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Volumn 101, Issue 6, 2016, Pages 2423-2431

Adipose insulin resistance in obese adolescents across the spectrum of glucose tolerance

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; FATTY ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INTERLEUKIN 6; TRIACYLGLYCEROL; GLUCOSE BLOOD LEVEL;

EID: 84973572993     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2016-1376     Document Type: Article
Times cited : (61)

References (40)
  • 1
    • 0029037649 scopus 로고
    • Pathophysiology of insulin resistance in human disease
    • Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev. 1995;75:473-486.
    • (1995) Physiol Rev , vol.75 , pp. 473-486
    • Reaven, G.M.1
  • 2
    • 41149140806 scopus 로고    scopus 로고
    • Metabolic complications of childhood obesity: Identifying and mitigating the risk
    • Weiss R, Kaufman FR. Metabolic complications of childhood obesity: Identifying and mitigating the risk. Diabetes Care. 2008;31 Suppl 2:S310-S316.
    • (2008) Diabetes Care , vol.31 , pp. S310-S316
    • Weiss, R.1    Kaufman, F.R.2
  • 3
    • 2542548063 scopus 로고    scopus 로고
    • Obesity and the metabolic syndrome in children and adolescents
    • Weiss R, Dziura J, Burgert TS, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004;350: 2362-2374.
    • (2004) N Engl J Med , vol.350 , pp. 2362-2374
    • Weiss, R.1    Dziura, J.2    Burgert, T.S.3
  • 4
    • 34548742845 scopus 로고    scopus 로고
    • Fat distribution and storage: How much, where, and how?
    • Weiss R. Fat distribution and storage: How much, where, and how? Eur J Endocrinol. 2007;157 Suppl 1:S39-S45.
    • (2007) Eur J Endocrinol , vol.157 , pp. S39-S45
    • Weiss, R.1
  • 5
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237:E214-E223.
    • (1979) Am J Physiol , vol.237 , pp. E214-E223
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 6
    • 84948817832 scopus 로고    scopus 로고
    • Effects of weight loss via high fat vs. Low fat alternate day fasting diets on free fatty acid profiles
    • Varady KA, Dam VT, Klempel MC, et al. Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles. Sci Rep. 2015;5:7561.
    • (2015) Sci Rep. , vol.5 , pp. 7561
    • Varady, K.A.1    Dam, V.T.2    Klempel, M.C.3
  • 7
    • 0029948212 scopus 로고    scopus 로고
    • Mechanism of free fatty acid-induced insulin resistance in humans
    • Roden M, Price TB, Perseghin G, et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. 1996;97: 2859-2865.
    • (1996) J Clin Invest , vol.97 , pp. 2859-2865
    • Roden, M.1    Price, T.B.2    Perseghin, G.3
  • 8
    • 61849141249 scopus 로고    scopus 로고
    • Effects of an intravenous lipid challenge and free fatty acid elevation on in vivo insulin sensitivity in African American versus caucasian adolescents
    • Burns SF, Kelsey SF, Arslanian SA. Effects of an intravenous lipid challenge and free fatty acid elevation on in vivo insulin sensitivity in African American versus Caucasian adolescents. Diabetes Care. 2009;32:355-360.
    • (2009) Diabetes Care , vol.32 , pp. 355-360
    • Burns, S.F.1    Kelsey, S.F.2    Arslanian, S.A.3
  • 9
    • 84891713797 scopus 로고    scopus 로고
    • β-Cell lipotoxicity in response to free fatty acid elevation in prepubertal youth: African American versus caucasian contrast
    • Michaliszyn SF, Bonadonna RC, Sjaarda LA, Lee S, Farchoukh L, Arslanian SA. β Cell lipotoxicity in response to free fatty acid elevation in prepubertal youth: African American versus Caucasian contrast. Diabetes. 2013;62:2917-2922.
