Microglia of rat ventral midbrain recovers its resting state over time in vitro: Let microglia rest before work

Journal of Neuroscience Research

Volumn 88, Issue 3, 2010, Pages 552-562

  Cristóvão, Ana Clara ^a,b   Saavedra, Ana ^c,d   Fonseca, Carla Pais ^a   Campos, Filipa ^a   Duarte, Emília Pedrosa ^b,e   Baltazar, Graça ^a  

^a UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF BARCELONA   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^e UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Dopaminergic neurotoxicity; Neuroinflammation; Parkinson's disease

Indexed keywords

CD68 ANTIGEN; REACTIVE OXYGEN METABOLITE; ZYMOSAN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; IN VITRO STUDY; MESENCEPHALON; MICROGLIA; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD11B; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CELL COUNT; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MESENCEPHALON; MICROGLIA; PHAGOCYTOSIS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TIME FACTORS; ZYMOSAN;

EID: 73949143395     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22219     Document Type: Article

References (48)

1. Block ML, Hong JS. 2005. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76:77-98.
2. Cho BP, Song DY, Sugama S, Shin DH, Shimizu Y, Kim SS, Kim YS, Joh TH. 2006. Pathological dynamics of activated microglia following medial forebrain bundle transection. Glia 53:92-102.
3. Colton CA, Gilbert DL. 1987. Production of superoxide anions by a CNS macrophage, the microglia. FEBS Lett 223:284-288.
4. Culbert AA, Skaper SD, Howlett DR, Evans NA, Facci L, Soden PE, Seymour ZM, Guillot F, Gaestel M, Richardson JC. 2006. MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease. J Biol Chem 281:23658-23667.
5. Dalmau I, Vela JM, Gonzalez B, Finsen B, Castellano B. 2003. Dynamics of microglia in the developing rat brain. J Comp Neurol 458:144-157.
6. Damoiseaux JG, Dopp EA, Calame W, Chao D, MacPherson GG, Dijkstra CD. 1994. Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. Immunology 83:140-147.
7. de Groot CJ, Hulshof S, Hoozemans JJ, Veerhuis R. 2001. Establishment of microglial cell cultures derived from postmortem human adult brain tissue: immunophenotypical and functional characterization. Microsc Res Techniq 54:34-39.
8. Dissing-Olesen L, Ladeby R, Nielsen HH, Toft-Hansen H, Dalmau I, Finsen B. 2007. Axonal lesion-induced microglial proliferation and microglial cluster formation in the mouse. Neuroscience 149:112-122.
9. Fitch MT, Doller C, Combs CK, Landreth GE, Silver J. 1999. Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci 19:8182-8198.
10. Floden AM, Combs CK. 2007. Microglia repetitively isolated from in vitro mixed glial cultures retain their initial phenotype. J Neurosci Methods 164:218-224.
11. Frank MG, Wieseler-Frank JL, Watkins LR, Maier SF. 2006. Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. J Neurosci Methods 151:121-130.
12. Fujita H, Tanaka J, Toku K, Tateishi N, Suzuki Y, Matsuda S, Sakanaka M, Maeda N. 1996. Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: a morphometrical study. Glia 18:269-281.
13. Gao HM, Jiang J, Wilson B, Zhang W, Hong JS, Liu B. 2002. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem 81:1285-1297.
14. Giulian D. 1987. Ameboid microglia as effectors of inflammation in the central nervous system. J Neurosci Res 18:132-153,155-171.
15. Giulian D, Baker TJ. 1986. Characterization of ameboid microglia isolated from developing mammalian brain. J Neurosci 6:2163-2178.
16. Giulian D, Vaca K, Corpuz M. 1993. Brain glia release factors with opposing actions upon neuronal survival. J Neurosci 13:29-37.
17. Graeber MB, Streit WJ, Kiefer R, Schoen SW, Kreutzberg GW. 1990. New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury. J Neuroimmunol 27:121-132.
18. Guillemin GJ, Brew BJ. 2004. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J Leukoc Biol 75:388-397.
19. Hiura TS, Li N, Kaplan R, Horwitz M, Seagrave JC, Nel AE. 2000. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles. J Immunol 165:2703-2711.
20. Kim WG, Mohney RP, Wilson B, Jeohn GH, Liu B, Hong JS. 2000. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J Neurosci 20:6309-6316.
21. Kreutzberg GW. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
