Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation

Journal of Neuroinflammation

Volumn 13, Issue 1, 2016, Pages

  Rocha, Sandra M ^a   Saraiva, Tatiana ^a   Cristóvão, Ana C ^a   Ferreira, Raquel ^a   Santos, Tiago ^a   Esteves, Marta ^a   Saraiva, Cláudia ^a   Je, Goun ^b   Cortes, Luísa ^c   Valero, Jorge ^c   Alves, Gilberto ^a   Klibanov, Alexander ^d   Kim, Yoon Seong ^b   Bernardino, Liliana ^a,e  

^a UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^b UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF VIRGINIA   (United States)

^e UNIVERSITY OF BEIRA INTERIOR   (Portugal)

Author keywords

Dopaminergic neurons; Histamine; Microglia; NADPH oxidase; Neurotoxicity; Phagocytosis

Indexed keywords

HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H4 RECEPTOR; LIPOSOME; PHOSPHATIDYLSERINE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; TYROSINE 3 MONOOXYGENASE; CD11B ANTIGEN; HISTAMINE AGONIST; HISTAMINERGIC RECEPTOR AFFECTING AGENT; LIPOCORTIN 5; OXIDOREDUCTASE;

ACTIN FILAMENT; ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL SURVIVAL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MICROGLIA; MOLECULAR DYNAMICS; MOUSE; NERVE CELL NECROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROMODULATION; NEURONAL SURVIVAL; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; POLYMERIZATION; SUBSTANTIA NIGRA; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; CYTOLOGY; CYTOSKELETON; DOPAMINERGIC NERVE CELL; DRUG EFFECTS; GENETICS; METABOLISM; NEWBORN; PATHOLOGY;

ANIMALS; ANIMALS, NEWBORN; ANNEXIN A5; ANTIGENS, CD11B; BRAIN; CELLS, CULTURED; CYTOSKELETON; DOPAMINERGIC NEURONS; HISTAMINE; HISTAMINE AGENTS; HISTAMINE AGONISTS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NADH, NADPH OXIDOREDUCTASES; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES; RECEPTORS, HISTAMINE H1; TYROSINE 3-MONOOXYGENASE;

EID: 84973169252     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0600-0     Document Type: Article

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