    • (2013) Diabetes , vol.62 , pp. 2917-2922
    • Michaliszyn, S.F.1    Bonadonna, R.C.2    Sjaarda, L.A.3    Lee, S.4    Farchoukh, L.5    Arslanian, S.A.6
  • 10
    • 0034005968 scopus 로고    scopus 로고
    • Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes
    • Carpentier A, Mittelman SD, Bergman RN, Giacca A, Lewis GF. Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes. Diabetes. 2000;49:399-408.
    • (2000) Diabetes , vol.49 , pp. 399-408
    • Carpentier, A.1    Mittelman, S.D.2    Bergman, R.N.3    Giacca, A.4    Lewis, G.F.5
  • 11
    • 0034504237 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome
    • Wajchenberg BL. Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome. Endocr Rev. 2000;21:697-738.
    • (2000) Endocr Rev. , vol.21 , pp. 697-738
    • Wajchenberg, B.L.1
  • 12
    • 0141763847 scopus 로고    scopus 로고
    • Prediabetes in obese youth: A syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning
    • Weiss R, Dufour S, Taksali SE, et al. Prediabetes in obese youth: A syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. Lancet. 2003;362:951-957.
    • (2003) Lancet , vol.362 , pp. 951-957
    • Weiss, R.1    Dufour, S.2    Taksali, S.E.3
  • 13
    • 84857422984 scopus 로고    scopus 로고
    • Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: A longitudinal study
    • Giannini C, Weiss R, Cali A, et al. Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: A longitudinal study. Diabetes. 2012;61: 606-614.
    • (2012) Diabetes , vol.61 , pp. 606-614
    • Giannini, C.1    Weiss, R.2    Cali, A.3
  • 14
    • 1042302780 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • American Diabetes Association
    • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2004;27 Suppl 1:S5-S10.
    • (2004) Diabetes Care , vol.27 , pp. S5-S10
  • 15
    • 0037076025 scopus 로고    scopus 로고
    • Prevalence of impaired glucose tolerance among children and adolescents with marked obesity
    • Sinha R, Fisch G, Teague B, et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med. 2002;346:802-810.
    • (2002) N Engl J Med , vol.346 , pp. 802-810
    • Sinha, R.1    Fisch, G.2    Teague, B.3
  • 16
    • 40749121780 scopus 로고    scopus 로고
    • High visceral and low abdominal subcutaneous fat stores in the obese adolescent: A determinant of an adverse metabolic phenotype
    • Taksali SE, Caprio S, Dziura J, et al. High visceral and low abdominal subcutaneous fat stores in the obese adolescent: A determinant of an adverse metabolic phenotype. Diabetes. 2008;57:367-371.
    • (2008) Diabetes , vol.57 , pp. 367-371
    • Taksali, S.E.1    Caprio, S.2    Dziura, J.3
  • 17
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
    • Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22:1462-1470.
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 18
    • 0028204065 scopus 로고
    • Understanding oral glucose tolerance: Comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion
    • Phillips DI, Clark PM, Hales CN, Osmond C. Understanding oral glucose tolerance: Comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabet Med. 1994;11:286-292.
    • (1994) Diabet Med , vol.11 , pp. 286-292
    • Phillips, D.I.1    Clark, P.M.2    Hales, C.N.3    Osmond, C.4
  • 19
    • 1642284417 scopus 로고    scopus 로고
    • Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents
    • Yeckel CW, Weiss R, Dziura J, et al. Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents. J Clin Endocrinol Metab. 2004;89:1096-1101.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1096-1101
    • Yeckel, C.W.1    Weiss, R.2    Dziura, J.3
  • 20
    • 34447132113 scopus 로고    scopus 로고
    • Degree of obesity and glucose allostasis are major effectors of glucose tolerance dynamics in obese youth
    • Weiss R, Cali AM, Dziura J, Burgert TS, Tamborlane WV, Caprio S. Degree of obesity and glucose allostasis are major effectors of glucose tolerance dynamics in obese youth. Diabetes Care. 2007; 30:1845-1850.
