MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model

Free Radical Biology and Medicine

Volumn 87, Issue , 2015, Pages 312-325

  Ray, Ajit ^a,b   Sehgal, Neha ^a   Karunakaran, Smitha ^a   Rangarajan, Govindan ^b   Ravindranath, Vijayalakshmi ^b  

^a NATIONAL BRAIN RESEARCH CENTRE   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Cell death; Graph theory; Neurodegeneration; Oxidativestress; Thiols

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; APOPTOSIS SIGNAL REGULATING KINASE 1; GAMMA INTERFERON; GLUTATHIONE TRANSFERASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 14; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE); THIOREDOXIN 1; TUMOR NECROSIS FACTOR ALPHA; MAP3K5 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE P38; THIOREDOXIN; TXN1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MALE; MESENCEPHALON; MOUSE; NONHUMAN; OXIDATION; PARKINSONISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DOPAMINERGIC NERVE CELL; DRUG EFFECTS; HUMAN; IMMUNOLOGY; METABOLISM; PARKINSON DISEASE; PATHOLOGY; SUBSTANTIA NIGRA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; ANTIBODIES, NEUTRALIZING; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; HUMANS; MAP KINASE KINASE KINASE 5; MAP KINASE SIGNALING SYSTEM; MESENCEPHALON; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PARKINSON DISEASE; SUBSTANTIA NIGRA; THIOREDOXINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84940661442     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.06.041     Document Type: Article

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