Different enzymatic activities recruitment by specific domains of TIF2 are involved in NF-κB transactivation;La actividad transcriptional de NF-κB es diferencialmente regulada por dominios especificos del coactivador TIF2

Medicina

Volumn 64, Issue 2, 2004, Pages 135-138

  Nojek, Ignacio M ^a   Werbajh, Santiago E ^b   Colo, Georgina P ^a   Rubio, Fernanda M ^a   Franco, Lorena D ^b   Nahmod, Victor E ^a   Costas, Monica A ^a  

^a INSTITUTO DE INVESTIGACIONES MÉDICAS ALFREDO LANARI   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

MAPK; NF B; Nuclear receptor coactivators; TIF2

Indexed keywords

CELL PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR RECEPTOR COACTIVATOR 2; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE P38; NCOA2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; DOSE RESPONSE; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; CELL NUCLEUS; CYTOPLASM; DRUG ANTAGONISM; ENZYME ACTIVATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

CELL NUCLEUS; CYTOPLASM; ENZYME ACTIVATION; HUMANS; NF-KAPPA B; NUCLEAR RECEPTOR COACTIVATOR 2; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 4444256335     PISSN: 00257680     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Matthews JR, Hay RT. Regulation of the DNA binding activity of NF-kappa B. Int J Biochem Cell Biol 1995; 27: 865-79.
2. Finco TS, Baldwin AS. Mechanistic aspects of NF-kappa B regulation: the emerging role of phosphorylation and proteolysis. Immunity 1995; 3: 263-72.
3. Kopp EB, Ghosh S. NF-kappa B and Rel proteins in innate immunity. Adv Immunol 1995; 58: 1-27.
4. Carter AB, Knudtson KL, Monick MM, Hunninghake GW. The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP). J Biol Chem 1999; 274: 30858-63.
5. Rosenfeld MG, Glass CK. Coregulator codes of transcriptional regulation by nuclear receptors. J Biol Chem 2001; 276: 36865-8.
6. Xu J, O'Malley BW. Molecular mechanisms and cellular biology of the steroid receptor coactivator (SRC) family in steroid receptor function. Rev Endocr Metab Disord 2002; 3: 185-92.
7. Lee SK, Kim HJ, Na SY, Kim TS, Choi HS, Im SY, Lee JW. Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits. J Biol Chem 1998; 273: 16651-4.
8. Na SY, Lee SK, Han SJ, Choi HS, Im SY, Lee JW. Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactiva-tions. J Biol Chem 1998; 273: 10831-4.
9. Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK, Rosenfeld MG. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 1997; 387: 677-84.
10. Werbajh S, Nojek I, Lanz R, Costas MA. RAC-3 is a NF-kappa B coactivator. FEBS Lett 2000; 485: 195-9.
11. Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 1996; 15: 3667-75.
12. Picard F, Gehin M, Annicotte J, et al. SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell 2002; 111: 931-41.
13. Goodman RH, Smolik S. CBP/p300 in cell growth, transformation, and development. Genes Dev 2000; 14: 1553-77.