    • (2007) Diabetes Care , vol.30 , pp. 1845-1850
    • Weiss, R.1    Cali, A.M.2    Dziura, J.3    Burgert, T.S.4    Tamborlane, W.V.5    Caprio, S.6
  • 21
    • 33846031943 scopus 로고    scopus 로고
    • Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test
    • Abdul-Ghani MA, Matsuda M, Balas B, DeFronzo RA. Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care. 2007;30:89-94.
    • (2007) Diabetes Care. , vol.30 , pp. 89-94
    • Abdul-Ghani, M.A.1    Matsuda, M.2    Balas, B.3    DeFronzo, R.A.4
  • 22
    • 0024392514 scopus 로고
    • Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus., Evidence for multiple sites of insulin resistance
    • Groop LC, Bonadonna RC, DelPrato S, et al. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest. 1989;84: 205-213.
    • (1989) J Clin Invest , vol.84 , pp. 205-213
    • Groop, L.C.1    Bonadonna, R.C.2    DelPrato, S.3
  • 23
    • 0031711610 scopus 로고    scopus 로고
    • Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels
    • Belfiore F, Iannello S, Volpicelli G. Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels. Mol Genet Metab. 1998;63:134-141.
    • (1998) Mol Genet Metab. , vol.63 , pp. 134-141
    • Belfiore, F.1    Iannello, S.2    Volpicelli, G.3
  • 24
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest. 2000;106:171-176.
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 25
    • 0034072554 scopus 로고    scopus 로고
    • Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans
    • Roden M, Stingl H, Chandramouli V, et al. Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes. 2000;49:701-707.
    • (2000) Diabetes , vol.49 , pp. 701-707
    • Roden, M.1    Stingl, H.2    Chandramouli, V.3
  • 26
    • 0037643536 scopus 로고    scopus 로고
    • Effects of free fatty acids (FFA) on glucose metabolism: Significance for insulin resistance and type 2 diabetes
    • Boden G. Effects of free fatty acids (FFA) on glucose metabolism: Significance for insulin resistance and type 2 diabetes. Exp Clin Endocrinol Diabetes. 2003;111:121-124.
    • (2003) Exp Clin Endocrinol Diabetes , vol.111 , pp. 121-124
    • Boden, G.1
  • 27
    • 0035512070 scopus 로고    scopus 로고
    • Longitudinal study on pubertal insulin resistance
    • Goran MI, Gower BA. Longitudinal study on pubertal insulin resistance. Diabetes. 2001;50:2444-2450.
    • (2001) Diabetes , vol.50 , pp. 2444-2450
    • Goran, M.I.1    Gower, B.A.2
  • 28
    • 58149168753 scopus 로고    scopus 로고
    • Effects of androgens on insulin action in women: Is androgen excess a component of female metabolic syndrome?
    • Corbould A. Effects of androgens on insulin action in women: Is androgen excess a component of female metabolic syndrome? Diabetes Metab Res Rev. 2008;24:520-532.
    • (2008) Diabetes Metab Res Rev , vol.24 , pp. 520-532
    • Corbould, A.1
  • 29
    • 84866171037 scopus 로고    scopus 로고
    • Higher fasting plasma free fatty acid levels are associated with lower insulin secretion in children and adults and a higher incidence of type 2 diabetes
    • Salgin B, Ong KK, Thankamony A, Emmett P, Wareham NJ, Dunger DB. Higher fasting plasma free fatty acid levels are associated with lower insulin secretion in children and adults and a higher incidence of type 2 diabetes. J Clin Endocrinol Metab. 2012;97: 3302-3309.
    • (2012) J Clin Endocrinol Metab. , vol.97 , pp. 3302-3309
    • Salgin, B.1    Ong, K.K.2    Thankamony, A.3    Emmett, P.4    Wareham, N.J.5    Dunger, D.B.6
  • 30
    • 36849084173 scopus 로고    scopus 로고
    • Regional fat deposition as a factor in FFA metabolism
    • Votruba SB, Jensen MD. Regional fat deposition as a factor in FFA metabolism. Annu Rev Nutr. 2007;27:149-163.
