, coumarins and flavones. Coord. Chem. Rev. 2009, 253, 2588-2598.
    • (2009) Coord. Chem. Rev. , vol.253 , pp. 2588-2598
    • Grazul, M.1    Budzisz, E.2
  • 16
  • 17
    • 79953214018 scopus 로고    scopus 로고
    • Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation
    • Belluti, F.; Bartolini, M.; Bottegoni, G.; Bisi, A.; Cavalli, A.; Andrisano, V.; Rampa, A. Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation. Eur. J. Med. Chem. 2011, 46, 1682-1693.
    • (2011) Eur. J. Med. Chem. , vol.46 , pp. 1682-1693
    • Belluti, F.1    Bartolini, M.2    Bottegoni, G.3    Bisi, A.4    Cavalli, A.5    Andrisano, V.6    Rampa, A.7
  • 19
    • 3242794178 scopus 로고    scopus 로고
    • From magic bullets to designed multiple ligands
    • Morphy, R.; Kay, C.; Rankovic, Z. From magic bullets to designed multiple ligands. Drug Discov. Today 2004, 9, 641-651.
    • (2004) Drug Discov. Today , vol.9 , pp. 641-651
    • Morphy, R.1    Kay, C.2    Rankovic, Z.3
  • 21
    • 84942303229 scopus 로고    scopus 로고
    • β-Secretase as a target for Alzheimer's disease drug discovery: An overview of in vitro methods for characterization of inhibitors
    • Mancini, F.; De Simone, A.; Andrisano, V. β-Secretase as a target for Alzheimer's disease drug discovery: An overview of in vitro methods for characterization of inhibitors. Anal. Bioanal. Chem. 2011, 400, 1979-1996.
    • (2011) Anal. Bioanal. Chem. , vol.400 , pp. 1979-1996
    • Mancini, F.1    De Simone, A.2    Andrisano, V.3
  • 24
    • 2442419479 scopus 로고    scopus 로고
    • Cold-storage affects antioxidant properties of apples in caco-2 cells
    • Tarozzi, A.; Marchesi, A.; Cantelli-Forti, G.; Hrelia, P. Cold-storage affects antioxidant properties of apples in caco-2 cells. J. Nutr. 2004, 134, 1105-1109.
    • (2004) J. Nutr. , vol.134 , pp. 1105-1109
    • Tarozzi, A.1    Marchesi, A.2    Cantelli-Forti, G.3    Hrelia, P.4
  • 25
    • 84875957320 scopus 로고    scopus 로고
    • Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines
    • Říha, M.; Karlíčková, J.; Filipský, T.; Macáková, K.; Hrdina, R.; Mladiěnka, P. Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines. J. Inorg. Biochem. 2013, 123, 80-87.
    • (2013) J. Inorg. Biochem. , vol.123 , pp. 80-87
    • Říha, M.1    Karlíčková, J.2    Filipský, T.3    Macáková, K.4    Hrdina, R.5    Mladiěnka, P.6
  • 26
    • 0037134637 scopus 로고    scopus 로고
    • Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals
    • Kim, D.O.; Lee, K.W.; Lee, H.J.; Lee, C.Y. Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J. Agric. Food Chem. 2002, 50, 3713-3717.
    • (2002) J. Agric. Food Chem. , vol.50 , pp. 3713-3717
    • Kim, D.O.1    Lee, K.W.2    Lee, H.J.3    Lee, C.Y.4
  • 28
    • 84930645183 scopus 로고    scopus 로고
    • Properties and applications of flavonoid metal complexes
    • Kasprzak, M.M.; Erxleben, A.; Ochocki, J. Properties and applications of flavonoid metal complexes. RSC Adv. 2015, 5, 45853-45877.
    • (2015) RSC Adv. , vol.5 , pp. 45853-45877
    • Kasprzak, M.M.1    Erxleben, A.2    Ochocki, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.