Inhibiting NF-κB activation and ROS production are involved in the mechanism of silibinin's protection against D-galactose-induced senescence

Pharmacology Biochemistry and Behavior

Volumn 98, Issue 1, 2011, Pages 140-149

  Wang, Qiong ^a   Zou, Libo ^a   Liu, Weiwei ^a   Hao, Wenbo ^b   Tashiro, Shin Ichi ^c   Onodera, Satoshi ^c   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHENYANG AGRICULTURAL UNIVERSITY   (China)

^c SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Autophagy; Nuclear factor B (NF B); Reactive oxygen species (ROS); Senescence; Silibinin

Indexed keywords

3 METHYLADENINE; CATALASE; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; GALACTOSE; GLUTATHIONE PEROXIDASE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; OXIDOREDUCTASE; PROTEIN P21; PROTEIN P53; PYRROLIDINE DITHIOCARBAMATE; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; SILIBININ; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; AUTOPHAGY; BRAIN NERVE CELL; COGNITIVE DEFECT; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL TEST; HIPPOCAMPUS; LIPID PEROXIDATION; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECOGNITION; SENESCENCE; SPATIAL MEMORY; STEP DOWN TEST; UPREGULATION;

AGING; ANIMALS; ANTIOXIDANTS; AUTOPHAGY; COGNITION; CYCLIN B1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GALACTOSE; HIPPOCAMPUS; MAZE LEARNING; MICE; NF-KAPPA B; REACTIVE OXYGEN SPECIES; SILYMARIN; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MURINAE; MUS;

EID: 78651281321     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.12.006     Document Type: Article

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