22. Le Cabec V, Cols C, Maridonneau-Parini I. 2000. Nonopsonic phagocytosis of zymosan and Mycobacterium kansasii by CR3 (CD11b/CD18) involves distinct molecular determinants and is or is not coupled with NADPH oxidase activation. Infect Immun 68:4736-4745.
23. Liu B, Wang K, Gao HM, Mandavilli B, Wang JY, Hong JS. 2001. Molecular consequences of activated microglia in the brain: overactivation induces apoptosis. J Neurochem 77:182-189.
24. Majed HH, Chandran S, Niclou SP, Nicholas RS, Wilkins A, Wing MG, Rhodes KE, Spillantini MG, Compston A. 2006. A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. J Neurosci 26:1730-1738.
25. Mayer AM, Hall ML, Lynch SM, Gunasekera SP, Sennett SH, Pomponi SA. 2005. Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines. BMC Pharmacol 5:6.
26. McCarthy KD, de Vellis J. 1980. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85:890-902.
27. McGeer PL, McGeer EG. 2004. Inflammation and the degenerative diseases of aging. Ann N Y Acad Sci 1035:104-116.
28. McGeer PL, Klegeris A, Walker DG, Yasuhara O, McGeer EG. 1994. Pathological proteins in senile plaques. Tohoku J Exp Med 174:269-277.
29. McGeer PL, Yasojima K, McGeer EG. 2001. Inflammation in Parkinson's disease. Adv Neurol 86:83-89.
30. Milner R, Campbell IL. 2002. Cytokines regulate microglial adhesion to laminin and astrocyte extracellular matrix via protein kinase C-dependent activation of the alpha6beta1 integrin. J Neurosci 22:1562-1572.
31. Min KJ, Yang MS, Kim SU, Jou I, Joe EH. 2006. Astrocytes induce hemeoxygenase-1 expression in microglia: a feasible mechanism for preventing excessive brain inflammation. J Neurosci 26:1880-1887.
32. Nagahata H, Higuchi H, Teraoka H, Takahashi K, Kuwabara M, Inanami O. 2004. Decreased apoptosis of beta 2-integrin-deficient bovine neutrophils. Immunol Cell Biol 82:32-37.
33. Park YK, Chung YS, Kim YS, Kwon OY, Joh TH. 2007. Inhibition of gene expression and production of iNOS and TNF-alpha in LPS-stimulated microglia by methanol extract of Phellodendri cortex. Int Immunopharmacol 7:955-962.
34. Perry VH, Gordon S. 1988. Macrophages and microglia in the nervous system. Trends Neurosci 11:273-277.
35. Petrova TV, Hu J, Van Eldik LJ. 2000. Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures. Brain Res 853:74-80.
36. Radkar V, Hardej D, Lau-Cam C, Billack B. 2007. Evaluation of resveratrol and piceatannol cytotoxicity in macrophages, T cells, and skin cells. Arh Hig Rada Toksikol 58:293-304.
37. Rosenstiel P, Lucius R, Deuschl G, Sievers J, Wilms H. 2001. From theory to therapy: implications from an in vitro model of ramified microglia. Microsc Res Techniq 54:18-25.
38. Saura J, Tusell JM, Serratosa J. 2003. High-yield isolation of murine microglia by mild trypsinization. Glia 44:183-189.
39. Shankaran M, Marino ME, Busch R, Keim C, King C, Lee J, Killion S, Awada M, Hellerstein MK. 2007. Measurement of brain microglial proliferation rates in vivo in response to neuroinflammatory stimuli: application to drug discovery. J Neurosci Res 85:2374-2384.
40. Slepko N, Levi G. 1996. Progressive activation of adult microglial cells in vitro. Glia 16:241-246.
41. Stence N, Waite M, Dailey ME. 2001. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33:256-266.
42. Streit WJ, Graeber MB, Kreutzberg GW. 1988. Functional plasticity of microglia: a review. Glia 1:301-307.
43. Sugita Y, Becerra SP, Chader GJ, Schwartz JP. 1997. Pigment epithelium-derived factor (PEDF) has direct effects on the metabolism and proliferation of microglia and indirect effects on astrocytes. J Neurosci Res 49:710-718.
44. Sweitzer SM, Colburn RW, Rutkowski M, DeLeo JA. 1999. Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat. Brain Res 829:209-221.
45. Uryu S, Tokuhiro S, Murasugi T, Oda T. 2002. A novel compound, RS-1178, specifically inhibits neuronal cell death mediated by beta-amyloid-induced macrophage activation in vitro. Brain Res 946:298-306.
46. Wang XJ, Yan ZQ, Lu GQ, Stuart S, Chen SD. 2007. Parkinson disease IgG and C5a-induced synergistic dopaminergic neurotoxicity: role of microglia. Neurochem Int 50:39-50.
47. Young SH, Ye J, Frazer DG, Shi X, Castranova V. 2001. Molecular mechanism of tumor necrosis factor-alpha production in 1→3-beta-glucan (zymosan)-activated macrophages. J Biol Chem 276:20781-20787.
48. Zietlow R, Dunnett SB, Fawcett JW. 1999. The effect of microglia on embryonic dopaminergic neuronal survival in vitro: diffusible signals from neurons and glia change microglia from neurotoxic to neuroprotective. Eur J Neurosci 11:1657-1667.