Effect of silibinin and vitamin E on the ASK1-p38 MAPK pathway in D-galactosamine/lipopolysaccharide induced hepatotoxicity

Experimental Biology and Medicine

Volumn 241, Issue 11, 2016, Pages 1250-1257

  Hashem, Reem M ^a   Hassanin, Kamel M A ^b   Rashed, Laila A ^c   Mahmoud, Mohamed O ^a   Hassan, Mohamed G ^a  

^a Beni Suef University   (Egypt)

^b Minia University   (Egypt)

^c CAIRO UNIVERSITY   (Egypt)

Author keywords

ASK1; hepatotoxicity; p38 MAPK; PP5; Trx1; TrxR1

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; APOPTOSIS SIGNAL REGULATING KINASE 1; ASPARTATE AMINOTRANSFERASE; CATALASE; GALACTOSAMINE; GLUTATHIONE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN PHOSPHATASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SILIBININ; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOREDOXIN 1; THIOREDOXIN REDUCTASE 1; ANTIOXIDANT; SILYMARIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL ANALYSIS; COLORIMETRY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HISTOPATHOLOGY; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY; WESTERN BLOTTING; ANIMAL; CHEMICAL AND DRUG INDUCED LIVER INJURY; CYTOCHEMISTRY; DRUG EFFECTS; LIVER; LIVER FUNCTION TEST; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TREATMENT OUTCOME;

ANIMALS; ANTIOXIDANTS; CHEMICAL AND DRUG INDUCED LIVER INJURY; GALACTOSAMINE; HISTOCYTOCHEMISTRY; LIPOPOLYSACCHARIDES; LIVER; LIVER FUNCTION TESTS; MAP KINASE KINASE KINASE 5; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; SIGNAL TRANSDUCTION; SILYMARIN; TREATMENT OUTCOME; VITAMIN E;

EID: 84973397942     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370216636719     Document Type: Article

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