    • (2007) Annu Rev Nutr. , vol.27 , pp. 149-163
    • Votruba, S.B.1    Jensen, M.D.2
  • 31
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • Després JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444:881-887.
    • (2006) Nature , vol.444 , pp. 881-887
    • Després, J.P.1    Lemieux, I.2
  • 32
    • 84872327440 scopus 로고    scopus 로고
    • Pathophysiology of human visceral obesity: An update
    • Tchernof A, Després JP. Pathophysiology of human visceral obesity: An update. Physiol Rev. 2013;93:359-404.
    • (2013) Physiol Rev , vol.93 , pp. 359-404
    • Tchernof, A.1    Després, J.P.2
  • 33
    • 84962433778 scopus 로고    scopus 로고
    • A role of the Inflammasome in the low storage capacity of the abdominal subcutaneous adipose tissue in obese adolescents
    • Kursawe R, Dixit VD, Scherer PE, et al. A role of the Inflammasome in the low storage capacity of the abdominal subcutaneous adipose tissue in obese adolescents. Diabetes. 2016;65:610-618.
    • (2016) Diabetes , vol.65 , pp. 610-618
    • Kursawe, R.1    Dixit, V.D.2    Scherer, P.E.3
  • 35
    • 79952984443 scopus 로고    scopus 로고
    • Changes in adiposederived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children
    • Roth CL, Kratz M, Ralston MM, Reinehr T. Changes in adiposederived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children. Metabolism. 2011;60:445-452.
    • (2011) Metabolism , vol.60 , pp. 445-452
    • Roth, C.L.1    Kratz, M.2    Ralston, M.M.3    Reinehr, T.4
  • 36
    • 13844270854 scopus 로고    scopus 로고
    • Insulin sensitivity indices of glucose and free fatty acid metabolism in obese children and adolescents in relation to serum lipids
    • Reinehr T, Kiess W, Andler W. Insulin sensitivity indices of glucose and free fatty acid metabolism in obese children and adolescents in relation to serum lipids. Metabolism. 2005;54:397-402.
    • (2005) Metabolism , vol.54 , pp. 397-402
    • Reinehr, T.1    Kiess, W.2    Andler, W.3
  • 37
    • 84918798518 scopus 로고    scopus 로고
    • Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance
    • Dubé JJ, Coen PM, DiStefano G, et al. Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance. Am J Physiol Endocrinol Metab. 2014; 307:E1117-E1124.
    • (2014) Am J Physiol Endocrinol Metab , vol.307 , pp. E1117-E1124
    • Dubé, J.J.1    Coen, P.M.2    DiStefano, G.3
  • 38
    • 84930820164 scopus 로고    scopus 로고
    • Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents
    • Toledo-Corral CM, Alderete TL, Richey J, Sequeira P, Goran MI, Weigensberg MJ. Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents. Acta Diabetol. 2015;52:277-284.
    • (2015) Acta Diabetol , vol.52 , pp. 277-284
    • Toledo-Corral, C.M.1    Alderete, T.L.2    Richey, J.3    Sequeira, P.4    Goran, M.I.5    Weigensberg, M.J.6
  • 39
    • 84876229901 scopus 로고    scopus 로고
    • Sex-associated differences in free fatty acid flux of obese adolescents
    • Adler-Wailes DC, Periwal V, Ali AH, et al. Sex-associated differences in free fatty acid flux of obese adolescents. J Clin Endocrinol Metab. 2013;98:1676-1684.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 1676-1684
    • Adler-Wailes, D.C.1    Periwal, V.2    Ali, A.H.3
  • 40
    • 84861996283 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: A longitudinal analysis
    • Reinehr T, Woelfle J, Wunsch R, Roth CL. Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: A longitudinal analysis. J Clin Endocrinol Metab. 2012;97:2143-2150.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2143-2150
    • Reinehr, T.1    Woelfle, J.2    Wunsch, R.3    Roth, C.L.4


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