Exploiting the Phenomenon of Liquid-Liquid Phase Separation for Enhanced and Sustained Membrane Transport of a Poorly Water-Soluble Drug

Molecular Pharmaceutics

Volumn 13, Issue 6, 2016, Pages 2059-2069

  Indulkar, Anura S ^a   Gao, Yi ^b   Raina, Shweta A ^b   Zhang, Geoff G Z ^b   Taylor, Lynne S ^a  

^a PURDUE UNIVERSITY   (United States)

^b ABBVIE INC   (United States)

Author keywords

liquid liquid phase separation; membrane transport; reservoir effect; supersaturation

Indexed keywords

CLOTRIMAZOLE; DELAYED RELEASE FORMULATION; DRUG; NANOPARTICLE; SOLUTION AND SOLUBILITY; WATER;

ARTICLE; CONCENTRATION AT STEADY-STATE; CONTROLLED STUDY; CRYSTALLIZATION; DISPERSION; DRUG SOLUBILITY; LIPOPHILICITY; LIQUID; LIQUID LIQUID PHASE SEPARATION; MATHEMATICAL MODEL; MEMBRANE TRANSPORT; PARTICLE SIZE; PASSIVE TRANSPORT; PH; PHASE SEPARATION; PRIORITY JOURNAL; STEADY STATE; SURFACE AREA; TEMPERATURE; VISCOSITY; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; MEDICINAL CHEMISTRY; MEMBRANE; METABOLISM; PHYSIOLOGY; PROCEDURES; SOLUBILITY; SOLUTION AND SOLUBILITY; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; DIFFUSION; MEMBRANES; NANOPARTICLES; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; SOLUTIONS; WATER;

EID: 84973622260     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.6b00202     Document Type: Article

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